WO2007100376A3 - Compositions and methods for dermal delivery of drugs - Google Patents

Compositions and methods for dermal delivery of drugs Download PDF

Info

Publication number
WO2007100376A3
WO2007100376A3 PCT/US2006/048059 US2006048059W WO2007100376A3 WO 2007100376 A3 WO2007100376 A3 WO 2007100376A3 US 2006048059 W US2006048059 W US 2006048059W WO 2007100376 A3 WO2007100376 A3 WO 2007100376A3
Authority
WO
WIPO (PCT)
Prior art keywords
volatile
formulation
methods
volatile solvent
drug
Prior art date
Application number
PCT/US2006/048059
Other languages
French (fr)
Other versions
WO2007100376A2 (en
Inventor
Jie Zhang
Kevin S Warner
Sanjay Sharma
Original Assignee
Zars Inc
Jie Zhang
Kevin S Warner
Sanjay Sharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zars Inc, Jie Zhang, Kevin S Warner, Sanjay Sharma filed Critical Zars Inc
Priority to CN200680052642XA priority Critical patent/CN101370453B/en
Priority to AU2006339350A priority patent/AU2006339350A1/en
Priority to EP06849969A priority patent/EP1968541A2/en
Priority to CA002633464A priority patent/CA2633464A1/en
Priority to JP2008545866A priority patent/JP2009519956A/en
Publication of WO2007100376A2 publication Critical patent/WO2007100376A2/en
Publication of WO2007100376A3 publication Critical patent/WO2007100376A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on

Abstract

The present invention is drawn to adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and at least one solidifying agent. The solvent vehicle can have a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The formulation can be formulated to contain at least two volatile solvents, at least two non-volatile solvents, or at least two solidifying agents. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
PCT/US2006/048059 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs WO2007100376A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN200680052642XA CN101370453B (en) 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs
AU2006339350A AU2006339350A1 (en) 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs
EP06849969A EP1968541A2 (en) 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs
CA002633464A CA2633464A1 (en) 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs
JP2008545866A JP2009519956A (en) 2005-12-14 2006-12-14 Compositions and methods for skin delivery of drugs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75063705P 2005-12-14 2005-12-14
US75052105P 2005-12-14 2005-12-14
US60/750,521 2005-12-14
US60/750,637 2005-12-14

Publications (2)

Publication Number Publication Date
WO2007100376A2 WO2007100376A2 (en) 2007-09-07
WO2007100376A3 true WO2007100376A3 (en) 2008-09-25

Family

ID=38459470

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/048059 WO2007100376A2 (en) 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs

Country Status (5)

Country Link
EP (1) EP1968541A2 (en)
JP (1) JP2009519956A (en)
AU (1) AU2006339350A1 (en)
CA (1) CA2633464A1 (en)
WO (1) WO2007100376A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5135441B2 (en) * 2008-10-08 2013-02-06 高田製薬株式会社 Tacrolimus external preparation
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
US20190083625A1 (en) 2010-11-22 2019-03-21 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
DE102011085509A1 (en) * 2011-10-31 2013-05-02 Beiersdorf Ag Fixation of perfume on wet skin
GB2496656B (en) * 2011-11-18 2015-12-09 Lrc Products Film-Forming Formulation
CN112006989A (en) * 2013-11-14 2020-12-01 立普妥公司 Sprayable topical carriers and compositions comprising phosphatidylcholine
JP6676548B2 (en) * 2015-01-30 2020-04-08 株式会社 メドレックス Aqueous external preparation
PL3310389T3 (en) 2015-06-18 2020-11-30 Bausch Health Ireland Limited Topical compositions comprising a corticosteroid and a retinoid for treating psoriasis
JP2022117477A (en) 2021-01-29 2022-08-10 花王株式会社 Composition for external application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives

Also Published As

Publication number Publication date
AU2006339350A1 (en) 2007-09-07
EP1968541A2 (en) 2008-09-17
JP2009519956A (en) 2009-05-21
WO2007100376A2 (en) 2007-09-07
CA2633464A1 (en) 2007-09-07

Similar Documents

Publication Publication Date Title
WO2007070695A3 (en) Flux-enabling compositions and methods for dermal delivery of drugs
WO2005120473A3 (en) Dermal peel-forming formulation
WO2009017767A3 (en) Compositions and methods for dermally treating neuropathy with minoxidil
WO2007100376A3 (en) Compositions and methods for dermal delivery of drugs
WO2007070643A3 (en) Compositions and methods for treating dermatological conditions
WO2007070679A3 (en) Compositions and methods for dermally treating pain
WO2007070694A3 (en) Spray-on formulations and methods for dermal delivery of drugs
WO2009085314A8 (en) Compositions and methods for treating diseases of the nail
CN101677969B (en) Matrix-type transdermal drug delivery system and preparation method thereof
WO2004089335A3 (en) Non-aqueous single phase vehicles and formulations utilizing such vehicles
WO2006065991A3 (en) Dispersion for delivering active agents
MY161895A (en) Dermal film-forming liquid formulations for drug release to skin
CA2567575A1 (en) Organo-gel formulations for therapeutic applications
WO2007133508A8 (en) Water dispersible films for delivery of active agents to the epidermis
WO2006129161A3 (en) Vitamin formulation
WO2005115336A3 (en) Sprayable formulations for the treatment of acute inflammatory skin conditions
WO2007123955A3 (en) Stable hydroalcoholic oral spray formulations and methods
WO2007133751A3 (en) Base-stabilized polyorthoester formulations
WO2007103257A3 (en) Method of powder coating medical devices
WO2010041141A3 (en) Oil-based foamable carriers and formulations
WO2009100441A3 (en) Depot formulations
WO2008005240A3 (en) Ropinirole-containing pharmaceutical compositions in the form of a gel, uses thereof
IN2014DN11232A (en)
WO2009089346A3 (en) Disinfectant alcohol-soluble quaternary ammonium polymers
WO2007100910A3 (en) Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2008545866

Country of ref document: JP

Ref document number: 2633464

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006339350

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2006849969

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1481/MUMNP/2008

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 2006339350

Country of ref document: AU

Date of ref document: 20061214

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 200680052642.X

Country of ref document: CN