WO2008001188A3 - An improved process for the preparation of substantially pure aripiprazole - Google Patents

An improved process for the preparation of substantially pure aripiprazole Download PDF

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Publication number
WO2008001188A3
WO2008001188A3 PCT/IB2007/001732 IB2007001732W WO2008001188A3 WO 2008001188 A3 WO2008001188 A3 WO 2008001188A3 IB 2007001732 W IB2007001732 W IB 2007001732W WO 2008001188 A3 WO2008001188 A3 WO 2008001188A3
Authority
WO
WIPO (PCT)
Prior art keywords
improved process
substantially pure
preparation
pure aripiprazole
aripiprazole
Prior art date
Application number
PCT/IB2007/001732
Other languages
French (fr)
Other versions
WO2008001188A2 (en
WO2008001188A8 (en
Inventor
Indravadan Ambalal Modi
Bakulesh Mafatlal Khamar
Keval Rameshkumar Sondagar
Nirav Keshavlal Kagathara
Manish Chandrakant Shukla
Ravi Ponnaiah
Original Assignee
Cadila Pharmaceuticals Ltd
Indravadan Ambalal Modi
Bakulesh Mafatlal Khamar
Keval Rameshkumar Sondagar
Nirav Keshavlal Kagathara
Manish Chandrakant Shukla
Ravi Ponnaiah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Pharmaceuticals Ltd, Indravadan Ambalal Modi, Bakulesh Mafatlal Khamar, Keval Rameshkumar Sondagar, Nirav Keshavlal Kagathara, Manish Chandrakant Shukla, Ravi Ponnaiah filed Critical Cadila Pharmaceuticals Ltd
Publication of WO2008001188A2 publication Critical patent/WO2008001188A2/en
Publication of WO2008001188A8 publication Critical patent/WO2008001188A8/en
Publication of WO2008001188A3 publication Critical patent/WO2008001188A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to an improved process for preparing substantially pure aripiprazole (HPLC >99.8 %), wherein 7,7'-[tetramethylenebis(oxy)]bis(3,4- dihydroquinolin-2(lH)-one) is present in pure aripiprazole in <0.01 % (w/w).
PCT/IB2007/001732 2006-06-29 2007-06-26 An improved process for the preparation of substantially pure aripiprazole WO2008001188A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1038MU2006 2006-06-29
IN1038/MUM/2006 2006-06-29

Publications (3)

Publication Number Publication Date
WO2008001188A2 WO2008001188A2 (en) 2008-01-03
WO2008001188A8 WO2008001188A8 (en) 2008-05-02
WO2008001188A3 true WO2008001188A3 (en) 2009-04-23

Family

ID=38846021

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/001732 WO2008001188A2 (en) 2006-06-29 2007-06-26 An improved process for the preparation of substantially pure aripiprazole

Country Status (1)

Country Link
WO (1) WO2008001188A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7714129B2 (en) 2003-12-16 2010-05-11 Teva Pharmaceutical Industries Ltd. Methods of preparing anhydrous aripiprazole form II
CN101781246B (en) * 2009-01-15 2012-02-29 成都康弘药业集团股份有限公司 Improved method for synthesizing Aripiprazole
WO2011030213A1 (en) * 2009-09-14 2011-03-17 Jubilant Organosys Limited Improved process for the preparation of 7.(4-bromobutoxy) 3,4-dihydrocarbostyril, a precursor of aripiprazole
WO2012131451A1 (en) * 2011-03-30 2012-10-04 Jubilant Life Sciences Limited Process for producing aripiprazole in anhydrous type i crystals
CN102863377A (en) * 2012-08-17 2013-01-09 南京正大天晴制药有限公司 Method for preparing high-purity aripiprazole
CN105037264A (en) * 2015-08-17 2015-11-11 苏州统华药品有限公司 Purifying method of aripiprazole
KR102176234B1 (en) * 2017-09-07 2020-11-09 주식회사 엘지화학 Reactor for manufacturing nano particle

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Also Published As

Publication number Publication date
WO2008001188A2 (en) 2008-01-03
WO2008001188A8 (en) 2008-05-02

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