WO2007072050A1 - Composition pour un usage dans le traitement d’une surface - Google Patents

Composition pour un usage dans le traitement d’une surface Download PDF

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Publication number
WO2007072050A1
WO2007072050A1 PCT/GB2006/004909 GB2006004909W WO2007072050A1 WO 2007072050 A1 WO2007072050 A1 WO 2007072050A1 GB 2006004909 W GB2006004909 W GB 2006004909W WO 2007072050 A1 WO2007072050 A1 WO 2007072050A1
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composition
formula
further defined
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PCT/GB2006/004909
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English (en)
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Thomas David Evans
Timothy Mark Howe
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Endurocide Limited
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Publication of WO2007072050A1 publication Critical patent/WO2007072050A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/26—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen nitrogen-containing groups
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes
    • C08L83/06—Polysiloxanes containing silicon bound to oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes
    • C08L83/08—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/162—Organic compounds containing Si

Definitions

  • the present invention relates to a composition for use in the treatment of a surface, and particularly to a polymer composition and a process for use in disinfecting a surface or the like.
  • US-B-6,465,409 discloses an aqueous composition
  • a biocidal agent and a polyorganosiloxane containing water-soluble or water-dispersible polyether groups.
  • the composition is used for disinfecting hard surfaces, such as floors, walls and work surfaces.
  • an aqueous medium typically water.
  • bacteria or other micro organisms present on the surface can only be killed when the biocidal agent is released from the composition on the surface and this only occurs when the surface is made wet. Consequently, bacteria and germs can accumulate on surfaces treated with the composition over time and after the surface has been washed.
  • the amount of biocidal agent that may be released from the composition is limited to the volume of the aqueous medium in contact with it. If a sufficient amount of water is not used to clean a surface, an insufficient amount of biocidal agent may be released meaning that all of the micro organisms present on the surface may not be killed. A further disadvantage is that the entire surface must be cleaned with water in order to release the biocidal agent to disinfect the overall surface.
  • GB-A-2,338,651 discloses a liquid polymer composition comprising polydimethylsiloxane and its use in treating surfaces, such as glass.
  • the composition may be applied to a surface, where it bonds to the surface and may kill micro organisms present on the surface when the composition is dry.
  • this composition relies on acid-etching of the surface prior to bonding and therefore may be difficult to apply and damaging, if contacted, by the user. Furthermore, the composition needs to be wet in order to be active.
  • composition for use in treating a surface comprising at least one polyorganosiloxane polymer having the formula A:
  • C 19 alkyl or alkylene group, linear or branched chain, z represents an acetate anion; r is an average value ranging from 1 to 500; s is an average value ranging from 1 to 10; and an active agent.
  • Formula A may be further defined in that the C 1 to C 6 alkyl radical of at least one of the R 8 or R 9 groups contains at least one secondary alcohol group.
  • Formula A may be further defined in that R 8 comprises -(CH 2 ) S -.
  • Formula A may be further defined in that R 9 comprises -CH 2 CHOHCH 2 -.
  • Formula A may be further defined in that X represents at least one primary alcohol group.
  • Formula A may be further defined in that X represents at least one quaternary amine group.
  • Formula A may be further defined in that X represents a quaternary amine group of the formula:
  • Formula A may be further defined in that T 2 comprises -(CH 2 )3NH 2 .
  • Formula A may be further defined in that at least one of T or T is a Methyl group.
  • Formula A may be further defined in that r has a value ranging from 1 to 300, preferably ranging from 1 to 200 and more preferably 1 to 80.
  • r represents a value of 80.
  • Formula A may be further defined in that s represents a value ranging from 1 to 10, preferably ranging from 1 to 5.
  • Formula A may be defined as:
  • Y represents a C 11 to Cj 3 alkyl radical
  • Z represents an acetate anion
  • r is an average value ranging from 1 to 200
  • s is an average value ranging from 2 to 5.
  • Formula A can take the form: Z- + (C 13 Me 2 )N-CH 2 CHOHCH 2 -0-(CH 2 ) 3 -(SiMe 2 ⁇ -) 8 o-(MeSiO-[CH 2 ] 3 -0- CH 2 CHOHCH 2 OH) 2 -SiMe 2 (CH 2 ) 3 -O-CH 2 CHOHCH 2 -N(Me 2 C 13 ) +"
  • s has a small value such as 2 (shown above) which also prevents steric hindrance.
  • the terminal quaternary amine groups are attached to the siloxane backbone with the aid of linking ether groups, such as ROR (-CH 2 CHOHCH 2 -O-(CH 2 )3-) because the quaternary amine groups in themselves are too large to attach to the siloxane backbone directly.
  • ROR -CH 2 CHOHCH 2 -O-(CH 2 )3-
  • Formula A may be defined as: Me 3 Si-O-(Me 2 Si-O-V-(MeSiR-O-VSiMe 3 wherein, the symbol R represents an alkyl amine of the formula:
  • Formula A hereinafter referred to as Polymer 2
  • Polymer 2 may take the form: Me 3 Si-0-(Me 2 Si-0-) 30 o-(MeSi[-(CH 2 ) 3 NH 2 ]-0-) 6 -SiMe 3
  • the repeating units within the polymer chain may be partly, predominantly or completely defined by dimethylsiloxane.
  • the active agent may be selected from the group consisting of a biocidal, antimicrobial, bactericidal, fungicidal, germicidal, yeasticidal, moldicidal, algicidal and virucidal agent.
  • a composition formed in accordance with the present invention may be incorporated into a functional material or article.
  • a process for use in treating a surface comprising applying an effective amount of a composition comprising one or more polyorganosiloxane polymers formed according to the present invention and an active agent to the surface.
  • an article treated with a composition as described herein and an active agent there is provided an article treated with a composition as described herein and an active agent.
  • composition for use in treating a surface comprising at least two different polyorganosiloxane polymers.
  • the polyorganosiloxane (which may comprise one polymer type or a blend of two or more polymer types) may be present in the composition in an amount of 5% to 95% by weight based on the weight of the composition. It is preferred that the polyorganosiloxane is present in an amount of from 10% to 50% and particularly preferred from 30% to 40% by weight based on the weight of the composition.
  • the composition may comprise a blend of between 5 to 95% of each polymer.
  • the active agent may be contained in a non- volatile carrier.
  • the active agent of the composition of the invention may be selected from the group consisting of a biocidal, anti-microbial, bactericidal, fungicidal, germicidal, yeasticidal, moldicidal, algicidal and virucidal agent.
  • the active agent or combination of agents selected may depend on the polymer composition used and on the intended use of the composition, in particular may be based on the type of micro organism that is required to be killed by treatment of the surface or implement with the composition of the invention.
  • the active agent may comprise one or more biocidal agents.
  • the biocidal agent may be selected from cationic, amphoteric, amino, phenolic and halogen containing biocides.
  • biocides which may be used include:
  • Cationic biocides such as quaternary monoammonium salts, for example
  • Cocoalkylbenzyldimethylammonium C 12 — Ci 4 alkylbenzyldimethylammonium, cocoalkyldichlorobenzyldimethylammonium, tetradecylbenzyldimethylammonium, didecyldimethylammonium and dioctyldimethylammonium chlorides,
  • Monoquaternary heterocyclic amine salts such as laurylpyridiniuni, cetylpyridinium and C 12 - Ci 4 alkylbenzyldimethylammonium chlorides,
  • Triphenylphosphonium fatty alkyl salts such as myristyltriphenylphosphonium bromide
  • Amphoteric biocides such as derivatives of N-(N'- C 8 - Cj 8 alkyl-3- aminopropyl)glycine, of N-(N'-(N"- C 8 - C 18 alkyl-2-ammoethyl)-2-aminoethyl) glycine, of N 5 N-Ws(N'- Cg - C 18 alkyl-2-aminoethyl)glycine, such as (dodecyle) (aminopropyl) glycine and (dodecyl) (diethylenediamine) glycine;
  • Amines such as N-(3-aminopropyl)-N-dodecyl-l,3-pr ⁇ panediamine;
  • Phenolic biocides such as para-chloro-meta-xylenol, dichloro-meta- xylenol, phenol, cresols, resorcinol, resorcinol monoacetate, and their derivatives or water-soluble salts;
  • Halogenated biocides such as iodophores and hypochlorite salts, for example sodium dichloroisocyanurate;
  • the active agent may be contained in a non volatile carrier.
  • the non-volatile carrier may be water, a glycol, an ester derivative of a glycol or an ether derivative of a glycol, hi particular, alkylene glycols and poly alkylene glycols such as diethylene glycol and polyethylene glycol may be used.
  • the carrier may be an alcohol having from 3 to 30 carbon atoms, preferably at least 10 carbon atoms.
  • the active agent in the composition may be present in an amount of from 0.1% to 20% by weight based on the weight of the composition. It is particularly preferred that the active agent is present in an amount of from 0.2% to 11% by weight based on the weight of the composition.
  • the active agent may comprise one or a combination of Bac 50,DDQ 50, SPX and MBS.
  • the polyorganosiloxane and the active agent may represent the main ingredients of the composition of the invention.
  • the composition may further comprise other ingredients, such as surfactants, chelating agents (such as aminocarboxylates, (ethylenediaminetetra-acetates, nitrilotriacetates, N,N-bis(carboxymethyl)- glutamates, citrates), alcohols (ethanol, isopropanol, glycols) detergency adjuvants (phosphates, silicates), dyes, and fragrances.
  • the composition may further comprise a surfactant.
  • the surfactants which may be present in the composition of the invention may include: non-ionic surfactants such as ethylene oxide/propylene oxide block polymers, polyethoxylated sorbitan esters, fatty esters of sorbitan, ethoxylated fatty esters (containing from 1 to 25 units of ethylene oxide) polyethoxylated C 8 - C 22 alcohols (containing from 1 to 25 units of ethylene oxide), polyethoxylated C 6 - C 22 alkylphenols (containing from 5 to 25 units of ethylene oxide), alkylpolyglycosides, amine oxides (such as C 10 - C 18 alkyldimethylamine oxides, C 8 - C 22 alkoxyethyldihydroxyethylamine oxides) amphoteric or zwitterionic surfactants such as C 6 - C 20 alkylamphoacetates or amphodiacetates (such as cocoamphoacetates), C 10 - C 18 alkyldimethyl
  • the composition may be in the form of an aqueous composition.
  • the polyorganosiloxane acts as a carrier to introduce the active agent to the surface, implement or the like to be treated by the composition of the invention.
  • the amino and/or polyether functions on the polyorganosiloxane allow adhesion to the treated surface by preferentially interacting with the biocidal agents and the surface.
  • composition of the invention provides disinfection of surfaces for a considerable time after application and will remain active after washing and/or abrading (polishing). This is advantageous over conventional biocides which quickly lose their efficacy after application particularly when the treated surface is washed or abraded.
  • the composition may be applied to a surface or implement, for example a floor, wall or medical instrument, in the form of a coating and the polymer assists in adhering the active agent to the surface or the implement.
  • the biocides in the composition of the invention are held to the treated surface by a polymer which is based on a polyorganosiloxane. This prevents the biocides from leaving the surface during washing or when abraded.
  • composition of the invention may advantageously be incorporated into other materials.
  • materials may include coatings such as paints and varnishes, which may be oil based or water soluble.
  • the composition may also be incorporated into settable or curable compositions such as fillers, grouts, adhesives, mastics, putties and other materials which form a solid matrix over a period of time.
  • settable or curable compositions such as fillers, grouts, adhesives, mastics, putties and other materials which form a solid matrix over a period of time.
  • Such prior art compositions are prone to the growth of mould and fungus, particularly in damp environments such as bathrooms and kitchens.
  • composition of the invention may also be incorporated into plastics materials which may then be used to manufacture food processing implements, work surfaces, packaging materials, containers, and furniture for bathrooms, kitchens, hospitals and the like.
  • the composition may be impregnated or otherwise incorporated into a fabric or textile.
  • composition When the composition is applied to a surface or instrument, it may form a coating layer thereon which contains one or more active agents, preferably biocidal agents, so that any micro organisms present on or subsequently contacting the surface or instrument are killed. If the composition further comprises a surfactant, this may enhance the spreading ability of the composition over substantially the entire surface whilst imparting cleaning and detergent properties to the composition.
  • active agents preferably biocidal agents
  • the composition is effective at killing micro organisms under dry or wet conditions.
  • composition of the invention may be used to disinfect any suitable surface or implement, for example floors, walls, work surfaces, kitchen utensils, surgical instruments and the like.
  • the composition may be used in different environments, that is in the medical or health care industry, for example in hospitals, in the food industry, for example in manufacturing plants and restaurants, in the commercial environment, for example in offices, and in the domestic environment, for example in kitchens and bathrooms.
  • composition may be used to treat different surfaces, such as, for example, those made from ceramic, glass, pvc, formica or other polymeric materials, stainless steel, aluminium and wood.
  • composition may be diluted before applying it to a surface or implement, such as by 1 to 100 fold or 1 to 1000 fold.
  • the composition may be effective at controlling the proliferation and/or elimination of many types of micro organisms, including gram-positive and gram- negative bacteria, such as: Bacillus cereus, Bacillus subtilis, Brevibacterium ammoniagenes, Brucella abortus, Klebsiella pneumonia, Lactobacillus casei, Proteus vulgaris, Listeria monocytogenes, Pseudomonas aeruginosa, Salmonella gallinarum, Salmonella typhosa, Staphylococcus aureus, Steptococcus faecalis, Flavobacterium species, Bacillus species, Escherichia species, Aeromonas species, Anchromobacter species and Alcaligenes species, fungi such as: Cephalosporium species, Cladosporium species, Fusarium species, Paecilomyces species, Penicillium species, Streptomyces species, Trichophyton interdigitale, Chaetorarium globesom, Aspergillus
  • the formulation was prepared by measuring the required volume of the biocides with a pipette and adding them to a 100ml volumetric flask. The volume of polymer required was also measured and added.
  • the formulation was prepared according to the following recipe:
  • Raw Material 2 20 % (50 % active Quaternary alkylbenzyl dimethylammonium chloride)
  • Raw Material 3 30 % (Approx. 20 % active polymer)
  • the solution was mixed on a shaker and the volume adjusted to 100ml with water. Three dilutions of the formulation were tested, concentrated, 1 in 10 and 1 in 20. The diluent used was water.
  • the culture was diluted in PBS such that there are 10 8 bacteria ml "1 . 550 ⁇ l is added to each plate and lOO ⁇ l immediately removed for sampling.
  • Steps 3 and 4 were repeated at 72 hours and 7 days.
  • CFU colony forming units
  • the beakers were either left to dry (7 hours), left to dry then rinsed with 25ml of water, or left to dry and wiped with a soft cloth (see Table of treatments shown below)
  • solution 1 demonstrates a greater durability to washing and wiping then solution 2.
  • Raw Material 1 is a mixture of benzisothiazolone and methylisothiazolone at 5% total activity. CAS Nos. 2634-33-5 and 2682-20-4
  • Raw Material 2 is a mixture of chloromethylisothiazolone and methylisothiazolone at 1.5% total activity.
  • Raw Material 3 is a solution of cocoalkyl dimethylbenzyl ammonium chloride at 50% activity. CAS No. 61789-71-7
  • Raw Material 4 is a solution of 50% di-n-decyl dimethyl ammonium chloride stablised with 20% propan-2-ol. CAS Nos. 7173-51-5 and 67-63-0
  • Raw Material 5 is an appoximate 20 % solution of a di-quaternary terminated polydimethylsiloxane polymer stabilised with an aliphatic alcohol ethoxylate at ⁇ 5% (CAS Nos. not available).
  • Versions may also be formulated without the isothiazolones, where a quick contact kill rate is not necessarily required, for example fabric treatment where preventing of organism growth is required.
  • An alternative formulation may comprise Polymer 2. This formulation is the same as described in Table 1 except that polymer 2 may be added to polymer 1 (pre- mixed) before adding to the remaining components. The combination of polymers
  • the ratio of different polymers in the polymer component in formulations where multiple polymers are used may be any suitable level, usually between 5% and 95%.
  • Polymer 2 may, of course also be used independently of Polymer 1.
  • the isothiazolone type and content of each formulation influences in particular, the shelf life of the formulation.
  • the shelf life of formulation C is greater than that of formulation B, which in turn is greater than that of formulation B, as exemplified below:
  • Formulation C has an indefinite shelf life, as shown from accelerated ageing tests at up to 60 0 C for 48 hours, where no visible changes were observed.
  • Formulation B has a shelf-life of at least 3 months. However, a colour change is observed after 40 hours during accelerated ageing tests carried out at 60 0 C. The concentration of CIT in the formulation dropped to about 60 % of its original value after 3 months natural storage, whilst the MIT concentration remained at over 90 %.
  • Formulation A demonstrated a shelf-life of at least six months in corresponding accelerated ageing tests.
  • the kill rate per minute was measured for each formulation against E.coli (0157), S.enteritidis, Kpneumoniae, C. albicans and MRSA by applying a 7 day application of a 1 :20 dilution.
  • This 7 day application of a 1 :20 dilution involves challenging treated surfaces with bacteria after increasing lengths of time to see if the bactericide was still working, as follows:
  • a batch of clean plates were sprayed with the appropriately diluted formulation and leaving to dry. After various time intervals, the plates were then challenged with bacterial cultures and incubated for testing. The resulting plates were then compared with plates sprayed with the same bactericide in the absence of polymer.
  • a 100 % kill rate in 1 minute was achieved against all the above-mentioned bacteria by a 1 :20 dilution of the formulation.
  • the speed of kill for each formulation appears to corresponds to the stability of the formulation in that the lower the stability of the formulation, the greater the speed of kill, such that formulation B demonstrates a greater speed of kill that formulation A, which in turn demonstrates a greater speed of kill than formulation
  • formulations exemplified above exhibit antibacterial activity, as evidenced by the biocidal properties of the formulations.
  • the kill spectrum is very similar for all of formulations A, B and C.
  • these particular formulations also have proven fungicidal properties.
  • This ability to effectively disinfect surfaces of bacteria, fungi (including yeast) as well as remain useable over a significant period of time allows the use of the formulations as disinfecting agents for the treatment of surfaces in, for example, the food and beverage industry, hospitals and the veterinary industry, where the formulations may be used, for example, to treat working surfaces and equipment, all industries in which high regulatory standards are applied and strict controls are maintained in respect of hygiene.
  • formulations A, B and C demonstrate a low speed of kill for Mycobacterium.
  • the pH needs to be carefully controlled.
  • formulation D (detailed below) demonstrates excellent results against Mycobacterium.
  • Raw Materials 4 and 5 are as for formulations A, B and C
  • Raw material 6 is 2-aminoethanol, CAS No. 141-43-5.
  • Raw Material 7 is a 30% solution of trisodium etbylenediamine disuccinate, CAS No. 178949-82-1.
  • Raw Material 8 is a 90% solution of an alcohol ethoxylate, CAS No. 68439-45-2.
  • Raw Material 7 can be replaced by 6% of Raw Material 9, a 40% solution of tetrasodium ethylenediamine tetra-acetate, CAS No. 64-02-8, increasing the water to 37.0% to make Formulation E.]

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  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne une composition pour un usage dans le traitement d’une surface, comprenant au moins un polymère polyorganosiloxane répondant à la formula A : T1R1R2SiO(R3R4SiO)r(R5T2SiO)sSiR6R7T3 où, les symboles R1, R2, R3, R4, R5, R6 et R7, qui sont identiques ou différents, représentent un radical phényle ou un radical alkyle en C1 à C6, et les symboles T1, T2 et T3, qui sont identiques ou différents, représentent un radical phényle ou un radical alkyle en C1 à C6, ou un radical alkyle répondant à la formule : -R8-O-R9-X où, les symboles R8 et R9, qui sont identiques ou différents, représentent un radical alkyle en C1 à C6, et le symbole X représente un alcool primaire, ou une amine quaternaire répondant à la formule : -N(R10R11R12)+Z- où, les symboles R10, R11 et R12, qui sont identiques ou différents, représentent un groupe alkyle ou alkylène en C1 à C19, à chaîne linéaire ou ramifiée, z représente un anion acétate ; r est une valeur moyenne comprise dans la gamme de 1 à 500 ; s est une valeur moyenne comprise dans la gamme de 1 à 10 ; et un agent actif.
PCT/GB2006/004909 2005-12-23 2006-12-22 Composition pour un usage dans le traitement d’une surface WO2007072050A1 (fr)

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GBGB0526292.8A GB0526292D0 (en) 2005-12-23 2005-12-23 A composition for use in the treatment of a surface
GB0526292.8 2005-12-23

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WO2007072050A1 true WO2007072050A1 (fr) 2007-06-28

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
US20120087963A1 (en) * 2009-02-27 2012-04-12 Bio Technics Limited Disinfectant composition comprising a biguanide compound
US9895304B2 (en) 2004-08-27 2018-02-20 Colgate-Palmolive Company Oral care composition with cross-linked polymer peroxide

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2980955B1 (fr) * 2011-10-05 2014-12-12 Anios Lab Sarl Compositions desinfectantes et detergentes.

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WO1996019194A1 (fr) * 1994-12-22 1996-06-27 The Procter & Gamble Company Compositions a base de silicone
EP1000959A2 (fr) * 1998-11-14 2000-05-17 Goldschmidt AG Polysiloxanes à fonction polyetherquat
WO2004047779A2 (fr) * 2002-11-22 2004-06-10 Petroferm Inc. Polymeres contenant des sels d'ammonium quaternaire

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GB991597A (en) * 1960-05-25 1965-05-12 Wallace Cameron & Co Ltd Improvements in or relating to detergent solutions
GB2338651A (en) * 1998-06-27 1999-12-29 Woollard Trevor P Liquid polymer composition
US6821943B2 (en) * 2001-03-13 2004-11-23 S. C. Johnson & Son, Inc. Hard surface antimicrobial cleaner with residual antimicrobial effect comprising an organosilane
GB0316927D0 (en) * 2003-07-18 2003-08-27 Stephens Michael J A composition for use in the treatment of a surface

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO1996019194A1 (fr) * 1994-12-22 1996-06-27 The Procter & Gamble Company Compositions a base de silicone
EP1000959A2 (fr) * 1998-11-14 2000-05-17 Goldschmidt AG Polysiloxanes à fonction polyetherquat
WO2004047779A2 (fr) * 2002-11-22 2004-06-10 Petroferm Inc. Polymeres contenant des sels d'ammonium quaternaire

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9895304B2 (en) 2004-08-27 2018-02-20 Colgate-Palmolive Company Oral care composition with cross-linked polymer peroxide
US20120087963A1 (en) * 2009-02-27 2012-04-12 Bio Technics Limited Disinfectant composition comprising a biguanide compound

Also Published As

Publication number Publication date
GB0526292D0 (en) 2006-02-01
GB0625777D0 (en) 2007-02-07
GB2433510A (en) 2007-06-27

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