WO2007119149A2 - Dispositif de dosage volumétrique et appareil mobile associé - Google Patents

Dispositif de dosage volumétrique et appareil mobile associé Download PDF

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Publication number
WO2007119149A2
WO2007119149A2 PCT/IB2007/000966 IB2007000966W WO2007119149A2 WO 2007119149 A2 WO2007119149 A2 WO 2007119149A2 IB 2007000966 W IB2007000966 W IB 2007000966W WO 2007119149 A2 WO2007119149 A2 WO 2007119149A2
Authority
WO
WIPO (PCT)
Prior art keywords
outlet
piston
casing
end portion
inlet
Prior art date
Application number
PCT/IB2007/000966
Other languages
English (en)
Other versions
WO2007119149A8 (fr
WO2007119149A3 (fr
Inventor
Paolo Tacchini
Original Assignee
Arcotronics Technologies S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcotronics Technologies S.R.L. filed Critical Arcotronics Technologies S.R.L.
Publication of WO2007119149A2 publication Critical patent/WO2007119149A2/fr
Publication of WO2007119149A3 publication Critical patent/WO2007119149A3/fr
Publication of WO2007119149A8 publication Critical patent/WO2007119149A8/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/26—Methods or devices for controlling the quantity of the material fed or filled
    • B65B3/30—Methods or devices for controlling the quantity of the material fed or filled by volumetric measurement
    • B65B3/32—Methods or devices for controlling the quantity of the material fed or filled by volumetric measurement by pistons co-operating with measuring chambers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B13/00—Pumps specially modified to deliver fixed or variable measured quantities
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B7/00—Piston machines or pumps characterised by having positively-driven valving
    • F04B7/04—Piston machines or pumps characterised by having positively-driven valving in which the valving is performed by pistons and cylinders coacting to open and close intake or outlet ports
    • F04B7/06—Piston machines or pumps characterised by having positively-driven valving in which the valving is performed by pistons and cylinders coacting to open and close intake or outlet ports the pistons and cylinders being relatively reciprocated and rotated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14216—Reciprocating piston type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14216—Reciprocating piston type
    • A61M5/1422—Reciprocating piston type with double acting or multiple pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16809—Flow controllers by repeated filling and emptying of an intermediate volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ

Definitions

  • Displacement dosing device and relative moving apparatus The present invention relates to a displacement dosing device, in particular a device for dosing fixed and exact amounts of liquid, suitable for the use in pharmaceutical, cosmetic, food field.
  • the invention concerns as well a moving apparatus suitable ford actuating said dosing device and similar others.
  • piston displacement pumps installed on automatic packaging machines for filling containers, such as phials, syringes, capsules, cruets and similar, with liquid products having variable viscosity.
  • the piston translates with alternating motion within a cavity or dosing space made in a tubular cylindrical hollow body.
  • the stroke of the piston enables a fixed volume of liquid to be sucked and then supplied, which is function of the same stroke and the diameter of the cavity of the cylinder.
  • the dosing space exhibits inlet and outlet openings connected respectively with an intake duct and a discharge duct of the liquid to be dosed. Stop valves are provided externally on said ducts for alternatively open and/or close said ducts during operation of the pump.
  • Some dosing devices in substitution of the external valves comprise commutating means, placed inside the dosing space of the cylinder and controlled so as to connect said dosing space alternatively with the intake ducts and the discharge ducts, in phase with the rectilinear motion of the piston.
  • Such commutating means may consist of a rotating valve inserted in the dosing space, suitable for opening and closing the inlet and outlet openings.
  • dosing devices are known wherein , the commutating means are obtained on the piston self which, besides to slide axially, • may rotate around its own longitudinal axis of translation for a prefixed angle, so as to place in communication the dosing space alternatively with the intake duct and the discharge duct.
  • Such piston in order to collect said feeding duct with the dosing space", exhibits, in fact, a cavity that during the intake phase is faced to the feeding duct.
  • the intake stroke of the piston determines a volume increase of the dosing space and consequently the suction of liquid from the feeding duct.
  • the piston-valve is rotated so that the cavity corresponds with the discharge duct, in order to enable the piston, during the return stroke or dosing stroke, to deliver the predefined amount of fluid.
  • the piston is brought again in the starting angular position and the disclosed dosing cycle can start again.
  • the devices disclosed above comprise an upwards open cylinder for enabling a piston-valve to be introduced from above, provided with an upper end protruding from the cylinder, suitable for being connected with proper actuating members that provide for the rotation and translation of said cylinder.
  • the dosing devices can be subjected to on site washing and sterilizing operations, without the need of dismounting any components thereof.
  • Such operations known with the term of CIP/SIP (Cleaning In Place / Sterilizing In Place) , consist substantially in a sequence of steps, suitable for being carried out in automatic or semi-automatic manner, in the course of which the interior of the dosing devices is passed through by washing fluids at different temperatures and by pressurized vapor.
  • CIP/SIP Camera In Place / Sterilizing In Place
  • any internal surface of the device that is in contact with the product, is conveniently reached and licked with the necessary flow speed by the washing and sterilizing fluids .
  • Ia structure and conformation of the device must assure the correct drainage and discharge of such fluids at the end of the washing and sterilizing cycles, i.e. the absence of point where said fluids can accumulate and stagnate.
  • the known dosing devices are associated with dosing/filling machines generally grouped together in variable number, so as to feed a plurality of respective filling noses of containers .
  • Supporting frames provide to support the dosing devices and, above said dosing devices, the actuating members of the pistons, said members being accommodated within suitable containers .
  • the actuating members comprise motors, transmission mechanisms and linkages, sensors, etc. that, for reasons of cleanliness and hygiene must be separated from the environment where packaging of the product occurs.
  • the sterility of the packaging environment of the products is assured, among other things, by the presence of a proper sterile flow of filtered air, that vertically flows from top to down with steady-state unidirectional and uniform motion, in particular at the operating regions, where for example dosing of the product in the containers occurs.
  • the air flow gives rise to a sterile air front that licks the containers and drags along towards the bottom contaminant particles possibly present in the environment.
  • the air flow further prevents such particles from being able to rise again from the bottom towards the top and enter the containers, so as to contaminate them.
  • the dimensions of the casings enclosing the actuating members and mainly their superelevated position with respect . to the dosing devices perturb the unidirectional and uniform flow of the air and force the set of the dosing devices to be positioned as far as possible from the dosing region. When this is not possible, for example due to the transversal dimensions of the dosing machine, a deviation and alteration of the air flow arises in said dosing region.
  • Dosing devices are known in which the piston can be actuated from below, its mounting end protruding downwards from the cylinder.
  • said devices require laborious procedures of manual filling and can be installed only in inclined position.
  • their inclined arrangement implies an increase of the volumes and therefore remarkable restrictions of structural and manufacturing type, mainly in the case of applications in aseptic/sterile environment.
  • the known piston displacement pumps are made generally of stainless steel, material that is suitable for contact with pharmaceutical and food products and may be subjected to washing and sterilizing procedures.
  • Ceramic materials owing to which components can be realized that show narrow dimensional tolerances and reduced values of surface roughness .
  • the ceramic materials exhibit very high strength coefficients to wear and high temperatures and very limited thermal expansion coefficients. Said properties make the ceramic materials particularly indicated for realizing piston pumps of high precision and predisposed for washing and sterilizing CIP/SIP procedures .
  • the ceramic materials exhibit however limitation in mechanical field, because are substantially brittle easily susceptible to breakage, fractures, chipping.
  • the cylinders of the pumps made of ceramic material are covered by a metallic jacket, typically of stainless steel. Said metallic jacket is- mounted by expansion fit with interference, so as to form with the ceramic cylinder a monolithic single body.
  • the external metallic casing besides to protect the internal ceramic cylinder, enables the pump to be fixed to a supporting frame and the mounts of the ducts for suction, discharge and drainage to be connected with said pump.
  • the unremovable and irreversible interference coupling between ceramic cylinder and steel jacket exhibits some disadvantages . It is actually possible that, due to a non optimal coupling, in the interface region between ceramic cylinder and metallic jacket slots, splits, interspaces are present of microscopic dimensions but sufficient for allowing seepage and diffusions of liquids, such as products to be dosed, washing and sterilizing liquids. In that case, it is not possible to provide to a correct and complete cleaning, because the cylinder-jacket assembly is not dismountable .
  • An object of the present invention is to improve the known displacement dosing devices.
  • Another object is to realize a device permitting an accurate and exact dosing in a wide range of filling volumes and enabling an efficient and complete discharge of the air in automatic manner, in particular during the starting stage.
  • a further object is to obtain a dosing device wherein the piston can be actuate from below, so that the respective moving means is arranged below the apparatus self.
  • Other object is to realize a dosing device configured and suitable for washing and sterilizing operations of CIP/SIP type.
  • a device for dosing amounts of liquid in desired volumes, comprising piston means movable in a cavity of casing means in order to collect an amount of liquid from an inlet of said casing means and direct said amount of liquid towards an outlet of said casing means, said piston means being provided with commutating means such to selectively make communicating said cavity with said inlet or with said outlet, said commutating means being provided with an operating end suitable for being faced with at least said outlet in order to define with said outlet an outflow wall such to inhibit the adhesion of possible air bubbles .
  • a dosing device can be obtained that enable an efficient and complete discharge of the air in automatic manner during the starting stage.
  • the operating end of the commutating means and the outlet of the casing means are actually coincident with the highest point of the internal cavity, i.e. the point where possible air bubbles could collect.
  • the commutating means of the piston means comprises a longitudinal channel configured for realizing with said outlet a discharge duct the shape and dimensions of which facilitate the air bubbles to spontaneously flow out of and prevent said air bubbles from stagnating within the cavity.
  • the particularly accurate and exact surface finish of the surfaces of the cavity and the piston means contribute the possible bubbles to be prevented from adhere.
  • said piston means may be translationally and rotationally operated by moving means arranged below the device .
  • the moving means is connected with a lower end of the piston means, protruding from below from the cavity of the casing means.
  • a device is provided for dosing amounts of liquid in desired volumes, said device being provided with piston means movable in a cavity of casing means and comprising covering means suitable for removably containing said casing means.
  • a device for dosing can be realized wherein the casing means, made for example of ceramic material, is contained, protected against possible breakage, fractures, chipping, inside covering means, of metallic material, for example stainless steel.
  • the covering means comprises two jackets configured for containing respective upper and lower portions of the casing means, said jackets being mutually removably connected by fixing means. That enables the device to be rapidly, easily and completely dismounted, in order to provide for a correct and detailed cleaning of the single components of the device. Namely, all the surfaces of said components can be accessed, slots, splits, interspaces of the interface region between .the casing means and the jackets of the covering means being made accessible for cleaning. The possibility of dismounting the covering means from the casing means enables said covering means to be substituted in case of failure, damage, wear.
  • a apparatus for moving a dosing device, comprising first actuating means and second actuating means suitable connectible with a lower portion end of piston means of said device in order to linearly and rotationally move said piston means.
  • a moving apparatus for dosing devices can be realized suitable for being actuated from below that may be arranged internally below said devices and accommodated within a containing volume suitable for being hermetically separated from the processing environment, for example the sterile dosing environment.
  • Figure 1 is a longitudinal section of the displacement dosing device of the invention, highlighting piston means in a first operating position of suction start stroke and, with dotted line, in a fourth operating position of discharge end stroke;
  • Figure 2 is a section like Figure 1, highlighting the piston means respectively in a second operating position of suction end stroke and, in dotted line, in a third operating position of discharge start stroke;
  • Figure 3 is a partial enlarged section like Figure 1, highlighting an operating end of commutating means of the piston means,-
  • Figure 4 is an enlarged cross section according to a plane IV-IV of Figure 1;
  • Figure 5 is a longitudinal section of a version of the device of Figure 1, wherein the piston means are in a fifth washing and sterilizing operating position;
  • Figure 6 is a partial schematic section of moving means of the device of Figure 1 associated with a frame of a packaging machine ;
  • Figure 7 is a front view, partially sectioned, of the moving means of Figure 6 with a plurality of devices of Figure 1.
  • a device is shown for dosing amounts of liquid in desired volumes, comprising piston means 3 moving in a cavity 4 of casing means 2 for collecting a desired amount of liquid from an inlet 12 of said casing means 2 and directing said desired amount of liquid toward an outlet 13 of said casing means 2.
  • the piston means 3 are provided with commutating means 8 such to make selectively communicating the cavity 4 with the inlet 12 or with the outlet 13 and provided with an operating end 8a suitable for being faced at least to said outlet 13 for defining with said operating end 8a- an outflow wall such as to prevent possible air bubbles from adhering and becoming stagnant, in particular during the starting or "turn-on" step of the device.
  • the piston means 3 are moving with alternating translating motion between a withdrawn or internal position and an extended or external position, and moving with as well alternating rotating motion, between an intake position, wherein the commutating means 8 places in communication the cavity 4 with the inlet 12 and a discharge position, wherein said commutating means 8 connects said cavity 4 with the outlet 13.
  • the piston means 3 is moving between four different operating positions, as explained in detail in the operation of the device.
  • the cavity 4 of substantially cylindrical shape extends longitudinally over the full length of the casing means 2, comprising a tubular, also substantially cylindrical element.
  • the cavity 4 is comprised of a lower chamber 4a and an upper chamber 4b, having different diameters and length.
  • the lower chamber 4a exhibits a greater diameter than the upper chamber 4b.
  • the upper chamber 4b of the internal cavity 4 is in flow communication with an intake duct 30 and with a discharge duct 31 of the liquid product to be dosed, respectively via said inlet 12 and said outlet 13, consisting of respective holes made on the tubular wall of said upper chamber 4b.
  • the inlet holes 12 and the outlet holes 13 are arranged at the same level or height with reference to a longitudinal axis Z of the device 1, said axis Z being coincident with the translation direction of the piston means 3.
  • the inlet holes 12 and the outlet holes 13 are arranged at the same level or height with reference to a longitudinal axis Z of the device 1, said axis Z being coincident with the translation direction of the piston means 3.
  • outlet holes 13 are mutually angularly spaced apart for an angle ranging between 30° and 180°, for example 120°
  • Said holes are further made virtually orthogonal to the tubular wall of the upper chamber 4b.
  • the internal wall of the upper chamber 4a exhibits a first groove 9 and a second groove 10, longitudinal, of elongate shape and substantially parallel to the longitudinal axis Z.
  • Said grooves 9, 10 extend towards the lower chamber 4a starting respectively from the inlet 12 and the outlet 13.
  • the piston means 3 consists substantially of a cylindrical elongate body comprising three portions coaxial with the longitudinal axis Z and having different diameters and lengths .
  • the piston means 3 comprises an upper end portion 7, an intermediate portion 6 and a lower end portion 5. This latter is configured for exiting out of the lower chamber 4a of the casing means 2 in order to enable to be connected with moving means suitable for to transmitting the movement to the piston means 3.
  • the intermediate portion 6 of the piston means 3 is predisposed. for tightly sliding within the lower chamber 4a, whereas the upper portion 7 is configured for tightly sliding , within the upper chamber 4b.
  • the diameter of the intermediate portion 6 is greater than the diameter of the upper portion 7.
  • the hydraulic tightness between the portions 6, 7 of the piston 3 and the respective chambers 4a, 4b is accomplished owing to the reduced clearances between the walls of said portions and said chambers, said clearances enabling sliding without friction of the piston 3, but excluding the passage of the liquid to be dosed.
  • the commutating means 8 comprises an elongate longitudinal channel, virtually parallel to the longitudinal axis Z of the device 1 and made in the upper end portion 7 of the piston 3.
  • the channel 8 is adapted for selectively matching the first groove 9 or the second groove 10 and placing in communication the lower chamber 4a respectively with said inlet 12 or said outlet 13, as a function of the angular position of the piston 3.
  • said channel 8 comprises, besides said operating end 8a designed for being faced to said inlet 12 and said outlet 13., a further operating end 8b, configured for conveying the liquid in the lower chamber 4a, and an intermediate connecting portion 8c of the two operating ends 8a, 8b.
  • Said intermediate portion 8c is substantially rectilinear and of width virtually equal to the width of the grooves 9, 10 of the casing means 2 ( Figure 3) .
  • the length of the channel 8 is such to always enable the flow connection between the lower chamber 4a and the first groove 9 or the second groove 10, regardless of the axial position of the piston means 3.
  • the piston means 3 is then rotated in a third operating position C, wherein the channel 8 is aligned with the second groove 10 with Ia operating end 8a thereof faced to said groove 10 and flowing into said groove 10, in order to connect the lower chamber 4a with the discharge duct 31.
  • the piston means 3 progressively forces the fluid out of the lower chamber 4a towards the discharge duct 31.
  • the inlet 12 is. tight closed by the upper portion 7 of the piston means 3.
  • the piston means 3 is in a fourth operating position D, i.e. in withdrawn position of discharge.
  • the channel 8 is arranged faced to the second groove 10 with the operating end 8a thereof arranged faced and virtually coincident with the outlet opening 13.
  • the further operating end 8b flow out in the lower chamber 4a in order to enable, similarly to what is occurring in the first operating position A, possible air bubbles present in the space 4a to flow out.
  • the air present in a liquid contained inside a cavity aims to rise back vertically for collecting itself in the upper portion of said cavity, as a combined effect of the lower density of the air with respect to the al liquid and the gravity. Since in the first operating position A and in the fourth operating position D of the piston 3 the highest point of the internal cavity 4 corresponds with the inlet 12 and the outlet 13 respectively, the possible air bubbles present can spontaneously exit from the device 1. The exit of the air is further favored by the vertical movement of the piston means 3 that axially moves in discharge from the third operating position C to the fourth operating position D and in intake from the first operating position to the second operating position B.
  • the holes of the inlet 12 and the outlet 13 are skew with respect to the side wall of ' the upper chamber 4b.
  • the axes of said holes are inclined upwards, starting from the internal surface of the upper chamber 4b, by an angle ranging between 1° and 30°.
  • the inlet 12 and the outlet 13 and the respective intake duct 30 and discharge duct 31 exhibit a slope directed toward the interior of the space 4 that further facilitates the outflow of possible air bubbles, therein present .
  • the longitudinal channel 8 and Ie grooves 9, 10 exhibit respective bottoms having concave cross section, in particular they consist of portions of cylindrical or ellipsoidal surfaces.
  • each groove 9, 10 establishes, when faced to the longitudinal channel 8, a substantially cylindrical passage duct of the liquid, of circular or elliptical section ( Figure 4) .
  • Le operating ends 8a, 8b of the channel 8 comprise, for example, portions spherical surfaces or portions of surfaces with double curvature, profiled so as join in accurate and exact manner the longitudinal channel 8 with the openings of inlet 12 and outlet 13.
  • the device of the invention enables depleting or bleeding of the air to be accomplished in automatic and efficient way, such procedure being to be carried out necessarily before the start of the production.
  • the volume of dosed liquid is defined with precision, being function of the dimensions of the chambers 4a, 4b of the cavity 4, of the portions 6, 7 of the piston means 3 and of the stroke of the piston means 3. Varying said stroke enables the dosing .device 1 to dose defined volumes of liquid contained within a range of values . From the fourth operating position D, the piston means 3 is rotated and brought again in the first operating condition A so as to repeat the dosing cycle.
  • covering means 15, 16 is provided suitable for covering and containing, in an assembled condition, the casing means 2.
  • the covering means 15, 16 is made of metallic material, typically stainless steel of the type commonly used for the pharmaceutical and/or food applications .
  • the covering means comprises a lower jacket 15 and an upper jacket 16, removably interconnected via blocking means 17.
  • Said blocking means 17 comprises, for example, a threaded ring nut, suitable for engaging a shoulder 15c of the lower jacket 15 and screwing with a threaded portion 16c of the upper jacket 16.
  • the lower jacket 15 comprises a first housing 15a configured for containing a lower portion of the casing means 2. Said first housing 15a is upwards open for enabling the casing means 2 to be introduced and exhibits a lower open 15b for the passage of the piston means 3.
  • the upper jacket 16 comprises a second blind housing 16a, pre-arranged for containing an upper portion of the casing means 2 and, partially, the upper end portion 7 of the piston 3, when this latter lies in withdrawn position.
  • the upper jacket 16 comprises first connection means 21 and second connection means 22 suitable for connecting respectively the intake duct 30 with the inlet 12 and the discharge duct 31 with the outlet 13.
  • the intake ducts 30 and the discharge ducts 31 comprise adapters of known type, suitable for being connected with rigid and/or flexible ducts and are removably suitable for being coupled with said connection means 21, 22 for example by means of threaded couplings or couplings of the type commonly known as "Tri-clamp".
  • the external jacket 16 comprises an upper mounting portion 16b suitable for securing the device 1 to support means, for example of a dosing machine with which the device 1 mat be associated.
  • a coupling element 18 is provided also made of stainless steel fixed to the lower end portion 5 of the piston means 3 for enabling this latter to be connected with moving means.
  • the casing means 2 and the piston means 3 of such version are identical to those of the device of the embodiment of which at the Figures 1-4.
  • the covering means 115, 116 comprises a feeding opening 25 and a discharging opening 26 predisposed respectively for the entry and the exit of said washing and/or sterilizing fluids.
  • the feeding opening 25 is " obtained on the upper jacket 116 and flow out in the second housing 116a at the bottom of this latter.
  • the discharging opening 26 is made on the lower jacket 115 at the lower opening 115a.
  • Connecting elements of known type may be attached to the feeding openings 25 and the discharging openings 26, for example of the ⁇ Tri-clamp" type, for connecting the device 1 with tubes and ducts of a washing and sterilizing plant or system.
  • the lower jacket 115 differs from that of the device of Figures 1-4, in that said lower jacket 115 exhibits a greater longitudinal development, because said lower jacket 115 besides the first housing 115a comprises an underlying washing chamber 115d connected with said housing.
  • the washing chamber 115d and Ia lower chamber 4a of the casing means 2 are capable of containing the upper end portion 7, the intermediate portion 6 and, partially, the lower end portion 5 of the piston means 3, in a fifth operating position E for washing said piston means 3. ;
  • the transversal dimensions, i.e. the diameter, of such washing chamber 115d is greater than the diameter of the intermediate portion 6 of the piston means 3 so that the contact of the walls is prevented and a properly dimensioned interspace is . obtained for the passage of washing and sterilizing fluids.
  • said washing and sterilizing fluids can licks the internal walls of the cavity 4 and the external walls of the piston means 3 that came into contact with the dosed, liquid, during the execution of a procedure of CIP/SIP type.
  • gasket means 29 is provided.
  • Said gasket means 29 is housed in a respective seat obtained at the lower opening 15b, below the discharging opening 26 and engages in the fifth washing operating position E an end portion 118a of the mounting element 118 that partially covers the lower end portion 5 of the piston 3.
  • Sealing means 27, 28 are interposed between the casing means 2 and the covering means 116, 115 for preventing washing liquids and/or vapors from being able to infiltrate and penetrate in the interspace or space obtained from the external surfaces of the casing means 2 and the covering means 115, 116.
  • a moving apparatus 40 is further provided suitable for actuating the piston means 3 with translation and rotation movement during the operation of the dosing device 1.
  • Said moving apparatus 40 is suitable for being associated with a packaging machine or, in a version not shown, with a dosing unit separated from the packaging machine, comprising one or more dosing devices 1.
  • the moving apparatus 40 comprises first actuating means 41, arranged for translationalIy actuating the piston means 3 and second actuating means 42, suitable for placing in rotation said piston means 3.
  • said actuating means 41, 42 operates on a single connecting shaft 50, one free end 53 of which is removably connected with the mounting element 18, 118 of the piston means 3.
  • the first actuating means 41 comprises first motor means 43 of rotating type, and consisting for example of an electric brushless motor, connected with, said connecting shaft 50 via first transmission means 44, 45.
  • Said transmission means is able to convert the rotation movement of the first motor means 43 in a rectilinear translation movement, along a movement direction X virtually- coincident with the longitudinal axis Z of the device 1.
  • Said first transmission means 44, 45 comprises, for example, coupling means of screw-nut type.
  • the first motor means 43 places in rotation a screw 44 on which a threaded sleeve or female screw 45 engages, prevented from rotating and thus forced to translate along said direction of movement X .
  • a supporting flange 46 fixed with the sleeve 45 rotationally supports the connecting shaft 50 by means of a respective bearing 47, at the lower end 54 thereof opposed to the free end 53.
  • the screw 44 is connected with the output shaft of the first motor means 43 by motion reduction means 48, comprising for example a pair of spur gears .
  • Support means 80, 81 is provided fixed to frame of the machine 100 for supporting the full moving apparatus 40.
  • the first motor means 43 may be of linear type, to directly translationally move the connecting shaft 50.
  • the second actuating means 42 comprises second motor means 49, this also of rotating type and consisting for example in an electric brushless motor, configured for placing in rotation said connecting shaft 50, via second transmission means 51, 52.
  • Said second transmission means 51, 52 comprises sleeve means 51 rotationally fixed with a supporting plate 81 and configured for slidingly engaging a splined portion 52 of the connecting shaft 50.
  • This latter may consists of a splined shaft of known type, for example a splined shaft provided with cylindrical ends 53, 54 for coupling with supporting bearings 47, 59.
  • the sleeve means 51 these also of known type, enables the shaft 50 to freely translationally slid, with which shaft 50 the sleeve means 51 transmits instead a rotation torque when driven by second motor means 49.
  • the sleeve means 51 is connected with an output shaft of the second motor means 49 by respective motion reduction means comprising, for example, a gear wheel 65 suitable for engaging a cylindrical toothed portion 51a of said sleeve means 51.
  • the moving apparatus 40 is arranged for being inserted and contained inside a containing volume 101, for example of the packaging machine 100, separated with respect to a processing environment 102, wherein for example dosing takes place, by means of a division wall 104.
  • a processing environment 102 wherein for example dosing takes place, by means of a division wall 104.
  • the separation of the environments has to be tight in the case of applications in pharmaceutical and food field, in order to preserve the processing environment 102, maintained in controlled sterile atmosphere, from contamination of any type, for example microbiological, particle, etc.
  • joint means 70 is consequently provided suitable for tight closing a passage opening 105 made on the division wall 104 for the passage of said connecting' shaft 50.
  • the joint means 70 comprises first tube means 56 inserted in the passage opening 105 and fixed with the wall 104, in order to slidingly support the connecting shaft 50.
  • the first tube means 56 has elongate tubular cylindrical shape.
  • Second tube means 57 is interposed between said first tube means 56 and said connecting shaft 50 and is rotationally connected with this latter via respective rolling bearings 59.
  • the second tube means 57 is coaxial with the first tube means 56 and the connecting shaft 50 and may axially slide with respect to this latter, because is free to slide within the first tube means 56.
  • the rotation of said second tube means 57 is instead prevented by an anti-rotation element 60 that slides within a slot 61 of the first tube means 56.
  • Containing means 55 is provided on the wall 104 to realize the tightness between the first tube means 56 and the opening 105.
  • the joint means 70 further comprises a connecting element 63 suitable for connecting the free end 53 of the connecting shaft 50 with the coupling element 18 of the piston means 3.
  • A' rotating seal 64 is provided, fixed to said connecting element 63 for engaging the external cylindrical surface of the second tube 57.
  • the seals 62, 64 assure Ia separation between the containing volume 101 and the processing environment 102.
  • the moving means 40 may comprise a plurality of actuating means 41 and 42, for driving respective dosing devices 1, as shown in Figure 7. Each dosing device 1 is thus operated by respective first motor means 43 and second motor means 49 in independent manner.
  • the second motor means 49 comprises only one motor capable of actuating the totality of the dosing devices 1.
  • the second actuating means 42 comprises respective coupling/releasing means configured for connecting or disconnecting respective second transmission means 51, 52 from, said motor 49, in the . case that the corresponding dosing device 1 is respectively to be actuated or blocked.
  • the moving apparatus 40 of the invention is fully accommodated inside the containing volume 101 of the packaging machine, which containing volume 101 is hermetically separated from the processing environment 102 and suitable for being accessed in independent and distinct manner, for example via lateral panels.
  • the moving apparatus 40 of the invention is fully accommodated inside the containing volume 101 of the packaging machine, which containing volume 101 is hermetically separated from the processing environment 102 and suitable for being accessed in independent and distinct manner, for example via lateral panels.
  • the moving apparatus 40 is arranged below the dosing devices, so as to actuate from below the piston means 3 of the device 1.
  • the apparatus 40 does not perturb such air flow, at an overhanging operating region, wherein dosing takes place.
  • the presence of any moving member is not necessary. Since also the connection between the piston means 3 and the actuating means 41, 42 is positioned below the operating region, possible particles or contaminants that may be generated by the movements of- translation and rotation of the piston means 3 are dragged downwards by the air flow, without being capable of rising again and involve said operating region.
  • dosing device or the devices of the invention within a dosing machine.
  • Such devices and relative moving means since do not perturb, or perturb very scarcely, said unidirectional air flow, can be arranged also near the operating region, in order to realize for example a machine of reduced transversal dimensions, enabling all the operating groups to be easily accessed from a. single frontal or rear side.
  • the dosing device 1 and the relative moving apparatus 40 result consequently particularly suitable for being associated with a dosing packaging machine, operating in aseptic and/or sterile atmosphere under unidirectional and uniform air flow, for example a machine placed within a sterile space or a machine provided with a sealing cabin or insulator.

Abstract

Dispositif servant à doser des quantités de liquide en volumes désirés et comprenant un piston (3) mobile dans une cavité (4) de boîtier (2) afin de prélever une quantité de liquide depuis une entrée (12) dudit boîtier et de diriger ladite quantité de liquide vers une sortie (13) dudit boîtier. Ledit piston (3) est pourvu de moyens de commutation (8) permettant à ladite cavité (4) de communiquer de façon sélective avec ladite entrée (12) ou ladite sortie (13), lesdits moyens de commutation (8) comportant une extrémité opérationnelle (8a) conçue pour être placée en face de ladite sortie (13), de manière à définir avec ladite sortie (13) une paroi de sortie empêchant l'adhérence d'éventuelles bulles d'air. Appareil mobile associé au dispositif de dosage et comprenant des premiers moyens d'actionnement (41) et des deuxièmes moyens d'actionnement (42) pouvant être accouplés de façon amovible avec une partie d'extrémité inférieure (5) du piston (3) dudit dispositif (1) afin d'imprimer un déplacement linéaire et une rotation audit piston (3).
PCT/IB2007/000966 2006-04-13 2007-04-12 Dispositif de dosage volumétrique et appareil mobile associé WO2007119149A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO20060276 ITBO20060276A1 (it) 2006-04-13 2006-04-13 Dispositivo di dosaggio volumetrico e relativo apparato di movimentazione
ITBO2006A000276 2006-04-13

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WO2007119149A3 WO2007119149A3 (fr) 2008-05-08
WO2007119149A8 WO2007119149A8 (fr) 2008-08-28

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Cited By (17)

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WO2009143188A3 (fr) * 2008-05-19 2010-04-01 Diperna Paul M Réservoir à pompe jetable et procédés associés
EP2361646A1 (fr) * 2008-09-12 2011-08-31 Roche Diagnostics GmbH Unité de dosage et dispositif de perfusion ambulatoire comportant l'unité de dosage
FR2959734A1 (fr) * 2010-05-10 2011-11-11 Spc France Systeme de fixation pour pompe de dosage
ITBO20110130A1 (it) * 2011-03-16 2012-09-17 Ima Life Srl Dispositivo di dosaggio
US8790316B2 (en) 2007-03-15 2014-07-29 Roche Diagnostics International Ag Dosing device for an infusion system and method thereof
US9211377B2 (en) 2009-07-30 2015-12-15 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
EP2992916A1 (fr) * 2014-04-18 2016-03-09 Becton Dickinson and Company Pompe de dosage à piston fendu
EP3045724A1 (fr) 2015-01-13 2016-07-20 Neoceram S.A. Pompe en céramique et carter correspondant
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9962486B2 (en) 2013-03-14 2018-05-08 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10258736B2 (en) 2012-05-17 2019-04-16 Tandem Diabetes Care, Inc. Systems including vial adapter for fluid transfer
WO2019152824A1 (fr) * 2018-02-02 2019-08-08 Fluid Metering, Inc. Appareil de pompe à déplacement positif à canaux multiples
CN110425129A (zh) * 2019-06-21 2019-11-08 中国计量大学上虞高等研究院有限公司 一种低泄漏双作用对称式流体流量精密计量装置
WO2019219272A1 (fr) * 2018-05-15 2019-11-21 Robert Bosch Gmbh Dispositif destiné à doser un liquide, en particulier un produit pharmaceutique
WO2021108591A1 (fr) * 2019-11-27 2021-06-03 Waters Technologies Corporation Soupape de dosage à gradient
CN114042207A (zh) * 2017-01-31 2022-02-15 松瑟博工业股份有限公司 药物输送装置
CN114042207B (zh) * 2017-01-31 2024-05-10 松瑟博工业股份有限公司 药物输送装置

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US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
CN106401894A (zh) * 2016-12-13 2017-02-15 无锡书谱尔精密机械科技有限公司 双槽精密计量泵

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US10034983B2 (en) 2007-03-15 2018-07-31 Roche Diabetes Care, Inc. Dosing device for an infusion system and method thereof
US10034977B2 (en) 2007-03-15 2018-07-31 Roche Diabetes Care, Inc. Dosing device for an infusion system and method thereof
US8790316B2 (en) 2007-03-15 2014-07-29 Roche Diagnostics International Ag Dosing device for an infusion system and method thereof
US9687604B2 (en) 2007-03-15 2017-06-27 Roche Diagnostics International Ag Dosing device for an infusion system and method thereof
US10029046B2 (en) 2007-03-15 2018-07-24 Roche Diabetes Care, Inc. Dosing device for an infusion system and method thereof
WO2009143188A3 (fr) * 2008-05-19 2010-04-01 Diperna Paul M Réservoir à pompe jetable et procédés associés
EP2361646A1 (fr) * 2008-09-12 2011-08-31 Roche Diagnostics GmbH Unité de dosage et dispositif de perfusion ambulatoire comportant l'unité de dosage
US8469930B2 (en) 2008-09-12 2013-06-25 Roche Diagnostics International Ag Dosing unit, ambulatory infusion device comprising dosing unit and method for operating a dosing unit
US8500700B2 (en) 2008-09-12 2013-08-06 Roche Diagnostics International Ag Dosing unit, ambulatory infusion device comprising dosing unit and method for operating a dosing unit
US9119911B2 (en) 2008-09-12 2015-09-01 Roche Diagnostics International Ag Dosing unit, ambulatory infusion device comprising dosing unit and method for operating a dosing unit
US11285263B2 (en) 2009-07-30 2022-03-29 Tandem Diabetes Care, Inc. Infusion pump systems and methods
US11135362B2 (en) 2009-07-30 2021-10-05 Tandem Diabetes Care, Inc. Infusion pump systems and methods
US9211377B2 (en) 2009-07-30 2015-12-15 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
FR2959734A1 (fr) * 2010-05-10 2011-11-11 Spc France Systeme de fixation pour pompe de dosage
ITBO20110130A1 (it) * 2011-03-16 2012-09-17 Ima Life Srl Dispositivo di dosaggio
US10258736B2 (en) 2012-05-17 2019-04-16 Tandem Diabetes Care, Inc. Systems including vial adapter for fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9962486B2 (en) 2013-03-14 2018-05-08 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
EP3804785A1 (fr) * 2014-04-18 2021-04-14 Becton, Dickinson and Company Pompe de dosage à piston fendu
US10004845B2 (en) 2014-04-18 2018-06-26 Becton, Dickinson And Company Split piston metering pump
US10512719B2 (en) 2014-04-18 2019-12-24 Becton, Dickinson And Company Split piston metering pump
EP3597234A1 (fr) * 2014-04-18 2020-01-22 Becton, Dickinson and Company Pompe de dosage à piston fendu
US11793929B2 (en) 2014-04-18 2023-10-24 Becton, Dickinson And Company Split piston metering pump
EP2992916A1 (fr) * 2014-04-18 2016-03-09 Becton Dickinson and Company Pompe de dosage à piston fendu
EP3045724A1 (fr) 2015-01-13 2016-07-20 Neoceram S.A. Pompe en céramique et carter correspondant
CN114042207B (zh) * 2017-01-31 2024-05-10 松瑟博工业股份有限公司 药物输送装置
CN114042207A (zh) * 2017-01-31 2022-02-15 松瑟博工业股份有限公司 药物输送装置
WO2019152824A1 (fr) * 2018-02-02 2019-08-08 Fluid Metering, Inc. Appareil de pompe à déplacement positif à canaux multiples
US11585340B2 (en) 2018-02-02 2023-02-21 Fluid Metering, Inc. Multi-channel positive displacement pump apparatus
WO2019219272A1 (fr) * 2018-05-15 2019-11-21 Robert Bosch Gmbh Dispositif destiné à doser un liquide, en particulier un produit pharmaceutique
CN110425129B (zh) * 2019-06-21 2020-12-29 中国计量大学上虞高等研究院有限公司 一种低泄漏双作用对称式流体流量精密计量装置
CN110425129A (zh) * 2019-06-21 2019-11-08 中国计量大学上虞高等研究院有限公司 一种低泄漏双作用对称式流体流量精密计量装置
CN115151816A (zh) * 2019-11-27 2022-10-04 沃特世科技公司 梯度比例阀
WO2021108591A1 (fr) * 2019-11-27 2021-06-03 Waters Technologies Corporation Soupape de dosage à gradient
US11821880B2 (en) 2019-11-27 2023-11-21 Waters Technologies Corporation Active dampening gradient proportioning valve
US11821881B2 (en) 2019-11-27 2023-11-21 Waters Technologies Corporation Passive dampening gradient proportioning valve
US11940424B2 (en) 2019-11-27 2024-03-26 Waters Technologies Corporation Gradient proportioning valve

Also Published As

Publication number Publication date
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WO2007119149A8 (fr) 2008-08-28
WO2007119149A3 (fr) 2008-05-08

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