WO2007136238A1 - Procédé de production d'un additif biologiquement actif dénommé 'calcium actif' - Google Patents
Procédé de production d'un additif biologiquement actif dénommé 'calcium actif' Download PDFInfo
- Publication number
- WO2007136238A1 WO2007136238A1 PCT/KZ2007/000007 KZ2007000007W WO2007136238A1 WO 2007136238 A1 WO2007136238 A1 WO 2007136238A1 KZ 2007000007 W KZ2007000007 W KZ 2007000007W WO 2007136238 A1 WO2007136238 A1 WO 2007136238A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- calcium
- mixture
- biologically active
- water
- producing
- Prior art date
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 11
- 239000011575 calcium Substances 0.000 title claims abstract description 11
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 11
- 239000000654 additive Substances 0.000 title claims abstract description 9
- 230000000996 additive effect Effects 0.000 title claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 title abstract description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 20
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 230000005855 radiation Effects 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 abstract description 4
- 239000001095 magnesium carbonate Substances 0.000 abstract description 4
- 229910000021 magnesium carbonate Inorganic materials 0.000 abstract description 4
- 235000010216 calcium carbonate Nutrition 0.000 description 6
- 235000015165 citric acid Nutrition 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000001354 calcium citrate Substances 0.000 description 3
- 235000014380 magnesium carbonate Nutrition 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- 235000013337 tricalcium citrate Nutrition 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- 206010006956 Calcium deficiency Diseases 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 208000037824 growth disorder Diseases 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 235000011167 hydrochloric acid Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000008611 intercellular interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 230000036435 stunted growth Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/32—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with electric currents without heating effect
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/30—Physical treatment, e.g. electrical or magnetic means, wave energy or irradiation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the invention relates to the food industry and pharmaceutical production of biologically active additives (B AD), namely calcium-containing additives, and may find application in clinical nutrition and in medicine.
- B AD biologically active additives
- Calcium deficiency is manifested in increased excitability of the nervous system, allergic reactions, convulsions, osteoporosis, in children - in the manifestations of rickets, stunted growth, frequent colds All this served as a theoretical foundation for the development and implementation in medical practice of calcium preparations based on its salts.
- calcium salts such as glycerophosphate, gluconate, carbonate, lactate, citrate, chloride, phosphate and many others are used in medical practice.
- Vitamin D hydrochloric and citric acids, lactose, phosphorus, magnesium contribute to the absorption of calcium ions.
- the well-known calcium-containing additive - calcium citrate 4-water manufactured by the Ural Chemical Reagents Plant (TU 6-09-09263-85, h), is a white crystalline powder obtained by mixing calcium carbonate CaCO3, with citric acid in a 1: 1 ratio. Citric acid is dissolved in distilled water at a concentration of 20-50 grams per liter, and an equivalent amount of CaCO3 is added with constant stirring. The resulting solution of calcium citrate is dried to form a white powder, which can be compressed into tablets.
- the disadvantage of this calcium citrate is that it is difficult to swallow, has a bitter taste and is poorly soluble in water.
- the disadvantage is that it is poorly absorbed by the body (no more than 30%).
- the aim of the present invention is to obtain a calcium-containing product that is well absorbed by the body, has a pleasant taste and is easily consumed.
- calcium-containing biologically active additive is an aqueous homogeneous fine suspension, devoid of unpleasant taste and smell, and is made from purified calcium carbonate with the addition of magnesium carbonate.
- Special processing of dietary supplements, in the process of its preparation, by magnetic field and infrared radiation increases consumer properties and digestibility by the human body.
- the proposed method of preparing dietary supplements is as follows. The water, preferably purified boiled or distilled, is treated with a constant magnetic field while stirring, then citric acid, chemically pure calcium carbonate and magnesium carbonate are added to it, and infrared radiation is applied to the mixture during mixing.
- One liter of distilled water at a temperature of 20-25 0 C is mixed with stirring for 10 minutes in a constant magnetic field with a strength of up to 5.5 a / m ( ⁇ 400 oersted). Then, 30 g of purified (grade "C") CaCO3, 0.3 MgCO3 and 30 g of 1 TWMOHHOn acid are added to the treated water with constant stirring.
- the mixture is exposed to infrared radiation with a wavelength of from 2 to 40 microns. Better results are achieved by sequential exposure to multiple radiation sources. For example, they are exposed to four groups of emitters lasting from 25 to 45 minutes each. The resulting mixture is maintained at a temperature of lO to 25 ° C for 24 hours.
- the resulting mixture is an aqueous homogeneous finely divided suspension, devoid of unpleasant taste and odor and with good consumer properties.
- the biologically active additive is quickly and almost completely (up to 90%) absorbed by the body and in a short time replenishes calcium deficiency, normalizes osteosynthesis, participates in the synthesis with ATP, normalizes the permeability of membranes and blood vessels, increases immunity, and restores cholesterol and mineral metabolism.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
L'invention se rapporte à un procédé permettant de préparer un additif biologiquement actif contenant du calcium, qui consiste : à mélanger du carbonate de calcium (CaCO3) avec de l'eau et de l'acide citrique, l'eau étant préalablement traitée à l'aide d'un champ magnétique constant; à ajouter, pendant le mélange, du carbonate de magnésium, et à exposer le mélange à un rayonnement infrarouge d'une longueur d'onde comprise entre 2 et 40 micromètres; et à maintenirle mélange, après préparation, à une température comprise entre 10 et 25 °C pendant au moins 20 heures.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA200601324 | 2006-05-23 | ||
EA200601324A EA009816B1 (ru) | 2006-05-23 | 2006-05-23 | Способ получения кальцийсодержащей биологически активной добавки |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007136238A1 true WO2007136238A1 (fr) | 2007-11-29 |
Family
ID=38723524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KZ2007/000007 WO2007136238A1 (fr) | 2006-05-23 | 2007-05-16 | Procédé de production d'un additif biologiquement actif dénommé 'calcium actif' |
Country Status (2)
Country | Link |
---|---|
EA (1) | EA009816B1 (fr) |
WO (1) | WO2007136238A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2703719C1 (ru) * | 2018-04-18 | 2019-10-22 | Федеральное государственное бюджетное научное учреждение "Поволжский научно-исследовательский институт производства и переработки мясомолочной продукции" (ГНУ НИИММП) | Способ получения цитрата кальция |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA020345B1 (ru) * | 2011-02-14 | 2014-10-30 | Абдухамит Абдувалиевич Фаттахов | Способ получения биологически активной добавки |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2030871C1 (ru) * | 1992-06-16 | 1995-03-20 | Акционерное общество закрытого типа "Деко" | Способ производства хлебобулочных и макаронных изделий |
JPH08198803A (ja) * | 1995-01-27 | 1996-08-06 | Fuji Chem Ind Co Ltd | 非晶質クエン酸・有機酸・カルシウム・マグネシウム組成物及びその製造法 |
RU2083140C1 (ru) * | 1994-09-20 | 1997-07-10 | Пальмов Федор Владимирович | Способ обработки жидкости излучением в тонком слое |
RU2155081C1 (ru) * | 1999-11-25 | 2000-08-27 | Солодилов Александр Иванович | Способ обработки вещества магнитным полем и устройство для его осуществления |
RU2261024C2 (ru) * | 1999-09-24 | 2005-09-27 | Сосьете Де Продюи Нестле С.А. | Жидкий пищевой продукт, обогащенный кальцием и магнием, и способ его получения (варианты) |
RU2270586C2 (ru) * | 2004-04-08 | 2006-02-27 | Дальневосточная Государственная Академия Экономики И Управления (Двгаэу) | Пищевая кальцийсодержащая добавка и функциональный пищевой продукт ее содержащий |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9603518D0 (en) * | 1996-02-20 | 1996-04-17 | Smithkline Beecham Plc | Novel process |
-
2006
- 2006-05-23 EA EA200601324A patent/EA009816B1/ru not_active IP Right Cessation
-
2007
- 2007-05-16 WO PCT/KZ2007/000007 patent/WO2007136238A1/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2030871C1 (ru) * | 1992-06-16 | 1995-03-20 | Акционерное общество закрытого типа "Деко" | Способ производства хлебобулочных и макаронных изделий |
RU2083140C1 (ru) * | 1994-09-20 | 1997-07-10 | Пальмов Федор Владимирович | Способ обработки жидкости излучением в тонком слое |
JPH08198803A (ja) * | 1995-01-27 | 1996-08-06 | Fuji Chem Ind Co Ltd | 非晶質クエン酸・有機酸・カルシウム・マグネシウム組成物及びその製造法 |
RU2261024C2 (ru) * | 1999-09-24 | 2005-09-27 | Сосьете Де Продюи Нестле С.А. | Жидкий пищевой продукт, обогащенный кальцием и магнием, и способ его получения (варианты) |
RU2155081C1 (ru) * | 1999-11-25 | 2000-08-27 | Солодилов Александр Иванович | Способ обработки вещества магнитным полем и устройство для его осуществления |
RU2270586C2 (ru) * | 2004-04-08 | 2006-02-27 | Дальневосточная Государственная Академия Экономики И Управления (Двгаэу) | Пищевая кальцийсодержащая добавка и функциональный пищевой продукт ее содержащий |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2703719C1 (ru) * | 2018-04-18 | 2019-10-22 | Федеральное государственное бюджетное научное учреждение "Поволжский научно-исследовательский институт производства и переработки мясомолочной продукции" (ГНУ НИИММП) | Способ получения цитрата кальция |
Also Published As
Publication number | Publication date |
---|---|
EA009816B1 (ru) | 2008-04-28 |
EA200601324A1 (ru) | 2007-12-28 |
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