WO2008025524A2

WO2008025524A2 - Aerosol preparation comprising peloides

Info

Publication number: WO2008025524A2
Application number: PCT/EP2007/007536
Authority: WO
Inventors: Stefan Biel; Peter Maurer; Melanie Maurath; Sabine Howe; Thomas NÜBEL; Christopher Mummert
Original assignee: Beiersdorf Ag
Priority date: 2006-08-30
Filing date: 2007-08-29
Publication date: 2008-03-06
Also published as: EP2059217A2; WO2008025524A3; DE102006040535A1; BRPI0716380A2

Abstract

The invention relates to a cosmetic aerosol preparation comprising one or more peloides having an average particle size of at least approximately 0.1 μm. Said peloides are used to reduce the sedimentation speed of the solid matter contained in the aerosol and to reduce losses due to shaking or dispersion prior to using said preparation.

Description

Aerosol preparation comprising peloids

The invention describes cosmetic aerosol formulations comprising one or more peloids having an average particle size of at least about 0.1 μm.

Aerosols have become indispensable because of the simplicity of handling and dosage from industry, craft and household. To be sprayed e.g. Hair and body care products, deodorants, perfumes, odor improvers, disinfectants and pesticides, floor, glass and furniture care products, paints and varnishes, car care products and many others.

Aerosol means colloidal systems of gases (e.g., air) with small solid or liquid particles dispersed therein, the aerosol particles, or the so-called suspended matter. The suspended solids in aerosols have a diameter of about 100 microns to 1 nm. The aerosol is usually only when using a suitable spray system by spraying solutions, emulsions or suspensions self-produced, including, for example, spray cans can be used, in which a liquefied compressed gas serves as a propellant gas. When the pressure valve is opened, the propellant-preparation mixture escapes through a fine nozzle which evaporates propellant and leaves the finely distributed spray material as an aerosol.

Active substances can be present in aerosol formulations both dissolved and in solid form; if they are in solid form, they must, however, be suspended in the propellant system accordingly.

Aerosol products for the regulation of axillary sweat production contain antiperspirant active ingredients usually as solids suspended in an oil phase.

The higher the aerosol concentration and the larger the aerosol particles are, the faster they settle on the ground. This disadvantage due to coagulation and / or sedimentation can be eliminated only by consuming formulation tricks, by centrifuging, ultrasonic action, electrical discharges, filtration and the like.

Aerosol products for the regulation of axillary sweat production contain antiperspirant agents (AT agents) as solids suspended in an oil phase. In order to prevent the AT agent from forming a solid sediment which can not be re-resuspendable by shaking even if the aerosol bottles are stored for a relatively long time, auxiliaries are frequently added to these products. Are used for this purpose often silicates, eg Betonite or aerosils. However, these silicates can sometimes deactivate the active substance by adsorption.

Furthermore, it is known that these adjuvants are often insoluble in water and lead to the skin or clothing to white, unahnsezlichen residues.

It would therefore be desirable to provide an aerosol product which does not have the disadvantages of the prior art described.

It is also important to avoid aerosols containing small, respirable particles. The physiological effect is dependent not only on the material composition but also on the particle size distribution and the dusting behavior of the aerosols. Inhaling the small respirable aerosol particles and resorbing them via the lungs may result in the spread of toxic and pathogenic substances in the body. The critical range is defined as particles having an average particle size of less than 10 μm.

Accordingly, it would also be desirable to provide an aerosol product in which the particles which can be sprayed in the aerosol could be shifted toward larger particle sizes.

The present invention is a cosmetic aerosol preparation comprising one or more peloids.

The peloids have an average particle size of at least about 0.1 μm.

Preferably, the particle size of the peloids is a maximum of about 100 microns, preferably at a maximum of about 30 microns. Especially preferred is to select the peloids having a particle size of at least about 1 μm.

Peloids are organic and / or inorganic substances resulting from geological processes. Peloids are known, inter alia. because of their good thermal properties. In fine-grained form, they are used in medical packs and baths, e.g. Moor, peat, mud, silt, fango, healing earth. In this form, the peloids are applied externally to the skin directly.

An example of peloids according to the invention is the Rügen healing chalk.

For 60 to 70 million years, the Rügen healing chalk lies in the "Rügener Kreidemeer." The chalk was formed from billions of shells and casings of the smallest organisms, such as coccolithophores, foraminifera and mossy animals. For about 100 years, the order of the Rügen healing chalk, directly on the skin as a pack or in the bathroom, has been increasingly successful in positively influencing different clinical pictures.

Rügen healing chalk is a pure natural product. It is particularly characterized by its aesthetic, snow-white color, the fine-grained structure and the good storage capacity of heat or cold. The Rügen healing chalk consists of about 98% calcium carbonate. As minor constituents are magnesium carbonate, silicon, iron and aluminum compounds and compounds containing minerals and trace elements (phosphorus, sulfur, etc.). The density of Rügen healing chalk is about 2.7 g / cm ³ .

It is advantageous that the dusting behavior of the healing chalk is very low and the use in cosmetic preparations is thus possible.

Further peloids are known and, according to the invention, are among the preferred peloids to be selected:

Rügen healing chalk, dolomite, talc, magnesite, serpentine, calcium salts, preferably calcium carbonate, magnesium salts, silicic acid, iron and aluminum oxides and their compounds, clays and / or silicates.

The proportion of peloids in the preparation is preferably 15 to 80% by weight, based on the total mass of the active ingredient solution. As a drug solution here is the combination of all ingredients, with the exception of the propellant to understand.

The aerosols according to the invention comprise cosmetic preparations of a colloidal system of gases with small solid, gaseous or liquid particles dispersed therein, the aerosol particles or so-called suspended matter. The aerosol particles have a particle size of about 100 microns to 1 nm in diameter.

As with other colloidal systems, dispersion and condensation methods can also be used in the production of aerosols. Thus aerosols are obtained, for example, by mechanical atomization of fine powders, by condensation of vapors when cooled below the dew point or freezing point, by combustion processes or spraying solutions, brines, emulsions or suspensions, the solvent or dispersion medium evaporating immediately. In the latter case, one usually uses so-called spray cans, compressed gas cans, sprays, in which a liquefied compressed gas serves as a propellant. When you press the valve button escapes the propellant-drug mixture through a nozzle out of the can; The propellant immediately evaporates and atomizes the active ingredient in the air, which then creates an aerosol.

Known AT or deodorant aerosols and their constituents are listed in the following table:

Drug solution of an aerosol 1 2 3 ^; 4

Octyldodecanol 0.9 0.8 0.8; o.9

Tocopheryl Acetate 0.0 0.1 0.0 0.3

Dimethicone 3.2 3.0 3.0 3.0

Persea Gratissima 0.9 0.8 0.8 ^■ 0.8

Disteardimonium hectorite 0,0 0,0 3,0, 2,0

Calcium carbonates 3.7 8.0 0.0 2.0

Perfume 3.0 5.0 4.0 5.0

Cyclomethicones 51, 4 52.3 56.450.0

Aluminum Chlorohydrate 37.0 30.0 32.0, 36.0

100.0 100.0 100.0 ^■ 100.0

The data are in% by weight of the active substance solution, which is mixed with propellant gas, e.g. Propane / butane can be bottled with 5 to 40% to the finished aerosol.

Surprisingly, the aerosol particles contained in the aerosols can be kept in a loose, easily aufschüttelbaren state by the addition of peloids having a particle size of at least 0.1 microns, without causing irreversible sedimentation. Aerosol-containing agents, such as AT agents or perfume oils, are not inactivated or altered by the peloids. The peloids can therefore be combined according to the invention with active ingredients.

In addition, due to the water solubility of the peloids, the whitening effect is reduced after application to the skin or clothing.

AT aerosols often contain aluminum chlorohydrate (ACH) as an AT agent. Surprisingly, the addition of peloids to aerosols comprising ACH reduces the skin irritation effect of aluminum chlorohydrates.

The aerosol particles of the cosmetic aerosol preparation may preferably be suspended Be solids, gases and / or liquids. As aerosol particles are preferably oils, solids or gas bubbles. As suspended solids, these are preferably antiperspirant active ingredients and / or deodorant active ingredients such as ACH, activated aluminum chlorohydrates (AACH), ADCH, ZnO and / or chitosan. Preferably, the aerosol particles are oil and ACH.

Preference is also beyond the use of so-called. Activated Aluminiumchlorohydraten. The following list of advantageous antiperspirant active agents should in no way be limiting:

Aluminum salts of empirical empirical formula [Al ₂ (OH) _m Cl _n ] (at m + n = 6):

- Aluminum Chloroydrat [Al ₂ (OH) ₅ Cl] x H ₂ O.

Standard aluminum complexes: Locron L, Locron LIC, Locron LIF (Clariant), Chlorhydrol (Reheis), ACH-303 (Summit), Aloxicoll L (Giulini).

Activated aluminum complexes: Reach 501 (Reheis), Aloxicoll 51 L

- Aluminum Sesquichlorohydrat [Al ₂ (OH) _41S _1S Ch] x H ₂ O

Standard Aluminum Complexes: Aloxicoll 31 L (Giulini), Westchlor 186 (Westwood Chemicals)

Activated Aluminum Complexes: Reach 301 (Reheis)

Aluminum dichlorohydrate [Al ₂ (OH) ₄ Cl ₂ ] x H ₂ O

The antiperspirant active ingredients are used in the formulations according to the invention in an amount of from 1 to 50% by weight, preferably from 10 to 35% by weight, in particular from 20 to 30% by weight, based in each case on the total mass of the active ingredient solution.

Particularly advantageous is the combination of cosmetic preparations with ACH, preferably in the range of 20 to 35 wt.%, Based on the total mass of the drug solution.

Advantageously, aerosol preparations according to the invention may also be added with deodorants. The usual cosmetic deodorants are based on different active principles. By using antimicrobial substances in cosmetic deodorants, the bacterial flora on the skin can be reduced. Ideally, only the odor causing microorganisms should be effectively reduced. The sweat flow itself is not influenced by this, ideally only the microbial decomposition of the sweat temporarily stopped. The combination of astringents with antimicrobial substances in the same composition is also common.

All active substances commonly used for deodorants can be used to advantage, for example odor maskers such as the common perfume ingredients, odor absorbers, for example the layer silicates described in DE 40 09 347, of these in particular montmorillonite, kaolinite, mit, beidellite, nontronite, saponite, hectorite, bentonite, smectite , Further, for example, zinc salts of ricinoleic acid. Germ-inhibiting agents are also suitable for incorporation into the preparations according to the invention. Advantageous substances are, for example, 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Irgasan), 1, 6-di- (4-chlorophenylbiguanido) hexane (chlorhexidine), 3,4,4'-trichlorocarbanilide, quaternary ammonium compounds , Clove oil, mint oil, thyme oil, triethyl citrate, farnesol (3,7,11-trimethyl-2,6,10-dodecatrien-1-ol) and in DE 37 40 186, DE 39 38 140, DE 42 04 321, DE 42 29 707, DE 42 29 737, DE 42 37 081, DE 43 09 372, DE 43 24 219 described effective agents. Also, sodium bicarbonate is advantageous to use.

Chitosan is described as a potent Deowirker because of its anti-adhesive effect. Since chitosan can not be dissolved in alcohol, but for the deodorant action must be present in the dissolved state, it has not been possible to formulate alcoholic deodorant aerosols without the addition of water and / or emulsifiers with chitosan as the main Deowirker.

Chitosan can now be used as Deowirkstoff preferred. The chitosan or the chitosan derivatives have been advantageously prepared of maritime origin or enzymatically via genetically modified microorganisms, wherein the chitosans or chitosan derivatives may be protonated, partially protonated or unprotonated. Among chitosan derivatives, the protonated, partially protonated and unprotonated forms of chitosans are hereby subsumed.

It has now been found that the peloids form agglomerates due to their surface properties associated with the aerosol particles. This shifts the particle size of the aerosol particles, such as ACH, chitosan and / or oil, to larger particle diameters (see Figure 1).

This effect is advantageous for the use of otherwise small and partially respirable aerosol particles. As illustrated in Figure 1, the aerosol particles, eg solid particles ACH, form in

Presence of peloids larger agglomerates, which are significantly larger than the solid particles alone. The peloids can themselves also form agglomerates. The on this

Areas of agglomeration formed particles are larger than the original

Aerosol particles and / or peloid particles.

The particle size of the aerosol particles and / or peloid particles is towards larger ones

Particle diameters have been moved. As a result, the particles are less inhalable and thus minimize the risk for the user, as Figure 2 illustrates.

It is particularly surprising that according to the invention it is possible to use peloids which themselves have a particle size in the critical range of 1 to 2 μm.

In the described use in aerosol, the peloids agglomerate into particles that are many times larger and thus fall outside the critical range.

Aerosol formulations according to the invention show larger and thus no or less respirable particles in the spray pattern than the same preparations without the addition of peloids according to the invention.

An aerosol preparation according to the invention therefore preferably comprises aerosol particles which may well have a particle size in the critical range, that is to say have a particle size of less than 10 μm. Due to the addition of peloids, the particle size of the forming agglomerates (aerosol particle peloid particles) is shifted out of the critical range due to the described agglomeration and the aerosol can be used safely, even though the aerosol particles per se have a critical size.

It is also surprising that the preparations according to the invention can be used to reduce the whiteness and / or the discoloration of textiles which come into contact with the preparation. That the addition of peliodes in the particle size range according to the invention leads to a reduced whiteness of antiperspirant aerosols.

In addition to these described advantages, the reduced sedimentation tendency of the aerosol particles by the addition of peloids according to the invention in the aerosol products according to the invention should also be mentioned above all.

The use of peloids, preferably Rügen healing chalk with a particle size between 0.1 and 100 .mu.m, more preferably between 1 and 30 .mu.m, in combination with ACH for reducing the sedimentation rate of the solids contained in the aerosol and / or to reduce the shaking or dispersing effort before the application of the preparation is thus also predestined.

The peloids lead to a reduction in the sedimentation rate of the solids contained in the aerosol and to reduce the shaking or dispersing effort before the application of the aerosol preparation.

Some aerosol formulations according to the invention are shown below. The data relate to parts by weight based on the drug solution.

Totals: 100 100 100 100

These drug solutions can be filled in bottling ratios of 60% active ingredient solution to 40% propellant gas to 4% active ingredient solution to 96% propellant gas. According to the invention, all known propellant gases can be used. Preferably, the propellant gas is a mixture of hydrocarbons such as propane, butane, isobutane, or their homologs.

Claims

claims

Cosmetic aerosol preparation comprising one or more peloids, characterized in that the peloids have an average particle size of at least about 0.1 microns.

2. Cosmetic aerosol preparation according to claim 1, characterized in that the peloids have a particle size of at most about 100 microns, in particular at most 30 microns.

Cosmetic aerosol preparation according to claim 1 or 2, characterized in that the aerosol particles are suspended solids and / or liquids.

4. Cosmetic aerosol preparation according to claim 3, characterized in that as aerosol particles solids are contained, which are selected from the group of antiperspirant active ingredients and / or deodorant active ingredients.

5. Cosmetic aerosol preparation according to one of the preceding claims, characterized in that as peloids one or more substances are selected from the group Rügen healing chalk, dolomite, talc, magnesite, serpentine, calcium salts and / or magnesium salts, preferably calcium carbonate and / or Rügen healing chalk.

6. Use of peloids, preferably Rügen healing chalk, having a particle size between 0.1 and 100 .mu.m, more preferably between 1 and 30 .mu.m, in aerosols for reducing the sedimentation velocity of the aerosol particles contained in the aerosol.

7. Use of peloids, preferably Rügen healing chalk, with a particle size between 0.1 and 100 .mu.m, more preferably between 1 and 30 .mu.m, in cosmetic aerosols to reduce the shaking or Dispersierenaufwandes before the application of the aerosol.