WO2008008187A2 - Dispositif mécanique pour mélanger un échantillon de fluide avec une solution traitante - Google Patents

Dispositif mécanique pour mélanger un échantillon de fluide avec une solution traitante Download PDF

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Publication number
WO2008008187A2
WO2008008187A2 PCT/US2007/014986 US2007014986W WO2008008187A2 WO 2008008187 A2 WO2008008187 A2 WO 2008008187A2 US 2007014986 W US2007014986 W US 2007014986W WO 2008008187 A2 WO2008008187 A2 WO 2008008187A2
Authority
WO
WIPO (PCT)
Prior art keywords
treatment solution
vent
septum
solution chamber
capillary channel
Prior art date
Application number
PCT/US2007/014986
Other languages
English (en)
Other versions
WO2008008187A3 (fr
Inventor
Urs A. Ramel
Original Assignee
Bayer Healthcare Llc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc. filed Critical Bayer Healthcare Llc.
Priority to MX2009000321A priority Critical patent/MX2009000321A/es
Priority to EP07796534.1A priority patent/EP2044411B1/fr
Priority to CA2654782A priority patent/CA2654782C/fr
Priority to BRPI0713069-4A priority patent/BRPI0713069A2/pt
Priority to JP2009519447A priority patent/JP2009543095A/ja
Publication of WO2008008187A2 publication Critical patent/WO2008008187A2/fr
Publication of WO2008008187A3 publication Critical patent/WO2008008187A3/fr
Priority to NO20090669A priority patent/NO20090669L/no

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Definitions

  • the present invention relates to mechanical devices for mixing a fluid sample (which may optionally be a blood sample) with a treatment solution (which may optionally be a buffer or diluent).
  • the present invention provides an integrated system for mixing a fluid sample with a treatment solution and for delivering the mixed fluid sample and treatment solution into a meter.
  • the fluid sample is a blood sample
  • the treatment solution is a buffer
  • the meter is a blood analyte meter
  • the present invention is not so limited.
  • the fluid sample may be a body fluid sample including interstitial fluid or a fluid sample containing a prostate specific antigen.
  • the blood analyte meter may optionally include a hemoglobin AIc (HbAIc) or lipid panel meter, the present invention is again not so limited.
  • the present invention provides a device for preparing a fluid sample for use in a fluid analyte meter, comprising: a first portion, comprising: a septum piercing projection, a capillary channel, and a vent on an outer surface of the first portion; and a second portion, comprising: a treatment solution chamber, and a septum sealing the treatment solution chamber, wherein the vent is open when the first portion of the device is initially inserted into the second portion of the device, and wherein the vent is closed when the first portion of the device is folly inserted into the second portion of the device.
  • the vent permits air to escape from within the second portion of the device as the first portion of the device is inserted into the second portion of the device.
  • the vent may comprise a slot extending along a portion of the outer surface of the first portion of the device.
  • the slot may extend from a leading edge of the outer surface part way along the length of the outer surface of the first portion of the device.
  • the present invention provides a device for preparing a fluid sample for use in a fluid analyte meter, comprising: a first portion having a capillary channel dimensioned to receive a fluid sample therein, and having a vent on an outer surface; a second portion having a treatment solution chamber enclosed by first and second septums, wherein the first portion penetrates the first septum when the first portion is inserted into the second portion such that contents of the treatment solution chamber mix with contents of the capillary channel, wherein the vent is open when the first portion of the device is initially inserted into the second portion of the device, and wherein the vent is closed when the first portion of the device is fully inserted into the second portion of the device; and a mechanism for penetrating the second septum such that contents of the treatment solution chamber and the capillary channel can be ejected from the device.
  • the present invention provides a device for preparing a fluid sample for use in a fluid analyte meter, comprising: a first portion having a capillary channel dimensioned to receive a fluid sample therein; a second portion having a treatment solution chamber enclosed by first and second septums, wherein the first portion penetrates the first septum when the first portion is inserted into the second portion such that contents of the treatment solution chamber mix with contents of the capillary channel; and a plunger having a mechanism for penetrating the second septum such that the contents of the treatment solution chamber and the capillary channel are ejected through the plunger.
  • the mechanism for penetrating the second septum may comprise a spike on the plunger.
  • the plunger may comprise a central flow channel, and wherein the spike is positioned adjacent to the central flow channel. A sharp end of the spike may be positioned over the centra! flow channel.
  • FIG. IA is a perspective view of a prior art embodiment of the invention, as seen in Published U.S. Patent Application 2005/0196872, Ser. No. 11/043,510, entitled "Mechanical Device For Mixing A Fluid Sample With A Treatment Solution”.
  • FIG. IB is a side elevation view of the device of Fig. IA.
  • FIG. 1C is sectional side elevation view corresponding to FIG. IB.
  • FIG. ID is a side elevation view of the first portion of the device being inserted into the second portion of the device.
  • FIG. IE is a sectional side elevation view corresponding to FIG. ID.
  • FIG. IF is a perspective view of the device being inserted into a meter.
  • FIG. IG is a sectional side elevation view corresponding to FIG. IF.
  • FIG: IH is an illustration of a system for easier washout in the first portion of the device.
  • FIG. 2A is a perspective view of an embodiment of the present invention showing the first portion of the device having a vent slot therein.
  • Fig. 2B is a side elevation view corresponding to Fig. 2A prior to the insertion of the first portion of the device into the second portion of the device.
  • Fig. 2C is a side elevation view corresponding to Fig. 2A showing partial insertion of the first portion of the device into the second portion of the device.
  • Fig. 2D is a side elevation view corresponding to Fig. 2A showing full insertion of the first portion of the device into the second portion of the device.
  • Fig. 3A is an exploded view of another embodiment of the present invention.
  • Fig. 30B is a cutaway view of the second portion, plunger and cap of Fig. 3A prior to use.
  • Fig. 3C is a cutaway view similar to Fig. 3B, but with the first portion of the device fully inserted into the second portion of the device.
  • Fig. 3D is a cutaway view similar to Fig. 3C, but with the cap removed and plunger fully inserted into the second portion of the device.
  • FIGS. IA to IH show a prior art device as was described in Figs. 8A to 8H of Published U.S. Patent Application 2005/0196872, Ser. No. 11/043,510, entitled “Mechanical Device For Mixing A Fluid Sample With A Treatment Solution”, as follows.
  • Device 100 includes a first portion 102 having a septum piercing portion 103 with a capillary channel 105 therein; and a second portion 104, including a treatment solution chamber 106, and a top septum 108 sealing treatment solution chamber 106.
  • a user places a drop of blood from their finger at the top end of capillary channel 105.
  • a stop junction 107 is provided at the opposite end of capillary channel 105.
  • Such a stop junction may preferably comprise a bore passing through first portion 102 of device 100. Stop junction 107 thereby facilitates a predetermined volume of blood being received into capillary channel 105.
  • first portion 102 is then inserted into second portion 104 such that septum piercing projection 103 pierces through top septum 108, such that capillary channel 105 is received into treatment solution chamber 106.
  • the contents of capillary channel 105 and treatment solution chamber 106 mix together. Mixing may be further enhanced by shaking the device.
  • dispensing nozzle 101 can be moved with respect to first portion 102 such that a second (i.e.: bottom) septum 109 is penetrated by first portion 102.
  • a second septum 109 is penetrated by first portion 102.
  • the mixed blood/treatment solution is ejected from the device through dispensing nozzle 101.
  • distal end 101 A of dispensing nozzle 101 is dimensioned to be received into a port of a blood analyte meter 10 (that may optionally comprise a hemoglobin AIc blood meter).
  • This device may be used with any suitable fluid analysis meter, or even with a simple containment vessel (e.g.: for preparing a sample for deposition in a well, such that it can be analyzed in future).
  • a simple containment vessel e.g.: for preparing a sample for deposition in a well, such that it can be analyzed in future.
  • FIG. IC 5 optional internal features of dispensing nozzle 101 are illustrated.
  • the internal channel 120 through which fluid is ejected can be flared. This has the advantage of slowing the flow of solution into meter 10, which prevents splashing inside meter 10.
  • an air vent 120 can also be provided to air pressure buildup during operation.
  • Dispensing nozzle 101 is received into first portion 104, as illustrated. This has the advantage of trapping the blood/treatment solution mixture such that it can all be ejected through dispensing nozzle 101.
  • First and second septums 108 and 109 may be made of foil or any suitable material, including plastic or rubber.
  • System 100 may also be used for preparing a blood sample for use in a blood analyte meter 10 by: drawing blood into capillary channel 105 in a body 102 having a septum piercing projection 103; piercing a first septum 108 covering treatment solution chamber 106 with septum piercing projection 103, thereby exposing the blood in capillary channel 105 to the contents of treatment solution chamber 106; shaking treatment solution chamber 106 with capillary channel 105 received therein, thereby mixing the blood with the contents of treatment solution chamber 106; and piercing a second septum 109 such that the mixed blood and treatment solution chamber contents are received into blood analyte meter 10.
  • System 100 may also be used for preparing a blood sample for use in blood analyte meter 10, by: drawing a blood sample into capillary channel 105 in first portion 102 of the device; moving a first portion 102 of the device with respect to second portion 104 to penetrate septum 108 of treatment solution chamber 106 such that contents of treatment solution chamber 106 are mixed with the blood sample in capillary channel 105; and ejecting the mixed treatment solution and blood sample through dispensing nozzle 106 and into a blood analyte meter 10.
  • FIG. IH illustrates a system for easier washout of capillary channel 105 in septum piercing projection 103 of first portion 102, as follows.
  • An open window 109 is provided in the side of capillary channel 105 to permit easier washout of the fluid sample, for better mixing.
  • Figs. 2A to 2D show an embodiment of the present invention having a vent in the first portion of the device. This vent ensures that first portion 202 is inserted into second portion 204 at the same time regardless of the user technique or the parts themselves.
  • An advantage of this controlled pressurization is that it ensures a correct volume delivery to a test cartridge that may be used with the device. Specifically, an exact pre-measured dose of the treated sample fluid can be squirted out of the device when the second septum in the second portion of the device is ruptured, as follows.
  • FIG. 2A to 3D operates' similar to the above described embodiment of the invention set forth in Figs. IA to IH, but has further novel features, including but not limited to, the following.
  • Device 200 (Fig. 2A) includes a first portion 202 having a septum piercing projection 203 with a capillary channel 205 therein; and a second portion 204 including a treatment solution chamber 206 with a top septum 208 sealing treatment solution chamber 206. Similar to the prior art device set forth in Figs. IA to IH, a user places a drop of blood in capillary channel 205. A stop junction 207 operates similar to stop junction 205. After capillary channel 205 has been filled with blood, first portion 202 is then inserted into second portion 204. Septum piercing projection 203 will then rupture 208 such that capillary channel 205 will be received within treatment solution chamber 206 (in second portion 204).
  • a vent 220 is provided in an outer surface 222 of first portion 202.
  • Vent 22 may simply comprise a slot cut out of first portion 202.
  • vent 220 extends from a leading edge 224 of outer surface 222 of first portion 202 of device 200.
  • vent 220 permits air to escape from within second portion 204 as first portion 202 is inserted into second portion 204 of the device.
  • Fig. 2B shows first portion 202 prior to insertion into second portion 204.
  • Fig. 2C shows first portion 202 partially inserted into second portion 204.
  • vent 220 permits air to escape from chamber 206 as first portion 202 is inserted into second portion 204.
  • Fig. 2D 5 first portion 202 is fully inserted into second portion 204. Therefore, the contents of capillary channel 205 and solution treatment chamber 206 can be mixed without any of the fluid dripping out of vent 220.
  • vent 220 becomes fully sealed when it passes seal ring 221 in second portion 204.
  • first portion 202 will travel about 0.001" past the sealing point until it is fully inserted into second portion 204. The movement (of first portion 202 into second portion 204) along this additional small travel distance pressurizes the chamber. This ensures a correct volume delivery to a test cartridge that may be used with the device.
  • an exact pre-measured dose of the treated sample fluid can be squirted out of device 200 when second septum 209 (Pigs. 2B and 2C) in second portion 204 of device 200 is ruptured. Therefore, an advantage of vent 220 is that its presence ensures that first portion 202 is inserted into second portion 204 at the same time regardless of the user technique or the parts themselves.
  • Figs. 2A to 2C show operation of device 200, as follows.
  • First portion 202 and second portion 204 operate similar to respective first and second portions 102 and 104 as seen in the prior art device of Figs. IA to IH.
  • a plunger 201 is provided.
  • Plunger 201 operates the same as dispensing nozzle 101 as described above.
  • a bottom cap is also provided.
  • plunger 201 initially sits in the bottom of second portion 204. Both plunger 201 and second portion 204 sit within cap 211.
  • first portion 202 is inserted into second portion 204 (as described above).
  • septum piercing projection 203 will rupture (top) septum 208 such that the contents of capillary channel 205 and sample treatment chamber 206 can be mixed.
  • cap 211 is removed, and plunger 201 is pushed upwardly into second portion 204.
  • a spike 215 on plunger 201 will rupture (bottom) septum 209 such that the mixed contents of sample treatment chamber 206 can be ejected from the bottom of device 200.
  • plunger 201 similar to the approach seen in Fig. IF).
  • plunger 201 includes a central flow channel 217.
  • the sharp top end of spike 215 can be positioned adjacent to central flow channel 217.
  • the sharp end of spike 215 can be positioned slightly over the top of central flow channel 217.
  • the present invention is not limited to use with blood samples. Instead, any other fluid that is to be analyzed in any type of fluid analysis meter may be substituted. As such, the present invention encompasses operation with various fluid samples, including body fluid samples that include analytes such as prostate specific antigen, lipids, creatinine, microalbumin, etc.
  • the meter with wchich device 200 is used is a HbAIc meter, however, it is to be understood that the present invention is not so limited. Instead, any form of analyte meter (for measuring one or more analytes) is compatible with the present invention.
  • the present invention may entail, but is not limited to, mixing a blood sample with a dilution buffer.
  • the present invention may also be useful for mixing blood with other substances, and may also be used in conjunction with other devices.
  • the functioning of an exemplary meter was described in U.S. Pat. Nos. 5,837,546; 5,945,345 and 5,580,794, incorporated by reference herein in their entirety.
  • the present the invention may also be used with any suitable fluid analysis meter, or even with a simple containment vessel (e.g.: for preparing a sample for deposition in a well, such that it can be analyzed in future).
  • a simple containment vessel e.g.: for preparing a sample for deposition in a well, such that it can be analyzed in future.
  • device 200 may be used with either: a single use test meter (as was described in U.S. Pat. Nos. 5,837,546; 5,945,345 and 5,580,794), or a multi- use cartridge system as described in U.S. Provisional Application No. 60/550,410.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un dispositif pour préparer un échantillon de fluide à utiliser dans un appareil de mesure d'analytes fluides, qui comprend : une première partie, qui comprend : une projection de percement de membrane, un canal capillaire, et un évent dans une surface externe de la première partie ; et une deuxième partie, qui comprend : une chambre de solution traitante, et une membrane fermant la chambre de solution traitante, où l'évent est ouvert lorsque la première partie du dispositif est initialement insérée dans la deuxième partie du dispositif, et où l'évent est fermé lorsque la première partie du dispositif est entièrement insérée dans la deuxième partie du dispositif.
PCT/US2007/014986 2006-07-12 2007-06-26 Dispositif mécanique pour mélanger un échantillon de fluide avec une solution traitante WO2008008187A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MX2009000321A MX2009000321A (es) 2006-07-12 2007-06-26 Dispositivo mecanico para mezclar una muestra de fluido con una solucion de tratamiento.
EP07796534.1A EP2044411B1 (fr) 2006-07-12 2007-06-26 Dispositif mécanique pour mélanger un échantillon de fluide avec une solution traitante
CA2654782A CA2654782C (fr) 2006-07-12 2007-06-26 Dispositif mecanique pour melanger un echantillon de fluide avec une solution traitante
BRPI0713069-4A BRPI0713069A2 (pt) 2006-07-12 2007-06-26 dispositivo para preparar uma amostra de fluido para uso em um medidor de analito fluido.
JP2009519447A JP2009543095A (ja) 2006-07-12 2007-06-26 流体試料を処理溶液と混合する機械装置
NO20090669A NO20090669L (no) 2006-07-12 2009-02-11 Mekanisk innretning for blanding av en fluidprøve med en behandlingsløsning

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/485,743 2006-07-12
US11/485,743 US7771655B2 (en) 2006-07-12 2006-07-12 Mechanical device for mixing a fluid sample with a treatment solution

Publications (2)

Publication Number Publication Date
WO2008008187A2 true WO2008008187A2 (fr) 2008-01-17
WO2008008187A3 WO2008008187A3 (fr) 2008-03-27

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PCT/US2007/014986 WO2008008187A2 (fr) 2006-07-12 2007-06-26 Dispositif mécanique pour mélanger un échantillon de fluide avec une solution traitante

Country Status (10)

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US (1) US7771655B2 (fr)
EP (1) EP2044411B1 (fr)
JP (1) JP2009543095A (fr)
CN (1) CN101490523A (fr)
BR (1) BRPI0713069A2 (fr)
CA (1) CA2654782C (fr)
MX (1) MX2009000321A (fr)
NO (1) NO20090669L (fr)
RU (1) RU2442968C2 (fr)
WO (1) WO2008008187A2 (fr)

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MX2016016267A (es) 2014-06-13 2017-03-31 Siemens Healthcare Diagnostics Inc Sistema de entrega de muestras.
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EP2044411B1 (fr) 2020-08-12
WO2008008187A3 (fr) 2008-03-27
MX2009000321A (es) 2009-01-26
BRPI0713069A2 (pt) 2012-07-17
NO20090669L (no) 2009-02-11
US20080081378A1 (en) 2008-04-03
EP2044411A4 (fr) 2015-10-14
RU2009104703A (ru) 2010-08-20
CN101490523A (zh) 2009-07-22
US7771655B2 (en) 2010-08-10
CA2654782A1 (fr) 2008-01-17
CA2654782C (fr) 2013-10-08
JP2009543095A (ja) 2009-12-03
RU2442968C2 (ru) 2012-02-20
EP2044411A2 (fr) 2009-04-08

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