WO2007064821A3 - Purified fabh polypeptides involved in bacterial fatty acid synthesis - Google Patents

Purified fabh polypeptides involved in bacterial fatty acid synthesis Download PDF

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Publication number
WO2007064821A3
WO2007064821A3 PCT/US2006/045892 US2006045892W WO2007064821A3 WO 2007064821 A3 WO2007064821 A3 WO 2007064821A3 US 2006045892 W US2006045892 W US 2006045892W WO 2007064821 A3 WO2007064821 A3 WO 2007064821A3
Authority
WO
WIPO (PCT)
Prior art keywords
purified
fatty acid
acid synthesis
polypeptides involved
bacterial fatty
Prior art date
Application number
PCT/US2006/045892
Other languages
French (fr)
Other versions
WO2007064821A2 (en
Inventor
Judd M Berman
Nachum Kaplan
Hui Ouyang
Bryan Beattie
Original Assignee
Affinium Pharm Inc
Judd M Berman
Nachum Kaplan
Hui Ouyang
Bryan Beattie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Judd M Berman, Nachum Kaplan, Hui Ouyang, Bryan Beattie filed Critical Affinium Pharm Inc
Publication of WO2007064821A2 publication Critical patent/WO2007064821A2/en
Publication of WO2007064821A3 publication Critical patent/WO2007064821A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.
PCT/US2006/045892 2005-12-01 2006-12-01 Purified fabh polypeptides involved in bacterial fatty acid synthesis WO2007064821A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74168405P 2005-12-01 2005-12-01
US60/741,684 2005-12-01

Publications (2)

Publication Number Publication Date
WO2007064821A2 WO2007064821A2 (en) 2007-06-07
WO2007064821A3 true WO2007064821A3 (en) 2008-01-31

Family

ID=38092795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/045892 WO2007064821A2 (en) 2005-12-01 2006-12-01 Purified fabh polypeptides involved in bacterial fatty acid synthesis

Country Status (1)

Country Link
WO (1) WO2007064821A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017779A1 (en) * 1996-10-23 1998-04-30 Smithkline Beecham Corporation NOVEL FabH
EP0916730A2 (en) * 1997-11-14 1999-05-19 Smithkline Beecham Corporation FabH from Staphylococcus aureus
WO2001038345A1 (en) * 1999-11-24 2001-05-31 Smithkline Beecham Corporation Regulatable fabh constructs
WO2002077183A2 (en) * 2001-03-21 2002-10-03 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017779A1 (en) * 1996-10-23 1998-04-30 Smithkline Beecham Corporation NOVEL FabH
EP0916730A2 (en) * 1997-11-14 1999-05-19 Smithkline Beecham Corporation FabH from Staphylococcus aureus
WO2001038345A1 (en) * 1999-11-24 2001-05-31 Smithkline Beecham Corporation Regulatable fabh constructs
WO2002077183A2 (en) * 2001-03-21 2002-10-03 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHOI K H ET AL: "beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis.", JOURNAL OF BACTERIOLOGY JAN 2000, vol. 182, no. 2, January 2000 (2000-01-01), pages 365 - 370, XP002451176, ISSN: 0021-9193 *
HAN CLIFF S ET AL: "Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis.", JOURNAL OF BACTERIOLOGY MAY 2006, vol. 188, no. 9, May 2006 (2006-05-01), pages 3382 - 3390, XP002451173, ISSN: 0021-9193 *
LAI CHIOU-YAN ET AL: "Beta-ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 19 DEC 2003, vol. 278, no. 51, 19 December 2003 (2003-12-19), pages 51494 - 51503, XP002451177, ISSN: 0021-9258 *
NIE ZHE ET AL: "Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents.", JOURNAL OF MEDICINAL CHEMISTRY 10 MAR 2005, vol. 48, no. 5, 10 March 2005 (2005-03-10), pages 1596 - 1609, XP002451175, ISSN: 0022-2623 *
QIU XIAYANG ET AL: "Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus.", PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY AUG 2005, vol. 14, no. 8, August 2005 (2005-08-01), pages 2087 - 2094, XP002451296, ISSN: 0961-8368 *
READ TIMOTHY D ET AL: "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.", NATURE 1 MAY 2003, vol. 423, no. 6935, 1 May 2003 (2003-05-01), pages 81 - 86, XP002451174, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO2007064821A2 (en) 2007-06-07

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