WO2007042848A3 - Procede de preparation de carbidopa - Google Patents

Procede de preparation de carbidopa Download PDF

Info

Publication number
WO2007042848A3
WO2007042848A3 PCT/HU2006/000092 HU2006000092W WO2007042848A3 WO 2007042848 A3 WO2007042848 A3 WO 2007042848A3 HU 2006000092 W HU2006000092 W HU 2006000092W WO 2007042848 A3 WO2007042848 A3 WO 2007042848A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
carbidopa
hydrazino
propionic acid
dihydroxyphenyl
Prior art date
Application number
PCT/HU2006/000092
Other languages
English (en)
Other versions
WO2007042848A2 (fr
Inventor
Fadgyas Katalin Kataine
Janos Farkas
Gyula Lukacs
Ferenc Lang
Ferenc Jurak
Istvanne Csala
Tamasne Koroknai
Marta Porcs-Makkay
Original Assignee
Egis Gyogyszergyar Nyrt
Fadgyas Katalin Kataine
Janos Farkas
Gyula Lukacs
Ferenc Lang
Ferenc Jurak
Istvanne Csala
Tamasne Koroknai
Marta Porcs-Makkay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyrt, Fadgyas Katalin Kataine, Janos Farkas, Gyula Lukacs, Ferenc Lang, Ferenc Jurak, Istvanne Csala, Tamasne Koroknai, Marta Porcs-Makkay filed Critical Egis Gyogyszergyar Nyrt
Publication of WO2007042848A2 publication Critical patent/WO2007042848A2/fr
Publication of WO2007042848A3 publication Critical patent/WO2007042848A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C243/18—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne un procédé permettant la préparation d'acide (-) - (L) -3- (3, 4-dihydroxyphényl) - 2 -hydrazino-2 -méthylpropionique (carbidopa) représenté par la formule (II), comprenant l'utilisation d'une 3, 3 -pentaméthylène oxaziridine de formule (IV). Ce procédé consiste à faire réagir un ester L-a-méthyldopa méthyle de formule (III) avec la 3,3-penta- méthylene oxaziridine de formule (IV), à isoler l'ester méthylique d'acide (+) - (L) -2- (N' - cyclohexylidène-hydrazino) -3- (3, 4-dihydroxyphényl) -2 -méthylpropionique de formule (I), et à le soumettre à une hydrolyse avec un acide. L'ester méthylique d'acide (+) - (L) -2- (N' -cyclohexylidène-hydrazino) -3- (3, 4-dihydroxyphényl) -2-méthylpropionique de formule (I) est un nouvel intermédiaire. L'acide (-) - (L) -3- (3, 4-dihydroxyphényl) -2-hydrazino-2- méthyl propionique (carbidopa) de (XI) obtenu par ce procédé est un ingrédient actif thérapeutique utile possédant la dénomination internationale commune carbidopa.
PCT/HU2006/000092 2005-10-12 2006-10-12 Procede de preparation de carbidopa WO2007042848A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP0500940 2005-10-12
HU0500940A HU227283B1 (en) 2005-10-12 2005-10-12 Process for the preparation of carbidopa

Publications (2)

Publication Number Publication Date
WO2007042848A2 WO2007042848A2 (fr) 2007-04-19
WO2007042848A3 true WO2007042848A3 (fr) 2007-05-31

Family

ID=89986337

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2006/000092 WO2007042848A2 (fr) 2005-10-12 2006-10-12 Procede de preparation de carbidopa

Country Status (2)

Country Link
HU (1) HU227283B1 (fr)
WO (1) WO2007042848A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102432496B (zh) * 2011-12-23 2013-01-30 浙江手心医药化学品有限公司 一种卡比多巴的精制方法
CN102702019B (zh) * 2012-06-16 2014-05-14 山东新华制药股份有限公司 卡比多巴的合成方法
CN114478303A (zh) * 2022-02-23 2022-05-13 浙江野风药业股份有限公司 一种卡比多巴的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD230865A1 (de) * 1982-08-09 1985-12-11 Dresden Arzneimittel Verfahren zur herstellung von hydrazinocarbonsaeurederivaten durch n-aminierung von aminocarbonsaeurederivaten
DD240818A3 (de) * 1981-02-10 1986-11-19 Ernst Schmitz Verfahren zur herstellung von hydrazinocarbonsaeurederivaten durch n-aminierung von aminocarbonsaeurederivaten
DE19700061A1 (de) * 1997-01-03 1998-07-09 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung von cyclischen N-Aminosulfonamiden

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD240818A3 (de) * 1981-02-10 1986-11-19 Ernst Schmitz Verfahren zur herstellung von hydrazinocarbonsaeurederivaten durch n-aminierung von aminocarbonsaeurederivaten
DD230865A1 (de) * 1982-08-09 1985-12-11 Dresden Arzneimittel Verfahren zur herstellung von hydrazinocarbonsaeurederivaten durch n-aminierung von aminocarbonsaeurederivaten
DE19700061A1 (de) * 1997-01-03 1998-07-09 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung von cyclischen N-Aminosulfonamiden

Also Published As

Publication number Publication date
HUP0500940A2 (en) 2007-05-29
HU0500940D0 (en) 2005-12-28
WO2007042848A2 (fr) 2007-04-19
HU227283B1 (en) 2011-01-28

Similar Documents

Publication Publication Date Title
SG170729A1 (en) Processes and intermediates for preparing steric compounds
MA29464B1 (fr) Methode de preparation d'acides 1,6-dihydro-6-oxo-4-pyrimidinecarboxyliques eventuellement 2-substitues
EP2277595A3 (fr) Composés pour potentialiser l'immunité
EP2172472A3 (fr) Dérivés d'acides aminophosphoniques et leurs sels d'addition en tant que modulateurs du récepteur S1P
WO2006081431A3 (fr) Composes utiles dans le traitement des maladies auto-immunes et des troubles de demyelinisation
EP2308828A3 (fr) Antagoniste de CaSR
WO2007057225A3 (fr) Procede de preparation de montelukast et produits intermediaires utilises pour la preparation
AU2001272504A1 (en) 4-alkoxy cyclohexane-1 amino carboxylic acid esters and method for the production thereof
WO2008118427A3 (fr) Synthèse de l'acide (s)-(+)-3-(aminométhyl)-5-méthylhexanoïque
WO2007042848A3 (fr) Procede de preparation de carbidopa
WO2007049729A3 (fr) Composes amides et utilisation de ceux-ci
NO20063058L (no) Fremgangsmate for fremstilling av (3-okso-2,3-dihydro-1H-isoindol-1-yl)acetylguanidinderivater
WO2002066664A3 (fr) Procede de production d'acide d-pantothenique et/ou de sels de cet acide comme complements d'aliments pour animaux
WO2007057767A3 (fr) Derives d'acides amines
WO2007084882A3 (fr) Synthese d'amides d'acide 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonique
HK1063819A1 (en) Process for preparation of optically active propoxyaniline derivatives
WO2004041167A3 (fr) Phospholipides a anneau substitue antiprotozooses
WO2005054175A3 (fr) Nouveau procede pour la preparation de derives nitro-oxy de paracetamol
WO2003091243A8 (fr) Derives ester d'un acide decahydroisoquinoline-3 carboxylique utiles en tant qu'analgesiques
AU2003272077A1 (en) Alpha-amino acid benzothiazolylthio ester as intermediates for manufacture of ace inhibitors and process for preparation thereof
AU2003216965A1 (en) Compounds, particularly of urea derivatives or ester derivatives of haloacetamidobenzoic acid and use thereof for the treatment of parasitic diseases
WO2005005403A3 (fr) Procede de preparation d'oxetan-2-ones
WO2007144129A3 (fr) Composés organiques
EP1403260A3 (fr) Composés époxy optiquement actifs et procédé pout leur préparation
GEP20084394B (en) Novel intermediate for the preparation of therapeutically active imidazopyridines

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06808801

Country of ref document: EP

Kind code of ref document: A2