WO2007070694A3 - Spray-on formulations and methods for dermal delivery of drugs - Google Patents

Spray-on formulations and methods for dermal delivery of drugs Download PDF

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Publication number
WO2007070694A3
WO2007070694A3 PCT/US2006/048060 US2006048060W WO2007070694A3 WO 2007070694 A3 WO2007070694 A3 WO 2007070694A3 US 2006048060 W US2006048060 W US 2006048060W WO 2007070694 A3 WO2007070694 A3 WO 2007070694A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
formulation
formulations
drug
drugs
Prior art date
Application number
PCT/US2006/048060
Other languages
French (fr)
Other versions
WO2007070694A2 (en
Inventor
Jie Zhang
Kevin S Warner
Sanjay Sharma
Original Assignee
Zars Inc
Jie Zhang
Kevin S Warner
Sanjay Sharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zars Inc, Jie Zhang, Kevin S Warner, Sanjay Sharma filed Critical Zars Inc
Priority to CA002633466A priority Critical patent/CA2633466A1/en
Priority to AU2006326033A priority patent/AU2006326033A1/en
Priority to EP06845634A priority patent/EP1959928A2/en
Priority to JP2008545867A priority patent/JP2009519957A/en
Publication of WO2007070694A2 publication Critical patent/WO2007070694A2/en
Publication of WO2007070694A3 publication Critical patent/WO2007070694A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention is drawn to sprayable formulations, methods of drug delivery, and resultant solidified layers for dermal delivery of a drug. The formulation can include a drug, a non-volatile solvent system, a solidifying agent, and a propellant. The formulation can have an initial viscosity suitable to be expelled out of a pressurized or manual pump container and applied onto a skin surface as a layer. When applied to the skin, the formulation can form a solidified layer after at least a portion of the propellant is evaporated.
PCT/US2006/048060 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs WO2007070694A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002633466A CA2633466A1 (en) 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs
AU2006326033A AU2006326033A1 (en) 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs
EP06845634A EP1959928A2 (en) 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs
JP2008545867A JP2009519957A (en) 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75063705P 2005-12-14 2005-12-14
US60/750,637 2005-12-14
US79509106P 2006-04-25 2006-04-25
US60/795,091 2006-04-25

Publications (2)

Publication Number Publication Date
WO2007070694A2 WO2007070694A2 (en) 2007-06-21
WO2007070694A3 true WO2007070694A3 (en) 2008-12-24

Family

ID=38163552

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/048060 WO2007070694A2 (en) 2005-12-14 2006-12-14 Spray-on formulations and methods for dermal delivery of drugs

Country Status (5)

Country Link
EP (1) EP1959928A2 (en)
JP (1) JP2009519957A (en)
AU (1) AU2006326033A1 (en)
CA (1) CA2633466A1 (en)
WO (1) WO2007070694A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100222304A1 (en) * 2006-11-02 2010-09-02 Lillian W Chiang Methods of Treating Neuropathic Pain by Modulation of Glycogenolysis or Glycolysis
US9675544B2 (en) 2008-01-22 2017-06-13 The Board Of Regents Of The University Of Texas System Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief
CA2730787A1 (en) * 2008-07-16 2010-01-21 David M. Cohen Topical drug delivery system
US20100160368A1 (en) 2008-08-18 2010-06-24 Gregory Jefferson J Methods of Treating Dermatological Disorders and Inducing Interferon Biosynthesis With Shorter Durations of Imiquimod Therapy
MX354480B (en) 2009-02-12 2018-03-07 Prec Dermatology Inc Star Foamable benzoyl peroxide compositions for topical administration.
EP2745692A1 (en) 2009-02-13 2014-06-25 Topica Pharmaceuticals, Inc anti-fungal formulation containing luliconazole
AU2010274097B2 (en) 2009-07-13 2016-06-16 Medicis Pharmaceutical Corporation Lower dosage strength imiquimod formulations and short dosing regimens for treating genital and perianal warts
RU2576607C2 (en) 2010-06-11 2016-03-10 Лео Фарма А/С Pharmaceutical aerosol formulation containing vitamin d analogue and corticosteroid
GB2496656B (en) * 2011-11-18 2015-12-09 Lrc Products Film-Forming Formulation
BR112015000147A2 (en) * 2012-07-06 2017-06-27 Leo Pharma As pharmaceutical composition for dermal film forming
US20180271813A1 (en) * 2014-11-10 2018-09-27 Achelios Therapeutics, Inc. Sprayable analgesic compositions
CN105169464B (en) * 2015-09-24 2018-05-15 中国人民解放军军事医学科学院放射与辐射医学研究所 A kind of natural honey wound dressing and preparation method and application
CN111067919A (en) * 2019-12-23 2020-04-28 李益谦 Spray analgesic

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059471A1 (en) * 1997-12-15 2003-03-27 Compton Bruce Jon Oral delivery formulation
US20050089539A1 (en) * 2003-09-09 2005-04-28 3M Innovative Properties Company Antimicrobial compositions and methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059471A1 (en) * 1997-12-15 2003-03-27 Compton Bruce Jon Oral delivery formulation
US20050089539A1 (en) * 2003-09-09 2005-04-28 3M Innovative Properties Company Antimicrobial compositions and methods

Also Published As

Publication number Publication date
AU2006326033A1 (en) 2007-06-21
JP2009519957A (en) 2009-05-21
CA2633466A1 (en) 2007-06-21
EP1959928A2 (en) 2008-08-27
WO2007070694A2 (en) 2007-06-21

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