WO2007070694A3 - Spray-on formulations and methods for dermal delivery of drugs - Google Patents

Spray-on formulations and methods for dermal delivery of drugs Download PDF

Info

Publication number
WO2007070694A3
WO2007070694A3 PCT/US2006/048060 US2006048060W WO2007070694A3 WO 2007070694 A3 WO2007070694 A3 WO 2007070694A3 US 2006048060 W US2006048060 W US 2006048060W WO 2007070694 A3 WO2007070694 A3 WO 2007070694A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
formulation
formulations
drug
drugs
Prior art date
Application number
PCT/US2006/048060
Other languages
French (fr)
Other versions
WO2007070694A2 (en
Inventor
Jie Zhang
Kevin S Warner
Sanjay Sharma
Original Assignee
Zars Inc
Jie Zhang
Kevin S Warner
Sanjay Sharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zars Inc, Jie Zhang, Kevin S Warner, Sanjay Sharma filed Critical Zars Inc
Priority to AU2006326033A priority Critical patent/AU2006326033A1/en
Priority to EP06845634A priority patent/EP1959928A2/en
Priority to CA002633466A priority patent/CA2633466A1/en
Priority to JP2008545867A priority patent/JP2009519957A/en
Publication of WO2007070694A2 publication Critical patent/WO2007070694A2/en
Publication of WO2007070694A3 publication Critical patent/WO2007070694A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

The present invention is drawn to sprayable formulations, methods of drug delivery, and resultant solidified layers for dermal delivery of a drug. The formulation can include a drug, a non-volatile solvent system, a solidifying agent, and a propellant. The formulation can have an initial viscosity suitable to be expelled out of a pressurized or manual pump container and applied onto a skin surface as a layer. When applied to the skin, the formulation can form a solidified layer after at least a portion of the propellant is evaporated.
PCT/US2006/048060 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs WO2007070694A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2006326033A AU2006326033A1 (en) 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs
EP06845634A EP1959928A2 (en) 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs
CA002633466A CA2633466A1 (en) 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs
JP2008545867A JP2009519957A (en) 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75063705P 2005-12-14 2005-12-14
US60/750,637 2005-12-14
US79509106P 2006-04-25 2006-04-25
US60/795,091 2006-04-25

Publications (2)

Publication Number Publication Date
WO2007070694A2 WO2007070694A2 (en) 2007-06-21
WO2007070694A3 true WO2007070694A3 (en) 2008-12-24

Family

ID=38163552

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/048060 WO2007070694A2 (en) 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs

Country Status (5)

Country Link
EP (1) EP1959928A2 (en)
JP (1) JP2009519957A (en)
AU (1) AU2006326033A1 (en)
CA (1) CA2633466A1 (en)
WO (1) WO2007070694A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2394647A1 (en) * 2006-11-02 2011-12-14 Aestus Therapeutics, Inc. Methods of treating neuropathic pain by modulation of glycogenolysis or glycolysis pathways
JP5789100B2 (en) * 2008-01-22 2015-10-07 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Volatile anesthetic composition for local anesthesia and / or pain reduction comprising extraction solvent
WO2010008600A1 (en) * 2008-07-16 2010-01-21 Dermworx Incorporated Topical drug delivery system
US20100160368A1 (en) 2008-08-18 2010-06-24 Gregory Jefferson J Methods of Treating Dermatological Disorders and Inducing Interferon Biosynthesis With Shorter Durations of Imiquimod Therapy
US20100202978A1 (en) 2009-02-12 2010-08-12 Gurge Ronald M Foamable benzoyl peroxide compositions for topical administration
JP5654497B2 (en) 2009-02-13 2015-01-14 トピカ ファーマシューティカルズ，インコーポレイテッド Antifungal preparation
AU2010274097B2 (en) 2009-07-13 2016-06-16 Medicis Pharmaceutical Corporation Lower dosage strength imiquimod formulations and short dosing regimens for treating genital and perianal warts
KR101619077B1 (en) 2010-06-11 2016-05-10 레오 파마 에이/에스 A pharmaceutical spray composition comprising a vitamin d analogue and a corticosteroid
GB2496656B (en) * 2011-11-18 2015-12-09 Lrc Products Film-Forming Formulation
WO2014006201A1 (en) * 2012-07-06 2014-01-09 Leo Pharma A/S A topical composition comprising a film-forming polymer for delivering an active ingredient to skin
JP6703987B2 (en) * 2014-11-10 2020-06-03 アケリオス セラピューティクス，インコーポレーテッド Sprayable analgesic composition
CN105169464B (en) * 2015-09-24 2018-05-15 中国人民解放军军事医学科学院放射与辐射医学研究所 A kind of natural honey wound dressing and preparation method and application
CN111067919A (en) * 2019-12-23 2020-04-28 李益谦 Spray analgesic
WO2024145192A1 (en) * 2022-12-28 2024-07-04 Basf Se Topical spray composition and preparation thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059471A1 (en) * 1997-12-15 2003-03-27 Compton Bruce Jon Oral delivery formulation
US20050089539A1 (en) * 2003-09-09 2005-04-28 3M Innovative Properties Company Antimicrobial compositions and methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059471A1 (en) * 1997-12-15 2003-03-27 Compton Bruce Jon Oral delivery formulation
US20050089539A1 (en) * 2003-09-09 2005-04-28 3M Innovative Properties Company Antimicrobial compositions and methods

Also Published As

Publication number Publication date
CA2633466A1 (en) 2007-06-21
WO2007070694A2 (en) 2007-06-21
AU2006326033A1 (en) 2007-06-21
JP2009519957A (en) 2009-05-21
EP1959928A2 (en) 2008-08-27

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