WO2008038311A1 - Mechanical stirrer - Google Patents

Mechanical stirrer Download PDF

Info

Publication number
WO2008038311A1
WO2008038311A1 PCT/IT2006/000688 IT2006000688W WO2008038311A1 WO 2008038311 A1 WO2008038311 A1 WO 2008038311A1 IT 2006000688 W IT2006000688 W IT 2006000688W WO 2008038311 A1 WO2008038311 A1 WO 2008038311A1
Authority
WO
WIPO (PCT)
Prior art keywords
stirrer
housings
plate
base
rotary device
Prior art date
Application number
PCT/IT2006/000688
Other languages
French (fr)
Inventor
Werner Rainer
Paolo Giribona
Daniele Baldassari
Alferino Gabbarrini
Original Assignee
Health Robotics S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Robotics S.R.L. filed Critical Health Robotics S.R.L.
Priority to PCT/IT2006/000688 priority Critical patent/WO2008038311A1/en
Priority to AT06831659T priority patent/ATE485096T1/en
Priority to CA2849554A priority patent/CA2849554C/en
Priority to CA2849553A priority patent/CA2849553C/en
Priority to EP06831659A priority patent/EP2054145B1/en
Priority to DE602006017753T priority patent/DE602006017753D1/en
Priority to AU2006346753A priority patent/AU2006346753A1/en
Priority to PCT/IB2006/003505 priority patent/WO2008012596A2/en
Priority to US12/374,875 priority patent/US8297320B2/en
Priority to JP2009521357A priority patent/JP5038414B2/en
Priority to CA2658803A priority patent/CA2658803C/en
Priority to RU2009106403/15A priority patent/RU2009106403A/en
Priority to KR1020097004076A priority patent/KR20090058510A/en
Publication of WO2008038311A1 publication Critical patent/WO2008038311A1/en
Priority to NO20090900A priority patent/NO20090900L/en
Priority to US13/661,398 priority patent/US8800608B2/en
Priority to US13/661,405 priority patent/US8905086B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/30—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles
    • B01F29/33—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles by imparting a combination of movements to two or more containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/30—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles
    • B01F29/32—Containers specially adapted for coupling to rotating frames or the like; Coupling means therefor
    • B01F29/322—Containers specially adapted for coupling to rotating frames or the like; Coupling means therefor of two or more containers supported for simultaneous mixing, e.g. for bottles in crates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/40—Parts or components, e.g. receptacles, feeding or discharging means
    • B01F29/403—Disposition of the rotor axis
    • B01F29/4033—Disposition of the rotor axis inclined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/40—Parts or components, e.g. receptacles, feeding or discharging means
    • B01F29/403—Disposition of the rotor axis
    • B01F29/4035—Disposition of the rotor axis with a receptacle rotating around two or more axes
    • B01F29/40353—Disposition of the rotor axis with a receptacle rotating around two or more axes being perpendicular axes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/40—Parts or components, e.g. receptacles, feeding or discharging means
    • B01F29/403—Disposition of the rotor axis
    • B01F29/4036—Disposition of the rotor axis with a plurality of rotating receptacles
    • B01F29/40363—Disposition of the rotor axis with a plurality of rotating receptacles having perpendicular axes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/10—Mixers with shaking, oscillating, or vibrating mechanisms with a mixing receptacle rotating alternately in opposite directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2209—Controlling the mixing process as a whole, i.e. involving a complete monitoring and controlling of the mixing process during the whole mixing cycle

Definitions

  • the present invention refers to a mechanical shaker, particularly useful for preparing solutions, even in the presence of toxic substances .
  • agitation plays a particularly important role.
  • agitation allows faster replacement of the solvent, containing a high percentage of the solute, near the latter, and therefore allowing a very low or even nil dissolution rate, with fresh solvent, at a lower or even nil concentration, so as to generate faster dissolution.
  • agitation accelerates the diffusion process, so as to obtain an even concentration of solute in the solvent within a reasonable time .
  • the present invention concerns precisely this last type.
  • these shakers the most common ones are centrifugal shakers. However, they are meant more for the separation of solid substances from liquid ones, than for the mixing of solvents and solutes, being capable of rotating at extremely high speeds and only in one direction.
  • the present invention originates in the fact that over the last few years medical-scientific evidence has been produced proving that hand agitation of vials, bottles or other containers to achieve good dissolution, in the long run causes damage to the operator's arm muscles and joints. Moreover, sometimes, especially in hospitals for the preparation of chemotherapeutic drugs, operations are carried out under highly toxic conditions, which are of course dangerous. Current shakers allow the agitation of containers of a predetermined shape and size only.
  • the present invention concerns a mechanical stirrer consisting of a base body and of a rotary device, characterised in that said rotary device is actuated by a stepping motor and in that said rotary device comprises a series of housings for the containers to be agitated.
  • fig. 1 is a perspective view of a stirrer according to the present invention
  • fig. 2 is a side view of the stirrer according to the present invention
  • fig. 3 is a plan view of the stirrer according to the present invention
  • fig. 4 is an exploded view of the stirrer according to the present invention.
  • the mechanical stirrer according to the present invention essentially comprises a base 1 and a rotary plate 2.
  • Plate 2 comprises one or more housings 3 (four in the drawings) , of a suitable size and shape, to retain the container to be agitated, sitting thereon. It can be provided, for example, to store in housings 3 a series of closed test tubes or bottles (as in fig. 1), lying on their lateral surface.
  • said plate 2 is interchangeable and plates 2 with housings 3 can be provided, having different sizes and shapes, in order to accommodate the most diverse containers.
  • the stirrer according to the present invention becomes extremely versatile.
  • plate 2 is fixed to base 1 through a pin 4, which engages with suitable holes 5 found both in plate 2 and in the upper surface of a rotary disc 6, carried by base 1.
  • base 1 comprises inside a stepping motor, electronic control devices (for example a PCB card) and a series of electric circuits for the power supply of the various components.
  • electronic control devices for example a PCB card
  • housings 3 comprise a series of grooves 7, perpendicular to the housing itself, through which concentric rings 8 run, carried by a fixed plate 9, found on base 1.
  • a plate 2 with housings 3 must be chosen of a size suitable to the containers whose contents are to be mixed.
  • Plate 2 is placed on base 1, taking care that through-holes 5 found on plate 2 match those found on rotary disc 6.
  • Through pin 4, plate 2 is made integral with rotary disc 6.
  • the stepping motor contained in base 1 is started.
  • the stepping motor drives into rotation rotary disc 6 which, through pin 4, drives into rotation also plate 2.
  • the rotation of plate 2 at suitable speed boosts agitation of the liquid contained in the container.
  • the stepping motor generally has a single rotation direction. However, it is also possible to provide the stepping motor with the option of running in alternate directions, thereby substantially boosting agitation, and hence mixing.
  • the concentric rings 8 of fixed plate 9 are sized so as to run over grooves 7. Thereby, the rotation of plate 2 causes the concentric rings to come into contact with the container to be agitated.
  • concentric rings 8 drive the container into rotation about its axis, imparting a two-fold agitation thereto: one according to the rotation of plate 2, the other according to the rolling of the container, activated by concentric rings 8.
  • stirrer according to the present invention allows optimal agitation of liquids in containers of virtually any size and shape, due to the option of interchanging plates 2.
  • the stirrer according to the present invention is fully and automatically managed by a microprocessor provided with nonvolatile internal memory, capable of storing the various working steps. In case of power failure it is thereby possible to resume the cycle precisely from the point it was broken off at .
  • the stirrer according to the present invention ensures maximum safety for the operator, especially in the case of mixing of toxic substances. It can be integrated in stations for the preparation of toxic substances and can operate in a controlled atmosphere .

Abstract

A mechanical stirrer is described, consisting of a base body (1) and of a rotary device (2) . The rotary device is actuated by a stepping motor. The rotary device further comprises a series of housings (3) accommodating the containers to be agitated. Said housings (3) are suitably shaped and sized to accommodate the container to be agitated, resting thereon. Preferably, said plate (2) is interchangeable. Advantageously, the housings (3) comprise a series of grooves (7) through which concentric rings (8) run, carried by a fixed plate (9) found on the base (1) .

Description

"MECHANICAL STIRRER"
* § * § * § *
The present invention refers to a mechanical shaker, particularly useful for preparing solutions, even in the presence of toxic substances .
During the preparation of solutions, agitation plays a particularly important role. As a matter of fact, agitation allows faster replacement of the solvent, containing a high percentage of the solute, near the latter, and therefore allowing a very low or even nil dissolution rate, with fresh solvent, at a lower or even nil concentration, so as to generate faster dissolution. Moreover agitation accelerates the diffusion process, so as to obtain an even concentration of solute in the solvent within a reasonable time .
For these reasons, the problem of agitation has always been deeply felt and various types of shakers have been developed. So magnetic stirrers exist, as well as rod and blade stirrers, and rotary plate shakers .
The present invention concerns precisely this last type. Among these shakers, the most common ones are centrifugal shakers. However, they are meant more for the separation of solid substances from liquid ones, than for the mixing of solvents and solutes, being capable of rotating at extremely high speeds and only in one direction.
The present invention originates in the fact that over the last few years medical-scientific evidence has been produced proving that hand agitation of vials, bottles or other containers to achieve good dissolution, in the long run causes damage to the operator's arm muscles and joints. Moreover, sometimes, especially in hospitals for the preparation of chemotherapeutic drugs, operations are carried out under highly toxic conditions, which are of course dangerous. Current shakers allow the agitation of containers of a predetermined shape and size only.
The above drawbacks are brilliantly solved by the present invention, which concerns a mechanical stirrer consisting of a base body and of a rotary device, characterised in that said rotary device is actuated by a stepping motor and in that said rotary device comprises a series of housings for the containers to be agitated.
The present invention will now be described in greater detail with reference to the accompanying drawings, wherein: fig. 1 is a perspective view of a stirrer according to the present invention; fig. 2 is a side view of the stirrer according to the present invention; fig. 3 is a plan view of the stirrer according to the present invention; and fig. 4 is an exploded view of the stirrer according to the present invention.
The mechanical stirrer according to the present invention essentially comprises a base 1 and a rotary plate 2. Plate 2 comprises one or more housings 3 (four in the drawings) , of a suitable size and shape, to retain the container to be agitated, sitting thereon. It can be provided, for example, to store in housings 3 a series of closed test tubes or bottles (as in fig. 1), lying on their lateral surface.
Preferably, said plate 2 is interchangeable and plates 2 with housings 3 can be provided, having different sizes and shapes, in order to accommodate the most diverse containers. Thereby, the stirrer according to the present invention becomes extremely versatile.
Advantageously, plate 2 is fixed to base 1 through a pin 4, which engages with suitable holes 5 found both in plate 2 and in the upper surface of a rotary disc 6, carried by base 1.
According to the invention, base 1 comprises inside a stepping motor, electronic control devices (for example a PCB card) and a series of electric circuits for the power supply of the various components.
Advantageously, housings 3 comprise a series of grooves 7, perpendicular to the housing itself, through which concentric rings 8 run, carried by a fixed plate 9, found on base 1.
In order to use the stirrer according to the present invention, first a plate 2 with housings 3 must be chosen of a size suitable to the containers whose contents are to be mixed. Plate 2 is placed on base 1, taking care that through-holes 5 found on plate 2 match those found on rotary disc 6. Through pin 4, plate 2 is made integral with rotary disc 6.
Once the container has been placed into its corresponding housing 3, the stepping motor contained in base 1 is started. The stepping motor drives into rotation rotary disc 6 which, through pin 4, drives into rotation also plate 2. The rotation of plate 2 at suitable speed boosts agitation of the liquid contained in the container.
The stepping motor generally has a single rotation direction. However, it is also possible to provide the stepping motor with the option of running in alternate directions, thereby substantially boosting agitation, and hence mixing.
Mixing can be encouraged also by the combination of grooves 7 and of concentric rings 8. As a matter of fact, the concentric rings 8 of fixed plate 9 are sized so as to run over grooves 7. Thereby, the rotation of plate 2 causes the concentric rings to come into contact with the container to be agitated. In the case, such as the one illustrated, wherein the container is a cylinder lying on its lateral surface, concentric rings 8 drive the container into rotation about its axis, imparting a two-fold agitation thereto: one according to the rotation of plate 2, the other according to the rolling of the container, activated by concentric rings 8.
It is apparent that the stirrer according to the present invention allows optimal agitation of liquids in containers of virtually any size and shape, due to the option of interchanging plates 2.
It is possible, owing to the electronic control devices found in base 1, to introduce viewing and control devices of the rotation speed of plate 2, of the mixing time, of the mixing start time and others. In particular, a device which allows to adjust the start time and the mixing time is particularly useful .
Preferably, the stirrer according to the present invention is fully and automatically managed by a microprocessor provided with nonvolatile internal memory, capable of storing the various working steps. In case of power failure it is thereby possible to resume the cycle precisely from the point it was broken off at .
Moreover, the stirrer according to the present invention ensures maximum safety for the operator, especially in the case of mixing of toxic substances. It can be integrated in stations for the preparation of toxic substances and can operate in a controlled atmosphere .
Other changes and variants, within the reach of a person skilled in the field, are in any case possible, without departing from the scope of the present invention.

Claims

1) Mechanical stirrer consisting of a base body (1) and of a rotary device (2) , characterised in that said rotary device is actuated by a stepping motor and in that said rotary device comprises a series of housings (3) for the containers to be agitated.
2) Stirrer as in claim 1), characterised in that said rotary device is a rotary plate (2) .
3) Stirrer as in claim 2), characterised in that said plate (2) is interchangeable .
4) Stirrer as in claim 3), characterised in that the plate (2) is fastened to the base (1) through a pin (4) , which engages with suitable holes (5) found both in the plate (2) an on the upper surface of a rotary disc (6) , carried by the base (1) .
5) Stirrer as in any one of the preceding claims, characterised in that a housing (3) is provided.
6) Stirrer as in any one of claims 1) to 2) , characterised in that multiple housings (3) are found.
7) Stirrer as in claim S) , characterised in that said housings (3) are four, arranged crosswise.
8) Stirrer as in any one of the preceding claims, characterised in that said housings (3) are of a suitable shape and size for accommodating the container to be agitated, resting thereon.
9) Stirrer as in any one of the preceding claims, characterised in that said containers are sealed test tubes or bottles, lying on their lateral surface.
10) Stirrer as in any one of the preceding claims, characterised in that said base comprises, inside, electronic control devices and a series of electric circuits for the power supply of the various components .
11) Stirrer as in claim 10) , characterised in that said electronic control devices consist of a PCB card.
12) Stirrer as in any one of the preceding claims, characterised in that the housings (3) comprise a series of grooves (7) through which concentric rings run (8) , carried by a fixed plate (9) found on the base (1) .
13) Stirrer as in claim 12), characterised in that said grooves (7) are perpendicular to said housings (3) .
14) Stirrer as in any one of the preceding claims, characterised in that the stepping motor has a single rotation direction.
15) Stirrer as in any one of claims 1) to 14) , characterised in that the stepping motor runs in an alternate direction.
16) Stirrer as in any one of the preceding claims, characterised in that it comprises one or more devices displaying and controlling the rotation speed of the plate (2) and/or the mixing duration and/or the mixing starting time .
17) Stirrer as in claim 16) , characterised in that it comprises a device which allows to adjust the mixing start time and duration.
18) Stirrer as in any one of the preceding claims, characterised in that it is fully managed by a microchip equipped with non-volatile internal memory, capable of storing the various working steps.
19) Use of a stirrer as in any one of the preceding claims for the mixing of toxic substances .
20) Use of a stirrer as in any one of claims 1) to 18) in a controlled atmosphere.
PCT/IT2006/000688 2006-07-26 2006-09-27 Mechanical stirrer WO2008038311A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
PCT/IT2006/000688 WO2008038311A1 (en) 2006-09-27 2006-09-27 Mechanical stirrer
PCT/IB2006/003505 WO2008012596A2 (en) 2006-07-26 2006-12-07 Machine for the preparation of pharmaceutical products
US12/374,875 US8297320B2 (en) 2006-07-26 2006-12-07 Machine for the preparation of pharmaceutical products
CA2849553A CA2849553C (en) 2006-07-26 2006-12-07 Machine for the preparation of pharmaceutical products
EP06831659A EP2054145B1 (en) 2006-07-26 2006-12-07 Device for the preparation of pharmaceutical products
DE602006017753T DE602006017753D1 (en) 2006-07-26 2006-12-07 DEVICE FOR PRODUCING PHARMACEUTICAL PRODUCTS
AU2006346753A AU2006346753A1 (en) 2006-07-26 2006-12-07 Machine for the preparation of pharmaceutical products
AT06831659T ATE485096T1 (en) 2006-07-26 2006-12-07 DEVICE FOR PRODUCING PHARMACEUTICAL PRODUCTS
CA2849554A CA2849554C (en) 2006-07-26 2006-12-07 Machine for the preparation of pharmaceutical products
JP2009521357A JP5038414B2 (en) 2006-07-26 2006-12-07 Pharmaceutical preparation equipment
CA2658803A CA2658803C (en) 2006-07-26 2006-12-07 Machine for the preparation of pharmaceutical products
RU2009106403/15A RU2009106403A (en) 2006-07-26 2006-12-07 PLANT FOR PREPARATION OF PHARMACEUTICALS
KR1020097004076A KR20090058510A (en) 2006-07-26 2006-12-07 Machine for the preparation of pharmaceutical products
NO20090900A NO20090900L (en) 2006-07-26 2009-02-26 Machine for manufacturing pharmaceutical products
US13/661,398 US8800608B2 (en) 2006-07-26 2012-10-26 Machine for the preparation of pharmaceutical products
US13/661,405 US8905086B2 (en) 2006-07-26 2012-10-26 Machine for the preparation of pharmaceutical products

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT2006/000688 WO2008038311A1 (en) 2006-09-27 2006-09-27 Mechanical stirrer

Publications (1)

Publication Number Publication Date
WO2008038311A1 true WO2008038311A1 (en) 2008-04-03

Family

ID=38006837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2006/000688 WO2008038311A1 (en) 2006-07-26 2006-09-27 Mechanical stirrer

Country Status (1)

Country Link
WO (1) WO2008038311A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2138223A2 (en) * 2008-06-25 2009-12-30 CS Automazione S.r.l. Storage, mixing, homogenising and dosing group
ITMI20091010A1 (en) * 2009-06-09 2010-12-10 Assoprint S P A IMPROVED STORAGE, MIXING, HOMOGENIZATION AND DOSAGE GROUP
CN102410953A (en) * 2011-11-25 2012-04-11 河南科技大学第一附属医院 Portable blending apparatus
EP2921221A1 (en) * 2014-03-20 2015-09-23 Döbelin, Werner High energy mixer for automatic sample preparation in a serial workflow
CN112191156A (en) * 2020-10-12 2021-01-08 澳优乳业（中国）有限公司 Automatic mixing system based on powder material packaging whole box and control method

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3235173A (en) * 1960-07-28 1966-02-15 Unger Hans Peter Olof Agitating and/or fractioning centrifuge
US3825178A (en) * 1971-12-17 1974-07-23 American Hospital Supply Corp Centrifuge rotor
US4293643A (en) * 1979-01-31 1981-10-06 Ohtake Works Company, Ltd. Rotary shaking culture measuring method and apparatus
GB2081118A (en) * 1980-08-04 1982-02-17 Technicon Instr Non-invasive mixing
EP1393797A2 (en) * 2002-08-29 2004-03-03 Heidolph Instruments GmbH & Co.KG Shaking and mixing apparatus
US20050083781A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Methods and apparatus for mixing of liquids
US20050277538A1 (en) * 2004-06-14 2005-12-15 Michael Sherman Automated device for homogenization and resuspension of substances, disintegration of cells, disruption of tissues and centrifugation of these media
US20060177936A1 (en) * 2005-02-07 2006-08-10 Shneider Alexander M Apparatus and methods for chemical and biochemical sample preparation

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3235173A (en) * 1960-07-28 1966-02-15 Unger Hans Peter Olof Agitating and/or fractioning centrifuge
US3825178A (en) * 1971-12-17 1974-07-23 American Hospital Supply Corp Centrifuge rotor
US4293643A (en) * 1979-01-31 1981-10-06 Ohtake Works Company, Ltd. Rotary shaking culture measuring method and apparatus
GB2081118A (en) * 1980-08-04 1982-02-17 Technicon Instr Non-invasive mixing
EP1393797A2 (en) * 2002-08-29 2004-03-03 Heidolph Instruments GmbH & Co.KG Shaking and mixing apparatus
US20050083781A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Methods and apparatus for mixing of liquids
US20050277538A1 (en) * 2004-06-14 2005-12-15 Michael Sherman Automated device for homogenization and resuspension of substances, disintegration of cells, disruption of tissues and centrifugation of these media
US20060177936A1 (en) * 2005-02-07 2006-08-10 Shneider Alexander M Apparatus and methods for chemical and biochemical sample preparation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2138223A2 (en) * 2008-06-25 2009-12-30 CS Automazione S.r.l. Storage, mixing, homogenising and dosing group
EP2138223A3 (en) * 2008-06-25 2010-03-31 CS Automazione S.r.l. Storage, mixing, homogenising and dosing group
ITMI20091010A1 (en) * 2009-06-09 2010-12-10 Assoprint S P A IMPROVED STORAGE, MIXING, HOMOGENIZATION AND DOSAGE GROUP
CN102410953A (en) * 2011-11-25 2012-04-11 河南科技大学第一附属医院 Portable blending apparatus
EP2921221A1 (en) * 2014-03-20 2015-09-23 Döbelin, Werner High energy mixer for automatic sample preparation in a serial workflow
CN112191156A (en) * 2020-10-12 2021-01-08 澳优乳业（中国）有限公司 Automatic mixing system based on powder material packaging whole box and control method

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