WO2007086078A3 - Novel pharmaceutical compositions and process of preparation thereof - Google Patents

Novel pharmaceutical compositions and process of preparation thereof Download PDF

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Publication number
WO2007086078A3
WO2007086078A3 PCT/IN2007/000029 IN2007000029W WO2007086078A3 WO 2007086078 A3 WO2007086078 A3 WO 2007086078A3 IN 2007000029 W IN2007000029 W IN 2007000029W WO 2007086078 A3 WO2007086078 A3 WO 2007086078A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pharmaceutical compositions
compositions
novel pharmaceutical
optionally
Prior art date
Application number
PCT/IN2007/000029
Other languages
French (fr)
Other versions
WO2007086078A2 (en
Inventor
Rajesh Jain
Kour Chand Jindal
Sampath Kumar Devarajan
Original Assignee
Panacea Biotec Ltd
Rajesh Jain
Kour Chand Jindal
Sampath Kumar Devarajan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Ltd, Rajesh Jain, Kour Chand Jindal, Sampath Kumar Devarajan filed Critical Panacea Biotec Ltd
Publication of WO2007086078A2 publication Critical patent/WO2007086078A2/en
Publication of WO2007086078A3 publication Critical patent/WO2007086078A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)

Abstract

Novel pharmaceutical compositions comprising at least one active agent(s) or its pharmaceutically acceptable salts, polymorphs, solvates, hydrates, analogues, enantiomers, tautomeric forms or mixtures thereof; at least one permeation enhancer(s); at least one adsorbent(s) and at least one bioadhesive polymer(s); optionally at least one acid soluble polymer(s) and optionally one or more other pharmaceutically acceptable excipient(s) are provided. Preferably the compositions are in the gastro-adhesive modified release form and/or fast disintegrating dosage form which release the active agent(s) over an extended period of time. Also provided are processes of preparation of such novel compositions and methods of using them.
PCT/IN2007/000029 2006-01-30 2007-01-29 Novel pharmaceutical compositions and process of preparation thereof WO2007086078A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN242/DEL/2006 2006-01-30
IN242DE2006 2006-01-30

Publications (2)

Publication Number Publication Date
WO2007086078A2 WO2007086078A2 (en) 2007-08-02
WO2007086078A3 true WO2007086078A3 (en) 2007-12-13

Family

ID=37898568

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000029 WO2007086078A2 (en) 2006-01-30 2007-01-29 Novel pharmaceutical compositions and process of preparation thereof

Country Status (1)

Country Link
WO (1) WO2007086078A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140065482A (en) * 2005-03-24 2014-05-29 다이이찌 산쿄 가부시키가이샤 Pharmaceutical composition
PE20080907A1 (en) * 2006-08-31 2008-08-22 Novartis Ag EXTENDED RELEASE GASTRO-RETENTIVE ORAL DRUG DELIVERY SYSTEM FOR VALSARTAN
AU2009219250A1 (en) * 2008-02-28 2009-09-03 Novartis Ag Valsartan solid oral dosage forms and methods of making such formulations
AR071375A1 (en) * 2008-04-22 2010-06-16 Solvay Pharm Gmbh FORMULATIONS FOR ACTIVE PHARMACEUTICAL INGREDIENTS OF DEFICIENT PERMEABILITY, PREPARATION AND PRODUCT PROCESS
US8287902B2 (en) * 2008-07-23 2012-10-16 Rainbow Medical Ltd. Enhanced-diffusion capsule
DE102008045854A1 (en) * 2008-09-05 2010-03-11 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Particles of ziprasidone and a disintegrant containing pharmaceutical composition
BE1018740A3 (en) * 2010-08-10 2011-07-05 Oystershell Nv COMPOSITION FOR THE TREATMENT OF HUMID EPITHELIAL SURFACES.
TR201010212A2 (en) * 2010-12-08 2012-06-21 Bi̇lgi̇ç Mahmut Solid oral dosage form containing cefdinir.
CN102028659A (en) * 2010-12-16 2011-04-27 苏州大学 Valsartan bio-adhesive coated micro-pellet preparation and preparation method thereof
JO3192B1 (en) 2011-09-06 2018-03-08 Novartis Ag Benzothiazolone compound
DE102012105512A1 (en) * 2012-06-25 2014-04-24 Hennig Arzneimittel Gmbh & Co. Kg Pharmaceutical form for prolonged release of active ingredients
EP3065718A4 (en) * 2013-10-06 2017-07-12 Sarfez Pharmaceuticals, Inc. Controlled-release formulations comprising torsemide
US9492396B2 (en) 2014-07-15 2016-11-15 Yossi Gross Enhanced drug delivery pill
CN104905409A (en) * 2015-06-05 2015-09-16 滁州卷烟材料厂 Healthcare cigarette filter tip composite adsorbent with functions of relieving cough and reducing sputum and preparation method thereof
CN104921299A (en) * 2015-06-05 2015-09-23 滁州卷烟材料厂 Cigarette filter composite absorbent with banana peel and preparing method thereof
CN104921300A (en) * 2015-06-05 2015-09-23 滁州卷烟材料厂 Immunity enhancing composite adsorbent for cigarette filter tips and method for preparing immunity enhancing composite adsorbent
CN105011366A (en) * 2015-06-05 2015-11-04 滁州卷烟材料厂 Composite adsorbent for health-care cigarette filter with function of relieving fatigue
CN104957768A (en) * 2015-06-05 2015-10-07 滁州卷烟材料厂 Health care cigarette filter tip composite adsorbent for promoting sleep and preparing method thereof
CN104957769A (en) * 2015-06-05 2015-10-07 滁州卷烟材料厂 Lung clearing and health care cigarette filter tip composite adsorbent and preparing method thereof
CN105011367A (en) * 2015-06-05 2015-11-04 滁州卷烟材料厂 Composite adsorbent for heat-clearing fire-purging cigarette filter and preparation method thereof
EP3368045A4 (en) 2015-10-30 2019-08-07 CMP Development LLC Spironolactone aqueous compositions
US10493083B2 (en) 2015-10-30 2019-12-03 Cmp Development Llc Spironolactone aqueous compositions
EP3681484A4 (en) * 2017-09-12 2021-07-28 Jina Pharmaceuticals Inc. Methods of preparing compositions containing thymoquinone
US10675248B2 (en) 2018-08-14 2020-06-09 Alma Therapeutics Ltd. Expandable pill

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0425154A1 (en) * 1989-10-23 1991-05-02 Dow Corning France S.A. Sustained release elements
WO1998052547A1 (en) * 1997-05-24 1998-11-26 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Gastroretentive controlled release microspheres for improved drug delivery
GB2328443A (en) * 1997-08-21 1999-02-24 Reckitt & Colmann Prod Ltd In situ formation of polymeric material on body surface; pharmaceutical applications
EP1062955A1 (en) * 1998-03-20 2000-12-27 Kowa Co., Ltd. Medicinal compositions adhering to stomach/duodenum
WO2002085333A1 (en) * 2001-04-25 2002-10-31 Lts Lohmann Therapie-Systeme Ag Gastric juice-resistant device for releasing mucoadhesive active substance excipients and method for producing this gastric juice-resistant device
WO2003051304A2 (en) * 2001-12-15 2003-06-26 Spherics, Inc. Bioadhesive drug delivery system with enhanced gastric retention
WO2003097018A1 (en) * 2002-02-04 2003-11-27 Ranbaxy Laboratories Limited Hydrodynamically balancing oral drug delivery system with biphasic release

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0425154A1 (en) * 1989-10-23 1991-05-02 Dow Corning France S.A. Sustained release elements
WO1998052547A1 (en) * 1997-05-24 1998-11-26 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Gastroretentive controlled release microspheres for improved drug delivery
GB2328443A (en) * 1997-08-21 1999-02-24 Reckitt & Colmann Prod Ltd In situ formation of polymeric material on body surface; pharmaceutical applications
EP1062955A1 (en) * 1998-03-20 2000-12-27 Kowa Co., Ltd. Medicinal compositions adhering to stomach/duodenum
WO2002085333A1 (en) * 2001-04-25 2002-10-31 Lts Lohmann Therapie-Systeme Ag Gastric juice-resistant device for releasing mucoadhesive active substance excipients and method for producing this gastric juice-resistant device
WO2003051304A2 (en) * 2001-12-15 2003-06-26 Spherics, Inc. Bioadhesive drug delivery system with enhanced gastric retention
WO2003097018A1 (en) * 2002-02-04 2003-11-27 Ranbaxy Laboratories Limited Hydrodynamically balancing oral drug delivery system with biphasic release

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAVIS S S: "Formulation strategies for absorption windows", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 10, no. 4, 15 February 2005 (2005-02-15), pages 249 - 257, XP004741335, ISSN: 1359-6446 *

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Publication number Publication date
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