WO2007070695A3 - Flux-enabling compositions and methods for dermal delivery of drugs - Google Patents

Flux-enabling compositions and methods for dermal delivery of drugs Download PDF

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Publication number
WO2007070695A3
WO2007070695A3 PCT/US2006/048061 US2006048061W WO2007070695A3 WO 2007070695 A3 WO2007070695 A3 WO 2007070695A3 US 2006048061 W US2006048061 W US 2006048061W WO 2007070695 A3 WO2007070695 A3 WO 2007070695A3
Authority
WO
WIPO (PCT)
Prior art keywords
volatile solvent
drug
flux
methods
formulation
Prior art date
Application number
PCT/US2006/048061
Other languages
French (fr)
Other versions
WO2007070695A2 (en
Inventor
Jie Zhang
Kevin S Warner
Sanjay Sharma
Original Assignee
Zars Inc
Jie Zhang
Kevin S Warner
Sanjay Sharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zars Inc, Jie Zhang, Kevin S Warner, Sanjay Sharma filed Critical Zars Inc
Priority to CA002633472A priority Critical patent/CA2633472A1/en
Priority to JP2008545868A priority patent/JP2009519958A/en
Priority to EP06847684A priority patent/EP1959930A2/en
Priority to AU2006326034A priority patent/AU2006326034A1/en
Publication of WO2007070695A2 publication Critical patent/WO2007070695A2/en
Publication of WO2007070695A3 publication Critical patent/WO2007070695A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein at least one non-volatile solvent is a flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
PCT/US2006/048061 2005-12-14 2006-12-14 Flux-enabling compositions and methods for dermal delivery of drugs WO2007070695A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002633472A CA2633472A1 (en) 2005-12-14 2006-12-14 Flux-enabling compositions and methods for dermal delivery of drugs
JP2008545868A JP2009519958A (en) 2005-12-14 2006-12-14 Fluxable compositions and methods for skin delivery of drugs
EP06847684A EP1959930A2 (en) 2005-12-14 2006-12-14 Flux-enabling compositions and methods for dermal delivery of drugs
AU2006326034A AU2006326034A1 (en) 2005-12-14 2006-12-14 Flux-enabling compositions and methods for dermal delivery of drugs

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US75052305P 2005-12-14 2005-12-14
US75065205P 2005-12-14 2005-12-14
US75063705P 2005-12-14 2005-12-14
US60/750,652 2005-12-14
US60/750,523 2005-12-14
US60/750,637 2005-12-14
US79509106P 2006-04-25 2006-04-25
US60/795,091 2006-04-25

Publications (2)

Publication Number Publication Date
WO2007070695A2 WO2007070695A2 (en) 2007-06-21
WO2007070695A3 true WO2007070695A3 (en) 2008-08-21

Family

ID=38163553

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/048061 WO2007070695A2 (en) 2005-12-14 2006-12-14 Flux-enabling compositions and methods for dermal delivery of drugs

Country Status (6)

Country Link
EP (1) EP1959930A2 (en)
JP (1) JP2009519958A (en)
CN (1) CN102670567A (en)
AU (1) AU2006326034A1 (en)
CA (1) CA2633472A1 (en)
WO (1) WO2007070695A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8741333B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for treating dermatitis or psoriasis
US8741332B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
EP2037999B1 (en) 2006-07-07 2016-12-28 Proteus Digital Health, Inc. Smart parenteral administration system
US9283177B2 (en) * 2007-01-16 2016-03-15 Juventio, Llc Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic
CA2675797A1 (en) 2007-01-16 2008-07-24 Dermworx, Incorporated Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
WO2010008600A1 (en) * 2008-07-16 2010-01-21 Dermworx Incorporated Topical drug delivery system
US20100160368A1 (en) 2008-08-18 2010-06-24 Gregory Jefferson J Methods of Treating Dermatological Disorders and Inducing Interferon Biosynthesis With Shorter Durations of Imiquimod Therapy
PL2453747T3 (en) 2009-07-13 2018-02-28 Medicis Pharmaceutical Corporation Lower dosage strength imiquimod formulations and short dosing regimens for treating genital and perianal warts
MY169700A (en) 2010-02-01 2019-05-13 Proteus Digital Health Inc Data gathering system
MX2012008922A (en) 2010-02-01 2012-10-05 Proteus Digital Health Inc Data gathering system.
JP2013528590A (en) * 2010-05-06 2013-07-11 ヌボ リサーチ インコーポレイテッド Triamcinolone acetonide formulation for treating dermatitis and psoriasis
WO2012107575A1 (en) 2011-02-10 2012-08-16 Moberg Derma Ab Novel formulations for dermal, transdermal and mucosal use 2
GB201115633D0 (en) 2011-09-09 2011-10-26 Univ Liverpool Compositions of efavirenz
GB2496656B (en) * 2011-11-18 2015-12-09 Lrc Products Film-Forming Formulation
US10632087B2 (en) 2012-02-06 2020-04-28 Innovative Med Concepts, LLC. Famciclovir and meloxicam combination therapy for functional somatic syndromes
EP2845591A1 (en) * 2013-09-04 2015-03-11 Polichem S.A. Use of trifluoroacetic acid as keratolytic agent to treat hyperkeratotic skin lesions
JP2018503689A (en) * 2015-01-27 2018-02-08 フローレンゲイル・エル・エル・シー Healing topical composition
US11090265B2 (en) * 2015-01-30 2021-08-17 Medrx Co., Ltd. Aqueous preparation for external use
US10080763B2 (en) * 2015-08-17 2018-09-25 Sidmak Laboratories (India) Pvt. Ltd. Topical film delivery system
BE1022817B1 (en) * 2015-08-25 2016-09-13 Stasisport Pharma Nv Antiviral composition and lipstick comprising said composition
DE102016001700A1 (en) * 2016-02-13 2017-08-17 M-I Consulting Auditing Developing GmbH Pharmaceutical preparation for the treatment of viral infections of the skin
EP3434267B1 (en) * 2016-03-24 2023-07-26 MEDRx Co., Ltd. Patch preparation having misuse prevention characteristics
US20170273974A1 (en) 2016-03-24 2017-09-28 Medrx Co., Ltd Patch preparations with misuse prevention features
EP3556368B1 (en) 2016-12-16 2021-05-26 Kaneka Corporation Onychomycosis therapeutic agent
CN107115329A (en) * 2017-04-28 2017-09-01 中国人民解放军第二军医大学第二附属医院 A kind of compound Butenafine preparation and its application
CN108524312B (en) * 2018-04-26 2019-11-22 珀莱雅化妆品股份有限公司 A kind of sulforaphen pik woods micro emulsion and preparation method thereof
TW202214220A (en) * 2020-09-28 2022-04-16 大陸商江蘇恒瑞醫藥股份有限公司 Pharmaceutical compositions of percutaneously absorbed local anesthetics containing amides and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562363B1 (en) * 1997-09-26 2003-05-13 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562363B1 (en) * 1997-09-26 2003-05-13 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same

Also Published As

Publication number Publication date
CA2633472A1 (en) 2007-06-21
JP2009519958A (en) 2009-05-21
AU2006326034A1 (en) 2007-06-21
CN102670567A (en) 2012-09-19
WO2007070695A2 (en) 2007-06-21
EP1959930A2 (en) 2008-08-27

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