WO2008038637A1 - Procédé de production d'amines libres - Google Patents

Procédé de production d'amines libres Download PDF

Info

Publication number
WO2008038637A1
WO2008038637A1 PCT/JP2007/068583 JP2007068583W WO2008038637A1 WO 2008038637 A1 WO2008038637 A1 WO 2008038637A1 JP 2007068583 W JP2007068583 W JP 2007068583W WO 2008038637 A1 WO2008038637 A1 WO 2008038637A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid
amine
amino
salt
ethylenediamine
Prior art date
Application number
PCT/JP2007/068583
Other languages
English (en)
Japanese (ja)
Inventor
Akira Nishiyama
Original Assignee
Kaneka Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corporation filed Critical Kaneka Corporation
Priority to JP2008536378A priority Critical patent/JP5254799B2/ja
Publication of WO2008038637A1 publication Critical patent/WO2008038637A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La présente invention concerne un procédé propre, simple et polyvalent destiné à produire une amine libre à partir d'un sel d'amine possédant de 1 à 10 atomes de carbone, qui peut avoir un substituant comprenant un acide, qui ne nécessite pas l'utilisation de l'eau ou de solvant organique et qui est réduit au maximum lors d'opérations compliquées et ne consomme donc pas plus d'énergie que nécessaire. L'invention porte spécifiquement sur un procédé simple et polyvalent qui comprend les étapes consistant à ajouter un aminoalcool ou une polyamine à un sel d'amine possédant de 1 à 10 atomes de carbone, qui peut avoir un substituant comprenant un acide, et à distiller le mélange, ce qui produit une forme libre d'amine possédant de 1 à 10 atomes de carbone pouvant renfermer le substituant.
PCT/JP2007/068583 2006-09-26 2007-09-25 Procédé de production d'amines libres WO2008038637A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008536378A JP5254799B2 (ja) 2006-09-26 2007-09-25 遊離アミンの製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-261108 2006-09-26
JP2006261108 2006-09-26

Publications (1)

Publication Number Publication Date
WO2008038637A1 true WO2008038637A1 (fr) 2008-04-03

Family

ID=39230073

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/068583 WO2008038637A1 (fr) 2006-09-26 2007-09-25 Procédé de production d'amines libres

Country Status (2)

Country Link
JP (1) JP5254799B2 (fr)
WO (1) WO2008038637A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013058241A1 (fr) * 2011-10-18 2013-04-25 株式会社カネカ Procédé de production de (r)-2-amino-éthylhexanol

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000026381A (ja) * 1998-07-13 2000-01-25 Sumika Chemical Analysis Service Ltd アミノアルコールの単離方法
WO2004089872A1 (fr) * 2003-04-08 2004-10-21 Schwarz Pharma Ag Bases de grande pureté de monoesters de 3,3-diphénylpropylamine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000026381A (ja) * 1998-07-13 2000-01-25 Sumika Chemical Analysis Service Ltd アミノアルコールの単離方法
WO2004089872A1 (fr) * 2003-04-08 2004-10-21 Schwarz Pharma Ag Bases de grande pureté de monoesters de 3,3-diphénylpropylamine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013058241A1 (fr) * 2011-10-18 2013-04-25 株式会社カネカ Procédé de production de (r)-2-amino-éthylhexanol

Also Published As

Publication number Publication date
JPWO2008038637A1 (ja) 2010-01-28
JP5254799B2 (ja) 2013-08-07

Similar Documents

Publication Publication Date Title
Engl et al. Stereoselective organocatalytic synthesis of oxindoles with adjacent tetrasubstituted stereocenters
JPH051790B2 (fr)
KR102643991B1 (ko) 환형 알킬렌 우레아를 그의 상응하는 알킬렌 아민으로 전환시키기 위한 반응 분리 공정
EP2958903A1 (fr) Procédé de fabrication de vortioxétine
SK18322002A3 (sk) Terapeutický prostriedok proti úzkosti alebo depresii a piperazínové deriváty
WO2007074386B1 (fr) Nouveau procédé de synthèse de l'itopride et nouvel intermédiaire -n-(4-hydroxybenzyl)-3,4-diméthoxybenzamide de celui-ci
FI63931C (fi) Foerfarande foer framstaellning av blodtryckshoejande 1-(3-substituerad-fenyl)-2-aminopropan
WO2008038637A1 (fr) Procédé de production d'amines libres
SK7598A3 (en) Continuous process for the preparation of 4-aminopiperidines
US8030501B2 (en) Process for producing optically active 3-amino nitrogen-containing compounds
Dalmolen et al. The Dutch resolution variant of the classical resolution of racemates by formation of diastereomeric salts: Family behaviour in nucleation inhibition
MXPA05005772A (es) Bromhidrato de escitalopram y un metodo para su preparacion.
JP2011506531A5 (fr)
Schiffers et al. Preparation of Enantiopure 3-Aminopiperidine and 3-Aminoazepane Derivatives from Ornithine and Lysine. Consecutive Syntheses of Pharmacologically Active Analogs, Such as Besifloxacin
Gonzalez-Sabin et al. A biocatalytic approach to synthesizing optically active orthogonally protected trans-cyclopentane-1, 2-diamine derivatives
JP2009023978A (ja) トランス−２−ベンジロキシシクロヘキシルアミンの製造法
US9890099B2 (en) Neutralization of acidic catalysts in the production of phenol
Bertolini et al. Dopamine receptor agonists. I. Synthesis and pharmacological evaluation of 4-aryl-substituted analogues of 6, 7-dihydroxy-2-amino tetralin (6, 7-ADTN) and related indane compounds
González-González et al. A novel and chemoselective process of N-alkylation of aromatic nitrogen compounds using quaternary ammonium salts as starting material
Tsujihara et al. CATALYTIC AND DIASTEREOSELECTIVE CASCADE REACTION FOR THE PREPARATION OF cis-1, 3-DISUBSTITUTED ISOINDOLINE-AMINAL HYBRID COMPOUNDS
JP2011057619A (ja) 光学活性アミン化合物の製造方法、並びに、ジアステレオマー塩及びその製造方法
JP2009040725A (ja) Ｎ，ｎ−ジメチルシクロヘキシルアミンの製造法
US20060014838A1 (en) Process for converting trans-sertraline to cis-sertraline
US20230356182A1 (en) Composition for carbon dioxide separation and method for separating carbon dioxide
Cao et al. Novel Synthetic Approach Toward C‐Substituted Piperazine Derivatives via C‐N Bonds Formation of α‐Bromoarylethanones and Ethanolamine

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07807852

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2008536378

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07807852

Country of ref document: EP

Kind code of ref document: A1