WO2007015871A1 - Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide - Google Patents

Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide Download PDF

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WO2007015871A1
WO2007015871A1 PCT/US2006/027878 US2006027878W WO2007015871A1 WO 2007015871 A1 WO2007015871 A1 WO 2007015871A1 US 2006027878 W US2006027878 W US 2006027878W WO 2007015871 A1 WO2007015871 A1 WO 2007015871A1
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Prior art keywords
methyl
salt
imidazol
phenyl
ylamino
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PCT/US2006/027878
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French (fr)
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Paul W. Manley
Wen-Chung Shieh
Paul Allen Sutton
Piotr H. Karpinski
Raeann Wu
Stéphanie MONNIER
Jörg Brozio
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Novartis Ag
Novartis Pharma Gmbh
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Priority to EP06787733A priority Critical patent/EP1910336B1/en
Priority to AU2006276205A priority patent/AU2006276205C1/en
Priority to AT06787733T priority patent/ATE514689T1/en
Priority to NZ564182A priority patent/NZ564182A/en
Priority to CA2615669A priority patent/CA2615669C/en
Priority to SI200631100T priority patent/SI1910336T1/en
Priority to PL06787733T priority patent/PL1910336T3/en
Priority to KR1020147007695A priority patent/KR20140047737A/en
Priority to MX2008000892A priority patent/MX2008000892A/en
Priority to JP2008522900A priority patent/JP5129132B2/en
Priority to CN200680026444.6A priority patent/CN101228151B/en
Application filed by Novartis Ag, Novartis Pharma Gmbh filed Critical Novartis Ag
Priority to KR1020157022022A priority patent/KR101755137B1/en
Priority to US11/995,898 priority patent/US8163904B2/en
Priority to BRPI0613605-2A priority patent/BRPI0613605A2/en
Priority to DK06787733.2T priority patent/DK1910336T3/en
Publication of WO2007015871A1 publication Critical patent/WO2007015871A1/en
Priority to IL187787A priority patent/IL187787A/en
Priority to TNP2008000028A priority patent/TNSN08028A1/en
Priority to NO20080897A priority patent/NO341313B1/en
Priority to HK08107504.6A priority patent/HK1116778A1/xx
Priority to AU2010241419A priority patent/AU2010241419C1/en
Priority to HR20110639T priority patent/HRP20110639T1/en
Priority to US13/419,132 priority patent/US8389537B2/en
Priority to US13/747,052 priority patent/US8580806B2/en
Priority to US14/051,725 priority patent/US9163005B2/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • This invention relates to salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide, as well as to methods of making the same, pharmaceutical compositions comprising the same and methods of treatment using the same.
  • WO 2004/005281 Al Valuable pharmacological properties are attributed to this compound; thus, it can be used, for example, as a protein kinase inhibitor useful in therapy for diseases which respond to inhibition of protein kinase activity.
  • WO 2004/005281 Al does not disclose any specific salts or salt hydrates or solvates of 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl- ⁇ henyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide.
  • the present invention is directed to salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)- 5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
  • Preferred embodiments of the present invention are directed to the hydrochloride, monophosphate, diphosphate, sulfate, methane sulfonate, ethane sulfonate, benzene sulfonate and p-toluene sulfonate salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
  • the present invention is further directed to a method of preparing a variety of crystalline salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridm-3-yl-pyrimidin-2-ylamino)-benzamide comprising the step of: reacting 4-methyl-N- [3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)-benzamide free base with an acid of formula HB in a solvent.
  • compositions comprising:
  • the present invention is also directed to a method of treating a disease which responds to an inhibition of protein kinase activity comprising the step of administering to a subject in need of such treatment a therapeutically effective amount of a salt of 4-methyl-N- [3-(4-methyl-imidazol-l-yl)-5-trifluoiOmethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)-benzamide.
  • Figure 1 shows the x-ray powder diffraction patterns (XRPDs) for forms A and B of the hydrochloride salt of 4-raethyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenylj- 3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
  • XRPDs x-ray powder diffraction patterns
  • Figure 2 shows the x-ray powder diffraction pattern (XRPD) for the monophosphate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin ⁇ 2-ylarnmo)-benzamide.
  • XRPD x-ray powder diffraction pattern
  • Figure 3 shows the x-ray powder diffraction pattern for the diphosphate salt of 4- methyl-N-[3-(4-metliyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
  • Figure 4 shows the x-ray powder diffraction patterns for forms A and B of the sulfate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
  • Figure 5 shows the x-ray powder diffraction pattern for the methane sulfonate (mesylate) salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
  • Figure 6 shows the x-ray powder diffraction pattern for the ethane sulfonate salt of 4- metliyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzarnide.
  • Figure 7 shows the x-ray powder diffraction pattern for the benzene sulfonate salt of
  • Figure 8 shows the x-ray powder diffraction pattern for the p-toluene sulfonate salt of
  • the present invention is directed to salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)- 5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide; prefei ⁇ ed embodiments of those salts are described below.
  • salt refers to a compound prepared by the reaction of an organic acid or base drug with a pharmaceutically acceptable mineral or organic acid or base; as used herein, “salt” includes hydrates and solvates of salts made in accordance with this invention.
  • Exemplary pharmaceutically acceptable mineral or organic acids or bases are as listed in Tables 1-8 in Handbook of Pharmaceutical Salts, P.H.
  • polymorph refers to a distinct “crystal modification” or “polymorphic form” or “crystalline form”, which differs from another with respect to x-ray powder diffraction pattern, physicochemical and/or pharmacokinetic properties, and thermodynamic stability.
  • the first embodiment of the present invention is directed to the hydrochloride salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
  • the hydrochloride salt (form B, monohydrate) is reproducibly produced from methanol when one equivalent hydrochloric acid is used. It is hygroscopic (when first tested, moisture uptake was up to 2% at 60% relative humidity and up to 2.7% at 95% relative humidity, though subsequent testing has shown even greater moisture uptake). It is very slightly soluble in water and slightly soluble in 0.1 N HCl, ethanol and 2-propanol.
  • thermogravimetric analysis TGA
  • two weight loss stages occur.
  • the first stage (onset at about 80°C) represents dehydration, and the second stage weight loss (at about 173°C) represents the loss of HCl (decomposition).
  • HCl decomposition
  • Its crystal structure ranges from good to excellent, it becomes amorphous upon grinding and it can withstand compression.
  • the hydrochloride salt is stable at room temperature in standard equilibration tests.
  • Other polymorphic forms of the hydrochloride salt i.e., forms A, A', A", B', S B , SB', C, C, Sc, D, and S E , were also isolated.
  • the second embodiment of the present invention is directed to the monophosphate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
  • the H 3 PO 4 mono-salt is reproducibly produced from methanol when one equivalent phosphoric acid is used.
  • the weight loss room temperature to 200°C
  • the sample melts at about 208 0 C and decomposes at about 212°C. Its crystal structure is excellent.
  • the third embodiment of the present invention is directed to the diphosphate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
  • the H 3 PO 4 di-salt can be produced from methanol when two equivalents phosphoric acid are used.
  • the weight loss room temperature to 200 0 C
  • the fourth embodiment of the present invention is directed to the sulfate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
  • the H 2 SO 4 salt (form B) is reproducibly produced from methanol when one equivalent sulfuric acid is used.
  • the weight loss room temperature to 200 0 C
  • the sample melts with decomposition at about 206 0 C. Its crystal structure ranges from poor to good.
  • One other form (form A) and an amorphous form were isolated.
  • the XRPD patterns for forms A and B of the sulfate salt of 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide are shown in Figure 4.
  • the fifth embodiment of the present invention is directed to the methane sulfonate (mesylate) salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
  • This salt is reproducibly produced from ethyl acetate when one equivalent methane sulfonic acid is used.
  • the weight loss (room temperature to 150°C) is about 0.44%, and the sample melts at about 160°C and decomposes at about 26O 0 C. Its crystal structure is poor.
  • the XRPD pattern for the methane sulfonate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide is shown in Figure 5.
  • the sixth embodiment of the present invention is directed to the ethane sulfonate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
  • This salt is reproducibly produced from ethyl acetate when one equivalent ethane sulfonic acid is used.
  • the weight loss room temperature to 150°C
  • the sample melts at about 259°C and decomposes at about 22O 0 C. Its crystal structure is poor.
  • the seventh embodiment of the present invention is directed to the benzene sulfonate salt of 4-methyl-N-[3-(4-methyl-imidazol- l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
  • This salt is reproducibly produced from ethyl acetate when one equivalent benzene sulfonic acid is used.
  • the weight loss room temperature to 25O 0 C
  • the sample melts with decomposition at about 26O 0 C. Its crystal structure ranges from poor to good.
  • the eighth embodiment of the present invention is directed to the p-toluene sulfonate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoiOmethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
  • This salt is reproducibly produced from ethyl acetate when one equivalent p-toluene sulfonic acid is used.
  • the weight loss room temperature to 150°C
  • the weight loss is about 0.26%, and the sample melts at about 187 0 C and decomposes at about 256 0 C. Its crystal structure ranges from good to excellent.
  • Another embodiment of the present invention is directed to a method of preparing a variety of crystalline salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl- phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide according to the following scheme:
  • 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl- phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide salts are made by reacting 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide free base with an acid of formula HB in a solvent.
  • Such reaction is typically conducted in two steps, though it is within the scope of this invention to simply combine both the free base and the acid in the solvent at the same time.
  • a first step 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromemyl-phenyl]-3- (4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base is dissolved or suspended in an appropriate amount of solvent at an appropriate temperature.
  • Solvents suitable for use in the present invention include, without limitation, methanol, ethanol, 2-propanol, acetone, ethyl acetate, acetonitrile, tetrahydrofuran and combinations thereof. It is within the skill of one of ordinary skill in the art to determine suitable amounts of base to be used, as well as suitable reaction temperatures.
  • salt forming acids with a pKa of ⁇ 3.1 have the potential to form stable crystalline salts therewith.
  • Suitable acids include, without limitation, inorganic acids such as hydrochloric acid, phosphoric acid, sulfuric acid, and sulfonic acid and organic acids such as methane sulfonic acid, ethane sulfonic acid, benzene sulfonic acid, p-toluene sulfonic acid, citric acid, fumaric acid, gentisic acid, malonic acid, maleic acid, and tartaric acid.
  • inorganic acids such as hydrochloric acid, phosphoric acid, sulfuric acid, and sulfonic acid
  • organic acids such as methane sulfonic acid, ethane sulfonic acid, benzene sulfonic acid, p-toluene sulfonic acid, citric acid, fumaric acid, gentisic acid, malonic acid, maleic acid, and tartaric acid.
  • the 4-methyl-N-[3-(4-methyl- imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide salt is isolated by filtration or some other suitable means and the isolated salt is dried to remove residual solvent.
  • the hydrochloride salt is first obtained as a methanol solvate which must be exposed to moisture in order to convert to the monohydrate hydrochloride salt.
  • a particularly preferred embodiment of the present invention is directed to a method of preparing 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin- 3-yl-pyrimidin-2-ylamino)-benzamide monohydrochloride monohydrate comprising the steps of:
  • stirring is conducted for about 15 minutes in step (c), cooling is accomplished over a period of about 30 minutes in step (e), cooling is accomplished over a period of about 45 minutes in step (g), stirring is conducted for about 3 hours in step (h), cooling is accomplished over a period of about 1.5 hours in step (i), stirring is conducted for about 30 minutes in step (j), the cold methanol of step (1) has a temperature of about -10°C, and/or drying is accomplished over a period of about 8-16 hours.
  • the tenth embodiment of the present invention is directed to a pharmaceutical composition
  • a pharmaceutical composition comprising:
  • a “therapeutically effective amount” is intended to mean the amount of the inventive salt that, when administered to a subject in need thereof, is sufficient to effect treatment for disease conditions alleviated by the inhibition of protein kinase activity.
  • the amount of a given compound of the invention that will be therapeutically effective will vary depending upon factors such as the disease condition and the severity thereof, the identity of the subject in need thereof, etc., which amount may be routinely determined by artisans of ordinary skill in the art.
  • the at least one pharmaceutically acceptable carrier, diluent, vehicle or excipient can readily be selected by one of ordinary skill in the art and will be determined by the desired mode of administration.
  • suitable modes of administration include oral, nasal, parenteral, topical, transdermal, and rectal.
  • the pharmaceutical compositions of this invention may take any pharmaceutical form recognizable to the skilled artisan as being suitable. Suitable pharmaceutical forms include solid, semisolid, liquid, or lyophilized formulations, such as tablets, powders, capsules, suppositories, suspensions, liposomes, and aerosols.
  • the eleventh embodiment of the present invention is directed to a method of treating a disease which responds to an inhibition of protein kinase activity comprising the step of administering to a subject in need of such treatment a therapeutically effective amount of a salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
  • illustrative modes of administration include oral, nasal, parenteral, topical, transdermal, and rectal.
  • Administration of the crystalline form may be accomplished by administration of a pharmaceutical composition of the ninth embodiment of the invention or via any other effective means.
  • the clear solution was transferred under nitrogen atmosphere to another 1 L, 4-neck, and round-bottom flask equipped with a mechanical stirrer, a thermometer, and heating/cooling capacity.
  • the batch was stirred and cooled to 30 0 C over a period of 30 minutes. Seeds (20 mg) were added at this temperature, and the batch was cooled to 23°C over a period of 45 minutes.
  • the batch was stirred for an additional 3 hours to obtain a thick white suspension.
  • the suspension was cooled to -1O 0 C over a period of 1.5 hours and stirred for an additional 30 minutes. Any solid was collected by filtration and rinsed with cold (-10 0 C) methanol (20 mL).
  • the mixture was stirred at 64°C for one hour, cooled down to room temperature by natural cooling (cooling rate ⁇ 0.5°C/min) and held at room temperature for 3-4 hours.
  • the solid was collected by filtration and was dried at 50-55°C/10-20 torr for 8-16 hours to obtain 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-tiifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide monophosphate salt (3.25 g) as a white solid.
  • the mixture was stirred at 76°C for 5 hours, cooled down to room temperature by natural cooling (cooling rate ⁇ 0.5°C/min) and held at room temperature for ⁇ 1 hour.
  • the solid was collected by filtration and was dried at 50-55°C/10-20 torr for 8-16 hours to obtain 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide mono benzyl sulfonate salt as a yellowish solid.
  • the LOD and decomposition temperature of the salts of the invention were determined by TGA, and the melting point was determined by DSC.
  • the hygroscopicity of the salts of the invention was determined by TGA after one day at ambient temperature and 93% relative humidity. Table 13.
  • the solubility of the salts of the invention was determined in pH 6.8, pH 3.0 and pH 1.0 buffers by suspending 1-5 mg of each salt in 10 mL of corresponding aqueous solution. The samples were allowed to equilibrate at ambient temperature for at least 20 hours for pH 6.8 and 3.0 or about 5 hours for pH 1.0. The supernatant was filtered and used for the solubility determination by UV-VIS spectroscopy. The solid residue was analyzed by XRPD.
  • IDR Intrinsic Dissolution Rate
  • Dissolution rate measurements were performed at 37 0 C using the rotating disk method (VanKell Instrument). A single rotation speed of 200 rpm was used. For IDR in 0.1 N HCl, an 800 mL volume, and for IDR in water, a 200 mL volume were used. The solution was continuously pumped through a UV measuring cell and recycled to the dissolution vessel.
  • Hygroscopicity Sorption/desorption isotherms were collected using a Surface Measurements Systems dynamic vapor sorption device (DVS-I). The measurements were carried out at 25°C.

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Abstract

Salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.

Description

SALTS OF 4 METHYL-N-f3-(4-METHYL-IMIDAZOL-l-YL)-5- TRIFLUOROMETHYL-PHENYL]-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2- YLAMINO)-
BENZAMIDE
This application claims the benefit of U.S. Provisional Patent Application No. 60/701,406, filed July 20, 2005, the entire disclosure of which is incorporated by reference herein.
Background of the Invention
Field of the Invention
[0001] This invention relates to salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide, as well as to methods of making the same, pharmaceutical compositions comprising the same and methods of treatment using the same.
Related Background Art
[0002] The compound 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3- (4-pyridm-3-yl-pyrimidin-2-ylamino)-benzamide of the formula
Figure imgf000002_0001
is described in WO 2004/005281 Al. Valuable pharmacological properties are attributed to this compound; thus, it can be used, for example, as a protein kinase inhibitor useful in therapy for diseases which respond to inhibition of protein kinase activity. WO 2004/005281 Al does not disclose any specific salts or salt hydrates or solvates of 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-ρhenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide.
Summary of the Invention
[0003] The present invention is directed to salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)- 5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide. Preferred embodiments of the present invention are directed to the hydrochloride, monophosphate, diphosphate, sulfate, methane sulfonate, ethane sulfonate, benzene sulfonate and p-toluene sulfonate salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
[0004] The present invention is further directed to a method of preparing a variety of crystalline salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridm-3-yl-pyrimidin-2-ylamino)-benzamide comprising the step of: reacting 4-methyl-N- [3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)-benzamide free base with an acid of formula HB in a solvent.
[0005] The invention is further directed to pharmaceutical compositions comprising:
(a) a therapeutically effective amount of a salt of 4-methyl-N-[3-(4-methyl-imidazol- l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide; and
(b) at least one pharmaceutically acceptable carrier, diluent, vehicle or excipient.
[0006] The present invention is also directed to a method of treating a disease which responds to an inhibition of protein kinase activity comprising the step of administering to a subject in need of such treatment a therapeutically effective amount of a salt of 4-methyl-N- [3-(4-methyl-imidazol-l-yl)-5-trifluoiOmethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)-benzamide. Brief Description of the Drawings
[0007] Figure 1 shows the x-ray powder diffraction patterns (XRPDs) for forms A and B of the hydrochloride salt of 4-raethyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenylj- 3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
[0008] Figure 2 shows the x-ray powder diffraction pattern (XRPD) for the monophosphate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin~2-ylarnmo)-benzamide.
[0009] Figure 3 shows the x-ray powder diffraction pattern for the diphosphate salt of 4- methyl-N-[3-(4-metliyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
[0010] Figure 4 shows the x-ray powder diffraction patterns for forms A and B of the sulfate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
[0011] Figure 5 shows the x-ray powder diffraction pattern for the methane sulfonate (mesylate) salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
[0012] Figure 6 shows the x-ray powder diffraction pattern for the ethane sulfonate salt of 4- metliyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzarnide.
[0013] Figure 7 shows the x-ray powder diffraction pattern for the benzene sulfonate salt of
4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide.
[0014] Figure 8 shows the x-ray powder diffraction pattern for the p-toluene sulfonate salt of
4-methyl-N-[3-(4-metliyl-imidazol-l-yl)-5-trifluoiOmethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide. - A -
Detailed Description of the Invention
[0015] The present invention is directed to salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)- 5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide; prefeiτed embodiments of those salts are described below. Generally, as used herein, "salt" refers to a compound prepared by the reaction of an organic acid or base drug with a pharmaceutically acceptable mineral or organic acid or base; as used herein, "salt" includes hydrates and solvates of salts made in accordance with this invention. Exemplary pharmaceutically acceptable mineral or organic acids or bases are as listed in Tables 1-8 in Handbook of Pharmaceutical Salts, P.H. Stahl and CG. Wermuth (eds.), VHCA, Zurich, pp. 334-345 (2002). As used herein, "polymorph" refers to a distinct "crystal modification" or "polymorphic form" or "crystalline form", which differs from another with respect to x-ray powder diffraction pattern, physicochemical and/or pharmacokinetic properties, and thermodynamic stability. Co-pending U.S. Patent Application No. 60/701,405 (Attorney Docket No. 4-34384), filed concurrently herewith, addresses the various polymorphic forms of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide and salts thereof; the disclosure of that co-pending application is incorporated in its entirety by reference herein.
[0016] The first embodiment of the present invention is directed to the hydrochloride salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide. The hydrochloride salt (form B, monohydrate) is reproducibly produced from methanol when one equivalent hydrochloric acid is used. It is hygroscopic (when first tested, moisture uptake was up to 2% at 60% relative humidity and up to 2.7% at 95% relative humidity, though subsequent testing has shown even greater moisture uptake). It is very slightly soluble in water and slightly soluble in 0.1 N HCl, ethanol and 2-propanol. When tested with thermogravimetric analysis (TGA), two weight loss stages occur. The first stage (onset at about 80°C) represents dehydration, and the second stage weight loss (at about 173°C) represents the loss of HCl (decomposition). Its crystal structure ranges from good to excellent, it becomes amorphous upon grinding and it can withstand compression. The hydrochloride salt is stable at room temperature in standard equilibration tests. Other polymorphic forms of the hydrochloride salt, i.e., forms A, A', A", B', SB, SB', C, C, Sc, D, and SE, were also isolated. The XRPD pattern for forms A and B of the hydrochloride salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are shown in Figure 1.
[0017] The second embodiment of the present invention is directed to the monophosphate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide. The H3PO4 mono-salt is reproducibly produced from methanol when one equivalent phosphoric acid is used. The weight loss (room temperature to 200°C) is about 0.29%, and the sample melts at about 2080C and decomposes at about 212°C. Its crystal structure is excellent. The XRPD pattern for the monophosphate salt of 4-methyl- N-[3-(4-metliyl-imidazol-l-yl)-5-trifluoromethyl"phenyl]-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)-benzamide is shown in Figure 2.
[0018] The third embodiment of the present invention is directed to the diphosphate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide. The H3PO4 di-salt can be produced from methanol when two equivalents phosphoric acid are used. The weight loss (room temperature to 2000C) is about 0.2%, and the sample decomposes at about 21O0C. The XRPD pattern for the diphosphate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide is shown in Figure 3.
[0019] The fourth embodiment of the present invention is directed to the sulfate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide. The H2SO4 salt (form B) is reproducibly produced from methanol when one equivalent sulfuric acid is used. The weight loss (room temperature to 2000C) is about 0.15%, and the sample melts with decomposition at about 2060C. Its crystal structure ranges from poor to good. One other form (form A) and an amorphous form were isolated. The XRPD patterns for forms A and B of the sulfate salt of 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide are shown in Figure 4. [0020] The fifth embodiment of the present invention is directed to the methane sulfonate (mesylate) salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide. This salt is reproducibly produced from ethyl acetate when one equivalent methane sulfonic acid is used. The weight loss (room temperature to 150°C) is about 0.44%, and the sample melts at about 160°C and decomposes at about 26O0C. Its crystal structure is poor. The XRPD pattern for the methane sulfonate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide is shown in Figure 5.
[0021] The sixth embodiment of the present invention is directed to the ethane sulfonate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide. This salt is reproducibly produced from ethyl acetate when one equivalent ethane sulfonic acid is used. The weight loss (room temperature to 150°C) is about 0.74%, and the sample melts at about 259°C and decomposes at about 22O0C. Its crystal structure is poor. The XRPD pattern for the ethane sulfonate salt of 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide is shown in Figure 6.
[0022] The seventh embodiment of the present invention is directed to the benzene sulfonate salt of 4-methyl-N-[3-(4-methyl-imidazol- l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide. This salt is reproducibly produced from ethyl acetate when one equivalent benzene sulfonic acid is used. The weight loss (room temperature to 25O0C) is about 0.63%, and the sample melts with decomposition at about 26O0C. Its crystal structure ranges from poor to good. The XRPD pattern for the benzene sulfonate salt of 4-methyl-N- [3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)-benzamide is shown in Figure 7.
[0023] The eighth embodiment of the present invention is directed to the p-toluene sulfonate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoiOmethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide. This salt is reproducibly produced from ethyl acetate when one equivalent p-toluene sulfonic acid is used. The weight loss (room temperature to 150°C) is about 0.26%, and the sample melts at about 1870C and decomposes at about 2560C. Its crystal structure ranges from good to excellent. The XRPD pattern for the p-toluene sulfonate salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide is shown in Figure 8.
[0024] Another embodiment of the present invention is directed to a method of preparing a variety of crystalline salts of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl- phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide according to the following scheme:
Figure imgf000008_0001
[0025] More specifically, 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl- phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide salts are made by reacting 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide free base with an acid of formula HB in a solvent. Such reaction is typically conducted in two steps, though it is within the scope of this invention to simply combine both the free base and the acid in the solvent at the same time.
[0026] In a first step, 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromemyl-phenyl]-3- (4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base is dissolved or suspended in an appropriate amount of solvent at an appropriate temperature. Solvents suitable for use in the present invention include, without limitation, methanol, ethanol, 2-propanol, acetone, ethyl acetate, acetonitrile, tetrahydrofuran and combinations thereof. It is within the skill of one of ordinary skill in the art to determine suitable amounts of base to be used, as well as suitable reaction temperatures.
[0027] In a second step of the present inventive method, the 4-methyl-N-[3-(4-methyl- imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base is treated with an appropriate acid of the formula HB. Given the pKa values for 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluorometliyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide free base of 5.1 and 3.9, salt forming acids with a pKa of <3.1 have the potential to form stable crystalline salts therewith. Suitable acids include, without limitation, inorganic acids such as hydrochloric acid, phosphoric acid, sulfuric acid, and sulfonic acid and organic acids such as methane sulfonic acid, ethane sulfonic acid, benzene sulfonic acid, p-toluene sulfonic acid, citric acid, fumaric acid, gentisic acid, malonic acid, maleic acid, and tartaric acid.
[0028] In optional steps of the present inventive method, the 4-methyl-N-[3-(4-methyl- imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide salt is isolated by filtration or some other suitable means and the isolated salt is dried to remove residual solvent. In a preferred embodiment of this invention, the hydrochloride salt is first obtained as a methanol solvate which must be exposed to moisture in order to convert to the monohydrate hydrochloride salt.
[0029] A particularly preferred embodiment of the present invention is directed to a method of preparing 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin- 3-yl-pyrimidin-2-ylamino)-benzamide monohydrochloride monohydrate comprising the steps of:
(a) combining 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3- (4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and hydrochloric acid in methanol under a nitrogen atmosphere;
(b) heating the reaction mixture to a temperature ranging from about 42-50°C;
(c) stirring the reaction mixture;
(d) filtering the reaction mixture while maintaining the temperature above 400C to obtain a clear solution;
(e) cooling the clear solution to about 300C while stirring under nitrogen atmosphere;
(f) seeding the solution;
(g) cooling the seeded solution to about 23°C; (h) stiπing the solution to obtain a suspension; (i) cooling the suspension to about -100C; (j) stirring the suspension;
(k) filtering solids;
(1) rinsing solids with cold methanol; and
(m) drying the solids at about 50-55°C and 10-20 torr to obtain 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)-benzamide monohydrochloride monohydrate salt.
In more preferred embodiments, stirring is conducted for about 15 minutes in step (c), cooling is accomplished over a period of about 30 minutes in step (e), cooling is accomplished over a period of about 45 minutes in step (g), stirring is conducted for about 3 hours in step (h), cooling is accomplished over a period of about 1.5 hours in step (i), stirring is conducted for about 30 minutes in step (j), the cold methanol of step (1) has a temperature of about -10°C, and/or drying is accomplished over a period of about 8-16 hours.
[0030] The tenth embodiment of the present invention is directed to a pharmaceutical composition comprising:
(a) a therapeutically effective amount of a salt of 4-methyl-N-[3-(4-methyl-imidazol- l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide; and
(b) at least one pharmaceutically acceptable carrier, diluent, vehicle or excipient.
[0031] A "therapeutically effective amount" is intended to mean the amount of the inventive salt that, when administered to a subject in need thereof, is sufficient to effect treatment for disease conditions alleviated by the inhibition of protein kinase activity. The amount of a given compound of the invention that will be therapeutically effective will vary depending upon factors such as the disease condition and the severity thereof, the identity of the subject in need thereof, etc., which amount may be routinely determined by artisans of ordinary skill in the art.
[0032] The at least one pharmaceutically acceptable carrier, diluent, vehicle or excipient can readily be selected by one of ordinary skill in the art and will be determined by the desired mode of administration. Illustrative examples of suitable modes of administration include oral, nasal, parenteral, topical, transdermal, and rectal. The pharmaceutical compositions of this invention may take any pharmaceutical form recognizable to the skilled artisan as being suitable. Suitable pharmaceutical forms include solid, semisolid, liquid, or lyophilized formulations, such as tablets, powders, capsules, suppositories, suspensions, liposomes, and aerosols.
[0033] The eleventh embodiment of the present invention is directed to a method of treating a disease which responds to an inhibition of protein kinase activity comprising the step of administering to a subject in need of such treatment a therapeutically effective amount of a salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide. As noted above, illustrative modes of administration include oral, nasal, parenteral, topical, transdermal, and rectal. Administration of the crystalline form may be accomplished by administration of a pharmaceutical composition of the ninth embodiment of the invention or via any other effective means.
[0034] Specific embodiments of the invention will now be demonstrated by reference to the following examples. It should be understood that these examples are disclosed solely by way of illustrating the invention and should not be taken in any way to limit the scope of the present invention.
Example 1 Preparation of Monohydrochloride M onohydrate Salt
Figure imgf000011_0001
AMN107 AMN107 HCI H2O salt
[0035] A l L, 4-neck, round-bottom flask equipped with a mechanical stirrer, a thermometer, heating/cooling capacity, and an addition funnel was charged in sequence with 4-methyl-N- [3-(4-methyl-imidazol-l-yl)-5-tπfluoiOmethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)-benzamide free base (10 g), methanol (250 mL), and 37% hydrochloric acid (1.85 g) under nitrogen purge. The mixture was heated to 42-5O0C and stirred for an additional 15 minutes. The resulting solution was filtered through a polypropylene pad, while maintaining the batch temperature above 400C. The clear solution was transferred under nitrogen atmosphere to another 1 L, 4-neck, and round-bottom flask equipped with a mechanical stirrer, a thermometer, and heating/cooling capacity. The batch was stirred and cooled to 300C over a period of 30 minutes. Seeds (20 mg) were added at this temperature, and the batch was cooled to 23°C over a period of 45 minutes. The batch was stirred for an additional 3 hours to obtain a thick white suspension. The suspension was cooled to -1O0C over a period of 1.5 hours and stirred for an additional 30 minutes. Any solid was collected by filtration and rinsed with cold (-100C) methanol (20 mL). The solid was dried at 50-55°C/10-20 torr for 8-16 hours to obtain 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide monohydrochloride monohydrate salt (9.8 g) as a white solid.
[0036] 1H NMR 300 MHz, DMSO-d6), δ 10.9 (s, IH), 9.58 (s, IH), 9.29 (s, IH), 9.20 (s, IH), 8.70 (d, IH), 8.63 (s, IH), 8.55 (d, IH), 8.49 (d, IH), 8.32 (d, 2H), 8.00 (s, IH), 7.91 (s, IH), 7.84 (d, IH), 7.56-7.44 (m, 3H), 2.50 (s, 3H), 2.35 (s, 3H); x-ray diffraction pattern showing maxima at 2Θ = 7.4°, 9.4°, 11.6°, 12.1°, 15.8°, 19.3°, 19.6°, 22.1°, 24.1°, 25.7°.
Example 2 Preparation of Monophosphate Salt
H3PO4
Figure imgf000012_0001
AMN107 AMN107 H3PO4 salt
[0037] To a 1 L round-bottom flask equipped with a mechanical stirrer, a thermometer, and a condenser, 4 g of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-ρhenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and 500 mL of methanol were charged. The slurry was stirred and heated to 640C and held at that temperature for -30 minutes. To the resulting clear solution, 7.5 mL of 1 M phosphorous acid solution (in methanol) was added. The mixture was stirred at 64°C for one hour, cooled down to room temperature by natural cooling (cooling rate ~0.5°C/min) and held at room temperature for 3-4 hours. The solid was collected by filtration and was dried at 50-55°C/10-20 torr for 8-16 hours to obtain 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-tiifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide monophosphate salt (3.25 g) as a white solid. Melting point = ~208°C (dec); x-ray diffraction pattern showing maxima at 2Θ = 6.1°, 7.5°, 9.1°, 15.8°, 17.5°, 18.3°, 21.8°, 23.1°, 24.9°, 26.6°.
Example 3 Preparation of Methane Sulfonate Salt
ethyl acetate
Figure imgf000013_0002
Figure imgf000013_0001
AMN107 AMN107 mesylate salt
[0038] To a 75 niL reactor equipped with a temperature probe and a condenser, 307 mg of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide free base and 30 mL of ethyl acetate were charged. The slurry was stirred and heated to 760C. To the solution, 580 μL of 1 M methane sulfonic acid solution (in ethyl acetate) was added. The mixture was stirred at 76°C for six hours, cooled to 25°C at a rate of 0.5°C/minute and held at 250C overnight. The solid was collected by filtration and was dried at 50-55°C/10-20 torr for 8-16 hours to obtain 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide mesylate salt (-250 mg) as a yellowish solid. X-ray diffraction pattern showing maxima at 2Θ = 7.7°, 10.1°, 20.3°, 26.2°.
Example 4 Preparation of Benzylsulfonate Salt
Ethyl Acetate
Figure imgf000013_0004
Figure imgf000013_0003
AWIN107 AMN107 benzylsulfonate salt
[0039] To a 1 L round-bottom flask equipped with a mechanical stirrer, a thermometer, and a condenser, 4 g of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and 500 mL of ethyl acetate were charged. The slurry was stirred and heated to 760C (reflux) and held at that temperature for 40 minutes. To the resulting clear solution, 7.5 niL of 1 M benzene sulfonic acid solution (in ethyl acetate) was added. The mixture was stirred at 76°C for 5 hours, cooled down to room temperature by natural cooling (cooling rate ~0.5°C/min) and held at room temperature for ~1 hour. The solid was collected by filtration and was dried at 50-55°C/10-20 torr for 8-16 hours to obtain 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide mono benzyl sulfonate salt as a yellowish solid. Melting point = ~260°C; x-ray diffraction pattern showing maxima at 2Θ = 6.5°, 7.8°, 9.4°, 10.4°, 13.7°, 17.0°, 17.5°, 17.9°, 18.8°, 21.2°.
Example 5 Preparation of p-Toluene Sulfonate Salt
Figure imgf000014_0001
AMN107
AMN107 p-tolysulfonate salt
[0040] To a 75 mL reactor equipped with a temperature probe and a condenser, 305.6 mg of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylammo)-benzamide free base and 30 mL of ethyl acetate were charged. The slurry was stirred and heated to 760C. To the solution, 580 μL of 1 M p-toluene sulfonic acid solution (in ethyl acetate) was added. The mixture was stirred at 760C for six hours, cooled to 25 °C at a rate of 0.5°C/minute and held at 25°C overnight. The solid was collected by filtration and was dried at 50-55°C/10-20 torr for 8-16 hours to obtain 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoiOmethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide p-toluene sulfonate salt (-250 mg) as a white solid. Melting point = -1870C; x-ray diffraction pattern showing maxima at 2Θ = 7.3°, 15.4°, 16.1°, 17.5°, 18.3°, 19.0°, 19.7°, 22.5°.
Example 6 Hydrochloride Salt
[0041] 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide free base and about 400 mL methanol are charged into a flask. While stirring, 744.4 mg of 37% HCl solution is added dropwise. The slurry becomes clear. The solution is stirred for 30 minutes. The solution is concentrated to 100 mL. The solution is then stirred for 2 hours; a slurry is obtained. The slurry is filtered and dried under house vacuum overnight at 50°C. Polymorphic form B is obtained with a yield of about 72.6%.
Example 7
[0042] About 50-60 mg of form A of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base was suspended in 0.75 mL of a listed solvent. The stoichiometric amount of a noted acid was subsequently added to the suspension. For inorganic acids, the mixture was stirred at ambient temperature for about 5 hours, and for sulfonic acids, it was stirred at 500C overnight. Solids were collected by filtration and analyzed by XRPD and NMR.
Table 1. Formation of Hydrochloride Salt
Figure imgf000015_0001
* excellent = when main peaks are sharp and their intensities above 70 counts good = when main peaks are sharp and their intensities within 30-70 counts
Table 2. Formation of Sulfate Salt
Figure imgf000015_0002
* good = when main peaks are sharp and their intensities within 30-70 counts poor = when main peaks are broad and their intensities below 30 counts; could be amorphous salt and free base form A Table 3. Formation of Methane Sulfonate Salt
Figure imgf000016_0001
* poor = when main peaks are broad and their intensities below 30 counts
Table 4. Formation of Ethane Sulfonate Salt
Figure imgf000016_0002
* good = when main peaks are sharp and their intensities within 30-70 counts poor = when main peaks are broad and their intensities below 30 counts
[0043] The ethane sulfonate salt from acetone has an x-ray diffraction pattern showing maxima at 2Θ = 6.6°, 7.9°, 9.5°, 14.2°, 17.8°.
Table 5. Formation of Benzene Sulfonate Salt
Figure imgf000016_0003
poor = when main peaks are broad and their intensities below 30 counts
Table 6. Formation of p-Toluene Sulfonate Salt
Figure imgf000016_0004
good = when main peaks are sharp and their intensities within 30-70 counts Example 8
[0044] About 300-310 mg of form B of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base was suspended in 9 mL of 2-propanol for HCl and 15 mL acetone for the sulfonic acids. The stoichiometric amount of the noted acid was subsequently added to the suspension. For HCl, the mixture was stirred at ambient temperature for 5 hours, and for sulfonic acids, it was stirred at 50°C overnight. Then, the mixture was cooled to ambient temperature, collected by filtration and analyzed by XRPD and NMR.
Table 7.
Figure imgf000017_0001
Example 9
[0045] About 100 mg of form B of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluorometliyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base was suspended in 15 mL of methanol for the inorganic acids and in 15 mL THF for the sulfonic acids noted below. The stoichiometric amount of the listed acid was subsequently added to the suspension, except for H3PO4, for which two equivalents were added. The solution was stirred at 5O0C for about 5 hours and then cooled to ambient temperature. Solids were collected by filtration if slurry formed; otherwise, a slow N2 flow was applied to evaporate some solvent to yield thicker slurry for filtration. The solids were analyzed by XRPD and NMR.
Table 8.
Figure imgf000018_0001
[0046] Elemental analysis was used to check salt formation for the diphosphate salt. The results are as follows:
Table 9.
Figure imgf000018_0002
Example 10
[0047] About 100 mg of form B of 4-methyl-N-[3-(4-metliyl-imidazol-l-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base was suspended in 15 mL of methanol for HCl and H2SO4 and in 15 mL of ethyl acetate for methane sulfonic acid. The listed amount of the listed acid was subsequently added to the suspension. The solution was stirred at ambient temperature (HCl) or 500C (H2SO4 and methane sulfonic acid). The solids were obtained by evaporating solvent to dryness using a slow N2 flow and analyzed by XRPD and NMR.
Table 10.
Figure imgf000019_0001
Example 11
[0048] About 300 mg of form B of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base was suspended in 30 mL of methanol for the inorganic acids and in 30 mL ethyl acetate for the sulfonic acids. The suspension was heated to reflux temperature -64°C for methanol and 76°C for ethyl acetate. The stoichiometric amount of the listed acid, dissolved in the corresponding solvent, was subsequently added to the solution. The solution was stirred under reflux for 5 hours and then cooled to ambient temperature. The solid was collected by filtration and analyzed by XRPD. Table 11.
Figure imgf000020_0001
Thermal Behavior
[0049] The LOD and decomposition temperature of the salts of the invention were determined by TGA, and the melting point was determined by DSC.
Table 12.
Figure imgf000020_0002
* The decomposition temperature was determined by the onset of the first derivative of the sample weight loss v. temperature of TGA data
Hvgroscopicity
[0050] The hygroscopicity of the salts of the invention was determined by TGA after one day at ambient temperature and 93% relative humidity. Table 13.
Figure imgf000021_0001
[0051] It should be noted that, upon further testing, hygroscopicity results have varied. At least with regard to the hydrochloride salt, moisture is lost too quickly upon testing to capture the true value; such may be true for the other salts as well.
Solubility
[0052] The solubility of the salts of the invention was determined in pH 6.8, pH 3.0 and pH 1.0 buffers by suspending 1-5 mg of each salt in 10 mL of corresponding aqueous solution. The samples were allowed to equilibrate at ambient temperature for at least 20 hours for pH 6.8 and 3.0 or about 5 hours for pH 1.0. The supernatant was filtered and used for the solubility determination by UV-VIS spectroscopy. The solid residue was analyzed by XRPD.
Table 14.
Figure imgf000021_0002
Comparative Testing
[0053] The stability of both 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl- phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base (form B) and 4-methyl- N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)-benzamide monohydrate hydrochloride salt (form B) were evaluated as described below.
Table 15.
Figure imgf000022_0001
Figure imgf000023_0001
I suspension * clear solution after stress test
A no change of color B slight discoloration
Mixture 1 : 30% 4-methyl-N-[3-(4-methyI-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide (free base or salt), 63% lactose 100 mesh/lactose 200 mesh (50:50), 5% crosprovidone, 1% Aerosil 200, 1% magnesium stearate
Mixture 2: 30% 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl- pyrimidin-2-ylamino)-benzamide (free base or salt), 34% mannitol 60, 34% Avicel PH102, 1% Aerosil 200, 1% magnesium stearate (% by weight of free base or salt) Table 16. Forced Decomposition Test
Figure imgf000024_0001
[0054] The chemical, physicochemical and morphic characteristics of both 4-methyl-N-[3- (4-methyl-imidazol-l-yl)-5-trifluorornethyl-phenyl]-3-(4-pyridin-3-yl-pyrirnidin-2-ylamino)- benzamide free base (form B) and 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl- phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide monohydrate hydrochloride salt (form B) were evaluated as described below.
[0055] Determination of Approximate Solubility: A weighted amount (20-50 mg) of sample was charged into 2 mL of the solvent. The obtained slurry was allowed to equilibrate for 24 hours at room temperature and then filtered. The concentration of DS in saturated filtrate was measured by either UV or HPLC.
[0056] Intrinsic Dissolution Rate (IDR): Dissolution rate measurements were performed at 370C using the rotating disk method (VanKell Instrument). A single rotation speed of 200 rpm was used. For IDR in 0.1 N HCl, an 800 mL volume, and for IDR in water, a 200 mL volume were used. The solution was continuously pumped through a UV measuring cell and recycled to the dissolution vessel. [0057] Hygroscopicity: Sorption/desorption isotherms were collected using a Surface Measurements Systems dynamic vapor sorption device (DVS-I). The measurements were carried out at 25°C.
Figure imgf000025_0001
[0058] While the invention has been described above with reference to specific embodiments thereof, it is apparent that many changes, modifications, and variations can be made without departing from the inventive concept disclosed herein. Accordingly, it is intended to embrace all such changes, modifications, and variations that fall within the spirit and broad scope of the appended claims. All patent applications, patents, and other publications cited herein are incorporated by reference in their entirety.

Claims

WHAT IS CLAIMED IS:
1. A salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
2. The salt of Claim 1, wherein the salt is a hydrochloride salt of 4-methyl-N-[3-(4- rnethyl- imidazol- 1-yl)- 5-trifluoromethyl-phenyl] -3 -(4-ρyridin-3 -yl-pyrimidm-2-ylamino)- benzamide.
3. The salt of Claim 2, wherein the salt is 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide monohydrochloride monohydrate.
4. The salt of Claim 1, wherein the salt is a monophosphate salt of 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide.
5. The salt of Claim 1, wherein the salt is a diphosphate salt of 4-methyl-N-[3-(4-methyl- imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
6. The salt of Claim 1, wherein the salt is a sulfate salt of 4-methyl-N-[3-(4-methyl- imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
7. The salt of Claim 1, wherein the salt is a methane sulfonate salt of 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide.
8. The salt of Claim 1, wherein the salt is an ethane sulfonate salt of 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoiOmethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide.
9. The salt of Claim 1, wherein the salt is a benzene sulfonate salt of 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluorometliyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide.
10. The salt of Claim 1, wherein the salt is a p-toluene sulfonate salt of 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylammo)- benzamide.
11. A method of preparing a salt of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide comprising the step of: reacting 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base with an acid of formula HB in a solvent.
12. The method of Claim 11, wherein the acid is selected from the group consisting of hydrochloric acid, phosphoric acid, sulfuric acid, sulfonic acid, methane sulfonic acid, ethane sulfonic acid, benzene sulfonic acid, p-toluene sulfonic acid, citric acid, fumaric acid, gentisic acid, malonic acid, maleic acid, and tartaric acid.
13. A method of preparing 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl- phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide monohydrochloride monohydrate comprising the steps of:
(a) combining 4-methyl-N-[3-(4-methyl-imidazol- l-yl)-5-trifluoromethyl-phenyl]-3- (4-pyridin-3-yl-pyrirnidin-2-ylamino)-benzamide free base and hydrochloric acid in methanol under a nitrogen atmosphere;
(b) heating the reaction mixture to a temperature ranging from about 42-500C;
(c) stirring the reaction mixture;
(d) filtering the reaction mixture while maintaining the temperature above 4O0C to obtain a clear solution;
(e) cooling the clear solution to about 300C while stirring under nitrogen atmosphere;
(f) seeding the solution;
(g) cooling the seeded solution to about 23°C; (h) stining the solution to obtain a suspension; (i) cooling the suspension to about -100C;
(j) stirring the suspension; (k) filtering solids;
(1) rinsing solids with cold methanol; and
(m) drying the solids at about 50-55°C and 10-20 torr to obtain 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)-benzamide monohydrochloride monohydrate salt.
14. A pharmaceutical composition comprising:
(a) a therapeutically effective amount of a salt according to claim 1; and
(b) at least one pharmaceutically acceptable carrier, diluent, vehicle or excipient.
15. The pharmaceutical composition of Claim 14, wherein the salt is 4-methyl-N-[3-(4- methyl-imidazol-l-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)- benzamide monohydrochloride monohydrate.
16. A method of treating a disease which responds to an inhibition of protein kinase activity comprising the step of administering to a subject in need of such treatment a therapeutically effective amount of a salt according to Claim 1.
17. The method of Claim 16, wherein the salt is 4-methyl-N-[3-(4-methyl-imidazol-l-yl)- 5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide monohydrochloride monohydrate.
PCT/US2006/027878 2005-07-20 2006-07-18 Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide WO2007015871A1 (en)

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KR1020157022022A KR101755137B1 (en) 2005-07-20 2006-07-18 Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
US11/995,898 US8163904B2 (en) 2005-07-20 2006-07-18 Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-Benzamide
AU2006276205A AU2006276205C1 (en) 2005-07-20 2006-07-18 Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
BRPI0613605-2A BRPI0613605A2 (en) 2005-07-20 2006-07-18 4-methyl-n- [3- (4-methyl-imidazol-1-yl) -5-trifluoromethyl-phenyl] -3- (4-pyridin-3-yl-pyrimidin-2-ylamino) -benzamide salts
CA2615669A CA2615669C (en) 2005-07-20 2006-07-18 Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
SI200631100T SI1910336T1 (en) 2005-07-20 2006-07-18 MONOHYDROCHLORIDE MONOHYDRATE SALT OF 4-METHYL-N-?á3-(4-METHYL-IMIDAZOL-1-YL)-5-TRIFLUOROMETHYL-PHENYL?å-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-BENZAMIDE
PL06787733T PL1910336T3 (en) 2005-07-20 2006-07-18 Monohydrochloride monohydrate salt of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
KR1020147007695A KR20140047737A (en) 2005-07-20 2006-07-18 Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
MX2008000892A MX2008000892A (en) 2005-07-20 2006-07-18 Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl -phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
JP2008522900A JP5129132B2 (en) 2005-07-20 2006-07-18 4-methyl-N- [3- (4-methyl-imidazol-1-yl) -5-trifluoromethyl-phenyl] -3- (4-pyridin-3-yl-pyrimidin-2-ylamino) -benzamide salt
CN200680026444.6A CN101228151B (en) 2005-07-20 2006-07-18 Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidine-2-ylamino)-benzamide
EP06787733A EP1910336B1 (en) 2005-07-20 2006-07-18 Monohydrochloride monohydrate salt of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
DK06787733.2T DK1910336T3 (en) 2005-07-20 2006-07-18 4-Methyl-N- [3- (4-methyl-imidazol-1-yl) -5-trifluoromethyl-phenyl] -3- (4-pyridin-3-yl-pyrimidin-2-ylamino) -benzamide monohydrochloridsalt- monohydrate
AT06787733T ATE514689T1 (en) 2005-07-20 2006-07-18 4-METHYL-N-Ä3-(4-METHYL-IMIDAZOLE-1-YL)-5- TRIFLUOROMETHYL-PHENYLÜ-3-(4-PYRIDINE-3-YL-PYRIMIDINE-2-YLAMINO)-BENZAMIDE- MONOHYDROCHLORIDE- MONOHYDRATE- SALT
NZ564182A NZ564182A (en) 2005-07-20 2006-07-18 Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
IL187787A IL187787A (en) 2005-07-20 2007-11-29 Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide, methods for preparing same, pharmaceutical compositions comprising them and use thereof in the manufacture of medicaments
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NO20080897A NO341313B1 (en) 2005-07-20 2008-02-20 Monohydrochloride monohydrate salt of 4-methyl-N- [3- (4-methylimidazol-1-yl) -5-trifluoromethylphenyl] -3- (4-pyridin-3-yl-pyrimidin-2-ylamino) -benzamide
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