DE102017200321A1 - Preparations with particulate Polyquaternium-6 polymers - Google Patents

Abstract

A preparation with particulate polyquaternium polymers can be sprayed in an oil-based aerosol and exhibits antimicrobial activity.

Description

The invention is an antimicrobially active, anhydrous preparation with particulate polyquaternium polymers, in particular polyquaternium-6 polymers, and preferably in the form of aerosol preparations.

Polyquaternium polymers are INCI nomenclature designations for complex quaternary ammonium polymer compounds. The various representatives of this group are distinguished by numbers. For example, polyquaternium-1, polyquaternium-16 (PQ-16), polyquaternium-42, etc. As quaternary ammonium compounds, polyquaternium polymers have quaternary nitrogen atoms, i. all four hydrogen atoms of the ammonium ion are replaced by organic radicals. The compounds are thus cationic, so they have a positive charge.

In the WO 2013052454 A1 is an overview of known polyquaternium polymers and their trade names listed.

Representatives of this group named after INCI are u. a. because of their film-forming and antistatic properties in many personal care products, e.g. In shampoos.

Thus, as a polyquaternium polymer, i.a. the Merquat ™ 550 polymer known, INCI name: Polyquaternium-7.

Polyquaternium-6 polymer (PQ-6) is a polymeric, quaternary ammonium salt formed from the homopolymerization of the diallyldimethylammonium chloride (DADMAC) monomer.

Mirapol 100 is known as the PQ-6 polymer.

In the WO 2009091794 A1 describes preparations comprising in addition to antiperspirant active agents cationic polyquaternium polymers, PQ-6, PQ-7, PQ-10, PQ-11, PQ-22 and in particular PQ-28.

In the EP 1761241 A1 describes antiperspirant active substances based on diallyldimethylammonium chlorides (DADMAC) and diallylethylammonium chlorides (DADEAC), in particular PQ-6 (Merquat® 100, Flocare® C106, Floquat FL45®), Polyquaternium-33 (Floerger FO 4190 VHM®, 4550 BPM®) Polyquaternium-5 (Merquat 5®, Reten®) and Polyquaternium-7 (Merquat 550 L®, Salcare Super 7®, Flocare C107®).

The prior art describes cosmetic preparations, for example as deodorants or antiperspirants, which comprise one or more polyquaternium polymers. The polyquaternium polymers are present here primarily in dissolved form. However, the use of dissolved polyquaternium polymers in aerosol formulations is problematic. It is therefore desirable to have available particulate PQ compounds and to be able to use them in oil-based aerosol formulations.

Polyquaternium polymers are water-soluble, hygroscopic. Consequently, the presence of water on the one hand is problematic, since particles can not be represented as such and on the other hand, the introduction into a lipophilic environment fails.

It is also desirable to provide cosmetic raw materials, such as polyquaternium polymers, anhydrous, particulate and therefore free-flowing to ensure a simple and manageable preparation of cosmetic or dermatological preparations.

In order to also produce nourishing oil-based deodorants, particles of the polymers are required because, for example, the aqueous PQ-6 raw materials, such as Merquat® 100, a 40% aqueous solution, can not be mixed with an oil base.

It is therefore desirable to use polyquaternium polymers in particular in oil-based aerosol formulations.

Furthermore, the demand for nourishing aerosol-based deodorants that do not comprise aluminum chlorohydrates as antiperspirant actives is high.

The deodorizing performance of aerosol preparations should also be improved.

The invention is a preparation comprising one or more particulate polyquaternium polymers, in particular polyquaternium-6 polymers.

Preference is given to cosmetic or dermatological preparations in aerosol form.

According to the invention, particulate polyquaternium polymers are preferably selected from the group of polyquaternium polymers. The particulate polyquaternium polymers, in particular the PQ-6 polymers, are present in preparations according to the invention in a proportion of 0.1 to 10% by weight, in particular in a proportion of 0.15 to 5% by weight, based on the total mass of the active substance solution, contain. With respect to the mass of the total preparation of an aerosol, including the propellant gas, the proportion of PQ polymers is preferably in the range of 0.005 to 0.1% by weight, in particular in the range of 0.01 to 0.06% by weight.

The particle size of the polyquaternium polymer particles, in particular PQ-6 particles, is selected in the range of 10 to 2000 .mu.m, preferably in the range of 30 and more, in particular up to a particle size of 1000 .mu.m.

These particle sizes according to the invention have the advantage of being usable without problems.

The polyquaternium polymer particles of the invention can be prepared anhydrous and free-flowing, as exemplified below. Particles having a defined particle size distribution are provided which ensure a simple and manageable production of cosmetic or dermatological preparations.

The production of anhydrous particles by simple spray drying does not succeed with Polyquaternium polymers.

The definition of the terms particle, particle, particle size distribution, etc. are to be understood as follows. Particles are three-dimensional structures. Three parameters (length, width, height) are usually required to give a complete description of particles. However, it is possible to describe a particle by giving a single number corresponding to the particle size. The majority of sizing methods therefore assume that the material to be measured is spherical because a sphere is the only shape that can be described by a single number (the diameter). This simplification is common to the skilled person and has proven to be executable in a variety of applications.

The particle size is after DIN 66160: 1992-09 Paragraph 2.2.5 "a fineness feature of length dimension". Initially, this refers to the particle diameter, which, strictly speaking, only applies to spherical particles or, in the case of isometric particles, can at least be applied mutatis mutandis. In the case of non-isometric particles, the mean particle size is an average particle size (Römpp Online 3.10).

If the product consists of spherical particles, the particle size is clearly defined by the indication of the ball diameter, as is preferred according to the invention in the range of 30 μm and more. Although the majority of the fine-grained materials do not consist of spheres, but of more or less irregularly shaped particles, which can be needle-shaped in one extreme case, platelet-shaped in the other. The dispersity property of the individual particles can be described here by the particle volume and additional parameters such as sphericity (sphere similarity). Instead of the one-parameter function for spheres, one obtains a multi-parameter dispersity function, the determination of which involves considerable metrological effort. Such an effort is justified only if it serves to gain essential information about product properties.

Therefore, in practice, and in accordance with the invention, it is limited to specifying a one-parameter distribution function for the particle size. According to the invention, therefore, a particle size of the PQ particles with the 1-dimensional parameter of the diameter in the range of 10 to 2000 .mu.m, preferably in the range of 30 and more, in particular up to a particle size of 1000 microns.

The preparations according to the invention are preferably sprays or aerosols. The necessary accompanying substances, such as aerosol propellants, can be selected by those skilled in the art from known means.

An aerosol is a disperse system in which a solid and / or a liquid are extremely finely dispersed in a gas. The aerosol is usually only when using a suitable spray system by spraying solutions, emulsions or suspensions self-produced, including, for example, spray cans can be used, in which a liquefied compressed gas serves as a propellant gas. When the pressure valve is opened, the mixture of propellant and active substance solution escapes through a fine nozzle which evaporates the propellant and leaves the finely distributed spray material as an aerosol. In terms of application technology, the term aerosol is frequently used by the skilled person also in the sense of aerosol sprays, ie here "aerosol" is understood not to be pure spray, but compressed gas packaging together with dispensing or metering device and contents. The contents include active ingredient solution and propellant. The active ingredient solution is the sum of all the constituents of preparation without the propellant. The term drug solution is also used when the preparation is present for example in the form of a suspension or emulsion. A suspension is to be understood as a dispersion in which the continuous phase is in the liquid state and the dispersed phase in the solid state.

By aerosol product or aerosol product is meant any container made of metal, glass or plastic, including the compressed, liquefied or dissolved under pressure gas with or without liquid, paste or powder, which is provided with a removal device that allows its contents in the form of solid or liquid particles suspended in gas as foam, paste, powder or in the liquid state.

Propane, propene, n-butane, isobutane, isobutene, n-pentane, n-pentene, isopentane, isopentene, methane and ethane are used singly or in combination as propellant in the aerosol according to the invention. Also hydrophilic propellants, such. As carbon dioxide, can be used advantageously in the context of the present invention, when the proportion of hydrophilic gases is selected low and lipophilic propellant gas (eg., Propane / butane) is present in excess.

The propellant gas is advantageously 40 to 90 wt.%, Based on the total mass of the preparation, including propellant gases.

Propane, butane, isobutane or mixtures of these propellant gases are particularly preferred. For the purposes of the present invention, the gases mentioned can be used individually or in any desired mixtures with one another. Preference is given to using mixtures with pressure stages from 1.0 to 3.5 bar. Preferably from 2.5 to 3.0, most preferably a pressure of 2.7 bar.

Preferably, the particulate polyquaternium-6 (PQ-6) is selected with the following particle size: particle size PQ-6 A 100-1000 μm Powder, grinded powder B 30-100 μm Powder, grinded powder

A: Linear PolyDADMAC (poly (diallyl dimethyl ammonium chlorides)) particles are obtainable by drying regular PQ-6 liquid polymers (PQ-6). White to yellow particles are obtained (88-100%).

The particle size distribution is in shown.

B: Linear PolyDADMAC particles are obtainable by drying regular PQ-6 liquid polymers (PQ-6). A crushed white powder is obtained (> 85%). The powder was sieved with a mesh size of 1 00pm. Parts larger than 100 μm are agglomerates of the individual particles.

According to the invention, the PQ polymers, in particular the preferred polyquaternium-6 and polyquaternium-16 particles, can thus be prepared.

The preparations according to the invention in which the PQ particles are used are oil-based.

Trapped water may be contained in the preparation to a small extent, so that the water content is below 3 wt.%, In particular less than 1 wt.%, Based on the mass of active ingredient solution, without propellant gases. Thus, according to the invention, an oil-based or anhydrous preparation is still included, since the entrained water exerts no influence.

Oils or lipids also include fats and fat-like substances. For cosmetics, they are of importance, above all, as emollient ingredients and as skin-specific lipids of the horny layer, which are stored between the horny cells. They enable the skin to store moisture. In addition to the care aspect, lipids, oils are added to the cosmetic preparations in order to ensure a better spreadability on the skin and to improve the sensory properties of the preparations.

Advantageous are polar oil components, which are preferably selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids having a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms and from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms. Such ester oils can then be advantageously selected from the group consisting of phenethyl benzoate, 2-phenylethyl benzoate, isopropyl lauroyl sarcosinate, phenyl trimethicone, cyclomethicone, dibutyl adipate, octyl palmitate, octyl cocoate, octyl isostearate, octyldodeceyl myristate, octyldodecanol, cetearyl isononanoate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate , n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, stearyl heptanoate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate, tridecyl stearate, tridecyl trimellitate, and synthetic, semisynthetic and natural mixtures of such esters, such as. B. jojoba oil.

Other preferred oils are selected from the group Caprylic / Capric triglycerides, tri-isostearin, octyl stearates, dicaprylyl carbonates and / or shea butter.

Exceptionally preferred oil components according to the invention are selected from fatty acid and fatty alcohol esters. Particularly preferred in this case is isopropyl palmitate.

It is further preferred that one or more vegetable oils be selected as the lipid component of the oil phase. Preferred vegetable oils are to be selected from almond oil, grapeseed oil, and / or sunflower oil.

Particularly preferred lipids are cyclomethicones, caprylic / capric triglyceride, C12-15 alkyl lactates and / or isopropyl palmitate.

In the prior art, volatile silicone oils, such as cyclomethicones, are used as the main ingredient in aerosol sprays. However, the proportion of cyclomethicones can be significantly reduced or cyclomethicones can be completely replaced.

Advantageously, therefore, can be dispensed with volatile cyclic silicone oils.

In the case of restrictions on preferred substances, whether lipids or further preferred components, their preferred ranges of proportions then also relate to the individual constituents then selected. The others, which are excluded from the restriction, will no longer be included in the listed proportions.

For good processing and application, it is important that the particles are stable in the preparation. For this purpose, analyzes of the solubility and particle size of Polyquaternium polymers, in particular PQ-6, were carried out by means of infrared spectroscopy and Raman spectroscopy.

It was determined whether PQ-6 particles in the surrounding matrix, an oil mixture as well as with or without perfume change, dissolve or shrink. The changes were observed over a longer period.

The results of the investigations show favorably that no dissolved portions of PQ-6 could be found in the oil phase (with and without perfume).

The particle shape does not change. The PQ-6 particles remain particulate globular (s. ).

In further investigations, the antibacterial activity of the preparations according to the invention was determined ( to ).

The so-called ATA test serves for the in-vivo determination of an antibacterial activity over 8 hours of cosmetic formulations after a single application. The application of the test product and the measurement of the effectiveness take place in the user-relevant area, the armpit. The target size is the germ count of the axillary bacteria.

The subjects have a preconditioning of 5 days on which they must not use a deodorant / antiperspirant and shave the armpit two days before the test start. After washing the armpits and rinsing the armpits, 1.4 g of aerosol are applied according to instructions with prior shaking. Rinse with a teflon ring, spatula and 1 ml rinse buffer for 1 minute. The rinse solution is diluted directly and later plated by means of a spiral plate on agar plates. The rinsing is then repeated at the appropriate times, 1h, 4h and 8h. Finally, the plates were incubated at 30 ° C for 48 hours and then evaluated using the Countermaten.

In the evaluation, the reduction factor was determined. The reduction factor is the factor by which the cell count (CFU) of the different time points is reduced compared to the T0 control or with each other.

• ■ Vergleich zur unbehandelten Kontrolle ⇒ Wirknachweis für Wirkstoff & Formulierung Getestete Zubereitung ist ein silikonhaltiges Aerosol mit 1,2 Gew.% PQ-6 Partikel (Beispiel 2).

The study design is designed to demonstrate antibacterial efficacy as follows:

• ■ Comparison to untreated control ⇒ Proof of active substance and formulation Tested preparation is a silicone-containing aerosol containing 1.2% by weight of PQ-6 particles (Example 2).

The results are shown in the following table and in played. reduction factors 1h 38 4h 17 8h 3

The in vivo microflora analysis ( ) shows the reduction factors of the PQ-6 particle-containing preparation in the armpit after 1, 4 and 8 h. A reduction factor greater than 10 means a reduction of bacteria by 90%.

Since the Polyquaternium polymers were applied in an oil matrix in the Achel, the oil must first evaporate, then the particles must dissolve in the sweat to then develop its antimicrobial effectiveness. In addition, particles are easily transferred from the armpit into the T-shirt. It is therefore surprising that the polyquaternium polymers, and in particular PQ-6, also have an antimicrobial effect from their particulate form. Due to the positive charge of Polyquaternium polymers, the active substance, after dissolving in the sweat, adheres to the slightly negative charged skin and can thus exert its effect.

The and show the synergistic efficacy of antimicrobial and antiperspirant agents, aluminum chlorohydrate (ACH), in combination with particulate polyquaternium particles.

The antimicrobial efficacy of two preparations was investigated.

The preparation Black & White is an antiperspirant aerosol with 16.6 wt.% Aluminum chlorohydrate, based on the total mass of the drug solution (without propellant gas).

The preparation black & white + particles includes the preparation black & white and additionally 1.2 wt.% Of PQ-6 particles, based on active ingredient solution (without propellant gas).

For the investigation, the bacterium C. jeikeium (DSM 7171) was streaked out of a cryotube according to EN 12353 on a corresponding agar plate (C + T agar) and incubated at 30 ° C. for 48 hours. From the grown bacteria, a second passage was applied as a liquid culture (AC medium).

The liquid culture was adjusted to 0.1 after an OD determination and diluted 1: 8 with thickened medium (AC medium + 0.2% agar). This bacterial suspension was then used for the test.

The pigskin infection assay was done by hand. For this purpose, 100.5 ul bacteria were applied to the skin (bacterial count of 1 * 10 ⁵ / cm ² ) and evenly distributed with a spatula. After a drying phase, the well plates were placed in a Sprühvorichtung and sprayed 1.4 g of the aerosol per punch. Before each spraying, it was shaken and weighed before and after. The plates with the skin are incubated for the appropriate time at 30 ° C and a humidity of about 90%. At the end of the time, all skin punches are covered with 2.01 ml rinse buffer and sonicated for 1 min in an ultrasonic bath. 200 μl of the rinsed solutions are pipetted into 800 μl of the disinhibition medium. These dilutions were plated out by means of a spiral plate on agar plates and incubated at 30 ° C for 48 hours, then the bacterial count was determined using the countermate (see also LW Bush, LM Benson and JH White "Pig Skin as Test Substrate for Evaluating Topical Antimicrobial Activity" Journal of Clinical Microbiology, Sept. 1986, p. 343-348 ). In the evaluation, the reduction factor was determined. The reduction factor is the factor by which the cell number (CFU) of the test substance is reduced compared to the control. 1h 4h 8h Black & White 9 3 4 Black & White + particles 3902 2465 4113

returns the counts after 1, 4 and 8 hours against control (K).

shows the reduction factors after 1, 4 and 8 hours.

The result shows that ACH does not achieve sufficient antimicrobial efficacy at this concentration. However, if one adds particulate Polyquaternium polymers surprisingly a significant effectiveness is achieved.

Basically, the efficacy is much more pronounced in in vitro studies than in in vivo tests.

In addition, an unexpected antimicrobial activity in aerosol preparations was unexpectedly apparent to the person skilled in the art if, in addition to anitranspirant and antimicrobial agents, such as ACH, particulate polyquaternium polymers are added.

Antiperspirants (AT) are antiperspirants that, in contrast to the deodorants which generally prevent microbial decomposition of already formed perspiration, are said to prevent the secretion of sweat at all.

The desired minimization of sweat secretion can be realized by various mechanisms.

Novel AT effectors are based, for example, on the principle of anticholinergics, which interrupt the nerve stimuli, which lead to increased secretion of the sweat glands.

Another principle of novel AT-effectors is based on the influence of membrane transport processes in the cell. Thus, specific aquaporin inhibitors inhibit the proteins that form channels in the cell membrane to facilitate the passage of water and other molecules. Ion channel inhibitors also have an effect on membrane transport or osmosis processes. Another novel AT mechanism can be realized by the use of short-chain, vicinal diols, possibly due to their osmotic activity.

Thus, by applying an agent no influence on the sweat secretion is exercised, so no antiperspirant effect is realized, according to the invention no antiperspirant.

Accordingly, antiperspirant active substances according to the invention include those substances which have an influence on perspiration secretion.

In contrast to the antiperspirants pure deodorants cause no active influence on the sweat secretion, but only the control or influence of the body or underarm odor (odor control agent). Common mechanisms of action for this are antibacterial effects, as they also show the non-colloidal silver, odor neutralization (masking), influencing bacterial metabolisms, pure perfuming as well as the use of precursors of certain perfume components, which are converted by enzymatic conversion to fragrant substances.

In addition to the actual antiperspirant active ingredients (AT-kneader) preparations may also contain substances that inhibit the microbial degradation of sweat, such as. B. butyloctanoic acid. Butyloctanoic Acid shows only a deodorizing effect and no antiperspirant effect, since no influence on the sweat secretion can be deduced from the influence on the bacterial skin flora.

In particular, in the case of antiperspirants based on aluminum salts, it may be possible to dispense with the further addition of substances having a purely deodorizing action, since these have per se an antimicrobial potential. Furthermore, the reduced supply of water due to the reduced sweat secretion also inhibits bacterial growth.

Antiperspirant active ingredients in the context of the present application are in particular to be selected from the following groups.

• Aluminiumsalze:
  • • Aluminiumsalze wie Aluminiumchlorid AlCl₃, Aluminiumsulfat Al2(SO4)3
  • • Aluminiumchloride der empirischen Summenformel [Al2(OH)mCln], wobei m+n=6
  • • Aluminiumchlorhydrat [Al2(OH)5Cl] × H2O
    • ■ Standard Al-Komplexe: Locron P (Clariant), Micro-Dry 323 (Summit Reheis), Aloxicoll PF 40 (BK Giulini).
    • ◯ Aktivierte Al-Komplexe: Reach 103 (Summit Reheis), AACH-7171/AACH-7172 (Summit Reheis), Aloxicoll P (BK Giulini), Aloxicoll SD100 (BK Giulini)
  • • Aluminiumsesquichlorhydrat [Al2(OH)4,5Cl1,5] × H2O Standard Al-Komplexe: Aloxicoll 31P (BK Giulini)
  • • Aluminiumdichlorhydrat [Al2(OH)4Cl2] × H2O

As antiperspirant active ingredients are used in particular astringents, especially aluminum compounds. The previously used, strongly acidic salts aluminum sulfate or chloride and the agaric acid have been largely replaced by aluminum hydroxychloride and alcoholates. The following list of advantageous antiperspirant active agents should not be restrictive in any way:

• Aluminum salts:
  • • aluminum salts such as aluminum chloride AlCl ₃ , aluminum sulfate Al 2 (SO 4) 3
  • • Aluminum chlorides of the empirical empirical formula [Al2 (OH) mCln], where m + n = 6
  • • Aluminum chlorohydrate [Al2 (OH) 5Cl] × H2O
    • ■ Standard Al complexes: Locron P (Clariant), Micro-Dry 323 (Summit Reheis), Aloxicoll PF 40 (BK Giulini).
    • ◯ Activated Al complexes: Reach 103 (Summit Reheis), AACH-7171 / AACH-7172 (Summit Reheis), Aloxicoll P (BK Giulini), Aloxicoll SD100 (BK Giulini)
  • Aluminum sesquichlorohydrate [Al 2 (OH) 4.5 Cl 1.5] × H 2 O Standard Al Complexes: Aloxicoll 31P (BK Giulini)
  • • Aluminum dichlorohydrate [Al2 (OH) 4Cl2] × H2O

The aluminum salts may be present in ground form or else as hollow spheres or as a mixture thereof. The density of these particles is advantageously in the range of 0.7 to 2.0 g / cm ³ .

Also advantageous may be the use of AT salt suspensions or gels in which aluminum salts present in powder form are dispersed in various oils.

The antiperspirant active ingredients from the above-described groups are preferably used in the formulations according to the invention in an amount of 0.5 to 10% by weight, preferably 2 to 6% by weight, based on the total mass of the preparation, i. including the possibly existing propellants used.

When using about 35 wt.% AACH (activated aluminum chlorohydrate) in the active substance solution for an aerosol spray (without propellant gas) and a filling ratio of about 15:85 (active substance solution to propellant gas) is a proportion of about 5.25 wt.% AACH im End product be present.

Of course, it is possible to add further or other antiperspirant active ingredients and / or deodorants as a cosmetically active ingredient.

The preparations according to the invention can be used as antimicrobially active agents and in particular as deodorants.

To avoid sinking and settling of the particles in the aerosol preparations, one or more phyllosilicates are advantageously added to the preparation.

For the skilled person unexpectedly, in the case of the aerosol preparations according to the invention, in addition, a better settling behavior of the particulate active ingredient in the aerosol with at the same time very good packaging material compatibility was demonstrated.

Suspension aids increase the stability of particles in suspensions. In anhydrous antiperspirant formulations therefore preferably modified phyllosilicates, clay minerals and / or silicas are used, for. B. hectorites, bentonites and / or silica.

Disteardimonium hectorites and / or stearalkonium bentonites are preferably to be selected, preferably to a proportion in the range from 2 to 5% by weight, based on the mass of the active ingredient solution.

The cosmetic or dermatological preparations according to the invention may further contain cosmetic adjuvants and active ingredients such as are commonly used in such preparations, for. As agents, preservatives, preservatives, bactericides, other lipids, substances for preventing foaming, dyes and color pigments, thickeners, moisturizing and / or moisturizing substances or other conventional ingredients of a cosmetic or dermatological formulation such as polyols, polymers, foam stabilizers, organic solvents or Silicone derivatives, provided that the additive does not impair or preclude the required properties.

The following examples are intended to illustrate the present invention without limiting it. Unless indicated otherwise, all amounts, proportions and percentages are based on the weight and the total amount of the active substance solution (without propellant gases) or on the total weight of the preparation.

The examples also show that the Polyquaternium particles can be easily incorporated into the aerosol preparation.

example recipes

Aerosol spray suspension

1 2 3 PQ-6 A (100-1000μm) 0.1 PQ-6 B (30-100μm) 1.2 0.8 isopropyl palmitate 10.00 15.00 10.00 Cyclomethicone ad 100.00 ad 100.00 ad 100.00 Disteardimonium hectorite 5.00 3.00 4.00 Dimethicone 4.00 2.00 1.00 Cyclomethicone + Dimethicone 2.00 5.00 4.00 octyldodecanol 0.50 0.60 0.5 Perfume q.s. q.s. q.s. Cetyl PEG / PPG-10/1 dimethicone 0.1

The liquid phase obtained by mixing together the respective constituents is filled with a propane-butane mixture (2: 7) in the ratio 17:83 in aerosol container oil spray 1 2 3 4 5 6 octyldodecanol 0 0.1 0.2 12:04 0.2 12:14 Isopropyl palmitate 1.65 1.25 2.5 2 2 11.9 Dimethicone 12:45 7.25 21.3 12:15 4.78 3675 Cyclomethicone 22.65 12025 15 5.79 6.82 14:35 Caprylic / Capric Triglycerides 0 0 0 0 1 0 C12-15 alkyl benzoates 0 1.25 0 0 0 0 Cyclomethicone + dimethiconol 3.9 1.25 5 0.8 3 3.5 PQ-6 (particles) 12:15 12:25 12:25 0.5 0.3 12:14 Disteardimonium hectorite 0.9 0625 1 0.1 0.7 1:05 Perfume 0 0875 4.5 0.6 1 0 Propylene carbonates 0.3 0125 12:25 12:02 0.2 0245 propellant 70 75 50 90 80 65 7 8th 9 10 11 12 13 octyldodecanol 12:06 12:24 0 0 12:58 12:07 12:05 Isopropyl palmitate 0.75 15 4 1545 1 0 0625 Dimethicone 0225 15 4 1545 2 5162 0 5 Cyclomethicone 10.65 13:38 25.4 6 6:44 8312 9175 5 Caprylic / Capric Triglycerides 0 0 0 1.8 4 0 0 C12-15 alkyl benzoates 0 4.8 0 0.6 2 0 0 Cyclomethicone + dimethiconol 1.5 5.7 3.96 1485 2 1.75 1.25 PQ-6 (particles) 12:18 12:12 12:32 12:18 12:18 0175 0187 5 Stearalkonium bentonite 0 0 0 0525 0.6 0 0 Disteardimoniu m hectorite 0525 1.5 0.8 0 0 0.7 0437 5 Perfume 1005 4:02 1:32 1.2 1 1172 0687 5 5 Propylene 0105 12:24 0.2 12:12 0.2 0157 0087 Carbonate 5 5 propellant 85 40 60 85 80 82.5 87.5

Production instructions:

The raw materials are to be mixed and the phyllosilicate activated by high energy input. Subsequently, the PQ-6 particles are added.

The formulation is loaded with propellant in aerosol cans. The propellant is to be selected from propane, butane, isobutane or any mixture of these components. Oil spray (Cyclomethicone D5 - free): 14 15 16 17 18 19 Dimethicone 0.6 1.2 1 2 0.4 0.2 octyldodecanol 12:13 0 12:22 0 0.0 0.1 5 5 9 8th Isopropyl palmitate 3 6.6 6.25 5 1.1 0 8th Dimethicone 1:35 2.7 1.25 6.95 2.5 6.4 Caprylic / Capric Triglycerides 3.3 3 3.75 6 2.5 4.2 Dimethicone 5.68 12.5 8.3 25.0 2 8.1 5 4 5 2 C12-15 alkyl benzoates 0 1.5 0.75 0 0 0 PQ-6 (particles) 12:18 12:15 12:25 12:25 0.5 0.3 Disteardimoniu m hectorite 0.6 1:05 0.87 1.5 0.2 0.4 5 5 Propylene carbonates 12:15 12:21 0.1 12:25 0.0 0.2 8th Perfume 0 1:05 2.25 3 0.5 0 propellant 85 70 75 50 90 80 20 21 22 23 24 25 26 Dimethicone 0 3.6 0.8 0.6 0.8 0.7 0.5 octyldodecanol 0315 12:54 2 0135 12:08 0157 0112 5 5 Isopropyl palmitate 5.25 18 2:36 4.5 7.5 1925 2.5 Dimethicone 4.2 0 2.8 2.25 1.5 1925 1.25 Caprylic / Capric Triglycerides 10.5 12:24 0 6:06 5.5 3675 2962 5 Dimethicone 8.75 12 27.04 0 2.6 5.25 3125 C12-15 alkyl benzoates 2835 9 0 0 0 2:03 0625 PQ-6 (particles) 12:14 12:12 12:32 12:18 12:18 0175 0187 5 Stearalkonium bentonite 0 0 0 0 0 0612 0375 5 Disteardimoniu m hectorite 12:35 2.1 1.2 0375 0.4 0 0 Propylene carbonates 0315 12:42 12:28 12:15 0.1 0087 0025 5 Perfume 2345 1.98 3.2 0.75 1:34 0962 0837 5 5 propellant 65 40 60 85 80 82.5 87.5

Production instructions:

The raw materials are to be mixed and the phyllosilicate activated by high energy input. Subsequently, the PQ-6 particles are added.

The formulation is loaded with propellant in aerosol cans. The propellant is to be selected from propane, butane, isobutane or any mixture of these components.

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• WO 2013052454 A1 [0003]
• WO 2009091794 A1 [0008]
• EP 1761241 A1 [0009]

Cited non-patent literature

• DIN 66160: 1992-09 [0025]
• L. W. Bush, L.M. Benson and J.H. White "Pig Skin as Test Substrate for Evaluating Topical Antimicrobial Activity" Journal of Clinical Microbiology, Sept. 1986, p. 343-348 [0068]

Claims (12)

Preparation comprising one or more particulate polyquaternium polymers characterized in that the proportion of water is less than 3 wt.%, In particular less than 1 wt.%, Based on the total mass of the preparation. Preparation after Claim 1 characterized in that are selected as Polyquaternium polymers Polyquaternium-6 polymers. Preparation according to one of the preceding claims, characterized in that the polyquaternium polymer particles have a particle size in the range of 10 microns and more, in particular 30 microns and more, preferably up to 2000 microns, more preferably up to 1000 microns. Preparation according to one of the preceding claims in the form of a spray or aerosol. Preparation after Claim 4 characterized in that the proportion of propellant gas in the range of 40 to 90 wt.%, Based on the total mass of the preparation, including propellant gases, is selected. Preparation according to one of the preceding claims, characterized in that one or more particulate polyquaternium polymers to a weight fraction of 0.1 to 10 wt.%, In particular to a proportion of 0.15 to 5 wt.%, Based on the total mass of the drug solution, are included. Preparation according to one of the preceding claims, characterized in that one or more lipids selected from the group Cyclomethicone, Caprylic / Capric triglyceride, C12-15 alkyl lactates and / or isopropyl palmitate are included. Preparation according to one of the preceding claims, characterized in that one or more antiperspirant active substances are contained, in particular aluminum chlorohydrates. Preparation according to one of the preceding claims, characterized in that one or more phyllosilicates, in particular Disteardimonium hectorites and / or stearalkonium bentonites, are included. Preparation after Claim 9 characterized in that the proportion of phyllosilicates in the range of 2 to 5 wt.%, Based on the mass of the drug solution is selected. Use of the preparation according to one of the preceding claims as an antimicrobial agent. Use of the preparation according to one of the preceding claims as a deodorant.

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