WO2007060437A3 - Spectrometre de masse - Google Patents

Spectrometre de masse Download PDF

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Publication number
WO2007060437A3
WO2007060437A3 PCT/GB2006/004387 GB2006004387W WO2007060437A3 WO 2007060437 A3 WO2007060437 A3 WO 2007060437A3 GB 2006004387 W GB2006004387 W GB 2006004387W WO 2007060437 A3 WO2007060437 A3 WO 2007060437A3
Authority
WO
WIPO (PCT)
Prior art keywords
fragmentation
mass spectra
ions
parent
ion mass
Prior art date
Application number
PCT/GB2006/004387
Other languages
English (en)
Other versions
WO2007060437A2 (fr
Inventor
Robert Harold Bateman
Original Assignee
Micromass Ltd
Robert Harold Bateman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/286,262 external-priority patent/US20060138320A1/en
Application filed by Micromass Ltd, Robert Harold Bateman filed Critical Micromass Ltd
Priority to EP06808660A priority Critical patent/EP1952425A2/fr
Priority to JP2008541822A priority patent/JP4959713B2/ja
Priority to CA2628927A priority patent/CA2628927C/fr
Publication of WO2007060437A2 publication Critical patent/WO2007060437A2/fr
Publication of WO2007060437A3 publication Critical patent/WO2007060437A3/fr

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

L'invention concerne un procédé de spectrométrie de masse dans lequel un dispositif de fragmentation par dissociation par collision d'électrons, dissociation par transfert d'électrons ou dissociation induite par une surface passe de manière répétée d'un mode fragmentation élevée à un mode fragmentation faible. Des ions parents provenant d'un premier échantillon traversent le dispositif, et on obtient un spectre de masse d'ions parents et un spectre de masse d'ions issus de la fragmentation. Des ions parents provenant d'un second échantillon traversent ensuite le dispositif et on obtient un second ensemble de spectres de masse d'ions parents et d'ions issus de la fragmentation. On compare ensuite les spectres de masse et, lorsque dans les deux exemples, certains ions parents ou certains ions issus de la fragmentation sont exprimés différemment, on effectue une analyse afin de les identifier.
PCT/GB2006/004387 2005-11-23 2006-11-23 Spectrometre de masse WO2007060437A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06808660A EP1952425A2 (fr) 2005-11-23 2006-11-23 Spectrometre de masse
JP2008541822A JP4959713B2 (ja) 2005-11-23 2006-11-23 質量分析計
CA2628927A CA2628927C (fr) 2005-11-23 2006-11-23 Spectrometre de masse

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/286,262 US20060138320A1 (en) 2002-07-24 2005-11-23 Mass spectrometer
US11/286,262 2005-11-23
GB0523811.8 2005-11-23
GBGB0523811.8A GB0523811D0 (en) 2005-11-23 2005-11-23 Mass stectrometer

Publications (2)

Publication Number Publication Date
WO2007060437A2 WO2007060437A2 (fr) 2007-05-31
WO2007060437A3 true WO2007060437A3 (fr) 2008-05-08

Family

ID=35601031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/004387 WO2007060437A2 (fr) 2005-11-23 2006-11-23 Spectrometre de masse

Country Status (5)

Country Link
EP (1) EP1952425A2 (fr)
JP (1) JP4959713B2 (fr)
CA (2) CA2835042A1 (fr)
GB (4) GB0523811D0 (fr)
WO (1) WO2007060437A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0806725D0 (en) 2008-04-14 2008-05-14 Micromass Ltd Mass spectrometer
GB0810125D0 (en) 2008-06-03 2008-07-09 Thermo Fisher Scient Bremen Collosion cell
US8604419B2 (en) 2010-02-04 2013-12-10 Thermo Fisher Scientific (Bremen) Gmbh Dual ion trapping for ion/ion reactions in a linear RF multipole trap with an additional DC gradient
GB201019337D0 (en) * 2010-11-16 2010-12-29 Micromass Ltd Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis
CA2873125A1 (fr) * 2012-05-18 2013-11-21 Micromass Uk Limited Procede ameliore de spectrometrie de masse ms e
RU2673551C2 (ru) * 2012-11-12 2018-11-28 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича" Российской академии медицинских наук (ФГБУ "ИБМХ" РАМН) Протеотипический пептид q9y4w6-02 и способ масс-спектрометрического анализа содержания afg3-подобного белка человека на его основе
JP6004002B2 (ja) 2012-11-22 2016-10-05 株式会社島津製作所 タンデム四重極型質量分析装置
GB201406981D0 (en) * 2014-04-17 2014-06-04 Micromass Ltd Hybrid acquisition method incorporating electron transfer dissociation triggered from fast sequential 2D MS/MS collision induced dissociation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040041091A1 (en) * 2002-07-24 2004-03-04 Bateman Robert Harold Method of mass spectrometry and a mass spectrometer
US20040155180A1 (en) * 2001-03-22 2004-08-12 Roman Zubarev Mass spectrometry methods using electron capture by ions
US20050199804A1 (en) * 2004-03-12 2005-09-15 Hunt Donald F. Electron transfer dissociation for biopolymer sequence analysis

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3300602B2 (ja) * 1996-06-20 2002-07-08 株式会社日立製作所 大気圧イオン化イオントラップ質量分析方法及び装置
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
JP2000241390A (ja) * 1999-02-17 2000-09-08 Japan Atom Energy Res Inst 中性種の解離を用いる電荷逆転質量分析法
US6545268B1 (en) * 2000-04-10 2003-04-08 Perseptive Biosystems Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
CA2340150C (fr) * 2000-06-09 2005-11-22 Micromass Limited Methodes et appareil pour la spectrometrie de masse
US6744040B2 (en) * 2001-06-13 2004-06-01 Bruker Daltonics, Inc. Means and method for a quadrupole surface induced dissociation quadrupole time-of-flight mass spectrometer
GB0121172D0 (en) * 2001-08-31 2001-10-24 Shimadzu Res Lab Europe Ltd A method for dissociating ions using a quadrupole ion trap device
JP4161125B2 (ja) * 2002-04-24 2008-10-08 滋雄 早川 質量分析法および質量分析装置
WO2003102545A2 (fr) * 2002-05-31 2003-12-11 Analytica Of Branford, Inc. Procedes de fragmentation pour spectrometrie de masse
GB2390935A (en) * 2002-07-16 2004-01-21 Anatoli Nicolai Verentchikov Time-nested mass analysis using a TOF-TOF tandem mass spectrometer
AU2002952747A0 (en) * 2002-11-18 2002-12-05 Ludwig Institute For Cancer Research Method for analysing peptides
JP2006518918A (ja) * 2003-02-21 2006-08-17 ジヨーンズ ホプキンズ ユニバーシティ タンデム飛行時間型質量分析計
GB2402260B (en) * 2003-05-30 2006-05-24 Thermo Finnigan Llc All mass MS/MS method and apparatus
JP4275545B2 (ja) * 2004-02-17 2009-06-10 株式会社日立ハイテクノロジーズ 質量分析装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040155180A1 (en) * 2001-03-22 2004-08-12 Roman Zubarev Mass spectrometry methods using electron capture by ions
US20040041091A1 (en) * 2002-07-24 2004-03-04 Bateman Robert Harold Method of mass spectrometry and a mass spectrometer
US20050199804A1 (en) * 2004-03-12 2005-09-15 Hunt Donald F. Electron transfer dissociation for biopolymer sequence analysis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DE HOFFMANN E: "Tandem mass spectrometry: A primer", JOURNAL OF MASS SPECTROMETRY, WILEY, CHICHESTER, GB, vol. 31, no. 2, 1996, pages 129 - 137, XP007903162, ISSN: 1076-5174 *

Also Published As

Publication number Publication date
GB2435714A (en) 2007-09-05
GB2451963B (en) 2010-06-16
GB2451963A (en) 2009-02-18
CA2835042A1 (fr) 2007-05-31
GB2443570A (en) 2008-05-07
GB2443570B (en) 2010-06-23
EP1952425A2 (fr) 2008-08-06
GB2435714B (en) 2010-06-23
CA2628927C (fr) 2017-09-05
GB0623377D0 (en) 2007-01-03
GB0523811D0 (en) 2006-01-04
JP2009516843A (ja) 2009-04-23
JP4959713B2 (ja) 2012-06-27
WO2007060437A2 (fr) 2007-05-31
CA2628927A1 (fr) 2007-05-31
GB0816196D0 (en) 2008-10-15
GB0801092D0 (en) 2008-02-27

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