WO2008041177A2 - Dispositif de distribution et son procédé d'utilisation - Google Patents

Dispositif de distribution et son procédé d'utilisation Download PDF

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Publication number
WO2008041177A2
WO2008041177A2 PCT/IB2007/053993 IB2007053993W WO2008041177A2 WO 2008041177 A2 WO2008041177 A2 WO 2008041177A2 IB 2007053993 W IB2007053993 W IB 2007053993W WO 2008041177 A2 WO2008041177 A2 WO 2008041177A2
Authority
WO
WIPO (PCT)
Prior art keywords
container
supporting body
liquid
eye
dose
Prior art date
Application number
PCT/IB2007/053993
Other languages
English (en)
Other versions
WO2008041177A3 (fr
Inventor
Mikkel Skou
Original Assignee
I-Shine Danmark Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I-Shine Danmark Aps filed Critical I-Shine Danmark Aps
Publication of WO2008041177A2 publication Critical patent/WO2008041177A2/fr
Publication of WO2008041177A3 publication Critical patent/WO2008041177A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye

Definitions

  • the present invention generally relates to dispensing devices for dispensing liquid to an eye. Specifically the present invention relates to a device for dispensing a dose, preferably a single dose, of liquid to an eye.
  • the device is of the kind, which comprises a container for storing the dose of liquid, which container has a discharge opening.
  • the invention also relates to a method of using the device.
  • the apparatus according to the teachings of the present invention is preferably used as an ophthalmic drug delivery device .
  • the device is particular suitable for self-application of medicaments to an eye, e.g. after having been through an operation performed on the eye or in treatment of other illnesses of the eye, e.g. inflammation of the eyes, conjunctivitis, trachoma or the like.
  • the device can be used by any person for applying any kind of liquid to the eye whether or not the liquid is for therapeutic treatment or just for wetting of the eye.
  • the novel and unique whereby this is achieved according to the present invention is the fact that the container is pivotingly connected to a supporting body adapted for abutting an area surrounding a human eye during discharge of the liquid.
  • the supporting body is the body that the person using the device holds while applying the liquid to the eye.
  • the supporting body is preferably shaped so that at least part of it rests against an area at the eyebrow of a person and an upper part of the cheek.
  • the actual size of the supporting body may be varied for devices suitable for adults, adolescents and/or small children.
  • the container is easily pivoted in relation to the supporting body and directed towards the eye.
  • the dose is a single dose.
  • the discharge opening is directed at the eye ball of the human eye.
  • the supporting body abuts the surrounding of the human eye and the discharge opening of the container, once the container is pivoted, points towards the eyeball allowing the liquid to be administered to the eye.
  • the device is configured so that the supporting body defines a periphery, said periphery defining characteristic dimensions allowing said device to abut to an area surrounding a human eye, a raised part of said supporting body being raised relative to said periphery, said container being mounted at said raised part of said supporting body, in an operable state said discharge opening is directed at the eye ball of said human eye when said device abuts said surrounding of said human eye, said container being made at least partly from a flexible material allowing a person to discharge said dose of liquid from said container to said eye.
  • the raised part of the supporting body is raised relative to the part adapted to abut the area surrounding the eye.
  • the raised part may define a part of the supporting body that is smooth.
  • the function of the raised part is at least partly to provide a distance of the discharge opening in the container to the eyeball when the device is positioned at the eye.
  • the size of the raised area may be varied depending of the use of the device, e.g. to adults, small children etc.
  • the raised part can be given any appropriate configuration which provides a suitable distance of the discharge opening of the container to the eye. Accordingly, the longitudinal cross-section of the raised part can be either edged or curved.
  • the container, or reservoir may comprise a realisably attached sealing member for sealing the container after filling the container with the liquid.
  • the sealing member may then be removed just before use.
  • the container may also be sealed in any other manner, e.g. by positioning the container and the discharge opening in contact with a part of the supporting body.
  • the container may also be united with and sealed to the supporting body at the discharge opening. The container may be released from this sealed state or position by e.g. breaking the seal .
  • the discharge opening of the container may be constructed as or with a nozzle.
  • the shape of the discharge opening may be varied depending on the type of application. Various kinds of nozzles are intended within the scope of the present invention.
  • the supporting body may define a surface, at least a part of the surface abutting the area surrounding the human eye.
  • the surface may be constituted by one, two or more parts of the supporting body.
  • the part of the supporting body abutting the area around the eye may be constituted by several parts of the supporting body, e.g. two parts.
  • the part of the supporting body abutting the area around the eye may define a geometry substantially corresponding to the contour of the face around the eye, or at least to the contour of the eye.
  • the supporting body abuts the surroundings of the eye at an area below the eyebrow and at the top of the cheek.
  • the part of the supporting body abutting the surroundings of eye is contemplated to at least to some degree hold the eyelid open while the liquid is being dispensed. It is a natural reflex to try to shut the eyelid when an object is approaching the eye. This is contemplated to at least partly be encountered by the parts of the supporting body abutting the surroundings of eye.
  • the surface may be a smooth surface, or in the alternative include one or more discontinuities.
  • the smooth surface is contemplated to provide a surface, which is comfortable for the person when using the device. At least the skin touching part of the surface may be a smooth surface.
  • the surface may include one or more discontinuities.
  • the discontinuities may be defined on areas that do not come into contact with the skin of the person using the device.
  • the discontinuities may in the alternative be defined on areas that come into contact with the skin to enable a better grip of the skin and keep the correct position of the device during dispensing the liquid to the eye.
  • the supporting body may be constituted by a continuous web or sheet comprising an aperture for receiving the discharge opening of the container. The aperture or opening may be positioned so that when the device is placed in front of the eye of the person using the device, the aperture and the discharge opening of the container is substantially at the centre of the visible part of a normal eye.
  • the supporting body may be constituted by an annular body and at least one arm surrounding, preferably supporting, the container.
  • the supporting body may e.g. be a ring-shaped body.
  • the arm or arms may extend into the space defined by the annular body.
  • the arm or arms may be enlarged surfaces.
  • the supporting body may be constituted by a continuous web or sheet comprising several apertures or openings .
  • the container may be operated from the sealed state to the open state e.g. by pivoting it at a pivot line or point on the supporting body, such that the container remains partly attached to the supporting body, e.g. at the pivot point or pivot line. Pivoting of the container may result in that the sealed connection between the container discharge opening and the supporting body is partly broken, in such a manner that a small part of the connection remains intact, which part may serve as a hinged suspension means for the container on the supporting body.
  • the intact connection part may e.g. serve as a flap hinge.
  • any other appropriate hinged arrangement of the container on the supporting part is intended within the scope of the present invention, including but not limited to e.g. strings connecting the exterior of the container with a part of the supporting body, which string allows the seal between the container discharge opening and the supporting body to be completely broken.
  • the strings provide for suspension of the container on the supporting body in a pivoting manner.
  • the container may be attached to the supporting body in a sealingly and releasable manner.
  • the container may be positioned flush with the supporting body when the container is in a sealed state. Furthermore, the container may be positioned substantially perpendicular to the supporting body when the container is in an operable state.
  • the container may be operable from the storage position, i.e. the flush orientation, to the operable state, i.e. the perpendicular state.
  • the container is not able to be placed in the sealingly storage position after use. The preferred intended use is to supply a single dose of the liquid to the eye and then dispose the device. Therefore, the supporting body and the container may be made from a disposable material.
  • the disposable material may be a plastic material, e.g. low-density polyethylene or polypropylene.
  • the container in the device according to the teachings of the present invention may comprise a single dose being between 0,1 ml to 10 ml. This amount may vary dependent on inter alia the size of the container.
  • the single dose comprised in the interval between 0,1 ml to 10 ml can be such as 0,3 ml to 5 ml, such as 0,5 ml to 2 ml, such as 0,8 ml to 1 ml, such as 0,1 ml to 0,2 ml, such as 0,2 ml to 0,4 ml, such as 0,4 ml to 0,6 ml, such as 0,6 ml to 0,8 ml, such as 0,8 ml to 1 ml, such as 1 to 1,5 ml, such as 1,5 ml to 2 ml, such as 2 ml to 3 ml, such as 3 ml to 4 ml, such as 4 ml to 5 ml. It is an object of the present invention to provide a supporting body further defining two
  • the liquid may comprise water and a medical compound.
  • the water may be purified water, or any other type of water suitable for use in an ophthalmic drug.
  • the liquid could be saline either alone or with another compound.
  • the saline is preferably a physiological saline.
  • the device may define an overall length of less than 10 cm and/or a width of less than 10 cm.
  • the size of the device may be chosen depending of the intended use on adults, children etc.
  • the device may include several parts of the supporting body adapted to abut the human eye, where a set of the parts is adapted to one eye size, and another set is adapted to another eye size.
  • the sets may include common parts of the supporting body.
  • the supporting body may be rigid, e.g. solid.
  • the rigid body is contemplated to be stable and allow the intended use of the device.
  • the supporting body may be provided with a shape- memory, allowing it to be forcibly shaped and automatically revert to the original shape when relaxed.
  • the opposing ends of the supporting body may be brought closer to each other by pressing on the ends of the supporting body, which subsequently may be arranged to abut the surroundings of the eye.
  • the supporting body Upon relaxation of the pressure force the supporting body automatically resumes its shape, the skin of the eyelid is stretched and the eye is in a very simple manner kept open during discharge of the liquid from the container.
  • the supporting body may alternatively be designed with a cavity, perforations or through-holes. These features either reduces the overall weight of the supporting body without compromising rigidity and/or allows the person to look through the device during application of the liquid. Also the supporting body can be made of a transparent material.
  • the convex supporting body may be coated with a soft material.
  • the coating is contemplated to make the device more comfortable for the user of the device.
  • the container may be flexible so that the dose, preferably the single dose, of liquid may be dispensed by squeezing the container.
  • the container may define an oblong structure having a pointed end, e.g. a pipette or flexible ampule having a dispensing part.
  • the liquid stored in the container may be dispensed by pressing or squeezing the container.
  • liquid is simply applied as one or more drops which is spread over the eyeball after blinking the eyelid.
  • liquid is a medical compound which shall be administered in an accurate dose.
  • the container is provided with means for spreading the liquid on the eyeball.
  • the means for spreading the liquid on the eyeball is a nozzle comprising at least one discharge channel.
  • the container may be provided with an alternative means for spreading the liquid on the eyeball which means may be a membrane having a weakening zone, which membrane defines a liquid chamber inside the container in a sealed state of the container.
  • the weakening zone will burst and the liquid force its way out of the chamber in spread condition.
  • the means for spreading the liquid on the eyeball is a closed membrane, such as a balloon or blister, of a material which can be ruptured in response to application of external pressure on the container.
  • Pressurisation furthermore provides the possibility of selectively producing a container having individual spreading degree and discharge speed.
  • the invention also relates to a method of using the device described above.
  • the method may advantageously comprise the steps of providing the device, pivoting the container from a sealed state to an operable state, arranging the device to abut the area surrounding the eye, and discharging the liquid.
  • Fig. 1 is a schematic side view of an embodiment of the device according to the present invention
  • fig. 2 is a schematic end view of the embodiment shown in fig. 1,
  • fig. 3 is a schematic top view of the embodiment shown in figs. 1 and 2,
  • fig. 4 is a schematic longitudinal sectional view taken along line A-A in fig. 3, illustrating the container containing a liquid drug
  • fig. 5 is a schematic perspective view of the embodiment shown in figs. 1, 2, 3 and 4,
  • fig. 6 shows in an enlarged scale a perspective view corresponding to fig. 5, in which the container is in the sealed state
  • fig. 7 shows the same but with the container in a operable, released pivoted state prior to dispensing
  • fig. 8 shows the embodiment shown in fig. 6 with the pivoted container arranged in front of an eye
  • fig. 9 shows a perspective view of an embodiment of a first container for use in the device according to the present invention.
  • fig. 10a shows a longitudinal sectional view of a second embodiment for a container suitable for use in the present device
  • fig. 10b shows a longitudinal sectional view of a third embodiment for a container suitable for use in the present device
  • fig. 10c shows a longitudinal sectional view of a fourth embodiment for a container suitable for use in the present device.
  • fig. 11 illustrates schematically a side view of a second embodiment of a device according to the present invention.
  • the curvature of the supporting body may vary and be used with containers of different configuration.
  • the container is illustrated as having a lengthwise asymmetrical design.
  • the skilled person will appreciate that other designs, including lengthwise symmetrical and spherical designs may also be suitable.
  • the opposing walls of the container may both be flexible or only one of the walls or part of the walls may be flexible.
  • the device 10 is used to deliver a dose of liquid to a human eye.
  • the liquid preferably comprises a medical compound.
  • the device 10 comprises a supporting body 12 whereto a container 14 is mounted.
  • the container 14 is positioned flush with the supporting body 12.
  • the container is made from a flexible material, so that a person using the device 10 is able to deliver the dose of liquid to the eye by pressing or squeezing the container 14.
  • the container 14 is illustrated being positioned in a storage state.
  • the container 14 is connected or mounted to the supporting body 12 in a sealed manner.
  • the container 14 is connected or mounted to the supporting body 12 in an at least partly releasable manner.
  • the container defines a longitudinal axis.
  • the supporting body 12 defines a lengthways direction along the line 16. In the storage state, the longitudinal axis of the container 14 is orientated substantially parallel to this line 16.
  • the person using the device wishes to deliver the dose of liquid to the eye
  • the person operates the device by moving, twisting or turning the container 14 in the direction indicated by the arrow 18. This exposes a discharge opening 20 of the container 14.
  • the person presses or squeezes the container 14 in order to deliver the liquid to the eye.
  • the supporting body 12 defines a raised portion 22 being raised relative to the portions denoted 24 and 26 of the supporting body 12. This is to achieve that the discharge opening of the container 14 is maintained at a distance relative to the eye of the person using the device 10.
  • the portions 24 and 26 abut the areas surrounding the eye of the person using the device.
  • the portions 24 and 26 are contemplated to abut the areas just below the eyebrow of a person and on the upper part of the cheek of the person. This is also contemplated to allow the device to assist in keeping the eyelids open during the application of the liquid to the eye, as it is a natural reflex of most people to try to close the eyelids when an object is nearing the eye.
  • Fig. 2 is a schematic end view of the device 10 of Fig. 1. In fig. 2 it is illustrated how the container 14 is positioned in a space or aperture 17 defined between two substantially parallel arms 28 and 30 extending from the body 12.
  • Fig. 3 is a schematic top view of the device 10. From fig. 3 it is seen that the device 10 may have a rounded tip part 32. The overall geometry of the device 10 may be another than shown in the figures.
  • Fig. 4 is a schematic longitudinal sectional view of the device 10 along the line A-A of Fig. 3.
  • a chamber 34 is formed in the container 14.
  • the liquid 35 to be stored and later discharged is stored in this chamber 34.
  • the supporting body 12 is in this embodiment solid.
  • the supporting body 12 may, in other embodiments, include apertures or openings (not shown) to lower the weight of the device, as well as provide a more aesthetically pleasing design .
  • the container is attached to the supporting body 12 at the raised portion 22 and the container is constituted by a small chamber 34 having a flexible wall 11 which the person using the device 10 may press to discharge the liquid 35.
  • Fig. 5 and 6 are substantially similar to each other. However, fig. 6 shows more clearly in an enlarged scale the various components and features of the device 10, in particular the sealing between the drug-prefilled container 14 and the supporting body 12.
  • the hollow container 14 is designed as an eye dropper or pipette 12 consisting of a chamber part 36 merging into a tapered dispenser part 37 through which a medicament 35 can be discharged or expelled when pressure is applied to opposing exterior faces 36a, 36b of the chamber part 36, e.g. by means of the index finger and thumb (not shown) , as will be described in more detail in relation to fig. 8.
  • the discharge opening 20 of the dispenser part 37 is sealingly joined to the supporting body 12 at a rupture zone 38, which rupture zone 38 also serves for sealing the discharge opening 20, to prevent leakage of liquid 35 from the chamber 34 during storage.
  • the container 14 is twisted by pivoting the container 14 about the pivot line P in the direction 18, as also indicated in fig. 1.
  • the device 10 reaches the operable state, i.e. the dispensing state where the container 14 is situated angularly to the supporting body
  • the rupture zone 38 ruptures and exposes the discharge opening 20, thereby making the container 14 ready for dispensing or applying the medicament 35 contained in the chamber part 36 to an eye.
  • the rupture zone 38 can be provided with various sophisticated features and alternative designs.
  • the rupture zone 38 may for example be substituted by a plug consisting of two mutually hinge-connected parts.
  • the first part extends between the opposing arms 28,30 of the supporting body 12 and is designed to fit sealingly into the neck of the dispensing part 37.
  • the second part is attached to the dispenser part 37 allowing the container to be pivoted on the first part.
  • a practical use of the device 10 is illustrated in fig. 8.
  • the device 10 is arranged in the operable dispensing state in front of the eye 39 with the discharge opening 20 of the dispenser part 37 pointing towards the eye.
  • the portion 24 of the supporting body 12 is placed on the area surrounding the eye just below the eyebrow 40, to completely or partly prevent the eyelid 41 from excessive blinking during dispensing. This can for example be done by approaching the portion 24 towards the relevant area and pull the skin above the eyelid 41 in the direction of the eyebrow 40 to keep the skin of the eyelid stretched.
  • the portion 26 rests on top of the cheekbone 42, i.e. just below the eye 39.
  • the chamber part 36 is then squeezed to discharge and expel the content of the chamber 34, i.e. the liquid, from the container directly onto the eyeball, without hurting the eyeball by unintentional contact with the tip of the dispenser part 37. Also direct contact with any infected area is avoided.
  • Fig. 9 shows a perspective view of a first embodiment of a container 12 for use in the device 10 according to the present invention. This embodiment corresponds to the first embodiment 10 described and shown in relation to the figures previously discussed, and for illustrative purposes the container is shown free of the supporting body 12.
  • the tapered dispenser part 37 extends from the chamber part 36. Opposite the dispenser part 37 the chamber part 36 has a charging end 43 for filling of a liquid 35 into the chamber 34. After filling, the chamber 34 is closed using known closing techniques including but not limited to heat sealing.
  • the dispenser part 37 can e.g. be secured to the supporting body during manufacturing the device 10, e.g. by moulding the device as an integrated unit.
  • the container 14 may be provided with various kinds of means for improving spreading of the liquid during discharge.
  • Fig. 10a, 10b and 10c illustrate longitudinal sectional views of various embodiments of such spreading means.
  • fig. 10a illustrates the interior arrangement of the dispensing part 37a of a second embodiment 14a of a container for use in the device 10.
  • the dispensing part 37a has a nozzle shaped as three diverging narrow discharge channels 44a, 44b, 44c thereby facilitating angular spreading of the liquid in response to compression of the chamber 34.
  • the liquid is stored in a closed membrane 45 of a separate material, which ruptures upon application of external pressure.
  • the closed membrane 45 or balloon is arranged inside the chamber 34 and the chamber 34 is subsequently sealed at the charging end 43.
  • the liquid is stored behind a membrane 46 traversing the chamber 34, which membrane 46 has a weakening zone 47.
  • the liquid is filled in the chamber 34 defined by the wall of the chamber part 36 and the membrane 46, and the charging end 43 is subsequently sealed.
  • Fig. 11 shows a second embodiment of a device 10' having a different suspension arrangement.
  • the connection between the container 14 and the supporting body 12 is substantially the same as in the first embodiment of a device 10 with the exception that no hinged connection remains after pivoting. Instead the supporting body 12 is provided about strings 48a, 48b which connect the exterior wall of the container 14 to the opposing arms 28,30, thereby defining a pivot line P'.
  • the device according to the present invention is easy, safe and hygienic to use.
  • the device can e.g. be used on a child suffering from infectious conjunctivitis for applying chloramphenicol without touching the infected areas. Bacterial matter is not transmitted from one application stage to the next application stage, and the device can be disposed immediately. Both features reduce infection risk and mode of transmission. It is presently intended that for self-administration the user friendly device according to the present invention is stacked and sold in sets. The exact content and dose can e.g be printed on the supporting body to improve medical administration safety.
  • the container may also be protected from accidental discharge of the liquid by a cap or the like mounted outside the flexible wall of the container. The cap may then be removed just prior to placing the device in front of the eye.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un dispositif (10) qui sert à distribuer une dose de liquide (35) à un œil (39). Le dispositif (10) comprend un contenant (14) apte à stocker la dose de liquide (35), le contenant (14) ayant une ouverture (20), et le contenant étant connecté de façon pivotante à un corps de support (12) apte à venir en butée contre une zone entourant un œil humain (39). Dans un état d'actionnement, l'ouverture de décharge (20) est dirigée sur le globe oculaire de l'œil humain (39) lorsque le dispositif (10) vient en butée sur la périphérie de l'œil humain (38). Le contenant (14) est fabriqué au moins partiellement à partir d'une matière flexible permettant à une personne de décharger ladite dose de liquide (35) à partir dudit contenant (14) dans ledit œil (38) simplement par pression sur les parois opposées du contenant une fois qu'il est amené à pivoter, de telle sorte que l'ouverture de décharge est tournée vers le globe oculaire.
PCT/IB2007/053993 2006-10-02 2007-10-02 Dispositif de distribution et son procédé d'utilisation WO2008041177A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200601270 2006-10-02
DKPA200601270 2006-10-02

Publications (2)

Publication Number Publication Date
WO2008041177A2 true WO2008041177A2 (fr) 2008-04-10
WO2008041177A3 WO2008041177A3 (fr) 2008-08-21

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105263449A (zh) * 2013-04-03 2016-01-20 布尔斯爱德罗伯公司 稳定性提高的点眼药器和将液体滴加到眼睛表面上的方法
US9763826B2 (en) 2013-01-07 2017-09-19 Clifford Cooper Guide for an eye drop dispenser bottle for the self-administration of eye drops
US10265216B2 (en) 2014-01-31 2019-04-23 Eye-go A/S Device for applying an ophthalmic fluid
US20210161707A1 (en) * 2018-08-10 2021-06-03 Azura Ophthalmics Ltd. Dispenser for precise extraction of a semi-solid product

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4834728A (en) * 1987-12-28 1989-05-30 Mckenna Bill Eye drop dispenser apparatus
US5516008A (en) * 1992-12-17 1996-05-14 Ryder International Corporation Medication dispensing container
US5902292A (en) * 1995-06-07 1999-05-11 Feldman; Edward L. Eye drop applicator
WO2006076922A1 (fr) * 2005-01-20 2006-07-27 I-Shine Danmark Aps Appareil distributeur de liquide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4834728A (en) * 1987-12-28 1989-05-30 Mckenna Bill Eye drop dispenser apparatus
US5516008A (en) * 1992-12-17 1996-05-14 Ryder International Corporation Medication dispensing container
US5902292A (en) * 1995-06-07 1999-05-11 Feldman; Edward L. Eye drop applicator
WO2006076922A1 (fr) * 2005-01-20 2006-07-27 I-Shine Danmark Aps Appareil distributeur de liquide

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9763826B2 (en) 2013-01-07 2017-09-19 Clifford Cooper Guide for an eye drop dispenser bottle for the self-administration of eye drops
CN105263449A (zh) * 2013-04-03 2016-01-20 布尔斯爱德罗伯公司 稳定性提高的点眼药器和将液体滴加到眼睛表面上的方法
EP2981234A4 (fr) * 2013-04-03 2016-04-06 Bullseye Dropper Llc Compte-gouttes oculaire ayant une stabilite amelioree et procede d'administration d'un liquide sur la surface de l' il
US10299959B2 (en) 2013-04-03 2019-05-28 Bullseye Dropper, Llc Eyedropper with improved stability and method of administering a liquid onto the surface of an eye
US10265216B2 (en) 2014-01-31 2019-04-23 Eye-go A/S Device for applying an ophthalmic fluid
US20210161707A1 (en) * 2018-08-10 2021-06-03 Azura Ophthalmics Ltd. Dispenser for precise extraction of a semi-solid product
EP3833631A4 (fr) * 2018-08-10 2022-04-20 Azura Ophthalmics Ltd Distributeur pour l'extraction précise d'un produit semi-solide

Also Published As

Publication number Publication date
WO2008041177A3 (fr) 2008-08-21

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