WO2007078007A1 - Structure de nanohorn de carbone, composition permettant de réguler la libération d'une substance organique contenue dans celle-ci, et méthode pour libération régulée - Google Patents
Structure de nanohorn de carbone, composition permettant de réguler la libération d'une substance organique contenue dans celle-ci, et méthode pour libération régulée Download PDFInfo
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- WO2007078007A1 WO2007078007A1 PCT/JP2007/050080 JP2007050080W WO2007078007A1 WO 2007078007 A1 WO2007078007 A1 WO 2007078007A1 JP 2007050080 W JP2007050080 W JP 2007050080W WO 2007078007 A1 WO2007078007 A1 WO 2007078007A1
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- carbon nanohorn
- cddp
- cation
- release
- nhox
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B32/00—Carbon; Compounds thereof
- C01B32/15—Nano-sized carbon materials
- C01B32/18—Nanoonions; Nanoscrolls; Nanohorns; Nanocones; Nanowalls
Definitions
- Carbon nanohorn structure composition capable of controlling release of organic substances therein, and method thereof
- the present invention makes it possible to control the release of endogenous organic substances, a new carbon nanohorn structure that is expected to be useful as a DDS drug or its carrier, a preparation method thereof, and the release of intrinsic organic substances.
- the present invention relates to a composition and a control method.
- cisplatin can be selectively delivered to the tumor site by increasing permeability and retention effect using a polymer carrier system, and has already been used in vivo using a cisbratin monopolymer system. Tumor growth is effectively suppressed, and in addition, studies of delivery systems using ribosomes, gelatin hydrogels, polymer micelles, etc. have shown that the nephrotoxic side effects of cisbratin are reduced in rats and mice.
- CNTs carbon nanotubes
- they are on a nanometer scale, they are well suited for transporting biomolecules such as DNA proteins. Since they are chemically and mechanically stable, they can be transported without degradation in the human body. Modifying CNTs is an answer that increases their biocompatibility by imparting targeting ability to them. Furthermore, the nanospace inside the C NTs is suitable for drug encapsulation.
- Non-patent Document 1 a non-nanohorn
- Non-patent Document 4 the number and size of holes can be changed by adjusting the heat treatment conditions (Non-patent Document 4), and the incorporated space has sufficient freedom of movement because of the large internal space. There are things. Open NHs are therefore well suited for drug uptake and controlled release purposes.
- the control medium is a carbon nanohorn structure-containing composition that enables a cation or hydrogen ion exchange reaction with a cation bonded to an oxygen-containing functional group.
- Figure 2 shows TG curves for (a) DMF-treated NHox, (b) DMF-treated NHh, (c) DMF-treated CDDP powder, (d) CDDP @ NHox, (e) CDDP @ NHh (Thin line) and DTG curve (thick line).
- FIG. 6 shows the numerical ratio of Na: P: Cl: K as a percentage.
- the pie charts are for (a) PBS-NHox, (b) PBS-NHox, (c) PBS.
- the effective hole size is determined by these van 'del' Wales regions and is indicated by a red circle (diameter: 0.6nm (b), 0.4nm (c)). In this model (c), the effective hole size is reduced to 0.4 nm, which is too small for CDDP molecules to pass through (shown in yellow). For comparison, an orange circle (diameter: about 0.8 nm) is shown, which represents the effective hole size with OH or COOH groups attached.
- NHs abbreviated as “NHs” indicating plural forms.
- the “opening” or “opening edge” means that the above is formed on each of one or more of the horn-shaped bodies constituting the NHs.
- the carbon nanohorn structure of the present invention is prepared by bringing into contact with a cation-containing liquid to form a bond between an oxygen-containing functional group at the opening edge and a cation.
- graphite is CO laser blurred at room temperature and Ar (760 Torr) conditions.
- NHs were prepared by following (according to Chem. Phys. Lett., 1999, 309, 165).
- NHs were applied for 10 minutes in an air stream at 570-580 ° C.
- CDDP @ NHox and CDDP @ NHh were subjected to X-ray diffraction (XRD) to show the size of CDDP crystallites deposited on the outside of NHox.
- (1) and (2) show internal and external emissions, respectively.
- the amount of NHox and NHh includes the amount of graphite particles.
- the weight loss at about 100 ° C corresponds to the desorption of DMF ( Figures 2d and 2e).
- Decomposition of plain CDDP crystallites was observed at approximately 330 ° C ( Figure 2c), CDDP @ NH ox CDDP burned or decomposed at different temperatures, which were approximately 250 ° C and approximately 400 ° C. C.
- CDDP @ NHh CDDP burned or decomposed at about 250 ° C.
- the XRD pattern of CDDP @ NHox and CDDP @ NHh showed a diffraction peak characteristic of CD DP with a 2-theta of approximately 14 ° (Fig. 3).
- the particle size estimated using the peak width and Scherrer equation is about 20-50 nm, which means that they are likely to exist outside of NHox and NHh.
- the CDDP crystallites with a size of 20-50 nm during HRTEM observations were unseen, so their amount is a small answer.
- the peak at about 26.5 ° ( Figure 3) is due to the graphite impurity in the nanohorn.
- the 1-2 nm sized CDDP clusters inside the nanospace of NHox (Fig. 1) or NHh (not shown) may show peaks due to their poor crystallinity or small crystal size. could not. When the crystallinity is poor or the crystal size is small, the XRD peak is usually too wide to observe.
- the hole size used here is considered to be 1.2 nm according to the previous report (Adv. Mater., 2004, 16, 397).
- Figure 7c shows that the effective hole size of 0.8 nm (orange circle) is reduced to 0.4 nm by changing the COOH group to -COONa group. Since the molecular size of CDDP is about 0.4 X 0.6 nm and the thickness is about 0.1 nm, it is difficult to pass CDDP molecules with COONa group and one ONa group bonded to the hole edge! / ,.
- CDDP @ NHox and CDDP @ NHh showed that they are similar in structure, CDDP uptake, CDDP cluster size, etc.
- the amount of CDDP released from CDDP @ NHox in PBS was only 15%, while that from CDDP @ NHh was 75%.
- the cessation of CDDP release from NHox is due to the embolic effect.
- the COONa group and —O Na group occupy the COOH group and OH group bonded to the hole edge of NHox, and NHox internal force also sterically hinders CDDP passing through the hole. It is. Since NHh has holes with hydrogen-terminated edges, such substitution does not occur, and therefore embolization was not observed.
- NHox As part of the safety assessment of NHox, a carbon substance, it was used as a test substance and administered to mice once in a single dose, and long-term toxicity was examined 2 weeks after administration, 4 weeks after administration, and 26 weeks after administration. .
- body weight was measured on the following schedule.
- Group 1 Measurements were made on Day 1 (before administration), 2, 3.5, 8, 12, and 15.
- Group 2 Measurements were made on Day 1 (administration ii), 2, 3, 5, 8> 12, 15, 22, and 29.
- Group 3 Day 1 (before administration), 2, 3, 5, 8, 12, 15, 22, 29, 36. 43, 50, 57, 64, 'F], F 8, 85, 92, 99,] 06, 113, 120. 127, 134, 141, 148, 155, 162,
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Composite Materials (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- General Engineering & Computer Science (AREA)
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Abstract
L'invention concerne une structure de nanohorn de carbone dans laquelle un groupe fonctionnel contenant de l'oxygène situé au niveau d'un bord ouvert du nanohorn est lié à un cation. L'invention concerne également une structure de nanohorn de carbone comprenant une substance organique contenue dans un espace intérieur du nanohorn. Une nouvelle structure de nanohorn de carbone permet de réguler la libération d'une substance contenue dans celle-ci par l'intermédiaire d'un site d'ouverture de manière précise et simple. L'utilisation de cette structure de nanohorn de carbone permet d'obtenir un nouveau moyen pour la libération régulée d'une substance contenue dans la structure de nanohorn de carbone.
Applications Claiming Priority (2)
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JP2006-001896 | 2006-01-06 | ||
JP2006001896 | 2006-01-06 |
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WO2007078007A1 true WO2007078007A1 (fr) | 2007-07-12 |
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PCT/JP2007/050080 WO2007078007A1 (fr) | 2006-01-06 | 2007-01-09 | Structure de nanohorn de carbone, composition permettant de réguler la libération d'une substance organique contenue dans celle-ci, et méthode pour libération régulée |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008004532A1 (fr) * | 2006-07-07 | 2008-01-10 | Nec Corporation | Composite de nanocornet de carbone contenant une substance doté d'une fiche de polyamine et procédé permettant de le produire |
JP2009184973A (ja) * | 2008-02-06 | 2009-08-20 | Nec Corp | カーボンナノホーンをキャリアとする抗菌剤徐放化製剤 |
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JPH0812310A (ja) * | 1994-07-05 | 1996-01-16 | Nec Corp | 液相におけるカーボン・ナノチューブの精製・開口方法および官能基の導入方法 |
JPH08325008A (ja) * | 1995-05-30 | 1996-12-10 | Nec Corp | イオン交換されたカーボンナノチューブおよびその製造方法および緩衝材および元素捕集方法 |
JP2000504002A (ja) * | 1996-01-30 | 2000-04-04 | ノバジェント オサケユイチア | 薬剤の経皮デリバリーのための組成物 |
WO2002075831A1 (fr) * | 2001-03-19 | 2002-09-26 | Nec Corporation | Électrode de pile à combustible, et pile à combustible pourvue de cette électrode |
JP2005343885A (ja) * | 2004-05-07 | 2005-12-15 | Japan Science & Technology Agency | 薬物カーボンナノホーン複合体とその製造方法 |
-
2007
- 2007-01-09 WO PCT/JP2007/050080 patent/WO2007078007A1/fr active Search and Examination
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JPH0812310A (ja) * | 1994-07-05 | 1996-01-16 | Nec Corp | 液相におけるカーボン・ナノチューブの精製・開口方法および官能基の導入方法 |
JPH08325008A (ja) * | 1995-05-30 | 1996-12-10 | Nec Corp | イオン交換されたカーボンナノチューブおよびその製造方法および緩衝材および元素捕集方法 |
JP2000504002A (ja) * | 1996-01-30 | 2000-04-04 | ノバジェント オサケユイチア | 薬剤の経皮デリバリーのための組成物 |
WO2002075831A1 (fr) * | 2001-03-19 | 2002-09-26 | Nec Corporation | Électrode de pile à combustible, et pile à combustible pourvue de cette électrode |
JP2005343885A (ja) * | 2004-05-07 | 2005-12-15 | Japan Science & Technology Agency | 薬物カーボンナノホーン複合体とその製造方法 |
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AJIMA K. ET AL.: "Effect of Functional Groups at Hole Edges on Cisplatin Release from Inside Single-Wall Carbon Nanohorns", THE JOURNAL OF PHYSICAL CHEMISTRY B, vol. 110, no. 11, 23 March 2006 (2006-03-23), pages 5773 - 5778, XP003015344 * |
MIYAWAKI J. ET AL.: "Solvent Effects on Hole-Edge Structure for Single-Wall Carbon Nanotubes and Single-wall Carbon Nanohorns", THE JOURNAL OF PHYSICAL CHEMISTRY B, vol. 108, no. 30, 2004, pages 10732 - 10735, XP003004045 * |
MURAKAMI T. ET AL.: "Carbon Nano Kagobutsu to Peptide Jinko Tanpakushitsu Fukugotai Sozai no Kaihatsu to DDS eno Riyo", BIO INDUSTRY, vol. 22, no. 11, 2005, pages 28 - 33, XP003015343 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008004532A1 (fr) * | 2006-07-07 | 2008-01-10 | Nec Corporation | Composite de nanocornet de carbone contenant une substance doté d'une fiche de polyamine et procédé permettant de le produire |
US8084505B2 (en) | 2006-07-07 | 2011-12-27 | Nec Corporation | Substance-containing carbon nanohorn composite having polyamine plug and process for producing the same |
JP5130544B2 (ja) * | 2006-07-07 | 2013-01-30 | 日本電気株式会社 | ポリアミンプラグを持つ物質内包カーボンナノホーン複合体、およびその製造方法 |
JP2009184973A (ja) * | 2008-02-06 | 2009-08-20 | Nec Corp | カーボンナノホーンをキャリアとする抗菌剤徐放化製剤 |
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