WO2007107679A3 - Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines - Google Patents

Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines Download PDF

Info

Publication number
WO2007107679A3
WO2007107679A3 PCT/FR2007/050986 FR2007050986W WO2007107679A3 WO 2007107679 A3 WO2007107679 A3 WO 2007107679A3 FR 2007050986 W FR2007050986 W FR 2007050986W WO 2007107679 A3 WO2007107679 A3 WO 2007107679A3
Authority
WO
WIPO (PCT)
Prior art keywords
mixture
cyclodextrins
association
oleaginous substance
preparing
Prior art date
Application number
PCT/FR2007/050986
Other languages
English (en)
Other versions
WO2007107679A2 (fr
Inventor
Mohamed Skiba
Malika Lahiani
Frederic Bounoure
Pierre Dechelotte
Original Assignee
In Cyclo
Mohamed Skiba
Malika Lahiani
Frederic Bounoure
Pierre Dechelotte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by In Cyclo, Mohamed Skiba, Malika Lahiani, Frederic Bounoure, Pierre Dechelotte filed Critical In Cyclo
Priority to JP2009500900A priority Critical patent/JP2009530357A/ja
Priority to US12/225,499 priority patent/US20090130218A1/en
Priority to EP07731799A priority patent/EP2003990A2/fr
Priority to CA002647089A priority patent/CA2647089A1/fr
Publication of WO2007107679A2 publication Critical patent/WO2007107679A2/fr
Publication of WO2007107679A3 publication Critical patent/WO2007107679A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16—Cyclodextrin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L91/00—Compositions of oils, fats or waxes; Compositions of derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nanotechnology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un mélange de complexes d'inclusion comprenant ou consistant en (1) au moins deux cyclodextrines différentes choisies parmi l'alpha-, la béta- et la gamma- cyclodextrine et/ou leurs dérivés, notamment leurs dérivés modifiés sur les groupements hydroxyles primaires et/ou secondaires, et (2) au moins une substance oléagineuse, notamment choisie parmi les huiles d'origine animales, végétales et synthétiques. La présente invention concerne également une composition comprenant ou consistant en un tel mélange, l'utilisation d'un tel mélange pour la préparation d'un médicament et un procédé de préparation de tels complexes d'inclusion.
PCT/FR2007/050986 2006-03-23 2007-03-22 Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines WO2007107679A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009500900A JP2009530357A (ja) 2006-03-23 2007-03-22 ２つ以上のシクロデキストリンからなる混合物と油性物質との会合
US12/225,499 US20090130218A1 (en) 2006-03-23 2007-03-22 Association of Oleaginous Substance With a Mixture of at Least Two Cyclodextrins
EP07731799A EP2003990A2 (fr) 2006-03-23 2007-03-22 Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines
CA002647089A CA2647089A1 (fr) 2006-03-23 2007-03-22 Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0602526A FR2898817B1 (fr) 2006-03-23 2006-03-23 Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines
FR0602526 2006-03-23

Publications (2)

Publication Number Publication Date
WO2007107679A2 WO2007107679A2 (fr) 2007-09-27
WO2007107679A3 true WO2007107679A3 (fr) 2007-11-15

Family

ID=37461380

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/050986 WO2007107679A2 (fr) 2006-03-23 2007-03-22 Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines

Country Status (6)

Country Link
US (1) US20090130218A1 (fr)
EP (1) EP2003990A2 (fr)
JP (1) JP2009530357A (fr)
CA (1) CA2647089A1 (fr)
FR (1) FR2898817B1 (fr)
WO (1) WO2007107679A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0710439D0 (en) * 2007-05-31 2007-07-11 Uni I Oslo Oral dosage form
WO2009078030A1 (fr) * 2007-12-17 2009-06-25 Alkem Laboratories Limited Substitut de graisse
US10328152B2 (en) 2011-06-16 2019-06-25 Nayan Patel Method for stabilization and delivery of therapeutic molecules
FR2999924B1 (fr) * 2012-12-21 2015-07-17 Oreal Association d'actifs comprenant au moins une huile essentielle, une cyclodextrine et un corps gras liquide et composition la contenant.
FR3009504A1 (fr) * 2013-08-12 2015-02-13 In Cyclo Nouveau systeme solide instantane auto-emulsionnant a base de cyclodextrines et d'huile pour l'administration orale
AR105019A1 (es) * 2015-06-25 2017-08-30 Acraf COMPOSICIÓN DESODORANTE QUE COMPRENDE DE UNA MEZCLA DE CICLODEXTRINA a, b Y g
JP6855001B2 (ja) * 2016-11-24 2021-04-07 池田食研株式会社 油溶性物質含浸食品の製造方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2206099A1 (fr) * 1972-11-11 1974-06-07 Teijin Ltd
FR2441389A1 (fr) * 1978-11-20 1980-06-13 Chinoin Gyogyszer Es Vegyeszet Complexes d'inclusion de cyclodextrine-camomille, procede pour leur preparation et compositions contenant de tels complexes
FR2547829A1 (fr) * 1983-05-28 1984-12-28 Sekimoto Hiroshi Compositions contenant des composes d'acides gras insatures et procede de stabilisation de tels composes
US4670419A (en) * 1982-07-28 1987-06-02 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its rectal use
EP0251132A1 (fr) * 1986-06-26 1988-01-07 SHIBANAI, Hiroko Un procédé de fabrication de papier
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
EP0470452A2 (fr) * 1990-08-09 1992-02-12 Staroil Limited Procédé de préparation de complexes d'acides gras polyinsaturés à longue chaîne avec des cyclodextrines
WO2005011393A1 (fr) * 2003-07-25 2005-02-10 General Mills, Inc. Produit d'acide gras trans reduit
US20060088648A1 (en) * 2004-10-15 2006-04-27 Teoh Heidi M Microwave popcorn with thaumatin and method of preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6058973A (ja) * 1983-09-13 1985-04-05 Mitsubishi Yuka Yakuhin Kk γ−プチロラクトン誘導体及びそれを有効成分とする免疫調節剤
FR2692168B1 (fr) * 1992-06-16 1995-03-24 Centre Nat Rech Scient Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.
US7799365B2 (en) * 2001-04-06 2010-09-21 Burnbrae Farms Limited Liquid egg composition including fish oil with omega-3 fatty acid

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2206099A1 (fr) * 1972-11-11 1974-06-07 Teijin Ltd
FR2441389A1 (fr) * 1978-11-20 1980-06-13 Chinoin Gyogyszer Es Vegyeszet Complexes d'inclusion de cyclodextrine-camomille, procede pour leur preparation et compositions contenant de tels complexes
US4670419A (en) * 1982-07-28 1987-06-02 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its rectal use
FR2547829A1 (fr) * 1983-05-28 1984-12-28 Sekimoto Hiroshi Compositions contenant des composes d'acides gras insatures et procede de stabilisation de tels composes
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
EP0251132A1 (fr) * 1986-06-26 1988-01-07 SHIBANAI, Hiroko Un procédé de fabrication de papier
EP0470452A2 (fr) * 1990-08-09 1992-02-12 Staroil Limited Procédé de préparation de complexes d'acides gras polyinsaturés à longue chaîne avec des cyclodextrines
WO2005011393A1 (fr) * 2003-07-25 2005-02-10 General Mills, Inc. Produit d'acide gras trans reduit
US20060088648A1 (en) * 2004-10-15 2006-04-27 Teoh Heidi M Microwave popcorn with thaumatin and method of preparation

Also Published As

Publication number Publication date
US20090130218A1 (en) 2009-05-21
FR2898817B1 (fr) 2008-08-08
WO2007107679A2 (fr) 2007-09-27
EP2003990A2 (fr) 2008-12-24
JP2009530357A (ja) 2009-08-27
CA2647089A1 (fr) 2007-09-27
FR2898817A1 (fr) 2007-09-28

Similar Documents

Publication Publication Date Title
WO2007107679A3 (fr) Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines
WO2011038388A3 (fr) Compositions pour engrais et procédés
WO2006084285A3 (fr) Oligomerisation d'olefines et compositions biodegradables de celle-ci
BRPI0812095A2 (pt) Composição biodegradável, método de preparação e sua aplicação na fabricação de recipientes funcionais para uso na agricultura e/ou silvicultura.
WO2007067597A3 (fr) Procedes et compositions d'apport sans aiguille de partenaires de liaison
WO2008036932A3 (fr) Compositions et procédés utilisant l'espèce boswellia
EP4238420A3 (fr) Compositions de protéines de lactosérum, procédés et utilisations
WO2007140312A3 (fr) Agents anti-réticulation et procédés permettant de bloquer la réticulation de préparations d'hydrogel injectables
WO2006083936A3 (fr) Anticorps anti-ephb2 et methodes d'utilisation associees
WO2007098281A3 (fr) Composés oxystérols et voie
WO2006107451A3 (fr) Derives d'honokiol pour traiter les maladies proliferantes
WO2008064351A3 (fr) (r)-n-stéréoisomères d'analogues 4,5-époxy-morphinanium saturé en position 7 et 8
WO2006138572A3 (fr) Conjugues a liaison degradable et reactifs polymeres utilises dans la preparation de ces conjugues
UA95310C2 (ru) Композиция, содержащая ингибитор chk1 и циклодекстрин, для лечения рака
WO2007059968A3 (fr) Utilisation d'une composition pour conserver des organes et des membres
WO2007007982A3 (fr) Modulateur de captage du glucose et procede de traitement du diabete et des complications du diabete
MX2009012010A (es) Composiciones de vegetal o fruta aireadas, liofilizadas y metodos para elaboracion de las mismas.
EP2540307A4 (fr) Agent auxiliaire antibactérien comprenant un extrait de konbu au titre de principe actif, composition antibactérienne et aliment ou boisson
WO2006049790A3 (fr) Methodes et trousses de conditionnement aseptique de produits
WO2008008348A3 (fr) Procédé et compositions pour traiter un accident cérébro-vasculaire accompagné de fièvre
WO2007034042A3 (fr) Extrait de vanilla planifolia, son procede d’obtention, et composition cosmetique ou dermatologique le contenant
WO2008118754A3 (fr) Compositions de docétaxel nanoparticulaires stérilisées par rayonnement gamma et procédés de fabrication associés
WO2006098998A3 (fr) Procedes et compositions de modulation de l'integrite vasculaire
BRPI0819220A2 (pt) proteína neurturina ou fragmento da mesma, sua composição farmacêutica e uso
WO2008104808A3 (fr) Composés et méthodes de modulation de la fonction d'une intégrine pour favoriser la réparation tissulaire

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2007731799

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2009500900

Country of ref document: JP

Ref document number: 2647089

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07731799

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 12225499

Country of ref document: US