WO2007103261A3 - Compositions immunogènes epha2 à base de la listeria - Google Patents

Compositions immunogènes epha2 à base de la listeria Download PDF

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Publication number
WO2007103261A3
WO2007103261A3 PCT/US2007/005512 US2007005512W WO2007103261A3 WO 2007103261 A3 WO2007103261 A3 WO 2007103261A3 US 2007005512 W US2007005512 W US 2007005512W WO 2007103261 A3 WO2007103261 A3 WO 2007103261A3
Authority
WO
WIPO (PCT)
Prior art keywords
listeria
immunogenic compositions
epha2
present
constructs
Prior art date
Application number
PCT/US2007/005512
Other languages
English (en)
Other versions
WO2007103261A2 (fr
Inventor
Elizabeth Bruckheimer
Michael S Kinch
Peter A Kiener
Thomas W Dubensky Jr
David N Cook
Original Assignee
Medimmune Inc
Cerus Corp
Elizabeth Bruckheimer
Michael S Kinch
Peter A Kiener
Thomas W Dubensky Jr
David N Cook
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Inc, Cerus Corp, Elizabeth Bruckheimer, Michael S Kinch, Peter A Kiener, Thomas W Dubensky Jr, David N Cook filed Critical Medimmune Inc
Priority to PCT/US2007/005512 priority Critical patent/WO2007103261A2/fr
Publication of WO2007103261A2 publication Critical patent/WO2007103261A2/fr
Publication of WO2007103261A3 publication Critical patent/WO2007103261A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des acides nucléiques de synthèse comprenant une séquence nucléotide codante pour un peptide antigène EphA2 et la Listeria contenant de tels produits de synthèse. L'invention concerne notamment la Listeria génétiquement modifiée pour exprimer une pluralité de peptides antigéniques EphA2 et des compositions immunogènes contenant une telle Listeria. L'invention concerne, inter alia, l'utilisation des compositions immunogènes pour déclencher une réponse immunitaire contre une cellule d'expression de EphA2 ainsi que pour traiter, gérer et/ou prévenir un trouble et/ou une maladie à hyperprolifération impliquant l'angiogénèse aberrante.
PCT/US2007/005512 2006-03-01 2007-03-01 Compositions immunogènes epha2 à base de la listeria WO2007103261A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2007/005512 WO2007103261A2 (fr) 2006-03-01 2007-03-01 Compositions immunogènes epha2 à base de la listeria

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60/778,426 2006-03-01
PCT/US2007/005512 WO2007103261A2 (fr) 2006-03-01 2007-03-01 Compositions immunogènes epha2 à base de la listeria

Publications (2)

Publication Number Publication Date
WO2007103261A2 WO2007103261A2 (fr) 2007-09-13
WO2007103261A3 true WO2007103261A3 (fr) 2008-12-04

Family

ID=38475444

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005512 WO2007103261A2 (fr) 2006-03-01 2007-03-01 Compositions immunogènes epha2 à base de la listeria

Country Status (1)

Country Link
WO (1) WO2007103261A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7935804B2 (en) 2006-03-01 2011-05-03 Aduro Biotech Engineered Listeria and methods of use thereof
JP5808349B2 (ja) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
KR20130043104A (ko) 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 질병용 순환 생물학적 지표들
US11096963B2 (en) 2015-06-26 2021-08-24 Cerus Corporation Cryoprecipitate compositions and methods of preparation thereof
EP3364986B1 (fr) 2015-10-23 2023-12-13 Cerus Corporation Plasma cryogénique inactivé par des agents pathogènes et procédé pour son utilisation
SG10202105561PA (en) 2016-11-30 2021-07-29 Advaxis Inc Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof
US11235090B2 (en) 2017-03-03 2022-02-01 Cerus Corporation Kits and methods for preparing pathogen-inactivated platelet compositions
MX2020006881A (es) 2017-12-29 2020-10-01 Cerus Corp Sistemas y metodos para tratar fluidos biologicos.
EP3838915A4 (fr) * 2018-08-02 2022-02-09 Suzhou Royaltech Med Co., Ltd Composition d'immunothérapie antitumorale basée sur des cellules présentatrices d'antigène activées par listeria monocytogenes atténuée, son procédé de préparation et son utilisation
CN114269394A (zh) 2019-06-28 2022-04-01 塞鲁斯公司 用于实现生物流体处理装置的系统和方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037233A2 (fr) * 2003-10-15 2005-04-28 Medimmune, Inc. Vaccins epha2 a base de listeria

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037233A2 (fr) * 2003-10-15 2005-04-28 Medimmune, Inc. Vaccins epha2 a base de listeria

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOODY G.E. ET AL.: "Recombinant Listeria monocytogenes-based immunotherapy targeting the Receptor Tyrosine Kinase EphA2", PROC. AMER. ASSOC. CANCER RES., vol. 45, 2004, pages 504, XP002449204 *

Also Published As

Publication number Publication date
WO2007103261A2 (fr) 2007-09-13

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