WO2008015703A3 - Procédé pour la préparation de montelukast et de ses sels - Google Patents
Procédé pour la préparation de montelukast et de ses sels Download PDFInfo
- Publication number
- WO2008015703A3 WO2008015703A3 PCT/IN2007/000314 IN2007000314W WO2008015703A3 WO 2008015703 A3 WO2008015703 A3 WO 2008015703A3 IN 2007000314 W IN2007000314 W IN 2007000314W WO 2008015703 A3 WO2008015703 A3 WO 2008015703A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- montelukast
- preparation
- salts
- amine salts
- conversion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne les sels d'alkyl amine de Montelukast et des procédés pour leur préparation et la conversion de sels d'amine de Montelukast en un sel de Montelukast ou un sel d'alcali / alcalin de Montelukast.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07827527A EP2069307A4 (fr) | 2006-08-04 | 2007-07-31 | Procédé pour la préparation de montelukast et de ses sels |
US12/376,354 US20110092708A1 (en) | 2006-08-04 | 2007-07-31 | Process for the preparation of montelukast and its salts thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1400CH2006 | 2006-08-04 | ||
IN1400/CHE/2006 | 2006-08-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008015703A2 WO2008015703A2 (fr) | 2008-02-07 |
WO2008015703A3 true WO2008015703A3 (fr) | 2009-04-09 |
Family
ID=38997582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2007/000314 WO2008015703A2 (fr) | 2006-08-04 | 2007-07-31 | Procédé pour la préparation de montelukast et de ses sels |
Country Status (3)
Country | Link |
---|---|
US (1) | US20110092708A1 (fr) |
EP (1) | EP2069307A4 (fr) |
WO (1) | WO2008015703A2 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2358923T3 (es) | 2005-07-05 | 2011-05-16 | Teva Pharmaceutical Industries, Ltd. | Purificación de montelukast. |
EP1886998A1 (fr) | 2006-08-09 | 2008-02-13 | Esteve Quimica, S.A. | Procédés de purification du montelukast et ses sels d'amine |
CZ302518B6 (cs) * | 2007-07-09 | 2011-06-29 | Zentiva, A. S. | Zpusob izolace a cištení montelukastu |
DE102007061630B4 (de) * | 2007-12-20 | 2013-07-04 | Formosa Laboratories, Inc. | Neue Verbindungen und Herstellung von Montelukast-Natrium |
EP2552892A1 (fr) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Synthèse efficace pour la préparation de montélukast et nouvelle forme cristalline d'intermédiaires dans celle-ci |
US9102665B2 (en) * | 2011-07-26 | 2015-08-11 | Sun Pharma Advanced Research Company Ltd. | Cysteinyl leukotriene antagonists |
US9487487B2 (en) * | 2012-05-18 | 2016-11-08 | Laurus Labs Private Limited | Process for preparation of montelukast sodium |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006058545A1 (fr) * | 2004-11-30 | 2006-06-08 | Medichem, S.A. | Nouveau procede de preparation d'un antagoniste de leucotriene |
US20060194839A1 (en) * | 2005-02-18 | 2006-08-31 | Chemi Spa | Process for the preparation of Montelukast |
WO2007004237A2 (fr) * | 2005-07-05 | 2007-01-11 | Matrix Laboratories Ltd | Procede de preparation de montelukast |
WO2007069261A1 (fr) * | 2005-12-13 | 2007-06-21 | Msn Laboratories Limited | Procede ameliore de preparation de montelukast et de ses sels pharmaceutiquement acceptables |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565473A (en) * | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
TW448160B (en) * | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
WO2006008750A2 (fr) * | 2004-07-19 | 2006-01-26 | Matrix Laboratories Ltd | Methyl 2-[(3s)-[3-[(2e)-(7-chloro quinolin-2-yl) ethenyl] phenyl]-3-halopropyl] benzoates |
EP1812394B1 (fr) * | 2004-07-19 | 2011-03-02 | Matrix Laboratories Ltd | Procede de preparation de montelukast et de ses sels |
PL205637B1 (pl) * | 2004-10-22 | 2010-05-31 | Inst Farmaceutyczny | Sposób wytwarzania kwasu (R,E)-(1-{1-{3-[2-(7-chlorochinolin-2-ylo)etenylo]fenylo}-3-[2-(1-hydroksy-1-metyloetylo)fenylo] propylosulfanylometylo}cyklopropylo)octowego i/lub jego farmaceutycznie dopuszczalnych soli |
-
2007
- 2007-07-31 EP EP07827527A patent/EP2069307A4/fr not_active Withdrawn
- 2007-07-31 WO PCT/IN2007/000314 patent/WO2008015703A2/fr active Application Filing
- 2007-07-31 US US12/376,354 patent/US20110092708A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006058545A1 (fr) * | 2004-11-30 | 2006-06-08 | Medichem, S.A. | Nouveau procede de preparation d'un antagoniste de leucotriene |
US20060194839A1 (en) * | 2005-02-18 | 2006-08-31 | Chemi Spa | Process for the preparation of Montelukast |
WO2007004237A2 (fr) * | 2005-07-05 | 2007-01-11 | Matrix Laboratories Ltd | Procede de preparation de montelukast |
WO2007069261A1 (fr) * | 2005-12-13 | 2007-06-21 | Msn Laboratories Limited | Procede ameliore de preparation de montelukast et de ses sels pharmaceutiquement acceptables |
Non-Patent Citations (1)
Title |
---|
See also references of EP2069307A4 * |
Also Published As
Publication number | Publication date |
---|---|
US20110092708A1 (en) | 2011-04-21 |
EP2069307A2 (fr) | 2009-06-17 |
EP2069307A4 (fr) | 2010-03-03 |
WO2008015703A2 (fr) | 2008-02-07 |
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