WO2007125888A1 - Liquid composition for oral dosage - Google Patents

Liquid composition for oral dosage Download PDF

Info

Publication number
WO2007125888A1
WO2007125888A1 PCT/JP2007/058792 JP2007058792W WO2007125888A1 WO 2007125888 A1 WO2007125888 A1 WO 2007125888A1 JP 2007058792 W JP2007058792 W JP 2007058792W WO 2007125888 A1 WO2007125888 A1 WO 2007125888A1
Authority
WO
WIPO (PCT)
Prior art keywords
oral composition
liquid oral
collagen
fruit juice
peptide
Prior art date
Application number
PCT/JP2007/058792
Other languages
French (fr)
Japanese (ja)
Inventor
Kimiko Hishiki
Hideaki Iwasaki
Original Assignee
Lion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corporation filed Critical Lion Corporation
Priority to JP2008513201A priority Critical patent/JP5136796B2/en
Publication of WO2007125888A1 publication Critical patent/WO2007125888A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a liquid oral composition containing a proteolytic peptide.
  • Proteolytic peptides such as collagen peptides are excellent components having functions such as a skin-beautifying effect and an effect of improving blood fluidity, which increase skin elasticity and prevent wrinkles.
  • the formulation is commercially available.
  • proteolytic peptides have a unique odor, there is a problem in terms of palatability when used for oral use.
  • Patent Document 1 Japanese Patent Laid-Open No. 2003-73403
  • Patent Document 2 Japanese Patent Publication No. Hei 5-199855
  • an aqueous liquid preparation containing collagen peptide and fruit juice causes precipitation due to storage under the influence of trace metals such as minerals contained in the fruit juice, and there is a problem in liquid stability.
  • Patent Document 1 Japanese Patent Application Laid-Open No. 2003-73403
  • Patent Document 2 JP-A-5-199855
  • Patent Document 3 Japanese Patent Laid-Open No. 2002-121148
  • Patent Document 4 Japanese Patent Laid-Open No. 2002-51734
  • Patent Document 5 Japanese Unexamined Patent Publication No. 2003-238597
  • Patent Document 6 Japanese Patent Application Laid-Open No. 2004-290102
  • Patent Document 7 Japanese Patent Application Laid-Open No. 2004-346132
  • Patent Document 8 Japanese Patent Laid-Open No. 2002-51734
  • An object of the present invention is to provide a liquid oral composition that suppresses an unpleasant odor of a proteolytic peptide such as a collagen peptide, suppresses agglomeration / precipitation, and has good storage stability. To do.
  • the present inventor suppresses unpleasant odor and improves the flavor by adding phosphoric acid and Z or a salt thereof to an aqueous composition containing a proteolytic peptide such as a collagen peptide and fruit juice. It was also found that a liquid oral composition excellent in storage stability can be obtained, in which cohesion * precipitation is suppressed.
  • a liquid oral composition comprising a proteolytic peptide, fruit juice, and phosphoric acid and Z or a salt thereof.
  • the unique unpleasant odor of proteolytic peptides such as collagen peptides is suppressed, the flavor is strong and the agglomeration force is aggregated * precipitation is suppressed, and liquid storage with good storage stability is achieved.
  • An oral composition can be provided.
  • Examples of the proteolytic peptide of the present invention include collagen peptides and elastin peptides, which may be used alone or in appropriate combination of two or more. Particularly preferred is a collagen peptide.
  • Collagen peptides can be obtained by hydrolyzing collagen or gelatin with high collagen strength with an acid or enzyme. Collagen is a major protein that forms the connective tissue of animals, and is abundant in bones, tendons, skin, and vascular walls.
  • Gelatin is a water-soluble protein obtained by hot water extraction of a raw material containing collagen.
  • the weight average molecular weight of the proteolytic peptide is 500-100 00 force S preferred ⁇ , more preferred ⁇ or 800-7500, and even more preferred ⁇ 1000 to 5000. The weight average molecular weight is measured by gel filtration chromatography (Pagii method: see JP-A-2002-51734).
  • the content of the proteolytic peptide in the composition is 20 to 40000 mg ZlOOmL, more preferably 200 to 30000 mg ZlOOmL, and still more preferably 400 to 20000 mg ZlOOmL.
  • a liquid oral composition can be obtained in which the effectiveness of collagen can be further obtained, and the flavor and stability are further improved.
  • the fruit juice of the present invention refers to a fruit juice obtained by reversibly removing insoluble solids. Insoluble solids may be removed or some or all of the insoluble solids removed may be returned to the juice.
  • the types of fruits include those belonging to the family Rosaceae, Occupiaceae, Saxifragaceae, Grapeaceae, Citrusaceae, Cucurbitaceae, Cucurbitaceae, Matatabidae, Solanum, Pepperaceae, Passifloraceae, and Pineapple. These can be used singly or in appropriate combination of two or more.
  • the content of the fruit juice in the composition is 200 to 100,000 mg / 100 mL, more preferably 400 to 60,000 mg / l OOmL as the amount of fruit juice (the amount obtained by reversibly removing the insoluble solid from the fruit juice). More preferably, it is 600-40000 mgZlOOmL.
  • the fruit juice may be blended as it is (equal size), but is preferably blended as a concentrated fruit juice. For example, when 5 times concentrated fruit juice is used, the amount of 1Z5 is added.
  • the phosphoric acid and Z or a salt thereof of the present invention are preferably used alone or in appropriate combination of two or more, which are preferably water-soluble phosphoric acid compounds.
  • Examples of phosphoric acid and Z or salts thereof include orthophosphates, pyrophosphates, polyphosphates, metaphosphates, tripolyphosphates, and salts include sodium salts and potassium salts.
  • orthophosphoric acid, pyrophosphoric acid, and metaphosphate are more preferable, and acidic metaphosphates such as sodium metaphosphate and potassium metaphosphate are more preferable.
  • the content of phosphoric acid and / or a salt thereof is preferably 2 to 1000 mg / 100 mL in the composition, more preferably 10 to 600 mgZl00 mL, still more preferably 20 to 600 mgZl00 mL, and particularly preferably 40 to 200 mgZl00 mL. . Within this range, it is possible to obtain a liquid oral composition that prevents the precipitation of the peptide and has better storage stability.
  • the liquid oral composition of the present invention contains one or more selected from force textile, proanthocyanin, anthocyanin and anthocyanin from the viewpoint of flavor stability.
  • the composition 2 to: LOOOmgZlOOmL, preferably 10 to 600mg / 100mL, more preferably 20 to 200mgZl00mL may be added.
  • proanthocyanidins or dimers to tetramers thereof, anthocyanins and anthocyanins are preferred. These may be formulated as a purified simple substance or a plant extract.
  • Plant extracts include blueberries, bilberry, grapes, strawberries, grand belly, cassis, red cabbage, nose, black rice, black beans (black soybeans), black sesame, purple koji, pine, green tea, etc. Extracted extract or Is a purified product. Of these, the above compounds of blueberry, bilberry, grape, strawberry and pine are preferred. In addition, the above-mentioned fruit juice may contain these compounds. In addition, by blending the extracted or purified compound, a liquid oral composition having particularly good flavor stability can be obtained.
  • the liquid oral composition of the present invention may contain a thickening polysaccharide.
  • thickening polysaccharides include dielan gum, carrageenan, pectin, guar gum, locust bean gum, tamarind gum, xanthan gum, curdlan (1,3 glucan) and the like.
  • the content of the thickening polysaccharide in the liquid oral composition is preferably 1 to 1 OOmg / 1 OOmL, and more preferably 10 to 50mgZ 1 OOmL.
  • liquid oral composition of the present invention can be blended with skin beautifying ingredients such as vitamins, moisturizers, metabolism improvers and the like.
  • vitamins B, B, B, B, C, A are examples of skin beautifying ingredients such as vitamins, moisturizers, metabolism improvers and the like.
  • Vitamin liquid is preferred.
  • the proper content in the composition for oral use is in accordance with the mixing limit of nutrients of each of the nutritional functional foods.
  • a component that enhances the moisture retention of the skin or improves the metabolism of the skin can be blended.
  • Examples thereof include hyanorelonic acid, elastin, coenzyme Q10, a-lipoic acid, aloe, ceramide, royal jelly, austaxanthin, amino acids, darcosamine, darcronoraton, ellagic acid, coenzyme and the like.
  • the liquid oral composition of the present invention usually contains other drugs used in the oral composition, sweeteners, sour agents, stabilizers, chelating agents, preservatives, fragrances, dyes, and the like. It can be blended within a range that does not impair the effects of the present invention.
  • the liquid oral composition of the present invention can be obtained as an aqueous liquid oral composition by mixing the above components and water (remainder).
  • the liquid oral composition of the present invention preferably has a viscosity at 20 ° C of 1 to 1 OOmPa ⁇ s U.
  • Viscosity is measured using a rotational viscosity type (RB viscometer: Toki Sangyo Co., Ltd.).
  • the drinks (liquid oral compositions) shown in Tables 1 to 3 were prepared, and the flavor and composition stability were evaluated based on the following methods. The results are also shown in the table.
  • the drink was stored at 35 ° C for 4 weeks, and the presence or absence of aggregation / precipitation after storage was judged visually. A result is shown by the following evaluation criteria.
  • the drink was stored at 35 ° C for 4 weeks, and the flavor stability after storage was evaluated by 20 panelists based on the following evaluation criteria.
  • the result shows that the average score of 20 panelists is 4.5 or more as “ ⁇ ”, 4 or more as “ ⁇ ”, 3 or more as “ ⁇ ”, and less than 3 as “X”.
  • composition stability immediately after production in each example was “ ⁇ ”, and the flavor was “ ⁇ ”.
  • Collagen 'Petide (weight average molecular weight 1000) 1 1
  • Potassium metaphosphate 20 20 20
  • Sodium pyrophosphate 20 20
  • Anthocyanin (derived from black beans) 50 20 30
  • Oligomeric Proanthocyanin (derived from buttou seeds) 20 20
  • Composition stability ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ Flavor ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ Fruit juice (manufactured by Kotobuki Foods Co., Ltd., 5-fold concentrated fruit juice),

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed is a liquid composition for oral dosage, which is produced by adding a fruit juice and phosphoric acid and/or a salt thereof to an aqueous composition comprising a protein-degraded peptide such as a collagen peptide. The liquid composition has reduced unpleasant odor, has a good flavor, hardly causes aggregation/precipitation, and has excellent storage stability.

Description

明 細 書  Specification
液体経口用組成物  Liquid oral composition
技術分野  Technical field
[0001] 本発明は、タンパク質分解ペプチドを含有する液体経口用組成物に関するもので ある。  [0001] The present invention relates to a liquid oral composition containing a proteolytic peptide.
背景技術  Background art
[0002] コラーゲンペプチド等のタンパク質分解ペプチドは、肌の弾力性を高めシヮを防ぐ 美肌効果や、血液流動性改善効果等の機能を有する優れた成分であり、これを含有 する外用剤、経口製剤が市販されている。しカゝしながら、タンパク質分解ペプチドは 独特の臭みを有しているため、経口用とする場合は、嗜好性の点で課題がある。  [0002] Proteolytic peptides such as collagen peptides are excellent components having functions such as a skin-beautifying effect and an effect of improving blood fluidity, which increase skin elasticity and prevent wrinkles. The formulation is commercially available. However, since proteolytic peptides have a unique odor, there is a problem in terms of palatability when used for oral use.
[0003] コラーゲンペプチドの臭みを低減する技術として、コラーゲン源を還元性物質の存 在下で抽出する工程を有する製造方法が提案されている (特許文献 1 :特開 2003— 73403号公報参照)。また、ハトムギ等のエキスと、コラーゲン加水分解物と、ビタミン と、梅果汁と、フルーツフレーバーとからなる飲料が提案されている（特許文献 2 :特 開平 5— 199855号公報参照)。しカゝしながら、コラーゲンペプチド及び果汁を含有 する水性液剤は、果汁に含まれるミネラル等の微量金属の影響で、保存により沈殿 を生じ、液安定性に課題がある。このことから、コラーゲンペプチド等のタンパク質分 解ペプチド及び果汁を含有する組成物の沈殿を抑制し、かつ風味を良好にする技 術が望まれていた。なお、本発明に関連する先行技術文献としては下記が挙げられ る。  [0003] As a technique for reducing the odor of collagen peptides, a production method having a step of extracting a collagen source in the presence of a reducing substance has been proposed (see Patent Document 1: Japanese Patent Laid-Open No. 2003-73403). In addition, beverages composed of extracts such as pearl barley, collagen hydrolyzate, vitamins, plum juice and fruit flavors have been proposed (see Patent Document 2: Japanese Patent Publication No. Hei 5-199855). However, an aqueous liquid preparation containing collagen peptide and fruit juice causes precipitation due to storage under the influence of trace metals such as minerals contained in the fruit juice, and there is a problem in liquid stability. For this reason, a technique for suppressing the precipitation of a composition containing a protein-degrading peptide such as a collagen peptide and fruit juice and improving the flavor has been desired. As prior art documents related to the present invention, the following may be mentioned.
[0004] 特許文献 1 :特開 2003— 73403号公報  [0004] Patent Document 1: Japanese Patent Application Laid-Open No. 2003-73403
特許文献 2：特開平 5— 199855号公報  Patent Document 2: JP-A-5-199855
特許文献 3 :特開 2002— 121148号公報  Patent Document 3: Japanese Patent Laid-Open No. 2002-121148
特許文献 4：特開 2002— 51734号公報  Patent Document 4: Japanese Patent Laid-Open No. 2002-51734
特許文献 5：特開 2003 - 238597号公報  Patent Document 5: Japanese Unexamined Patent Publication No. 2003-238597
特許文献 6：特開 2004— 290102号公報  Patent Document 6: Japanese Patent Application Laid-Open No. 2004-290102
特許文献 7：特開 2004 - 346132号公報 特許文献 8：特開 2002— 51734号公報 Patent Document 7: Japanese Patent Application Laid-Open No. 2004-346132 Patent Document 8: Japanese Patent Laid-Open No. 2002-51734
発明の開示  Disclosure of the invention
発明が解決しょうとする課題  Problems to be solved by the invention
[0005] 本発明は、コラーゲンペプチド等のタンパク質分解ペプチドの不快臭を抑制し、し カゝも凝集 ·沈殿が抑制され、保存安定性が良好な液体経口用組成物を提供すること を目的とする。 [0005] An object of the present invention is to provide a liquid oral composition that suppresses an unpleasant odor of a proteolytic peptide such as a collagen peptide, suppresses agglomeration / precipitation, and has good storage stability. To do.
課題を解決するための手段  Means for solving the problem
[0006] 本発明者は、コラーゲンペプチド等のタンパク質分解ペプチド及び果汁を含有する 水性組成物中に、リン酸及び Z又はその塩を配合することによって、不快臭が抑制さ れ、風味が良ぐし力も凝集 *沈殿が抑制され、保存安定性に優れた液体経口用組 成物が得られることを知見した。 [0006] The present inventor suppresses unpleasant odor and improves the flavor by adding phosphoric acid and Z or a salt thereof to an aqueous composition containing a proteolytic peptide such as a collagen peptide and fruit juice. It was also found that a liquid oral composition excellent in storage stability can be obtained, in which cohesion * precipitation is suppressed.
[0007] 従って、下記発明を提供する。  [0007] Accordingly, the following invention is provided.
[1].タンパク質分解ペプチドと、果汁と、リン酸及び Z又はその塩とを含有することを 特徴とする液体経口用組成物。  [1] A liquid oral composition comprising a proteolytic peptide, fruit juice, and phosphoric acid and Z or a salt thereof.
[2].タンパク質分解ペプチドがコラーゲンペプチドである [1]記載の液体経口用組成 物。  [2] The liquid oral composition according to [1], wherein the proteolytic peptide is a collagen peptide.
[3].果汁がバラ科、ッッジ科、ユキノシタ科、ブドウ科、ミカン科、ムクロジ科、ゥリ科、 マタタビ科、ナス科、バショウ科、トケイソゥ科及びパインアップル科力 選ばれる科に 属する果実力も得られた果汁である [1]又は [2]記載の液体経口用組成物。  [3]. Fruits belonging to the selected family of roses, wedges, saxifrage, vines, citrus, cucumbers, cucumbers, matabidae, eggplants, peppers, passilaceae and pineapples The liquid oral composition according to [1] or [2], which is a fruit juice obtained with strength.
[4].さらに、カテキン、プロアントシァニジン、アントシァニン及びアントシァニジンから 選ばれる 1種又は 2種以上を、組成物中に 2〜： LOOOmgZlOOmL含有する [1]〜[3] の!、ずれかに記載の液体経口用組成物。  [4]. Further, one or more selected from catechin, proanthocyanidins, anthocyanins and anthocyanidins are contained in the composition in 2 to: LOOOmgZlOOmL [1] to [3]! The liquid oral composition as described.
[5].さらに、増粘多糖類を含有する [1]〜[4]のいずれかに記載の液体経口用組成 物。  [5] The liquid oral composition according to any one of [1] to [4], further comprising a thickening polysaccharide.
発明の効果  The invention's effect
[0008] 本発明によれば、コラーゲンペプチド等のタンパク質分解ペプチドの独特な不快臭 が抑制され、風味がよぐし力も凝集 *沈殿が抑制され、保存安定性が良好な液体経 口用組成物を提供することができる。 [0008] According to the present invention, the unique unpleasant odor of proteolytic peptides such as collagen peptides is suppressed, the flavor is strong and the agglomeration force is aggregated * precipitation is suppressed, and liquid storage with good storage stability is achieved. An oral composition can be provided.
発明を実施するための最良の形態  BEST MODE FOR CARRYING OUT THE INVENTION
[0009] 本発明のタンパク質分解ペプチドとしては、コラーゲンペプチド、エラスチンべプチ ドが挙げられ、 1種単独で又は 2種以上を適宜組み合わせて用いることができる。特 にコラーゲンペプチドが好ましい。コラーゲンペプチドは、コラーゲン又はコラーゲン 力も得られたゼラチンを、酸又は酵素で加水分解することにより得ることができる。コラ 一ゲンは、動物の結合組織を構成する主要タンパク質で、骨、腱、皮膚、血管壁等に 多く含まれる。ゼラチンは、コラーゲンを含む原料を温水抽出することにより得られる 水溶性タンパク質である。タンパク質分解ペプチドの重量平均分子量は、 500-100 00力 S好まし <、より好まし <ίま 800〜7500、さらに好まし <ίま 1000〜5000である。な お、重量平均分子量の測定はゲルろ過クロマトグラフィ法 (パギィ法:特開 2002— 51 734号公報参照)で測定する。  [0009] Examples of the proteolytic peptide of the present invention include collagen peptides and elastin peptides, which may be used alone or in appropriate combination of two or more. Particularly preferred is a collagen peptide. Collagen peptides can be obtained by hydrolyzing collagen or gelatin with high collagen strength with an acid or enzyme. Collagen is a major protein that forms the connective tissue of animals, and is abundant in bones, tendons, skin, and vascular walls. Gelatin is a water-soluble protein obtained by hot water extraction of a raw material containing collagen. The weight average molecular weight of the proteolytic peptide is 500-100 00 force S preferred <, more preferred <ί or 800-7500, and even more preferred <ί 1000 to 5000. The weight average molecular weight is measured by gel filtration chromatography (Pagii method: see JP-A-2002-51734).
[0010] タンパク質分解ペプチドの含有量は、組成物中 20〜40000mgZl00mL力 子ま しく、より好ましくは 200〜30000mgZlOOmL、さらに好ましくは 400〜20000mg ZlOOmLである。この範囲で、コラーゲンの有効性をより得ることができ、かつ風味と 安定性にさらに優れた液体経口用組成物が得られる。  [0010] The content of the proteolytic peptide in the composition is 20 to 40000 mg ZlOOmL, more preferably 200 to 30000 mg ZlOOmL, and still more preferably 400 to 20000 mg ZlOOmL. Within this range, a liquid oral composition can be obtained in which the effectiveness of collagen can be further obtained, and the flavor and stability are further improved.
[0011] 本発明の果汁は、果実の搾汁力 不溶性固形物を可逆的に除いたものをいう。不 溶性固形物は取り除いてもよぐ取り除いた不溶性固形物の一部又は全部を再度搾 汁液分に戻してもよい。果実の種類としては、バラ科、ッッジ科、ユキノシタ科、ブドウ 科、ミカン科、ムクロジ科、ゥリ科、マタタビ科、ナス科、バショウ科、トケイソゥ科及びパ インアップル科に属するものが挙げられ、 1種単独で又は 2種以上を適宜組み合わせ て用いることができる。バラ科としては、ストロベリー、キイチゴ、ワイルドストロベリー、 ラズベリー、ブラックベリー、モモ、チェリー、リンゴ、ブルーン、ナシ、西洋ナシ、スモ モ、アンズ、ッッジ科としては、ブルーベリー、グランべリー、ツルコケモモ、カウべリー 、ビルべリー、リンゴンベリー、ホワートルベリー、ユキノシタ科としては、ブラックカラン ト、レッド力ラント、ホワイト力ラント、カシス、ブドウ科としてはブドウ、ミカン科としては、 オレンジ、グレープフノレーッ、ュズ、キンカン、レモン、ミカン、ムクロジ科としてはライ チ、ゥリ科としてはメロン、スイカ、マタタビ科としてはキウイフルーツ、ナス科としてはト マト、バショウ科としてはバナナ、トケイソゥ科としてはパッションフルーツ、ノインアツ プル科としてはパインアップルが挙げられる。この中でも、バラ科、ッッジ科、ユキノシ タ科、ブドウ科、ミカン科、ナス科が好ましぐ特に、ミカン、レモン、グレープフルーツ 、ブルーベリー、グランべリー、ストロベリー、リンゴ、ブドウ、モモ、カシス、チェリー、ト マトが好ましい。 [0011] The fruit juice of the present invention refers to a fruit juice obtained by reversibly removing insoluble solids. Insoluble solids may be removed or some or all of the insoluble solids removed may be returned to the juice. The types of fruits include those belonging to the family Rosaceae, Occupiaceae, Saxifragaceae, Grapeaceae, Citrusaceae, Cucurbitaceae, Cucurbitaceae, Matatabidae, Solanum, Pepperaceae, Passifloraceae, and Pineapple. These can be used singly or in appropriate combination of two or more. As for the rose family, strawberry, raspberry, wild strawberry, raspberry, blackberry, peach, cherry, apple, brune, pear, pear, plum, apricot, assorted family, blueberry, granberry, cranberry, cow bee Lee, Bilberry, Lingonberry, White berry, Saxifragaceae, black currant, red power runt, white power runt, cassis, grapes as vines, oranges, grape funnels as citrus Lychee for cucumbers, kumquats, lemons, mandarin oranges, melons for cucumbers, melons for cucumbers, watermelons, kiwifruits for matabidae, and trout for eggplants Bananas are used for the mates and peppers, passion fruits are used for the cicadas, and pine apples are used for the noinupuls. Of these, roses, wedges, saxifrage, grapes, citrus, and eggplants are preferred, especially mandarin, lemon, grapefruit, blueberry, grandberry, strawberry, apple, grape, peach, cassis, cherry Tomato is preferred.
[0012] 果汁の組成物中の含有量は、果汁量 (果実の搾汁から不溶性固形物を可逆的に 除 ヽた量）として 200〜100000mg/100mL、より好ましくは 400〜60000mg/l OOmL、さらに好ましくは 600〜40000mgZl00mLである。果汁は、果汁そのまま（ 等倍)を配合してもよいが、濃縮果汁として配合することが好ましい。例えば 5倍濃縮 果汁を使用した場合は、配合する量は上記の 1Z5量を配合する。  [0012] The content of the fruit juice in the composition is 200 to 100,000 mg / 100 mL, more preferably 400 to 60,000 mg / l OOmL as the amount of fruit juice (the amount obtained by reversibly removing the insoluble solid from the fruit juice). More preferably, it is 600-40000 mgZlOOmL. The fruit juice may be blended as it is (equal size), but is preferably blended as a concentrated fruit juice. For example, when 5 times concentrated fruit juice is used, the amount of 1Z5 is added.
[0013] 本発明のリン酸及び Z又はその塩は、水溶性リン酸ィ匕合物が好ましぐ 1種単独で 又は 2種以上を適宜組み合わせて用いることができる。リン酸及び Z又はその塩とし ては、正リン酸塩、ピロリン酸塩、ポリリン酸塩、メタリン酸塩、トリポリリン酸塩等が挙げ られ、塩としてはナトリウム塩、カリウム塩が挙げられる。この中でも、正リン酸、ピロリン 酸、メタリン酸塩が好ましぐより好ましくはメタリン酸ナトリウム、メタリン酸カリウム等の 酸性メタリン酸塩である。  [0013] The phosphoric acid and Z or a salt thereof of the present invention are preferably used alone or in appropriate combination of two or more, which are preferably water-soluble phosphoric acid compounds. Examples of phosphoric acid and Z or salts thereof include orthophosphates, pyrophosphates, polyphosphates, metaphosphates, tripolyphosphates, and salts include sodium salts and potassium salts. Among these, orthophosphoric acid, pyrophosphoric acid, and metaphosphate are more preferable, and acidic metaphosphates such as sodium metaphosphate and potassium metaphosphate are more preferable.
[0014] リン酸及び/又はその塩の含有量は、組成物中 2〜1000mg/100mLが好ましく 、より好ましくは 10〜600mgZl00mL、さらに好ましくは 20〜600mgZl00mL、 特〖こ好ましくは 40〜200mgZl00mLである。この範囲で、ペプチドの沈殿をより防 ぎ、保存安定性がより良好な液体経口用組成物が得られる。  [0014] The content of phosphoric acid and / or a salt thereof is preferably 2 to 1000 mg / 100 mL in the composition, more preferably 10 to 600 mgZl00 mL, still more preferably 20 to 600 mgZl00 mL, and particularly preferably 40 to 200 mgZl00 mL. . Within this range, it is possible to obtain a liquid oral composition that prevents the precipitation of the peptide and has better storage stability.
[0015] 本発明の液体経口用組成物には、上記成分の他に、風味安定性の点から、力テキ ン、プロアントシァ-ジン、アントシァニン及びアントシァ-ジンから選ばれる 1種又は 2種以上を、組成物中に 2〜： LOOOmgZlOOmL、好ましくは 10〜600mg/100mL 、より好ましくは 20〜200mgZl00mL配合するとよい。この中でも、プロアントシァ 二ジン又はその 2〜4量体、アントシァニン、アントシァ-ジンが好ましい。これらは植 物抽出物を配合してもよぐ精製された単体として配合してもよい。植物抽出物として は、ブルーベリー、ビルべリー、ブドウ、イチゴ、グランべリー、カシス、赤キャベツ、ナ ス、黒米、黒豆 (黒大豆)、黒ゴマ、紫芋、松、緑茶等の茶等から抽出されたエキス又 は精製物が挙げられる。この中でも、ブルーベリー、ビルべリー、ブドウ、イチゴ、松由 来の上記化合物が好ましい。なお、上記果汁中にこれらの化合物を含む場合がある 力 さらに抽出又は精製された上記化合物を配合することにより、特に風味安定性の 良 、液体経口用組成物が得られる。 [0015] In addition to the above components, the liquid oral composition of the present invention contains one or more selected from force textile, proanthocyanin, anthocyanin and anthocyanin from the viewpoint of flavor stability. In the composition, 2 to: LOOOmgZlOOmL, preferably 10 to 600mg / 100mL, more preferably 20 to 200mgZl00mL may be added. Of these, proanthocyanidins or dimers to tetramers thereof, anthocyanins and anthocyanins are preferred. These may be formulated as a purified simple substance or a plant extract. Plant extracts include blueberries, bilberry, grapes, strawberries, grand belly, cassis, red cabbage, nose, black rice, black beans (black soybeans), black sesame, purple koji, pine, green tea, etc. Extracted extract or Is a purified product. Of these, the above compounds of blueberry, bilberry, grape, strawberry and pine are preferred. In addition, the above-mentioned fruit juice may contain these compounds. In addition, by blending the extracted or purified compound, a liquid oral composition having particularly good flavor stability can be obtained.
[0016] 本発明の液体経口用組成物には、増粘多糖類を配合するとよい。増粘多糖類とし ては、ジエランガム、カラギーナン、ぺクチン、グァーガム、ローカスビーンガム、タマリ ンドガム、キサンタンガム、カードラン（ 1, 3 グルカン)等が挙げられる。増粘多 糖類の液体経口用組成物中の含有量は 1〜 1 OOmg/ 1 OOmLが好ましく、より好ま しくは 10〜 50mgZ 1 OOmLである。  [0016] The liquid oral composition of the present invention may contain a thickening polysaccharide. Examples of thickening polysaccharides include dielan gum, carrageenan, pectin, guar gum, locust bean gum, tamarind gum, xanthan gum, curdlan (1,3 glucan) and the like. The content of the thickening polysaccharide in the liquid oral composition is preferably 1 to 1 OOmg / 1 OOmL, and more preferably 10 to 50mgZ 1 OOmL.
[0017] その他、本発明の液体経口用組成物には、ビタミン、保湿剤、新陳代謝向上剤等 の美肌成分を配合することができる。ビタミンとしては、ビタミン B、 B、 B、 B 、 C、 A  [0017] In addition, the liquid oral composition of the present invention can be blended with skin beautifying ingredients such as vitamins, moisturizers, metabolism improvers and the like. Vitamins B, B, B, B, C, A
1 2 6 12 1 2 6 12
、 D、 E、 K、ナイァシン、葉酸、パントテン酸、ピオチン、ュビキノン、及びこれらの誘 導体が挙げられる。この中でも、ビタミン Β、 Β、 Β、 Β 、 Cが好ましい。ビタミンの液 , D, E, K, niacin, folic acid, pantothenic acid, piotin, ubiquinone, and derivatives thereof. Of these, vitamins Β, Β, Β, Β and C are preferred. Vitamin liquid
1 2 6 12  1 2 6 12
体経口用組成物中の適切な含有量は、各々栄養機能食品の栄養素の配合限度量 に従うのが好ましい。  It is preferable that the proper content in the composition for oral use is in accordance with the mixing limit of nutrients of each of the nutritional functional foods.
[0018] 美肌成分としては、肌の保湿力を高めたり、肌の新陳代謝を向上させる成分を配合 することができる。例えば、ヒアノレロン酸、エラスチン、コェンザィム Q10、 a—リポ酸、 アロエ、セラミド、ローヤルゼリー、ァスタキサンチン、アミノ酸類、ダルコサミン、ダルク ロノラタトン、エラグ酸、補酵素等が挙げられる。  [0018] As the beautifying skin component, a component that enhances the moisture retention of the skin or improves the metabolism of the skin can be blended. Examples thereof include hyanorelonic acid, elastin, coenzyme Q10, a-lipoic acid, aloe, ceramide, royal jelly, austaxanthin, amino acids, darcosamine, darcronoraton, ellagic acid, coenzyme and the like.
[0019] 本発明の液体経口用組成物には、通常、経口用組成物に使用される他の薬物や、 甘味剤、酸味剤、安定化剤、キレート剤、防腐剤、香料、色素等を本発明の効果を損 なわない範囲で配合することができる。本発明の液体経口用組成物は、上記成分、 及び水 (残部）を混合して水性の液体経口用組成物として得ることができる。  [0019] The liquid oral composition of the present invention usually contains other drugs used in the oral composition, sweeteners, sour agents, stabilizers, chelating agents, preservatives, fragrances, dyes, and the like. It can be blended within a range that does not impair the effects of the present invention. The liquid oral composition of the present invention can be obtained as an aqueous liquid oral composition by mixing the above components and water (remainder).
[0020] 本発明の液体経口用組成物の 20°Cにおける粘度は 1〜 1 OOmPa · sが好ま U、。  [0020] The liquid oral composition of the present invention preferably has a viscosity at 20 ° C of 1 to 1 OOmPa · s U.
粘度の測定方法は回転粘度形 (RB型粘度計：東機産業 (株) )を用いて測定する。 実施例  Viscosity is measured using a rotational viscosity type (RB viscometer: Toki Sangyo Co., Ltd.). Example
[0021] 以下、実施例及び比較例を示し、本発明を具体的に説明するが、本発明は下記の 実施例に制限されるものではな 、。 [0022] [実施例 1〜22、比較例 1] Hereinafter, the present invention will be specifically described with reference to examples and comparative examples. However, the present invention is not limited to the following examples. [0022] [Examples 1 to 22, Comparative Example 1]
表 1〜3のドリンク剤 (液体経口用組成物）を調製し、下記方法に基づいて、風味と 組成物安定性を評価した。結果を表中に併記する。  The drinks (liquid oral compositions) shown in Tables 1 to 3 were prepared, and the flavor and composition stability were evaluated based on the following methods. The results are also shown in the table.
[0023] (1)組成物安定性 [0023] (1) Composition stability
ドリンク剤を 35°C'4週間保存し、保存後の凝集 ·沈殿の有無を目視にて判定した。 結果を下記評価基準で示す。  The drink was stored at 35 ° C for 4 weeks, and the presence or absence of aggregation / precipitation after storage was judged visually. A result is shown by the following evaluation criteria.
〈評価基準〉  <Evaluation criteria>
〇:凝集 '沈殿がない。  〇: Aggregation 'No precipitation.
△：凝集'沈殿がわずかに見られる。  Δ: Slight aggregation / precipitation
X：凝集 '沈殿が顕著に見られる。  X: Aggregation 'Precipitation is noticeable.
(2)風味の評価  (2) Flavor evaluation
ドリンク剤を 35°C'4週間保存し、保存後の風味安定性を、下記評価基準に基づい て、パネラー 20名にて評価した。  The drink was stored at 35 ° C for 4 weeks, and the flavor stability after storage was evaluated by 20 panelists based on the following evaluation criteria.
〈評価基準〉  <Evaluation criteria>
5 :風味が良い。  5: Flavor is good.
4：不快な風味をほとんど感じな!/、。  4: Almost unpleasant flavor!
3：やや不快な風味を感じる。  3: A slightly unpleasant flavor is felt.
2:不快な風味を感じる。  2: I feel an unpleasant flavor.
1：非常に不快な風味を感じる。  1: A very unpleasant flavor is felt.
結果は、パネラー 20名の平均点が 4. 5以上を「◎」、 4以上を「〇」、 3以上を「△」、 3未満を「X」として示す。  The result shows that the average score of 20 panelists is 4.5 or more as “◎”, 4 or more as “◯”, 3 or more as “△”, and less than 3 as “X”.
なお、各例の製造直後の組成物安定性は「〇」、風味は「◎」であった。  The composition stability immediately after production in each example was “◯”, and the flavor was “「 ”.
[0024] [表 1] 実施例 比較例 組成 (mg) [0024] [Table 1] Example Comparative Example Composition (mg)
1 2 3 4 5 6 7 1 コラーケ"ンへ °フ°チト"（重量平均分子量 1000) *1 2000 2000 2000 コラ—ケ "ン フ°チト"（重量平均分子量 2000) *2 2000 2000 コラーケ'ンへ °フ°チト'（重量平均分子量 3000) *3 2000  1 2 3 4 5 6 7 1 Collagen “Cheap” (weight average molecular weight 1000) * 1 2000 2000 2000 Collagen “Cheet” (weight average molecular weight 2000) * 2 2000 2000 To ° F ° Chito '(weight average molecular weight 3000) * 3 2000
コラーケ"ンへ 'フ 'チト "（重量平均分子量 4000) *4 2000  Collagen's' F 'Chito' (weight average molecular weight 4000) * 4 2000
コラーケ"ンへ 'フ 'チト "（重量平均分子量 5000) *5 2000  Collagen "He'Fito" (weight average molecular weight 5000) * 5 2000
フ'ルーへ'リー濃縮果汁 3000 3000 3000 フ 'ドク濃縮果汁 3000  'Fruhe' Lee concentrated juice 3000 3000 3000 'Doc concentrated juice 3000
かンス濃縮果汁 3000  Kansu concentrated juice 3000
ク'ランへ'リ 濃縮果汁 3000  Ku'ran He 'Concentrated Juice 3000
スト口へ'リー濃縮果汁 3000  Strike mouth 'Lee concentrated juice 3000
チェリ 濃縮果汁 3000  Cheri concentrated juice 3000
メタリン酸ナトリウム 20 20  Sodium metaphosphate 20 20
メタリン酸カリウム 20 20 20  Potassium metaphosphate 20 20 20
ピロリン酸ナトリウム 20 20 水 ランス  Sodium pyrophosphate 20 20 Water Lance
50mL  50mL
組成物安定性 〇 〇 〇 〇 〇 〇 〇 X 風味 ◎ ◎ © © © © ◎ © 果汁 (寿高原食品（株）製、 5倍濃縮果汁）、  Composition stability ○ ○ ○ ○ ○ ○ ○ X Flavor ◎ ◎ © © ©
(表中の数値は 5倍濃縮品配合量、即ち実際の果汁量は表中数値の 5倍量となる)  (The values in the table are 5 times the concentration of the concentrated product, that is, the actual juice amount is 5 times the value in the table.)
*1:新田セ 7チン社製  * 1: Made by Nitta Se 7 Chin
*2:LCP;新田セ "ラチン社製  * 2: LCP; Nitta Se "Latin
*3:SCP - 3100;新田セ 7チン社 K  * 3: SCP-3100; Nitta Se 7 Chin K
*4:80(^;新田セ"ラチン社製  * 4: 80 (^; Nitta Se) made by Latin
*5:SCP - 5100;新田セ 'ラチン社製  * 5: SCP-5100; Nitta Se 'Latin Corporation
[0025] [表 2]  [0025] [Table 2]
Figure imgf000008_0001
Figure imgf000008_0001
果汁 (寿高原食品（株)製、 5倍濃縮果汁）、  Fruit juice (manufactured by Kotobuki Kogen Foods Co., Ltd., 5 times concentrated fruit juice),
(表中の数値は 5倍濃縮品配合量、即ち実際の果汁量は表中数値の 5倍量となる)  (The values in the table are 5 times the concentration of the concentrated product, that is, the actual juice amount is 5 times the value in the table.)
*3:SCP_3100;新田セ チン社製  * 3: SCP_3100; made by Nitta Sechin
[0026] [表 3] 実施例 [0026] [Table 3] Example
組成 (mg)  Composition (mg)
16 17 18 19 20 21 22 コラ ゲンへ 'プチト'（重量平均分子量 1000) *1 2000 2000 コラーゲンへ。プチ '（重量平均分子量 2000) *2 2000 2000 コラ-ゲンへ。プチド（重量平均分子量 3000) *3 2000  16 17 18 19 20 21 22 Collagen 'Petite' (weight average molecular weight 1000) * 1 2000 2000 To collagen. Petit '(weight average molecular weight 2000) * 2 2000 2000 To collagen. Puchido (weight average molecular weight 3000) * 3 2000
コラ ゲンへ。プチド（重量平均分子量 4000) *4 2000 To Collagen. Puchido (weight average molecular weight 4000) * 4 2000
コラーゲンへ 'プチド（重量平均分子量 5000) *5 2000 To collagen 'Petide (weight average molecular weight 5000) * 5 2000
コラ ゲンへ 'プチド (重量平均分子量 1000) 1 1 Collagen 'Petide (weight average molecular weight 1000) 1 1
モモ濃縮果汁 3000 3000 ブト"ゥ濃縮果汁 3000 Peach concentrated juice 3000 3000 Buttou concentrated juice 3000
かンス濃縮果汁 3000 Kansu concentrated juice 3000
リンゴ'濃縮果汁 3000 Apple 'concentrated juice 3000
スト口へ'リー濃縮果汁 3000 Strike mouth 'Lee concentrated juice 3000
チ^-濃縮果汁 3000 メタリン酸ナトリウム 20 20 ^^-concentrated juice 3000 sodium metaphosphate 20 20
メタリン酸カリウム 20 20 20 ピロリン酸ナトリウム 20 20 アントシァニン（黒豆由来） 50 20 30 30 30 カテキン（緑茶由来） 100 Potassium metaphosphate 20 20 20 Sodium pyrophosphate 20 20 Anthocyanin (derived from black beans) 50 20 30 30 30 Catechin (derived from green tea) 100
オリゴメリックプロアントシァニシ 'ン (ブト'ゥ種子由来） 20 20 Oligomeric Proanthocyanin (derived from buttou seeds) 20 20
シ 'エラン力"ム 10 20 10 カラキ'一ナン 15 10 Shi 'Elan power' 10 20 10 Karaki Ichinan 15 10
ヒアルロン酸 1 1 Hyaluronic acid 1 1
コンドロィチン硫酸ナトリウム 2 ク'.ルコサミン 50 50 1 ビタミン C 450 500 500 500 ビタミン ¾ 6 5 5 5 ビタミン ¾ 8 5 5 5 ナイァシン 8 5 5 5 クェン酸 50 30 25 酢酸 30 25 ク"レーフ°フレーハ"一 100 100 100 レモンフレーハ'一 100 100 水 ランス Sodium chondroitin sulfate 2 50'.Lucosamine 50 50 1 Vitamin C 450 500 500 500 Vitamin ¾ 6 5 5 5 Vitamin ¾ 8 5 5 5 Niacin 8 5 5 5 Chenic acid 50 30 25 Acetic acid 30 25 100 100 Lemon Flacher 'One 100 100 Water Lance
50mL  50mL
組成物安定性 〇 〇 〇 〇 〇 〇 〇 風味 ◎ ◎ ◎ ◎ ◎ ◎ 果汁 (寿高原食品（株）製、 5倍濃縮果汁）、 Composition stability 〇 〇 〇 〇 〇 〇 Flavor ◎ ◎ ◎ ◎ ◎ ◎ Fruit juice (manufactured by Kotobuki Foods Co., Ltd., 5-fold concentrated fruit juice),
(表中の数値は 5倍濃縮品配合量、即ち実際の果汁量は表中数値の 5倍量となる)  (The values in the table are 5 times the concentration of the concentrated product, that is, the actual fruit juice amount is 5 times the value in the table.)
*1 :新田セ'ラチン社製  * 1: Nitta Se'Latin
*2 : LCP ;新田セ'ラチン社製 * 2: LCP; Nitta Seirin Co., Ltd.
*3 : SCP - 3100 ;新田セ チン社製 * 3: SCP-3100; manufactured by Nitta Cecin
*4 : 800F;新田セ チン社製 * 4: 800F; Nitta Sechin
*5 : 5じ？-5100 ;新田セ チン社製 * 5: 5? -5100; Nitta Cetin

Claims

請求の範囲 The scope of the claims
[1] タンパク質分解ペプチドと、果汁と、リン酸及び Z又はその塩とを含有することを特 徴とする液体経口用組成物。  [1] A liquid oral composition comprising a proteolytic peptide, fruit juice, and phosphoric acid and Z or a salt thereof.
[2] タンパク質分解ペプチドがコラーゲンペプチドである請求項 1記載の液体経口用組 成物。  [2] The liquid oral composition according to claim 1, wherein the proteolytic peptide is a collagen peptide.
[3] 果汁がバラ科、ッッジ科、ユキノシタ科、ブドウ科、ミカン科、ムクロジ科、ゥリ科、マ タタビ科、ナス科、バショウ科、トケイソゥ科及びパインアップル科カゝら選ばれる科に属 する果実力 得られた果汁である請求項 1又は 2記載の液体経口用組成物。  [3] Juice is selected as a family of roses, wedges, saxifrage, grapes, citrus, succulents, cucumbers, matabidae, eggplants, peppers, passiflora and pineapples The liquid oral composition according to claim 1 or 2, which is a fruit juice obtained.
[4] さらに、カテキン、プロアントシァニジン、アントシァニン及びアントシァニジンから選 ばれる 1種又は 2種以上を、組成物中に 2〜： L OOOmg/ 1 OOmL含有する請求項 1〜 3の 、ずれか 1項記載の液体経口用組成物。  [4] Furthermore, 1 or 2 or more types selected from catechin, proanthocyanidins, anthocyanins and anthocyanidins are contained in the composition from 2 to: L OOOmg / 1 OOmL. The liquid oral composition according to Item.
[5] さらに、増粘多糖類を含有する請求項 1〜4の 、ずれか 1項記載の液体経口用組 成物。  [5] The liquid oral composition according to any one of claims 1 to 4, further comprising a thickening polysaccharide.
PCT/JP2007/058792 2006-04-28 2007-04-24 Liquid composition for oral dosage WO2007125888A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008513201A JP5136796B2 (en) 2006-04-28 2007-04-24 Liquid oral composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-125315 2006-04-28
JP2006125315 2006-04-28

Publications (1)

Publication Number Publication Date
WO2007125888A1 true WO2007125888A1 (en) 2007-11-08

Family

ID=38655414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/058792 WO2007125888A1 (en) 2006-04-28 2007-04-24 Liquid composition for oral dosage

Country Status (2)

Country Link
JP (1) JP5136796B2 (en)
WO (1) WO2007125888A1 (en)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009171862A (en) * 2008-01-22 2009-08-06 Uha Mikakuto Co Ltd Collagen peptide-containing gumi candy, and method for producing the same
JP2009183212A (en) * 2008-02-06 2009-08-20 Q P Corp Acidic beverage
JP2010006743A (en) * 2008-06-26 2010-01-14 Toyo Shinyaku Co Ltd In vivo collagen synthesis accelerator
JP2010222287A (en) * 2009-03-23 2010-10-07 Lion Corp Liquid composition for oral administration
JP2011030486A (en) * 2009-07-31 2011-02-17 Uha Mikakuto Co Ltd Collagen peptide-containing jelly and method for producing the same
JP2011051967A (en) * 2009-08-03 2011-03-17 Fancl Corp Contracting agent for collagen gel
JP2011103822A (en) * 2009-11-18 2011-06-02 Fujifilm Corp Collagen peptide-containing beverage
CN102166021A (en) * 2010-02-26 2011-08-31 美乐迪安股份有限公司 Nutritious subsidy food and producing method thereof
JP2012062278A (en) * 2010-09-16 2012-03-29 Fancl Corp Cosmetic beverage containing apple extract and collagen tripeptide
JP2013000073A (en) * 2011-06-17 2013-01-07 Uha Mikakuto Co Ltd Gallate catechin-containing beverage
WO2013051556A1 (en) 2011-10-07 2013-04-11 富士フイルム株式会社 Drink composition
WO2014050922A1 (en) * 2012-09-27 2014-04-03 サントリーホールディングス株式会社 Aqueous liquid composition containing collagen peptides
JP2015181349A (en) * 2014-03-20 2015-10-22 高田香料株式会社 Flavor improver and method of improving flavor of collagen-containing food and beverage using the same
JP2018134070A (en) * 2017-02-22 2018-08-30 株式会社たらみ Jelly, method for producing jelly, and method for suppressing collagen smell of jelly
JP2019522635A (en) * 2016-06-03 2019-08-15 ソシエテ・デ・プロデュイ・ネスレ・エス・アー Compositions and methods for improving hydration in individuals with difficulty swallowing
WO2019155955A1 (en) * 2018-02-09 2019-08-15 サントリーホールディングス株式会社 Liquid composition for oral use containing collagen peptide, and method for improving flavor of liquid composition for oral use including collagen peptide
JP2021061777A (en) * 2019-10-11 2021-04-22 アサヒ飲料株式会社 Beverage, photo-degradation odor inhibitor, and photo-degradation odor inhibition method

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106578825A (en) * 2016-11-22 2017-04-26 河源农社食品有限公司 Extraction method and application of passion fruit anthocyanin and passion fruit juice drink

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001340069A (en) * 2000-06-01 2001-12-11 Kyowa Hakko Kogyo Co Ltd Fruit or vegetable juice-containing protein beverage
JP2002051734A (en) * 2000-08-08 2002-02-19 Nitta Gelatin Inc Collagen added food and drink
JP2003116503A (en) * 2001-10-15 2003-04-22 Morinaga Milk Ind Co Ltd Beverage having viscosity
JP2004097119A (en) * 2002-09-11 2004-04-02 Nof Corp Composition for liquid food and drink, and food and drink
JP2004290102A (en) * 2003-03-27 2004-10-21 Toyo Shinyaku:Kk Food composition
JP2004346132A (en) * 2003-05-20 2004-12-09 Toyo Shinyaku:Kk Flavan compound-containing composition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07298842A (en) * 1994-05-06 1995-11-14 Asahiya Kurosaki Shokuhin Kogyo:Kk Food or drink material using devil's tongue as raw material and its production
AU2004257595B2 (en) * 2003-07-03 2007-12-20 The Procter & Gamble Company Compositions containing green tea catechins and one or more polyvalent mineral cations
US20080317928A1 (en) * 2004-04-14 2008-12-25 Charles Towler Dairy Product and Process

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001340069A (en) * 2000-06-01 2001-12-11 Kyowa Hakko Kogyo Co Ltd Fruit or vegetable juice-containing protein beverage
JP2002051734A (en) * 2000-08-08 2002-02-19 Nitta Gelatin Inc Collagen added food and drink
JP2003116503A (en) * 2001-10-15 2003-04-22 Morinaga Milk Ind Co Ltd Beverage having viscosity
JP2004097119A (en) * 2002-09-11 2004-04-02 Nof Corp Composition for liquid food and drink, and food and drink
JP2004290102A (en) * 2003-03-27 2004-10-21 Toyo Shinyaku:Kk Food composition
JP2004346132A (en) * 2003-05-20 2004-12-09 Toyo Shinyaku:Kk Flavan compound-containing composition

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009171862A (en) * 2008-01-22 2009-08-06 Uha Mikakuto Co Ltd Collagen peptide-containing gumi candy, and method for producing the same
JP2009183212A (en) * 2008-02-06 2009-08-20 Q P Corp Acidic beverage
JP2010006743A (en) * 2008-06-26 2010-01-14 Toyo Shinyaku Co Ltd In vivo collagen synthesis accelerator
JP2010222287A (en) * 2009-03-23 2010-10-07 Lion Corp Liquid composition for oral administration
JP2011030486A (en) * 2009-07-31 2011-02-17 Uha Mikakuto Co Ltd Collagen peptide-containing jelly and method for producing the same
JP2011051967A (en) * 2009-08-03 2011-03-17 Fancl Corp Contracting agent for collagen gel
JP2011103822A (en) * 2009-11-18 2011-06-02 Fujifilm Corp Collagen peptide-containing beverage
CN102166021A (en) * 2010-02-26 2011-08-31 美乐迪安股份有限公司 Nutritious subsidy food and producing method thereof
TWI449500B (en) * 2010-02-26 2014-08-21 Melodian Co Ltd Nutritional supplement food and manufacturing method
JP2012062278A (en) * 2010-09-16 2012-03-29 Fancl Corp Cosmetic beverage containing apple extract and collagen tripeptide
JP2013000073A (en) * 2011-06-17 2013-01-07 Uha Mikakuto Co Ltd Gallate catechin-containing beverage
CN103841840A (en) * 2011-10-07 2014-06-04 富士胶片株式会社 Drink composition
WO2013051556A1 (en) 2011-10-07 2013-04-11 富士フイルム株式会社 Drink composition
TWI656885B (en) * 2012-09-27 2019-04-21 日商三得利控股股份有限公司 Aqueous liquid composition containing collagen
CN104640462A (en) * 2012-09-27 2015-05-20 三得利控股株式会社 Aqueous liquid composition containing collagen peptides
WO2014050922A1 (en) * 2012-09-27 2014-04-03 サントリーホールディングス株式会社 Aqueous liquid composition containing collagen peptides
JPWO2014050922A1 (en) * 2012-09-27 2016-08-22 サントリーホールディングス株式会社 Collagen peptide-containing aqueous liquid composition
JP2015181349A (en) * 2014-03-20 2015-10-22 高田香料株式会社 Flavor improver and method of improving flavor of collagen-containing food and beverage using the same
JP2019522635A (en) * 2016-06-03 2019-08-15 ソシエテ・デ・プロデュイ・ネスレ・エス・アー Compositions and methods for improving hydration in individuals with difficulty swallowing
JP2022084874A (en) * 2016-06-03 2022-06-07 ソシエテ・デ・プロデュイ・ネスレ・エス・アー Composition and method for improving water supply of individual having dysphagia
US11534400B2 (en) 2016-06-03 2022-12-27 Societe Des Produits Nestle S.A. Compositions and methods for improving hydration of individuals having dysphagia
JP7410204B2 (en) 2016-06-03 2024-01-09 ソシエテ・デ・プロデュイ・ネスレ・エス・アー Compositions and methods for improving hydration in individuals with dysphagia
JP7493909B2 (en) 2016-06-03 2024-06-03 ソシエテ・デ・プロデュイ・ネスレ・エス・アー Compositions and methods for improving hydration in individuals with swallowing difficulties
JP2018134070A (en) * 2017-02-22 2018-08-30 株式会社たらみ Jelly, method for producing jelly, and method for suppressing collagen smell of jelly
WO2019155955A1 (en) * 2018-02-09 2019-08-15 サントリーホールディングス株式会社 Liquid composition for oral use containing collagen peptide, and method for improving flavor of liquid composition for oral use including collagen peptide
CN111712139A (en) * 2018-02-09 2020-09-25 三得利控股株式会社 Liquid oral composition containing collagen peptide and method for improving flavor of liquid oral composition containing collagen peptide
JP2021061777A (en) * 2019-10-11 2021-04-22 アサヒ飲料株式会社 Beverage, photo-degradation odor inhibitor, and photo-degradation odor inhibition method

Also Published As

Publication number Publication date
JP5136796B2 (en) 2013-02-06
JPWO2007125888A1 (en) 2009-09-10

Similar Documents

Publication Publication Date Title
WO2007125888A1 (en) Liquid composition for oral dosage
US20070269576A1 (en) Exotic fruit juice and silver-containing beverage
CN104640462B (en) Aqueous liquid composition containing collagen peptide
US20080199586A1 (en) Nutritional herb and fruit beverage
JP5775373B2 (en) Galate-type catechin-containing beverage
KR101367741B1 (en) Compositions comprising garcinia cambogia extract and methods for preparing the same
JP2008099682A (en) Composition containing functional raw material and/or extract
JP2010222287A (en) Liquid composition for oral administration
JP3825037B2 (en) Vegetable and / or fruit beverage composition
JP2008245539A (en) Vinegar drink
CN103478811A (en) Blueberry-blackberry mixed juice beverage and preparation method thereof
CN107897589A (en) Fruit juice energy drink and preparation method
KR101177336B1 (en) Vegetable and/or fruit drink composition
KR101430803B1 (en) Apple jel beverage and method for making the same
JP2012246241A (en) Aspartate-containing oral composition
NZ530381A (en) Formulation comprising a phenolic compound, an amino acid, active soluble fibre and an aqueous diluent for modulation of sugar metabolism in a mammal
JP4806590B2 (en) Vegetable and / or fruit beverage composition
KR102049769B1 (en) Amino acid beverage comprising allulose
JP2018030815A (en) Fat-derived stem cell activator
WO2006137529A1 (en) Vegetable and/or fruit beverage composition
JP2015130840A (en) Powder food
JP2004346132A (en) Flavan compound-containing composition
CN108013316A (en) A kind of Rosa roxburghii Tratt Fruit treasure and preparation method thereof
TWI676485B (en) Composition containing collagen peptide
KR101631657B1 (en) Ovotrasferrin hydrolysate having with antioxidant activity and method for preparation thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07742227

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2008513201

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07742227

Country of ref document: EP

Kind code of ref document: A1