WO2007009656A2 - Neues 1,4-benzothiazepin-1,1-dioxidderivat mit verbesserten eigenschaften, verfahren zu dessen herstellung, diese verbindung enthaltende arzneimittel und dessen verwendung - Google Patents
Neues 1,4-benzothiazepin-1,1-dioxidderivat mit verbesserten eigenschaften, verfahren zu dessen herstellung, diese verbindung enthaltende arzneimittel und dessen verwendung Download PDFInfo
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- WO2007009656A2 WO2007009656A2 PCT/EP2006/006849 EP2006006849W WO2007009656A2 WO 2007009656 A2 WO2007009656 A2 WO 2007009656A2 EP 2006006849 W EP2006006849 W EP 2006006849W WO 2007009656 A2 WO2007009656 A2 WO 2007009656A2
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- agonists
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- SWCUPFPMBPLCNP-ZVEOZEOGSA-N CCCCC(CCCC)(C1)N[C@H](c2cccc(NC([C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)=O)c2)c2cc(N(C)C)ccc2S1(=O)=O Chemical compound CCCCC(CCCC)(C1)N[C@H](c2cccc(NC([C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)=O)c2)c2cc(N(C)C)ccc2S1(=O)=O SWCUPFPMBPLCNP-ZVEOZEOGSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Definitions
- Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, process for its preparation, medicines containing it and its use
- the invention relates to a substituted 1, 4-benzothiazepine-1, 1 -Dioxidderivat and its physiologically acceptable salts.
- the invention therefore relates to the compound of the formula A.
- Suitable pharmaceutically acceptable acid addition salts of the compound according to the invention are salts of inorganic acids, such as hydrochloric acid, hydrogen bromide, phosphoric, metaphosphoric, nitric and sulfuric acid and organic acids, such as acetic acid, benzenesulfonic, benzoic, citric, ethanesulfonic, Fumaric, gluconic, glycolic, isethionic, lactic, lactobionic, maleic, malic, methanesulfonic, succinic, p-toluenesulfonic and tartaric acids.
- inorganic acids such as hydrochloric acid, hydrogen bromide, phosphoric, metaphosphoric, nitric and sulfuric acid and organic acids, such as acetic acid, benzenesulfonic, benzoic, citric, ethanesulfonic, Fumaric, gluconic, glycolic, isethionic, lactic, lactobionic, maleic, malic, me
- Salts with a non-pharmaceutically acceptable anion are also within the scope of the invention as useful intermediates for the preparation or purification of pharmaceutically acceptable salts and / or for use in non-therapeutic, for example, in vitro applications.
- the compound of the invention may also be in various polymorphic forms, e.g. as amorphous and crystalline polymorphic form. All polymorphic forms of the compound of the invention are within the scope of the invention and are a further aspect of the invention.
- the compound of formula A can also be administered in combination with other active ingredients.
- the amount of a compound of Formula A required to produce the to achieve the desired biological effect depends on a number of factors, for example the specific compound chosen, the intended use, the mode of administration and the clinical condition of the patient. In general, the daily dose will be in the range of 0.01 mg to 100 mg (typically 0.05 mg and 50 mg) per day per kilogram of body weight, eg 0.1-10 mg / kg / day.
- Orally administrable dosage unit formulations such as tablets or capsules, may contain, for example, from 1.0 to 1000 mg, more typically from 10 to 600 mg.
- the compounds according to formula A can themselves be used as compound, but they are preferably present with a tolerable carrier in the form of a pharmaceutical composition.
- the carrier must of course be compatible in the sense that it is compatible with the other ingredients of the composition and is not harmful to the patient.
- the carrier may be a solid or a liquid, or both, and is preferably formulated with the compound as a single dose, for example, as a tablet, which may contain from 0.05% to 95% by weight of the active ingredient.
- Other pharmaceutically active substances may also be present, including further compounds according to formula A.
- the pharmaceutical compositions according to the invention can be prepared by one of the known pharmaceutical methods, which consist essentially in that the ingredients are mixed with pharmacologically acceptable carriers and / or excipients ,
- compositions according to the invention are those which are suitable for oral and peroral (eg sublingual) administration, although the most suitable mode of administration in each individual case depends on the type and severity of the condition to be treated and on the nature of the particular compound of formula A used. Also coated formulations and coated slow release formulations are within the scope of the invention. Preference is given to acid and enteric formulations. Suitable enteric coatings include cellulose acetate phthalate, polyvinyl acetate phthalate, Hydroxypropylmethylcellulosephthalat and anionic polymers of methacrylic acid and methyl methacrylate.
- Suitable pharmaceutical compounds for oral administration may be in separate units, such as capsules, cachets,
- Lozenges or tablets each containing a certain amount of the compound of formula A; as a powder or granules; as a solution or suspension in an aqueous or non-aqueous liquid; or as an oil-in-water or water-in-oil emulsion.
- these compositions may be prepared by any suitable pharmaceutical method comprising a step of contacting the active ingredient and the carrier (which may consist of one or more additional ingredients).
- the compositions are prepared by uniformly and homogeneously mixing the active ingredient with a liquid and / or finely divided solid carrier, after which the product is molded, if necessary.
- a tablet can be made by compressing or molding a powder or granules of the compound, optionally with one or more additional ingredients.
- Compressed tablets can be prepared by tableting the compound in free-flowing form, such as a powder or granules, optionally mixed with a binder, lubricant, inert diluent and / or surfactant / dispersant in a suitable machine.
- Molded tablets can be prepared by shaping the powdered compound moistened with an inert liquid diluent in a suitable machine.
- compositions suitable for peroral (sublingual) administration include lozenges containing a compound of formula A with a flavor, usually sucrose and gum arabic or tragacanth, and lozenges containing the compound in an inert base such as gelatin and glycerol or sucrose and gum arabic.
- suitable metal salts such as calcium, aluminum, iron, copper, zinc, magnesium, manganese, or zinc salts.
- calcium and zinc salts such as calcium phosphate, calcium lactate, calcium carbonate, calcium gluconate, calcium acetate, zinc phosphate, zinc lactate, zinc carbonate, zinc gluconate or zinc acetate.
- the addition of these salts to the pharmaceutical composition may mitigate or prevent the onset of diarrhea in the patient.
- Antidiabetics include insulin and insulin derivatives, such as Lantus ® (see www.lantus.com) or HMR 1964 fast-acting insulins (see US 6,221, 633), GLP-1 derivatives such as those described in WO 98/08871 of Novo Nordisk A / S, in WO 01/04156 of Zealand or in WO 00/34331 of Beaufour-Ipsen, as well as orally active hypoglycemic agents.
- insulin and insulin derivatives such as Lantus ® (see www.lantus.com) or HMR 1964 fast-acting insulins (see US 6,221, 633), GLP-1 derivatives such as those described in WO 98/08871 of Novo Nordisk A / S, in WO 01/04156 of Zealand or in WO 00/34331 of Beaufour-Ipsen, as well as orally active hypoglycemic agents.
- the orally active hypoglycemic agents preferably include sulphonyl fluorides, biguanidines, meglitinides, oxadiazolidinediones, thiazolidinediones, glucosidase inhibitors, glycogen phosphorylase inhibitors, glucagon antagonists, GLP-1 agonists, potassium channel openers, such as those described in WO 97/26265 and WO 99 Insulin sensitizers, inhibitors of liver enzymes involved in the stimulation of gluconeogenesis and / or glycogenolysis, modulators of glucose uptake, of the...
- lipid metabolism-altering compounds such as antihyperlipidemic agents and antilipidemic agents, compounds that reduce food intake, PPAR and PXR agonists and drugs that act on the ATP-dependent potassium channel of beta cells.
- the compounds of formula A are administered in combination with an HMGCoA reductase inhibitor such as simvastatin, fluvastatin, pravastatin, lovastatin, atorvastatin, cerivastatin, rosuvastatin.
- an HMGCoA reductase inhibitor such as simvastatin, fluvastatin, pravastatin, lovastatin, atorvastatin, cerivastatin, rosuvastatin.
- the compounds of formula I are administered in combination with a cholesterol resorption inhibitor, e.g. Ezetimibe, Tiqueside, Pamaqueside, or with a compound as described in PCT / EP 2004/00269, PCT / EP 2003/05815, PCT / EP 2003/05814, PCT / EP 2003/05816, EP 0114531 or US 6,498,156 described.
- a cholesterol resorption inhibitor e.g. Ezetimibe, Tiqueside, Pamaqueside
- the compounds of formula A in combination with a PPAR gamma agonist e.g. Rosiglitazone, pioglitazone, JTT-501, Gl 262570.
- the compounds of formula A in combination with PPAR alpha agonist e.g. GW 9578, GW 7647.
- the compounds of formula A are used in combination with a mixed PPAR alpha / gamma agonist, e.g. GW 1536, AVE 8042, AVE 8134, AVE 0847, or as described in PCT / US 00/11833, PCT / US 00/11490, WO 03/020269.
- a mixed PPAR alpha / gamma agonist e.g. GW 1536, AVE 8042, AVE 8134, AVE 0847, or as described in PCT / US 00/11833, PCT / US 00/11490, WO 03/020269.
- the compounds of formula A in combination with a fibrate such as fenofibrate, clofibrate, bezafibrate, administered.
- the compounds of formula A are used in combination with an MTP inhibitor, e.g. Implitapide, BMS-201038, R-103757.
- an MTP inhibitor e.g. Implitapide, BMS-201038, R-103757.
- the compounds of formula A are used in combination with a CETP inhibitor, e.g. JTT-705.
- the compounds of formula A are used in combination with a polymeric bile acid adsorber, e.g. Cholestyramine, colesevelam.
- a polymeric bile acid adsorber e.g. Cholestyramine, colesevelam.
- the compounds of formula A are administered in combination with an LDL receptor inducer (see US 6,342,512).
- the compounds of formula A are used in combination with an ACAT inhibitor, e.g. Avasimibe, administered.
- an ACAT inhibitor e.g. Avasimibe
- the compounds of formula A in combination with an antioxidant e.g. OPC-14117 administered.
- the compounds of formula A are used in combination with a lipoprotein lipase inhibitor, e.g. NO-1886, administered.
- a lipoprotein lipase inhibitor e.g. NO-1886
- the compounds of formula A are used in combination with an ATP citrate lyase inhibitor, e.g. SB-204990 administered.
- an ATP citrate lyase inhibitor e.g. SB-204990 administered.
- the compounds of formula A are administered in combination with a squalene synthetase inhibitor such as BMS-188494. In one embodiment of the invention, the compounds of formula A are administered in combination with a lipoprotein (a) antagonist such as CI-1027 or nicotinic acid.
- a squalene synthetase inhibitor such as BMS-188494.
- the compounds of formula A are administered in combination with a lipoprotein (a) antagonist such as CI-1027 or nicotinic acid.
- the compounds of formula A are used in combination with a lipase inhibitor, e.g. Orlistat, administered.
- a lipase inhibitor e.g. Orlistat
- the compounds of the formula A are administered in combination with insulin.
- the compounds of formula A are used in combination with a sulphonylurea, e.g. Tolbutamide, glibenclamide, glipizide or glimepiride.
- a sulphonylurea e.g. Tolbutamide, glibenclamide, glipizide or glimepiride.
- the compounds of formula A are used in combination with a biguanide, e.g. Metformin, administered.
- a biguanide e.g. Metformin
- the compounds of formula A are used in combination with a meglitinide, e.g. Repaglinide, administered.
- the compounds of formula A are used in combination with a thiazolidinedione, e.g. Troglitazone, ciglitazone, pioglitazone, rosiglitazone or those described in WO 97/41097 by Dr. med. Reddy's Research Foundation disclosed compounds, particularly 5 - [[4 - [(3,4-dihydro-3-methyl-4-oxo-2-quinazolinylmethoxy) phenyl] methyl] -2,4-thiazolidinedione.
- the compounds of formula A are used in combination with a ⁇ -glucosidase inhibitor, e.g. Miglitol or acarbose, administered.
- a ⁇ -glucosidase inhibitor e.g. Miglitol or acarbose
- the compounds of formula I in combination with adenosine A1 agonists, such as.
- adenosine A1 agonists such as.
- the compounds of formula A are administered in combination with an agent that acts on the ATP-dependent potassium channel of beta cells, such as tolbutamide, glibenclamide, glipizide, glimepiride or repaglinide.
- the compounds of formula A are used in combination with more than one of the aforementioned compounds, e.g. in combination with a sulphonylurea and metformin, a sulphonylurea and acarbose, repaglinide and metformin, insulin and a sulphonylurea, insulin and metformin, insulin and troglitazone, insulin and lovastatin, etc.
- the compounds of the formula A are used in combination with CART modulators (see “Cocaine-amphetamine-regulated transcript-influenced transient influenza energy metabolism, anxiety and gastric emptying in mice" Asakawa, A, et al., M .: Hormones and Metabolism Research (2001), 33 (9), 554-558), NPY antagonists eg naphthalene-1-sulfonic acid ⁇ 4 - [(4-amino-quinazolin-2-ylamino) -methyl] -cyclohexylmethyl ⁇ -amide hydrochloride ( CGP 71683A), cannabinoid receptor 1 antagonists (see eg EP 0656354, WO 00/15609 or WO 02/076949), MC4 agonists (eg 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid [2- (3a-benzyl-2-methyl-3-oxo-2,3,3a, 4,
- TRH agonists see eg EP 0 462 884 decoupling protein 2- or 3-modulators, leptin agonists (see eg Lee, Daniel W ; Leinung, Matthew C; Rozhavskaya Arena; Marina; Grasso, Patricia. Leptin agonists as a Potential Approach to the Treatment of Obesity. Drugs of the Future (2001), 26 (9), 873-881), DA agonists
- the further active ingredient is leptin; see, e.g. "Perspectives in the therapeutic use of leptin", Salvador, Javier; Gomez-Ambrosi, Javier; Fruhbeck, Gema, Expert Opinion on Pharmacotherapy (2001),
- the other active ingredient is dexamphetamine or amphetamine.
- the other active ingredient is fenfluramine or
- the other active ingredient is sibutramine.
- the other active ingredient is orlistat.
- the other active ingredient is mazindol or phentermine.
- the compounds of Formula A in combination with bulking agents, preferably insoluble bulking agents see, for example, carob / Caromax ® (Zunft HJ; et al, Carob pulp preparation for treatment of hypercholesterolemia, ADVANCES IN THERAPY (2001 Sep-Oct). 18 (5), 230-6.)
- Caromax is a carob-containing product of the company Nutrinova, Nutrition Specialties & Food Ingredients GmbH, Industriepark availability, 65926 Frankfurt / Main)) administered.
- Combination with Caromax ® is possible in one preparation or by separate administration of compounds of formula A and Caromax ®.
- Caromax ® can also be administered in the form of food, such as in baked goods or muesli bars.
- Compound A was prepared as follows:
- the enantiomerically pure compound 1a is obtained from the racemic anilide 1 (EP 1 169 313 compound 8a / b) by a chiral chromatography with Chrialpak AS-H76 with the eluent n-heptane / methanol / ethanol 10/1/1 plus 0.1% DEA.
- Chrialpak AS-H76 with the eluent n-heptane / methanol / ethanol 10/1/1 plus 0.1% DEA.
- THF / EE / n-heptane compound 1a can be highly purified (ee of 99.9%).
- the eutomer has a positive rotation and the absolute stereochemistry was determined with a single crystal X-ray structure.
- the cDNA (complementary deoxyribonucleic acid) of human IBAT was determined by standard molecular biological methods, such as e.g. in Molecular Cloning: A Laboratory Manual by Joseph Sambrook and David Russell, cloned and incorporated into the pcDNAI vector from Invitrogen. Subsequent sequencing of the insert revealed complete identity with bases 599-1645 of P.A. Dawson described and stored in the GenBank sequence database base sequence for the human IBAT (GenBank Accession number: U10417). Bases 599 to 1645 correspond to the complete coding region of the human IBAT.
- the expression vector for human IBAT was introduced by stable transfection into CHO (Chinese hamster ovary) cells.
- CHO Choinese hamster ovary
- Single cell clones were added to the cell culture medium (Ham's F12 medium supplemented with 10% fetal calf serum, 100 units / ml penicillin, 100 units / ml streptomycin) 400 ⁇ g / ml geneticin.
- the functionality of the individual cell clones resulting from the selection was tested by their uptake activity for radiolabelled taurocholic acid ([ 3 H] -TCA).
- CHO-hlBAT The cell clone with the highest uptake activity for [ 3 H] -TCA, hereinafter referred to as CHO-hlBAT, was selected for the further tests and further cultured in the presence of 400 ⁇ g / ml of geneticin.
- CHO-hlBAT cells were seeded at a concentration of 40,000 cells per well in poly-D-lysine-coated 96-well plates in cell culture medium and cultured for 24 h. Then the cells were washed once with sodium-free transport assay
- Buffer 140 mM choline chloride, 2 mM potassium chloride, 1 mM magnesium chloride, 1 mM calcium chloride, 10 mM HEPES / Tris, pH 7.5
- sodium-free transport assay buffer 14OmM Sodium chloride, 2 mM potassium chloride, 1 mM magnesium chloride, 1 mM calcium chloride, 10 mM HEPES / Tris, pH 7.5
- sodium-containing transport assay buffer 14OmM Sodium chloride, 2 mM potassium chloride, 1 mM magnesium chloride, 1 mM calcium chloride, 10 mM HEPES / Tris, pH 7.5
- the test wells were also incubated in different concentrations in the presence of the compound to be investigated for 30 min at room temperature in sodium-containing transport assay buffer.
- the test substances were prepared starting from a 10 mM stock solution in dimethylsulfoxide corresponding to
- Dilute transport assay buffer 40 ⁇ l / well.
- the test was then started by adding 10 ⁇ l / well of a mixture of radiolabelled taurocholic acid ([ 3 H] -TCA) and unlabeled taurocholic acid.
- the final concentration of taurocholic acid in the test was 10 ⁇ M. After an incubation period of 60 min at room temperature, the reaction was sodium-free by adding 100 ⁇ l / well
- Transport assay buffer (4 ° C) stopped and washed each well three times with sodium-free transport assay buffer. Last, each well was 100 ⁇ l Scintillation fluid added and recorded in the cells radioactivity in a MicroBeta Scintillation Microplate Reader from the company Wallac determined.
- IC50 value The half-maximal inhibitory activity of the test compound (IC50 value, inhibitory concentration 50) was determined as follows:
- the compound A according to the invention exhibits a 206% higher effect than this comparative example from EP 1 169 313.
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Abstract
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Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06776212A EP1907370B1 (de) | 2005-07-15 | 2006-07-13 | Neues 1,4-benzothiazepin-1,1-dioxidderivat mit verbesserten eigenschaften, verfahren zu dessen herstellung, diese verbindung enthaltende arzneimittel und dessen verwendung |
AU2006272043A AU2006272043A1 (en) | 2005-07-15 | 2006-07-13 | Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof |
CA002614697A CA2614697A1 (en) | 2005-07-15 | 2006-07-13 | Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof |
BRPI0613041-0A BRPI0613041A2 (pt) | 2005-07-15 | 2006-07-13 | derivado de 1,4-benzotiazepina-1,1-àxido tendo propriedades melhoradas, mÉtodo para a produÇço do mesmo, medicamentos contendo o dito composto e uso dos mesmos |
MX2008000355A MX2008000355A (es) | 2005-07-15 | 2006-07-13 | Nuevo derivado de 1,-dioxido de 1,4-benzotiazepina con mejores propiedades, metodo para su produccion, medicamentos que contienen este compuesto y su uso. |
DE502006002956T DE502006002956D1 (de) | 2005-07-15 | 2006-07-13 | Neues 1,4-benzothiazepin-1,1-dioxidderivat mit verbesserten eigenschaften, verfahren zu dessen herstellung, diese verbindung enthaltende arzneimittel und dessen verwendung |
JP2008520795A JP2009501178A (ja) | 2005-07-15 | 2006-07-13 | 改善された特性を有する新規な1,4−ベンゾチアゼピン1,1−ジオキシド誘導体、その製造方法、該化合物を含有する医薬、及びその使用 |
NZ565293A NZ565293A (en) | 2005-07-15 | 2006-07-13 | Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof |
IL188606A IL188606A0 (en) | 2005-07-15 | 2008-01-06 | Novel 1,4-benzothiazepine-1,1-dioxide, derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof |
US11/970,293 US20080207592A1 (en) | 2005-07-15 | 2008-01-07 | Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof |
NO20080728A NO20080728L (no) | 2005-07-15 | 2008-02-08 | Nye 1,4-benzotiazepin-1,1-dioksidderivater som har forbedrede egenskaper, fremgangsmate for fremstilling derav, medikamenter inneholdende nevnte forbindelsene og anvendelse derav |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005033100A DE102005033100B3 (de) | 2005-07-15 | 2005-07-15 | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, diese Verbindung enthaltene Arzneimittel und Verfahren zu deren Herstellung |
DE102005033100.9 | 2005-07-15 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/970,293 Continuation US20080207592A1 (en) | 2005-07-15 | 2008-01-07 | Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007009656A2 true WO2007009656A2 (de) | 2007-01-25 |
WO2007009656A3 WO2007009656A3 (de) | 2007-04-19 |
Family
ID=37575930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/006849 WO2007009656A2 (de) | 2005-07-15 | 2006-07-13 | Neues 1,4-benzothiazepin-1,1-dioxidderivat mit verbesserten eigenschaften, verfahren zu dessen herstellung, diese verbindung enthaltende arzneimittel und dessen verwendung |
Country Status (20)
Country | Link |
---|---|
US (1) | US20080207592A1 (de) |
EP (1) | EP1907370B1 (de) |
JP (1) | JP2009501178A (de) |
KR (1) | KR20080027841A (de) |
CN (1) | CN101218217A (de) |
AR (2) | AR055076A1 (de) |
AT (1) | ATE423774T1 (de) |
AU (1) | AU2006272043A1 (de) |
BR (1) | BRPI0613041A2 (de) |
CA (1) | CA2614697A1 (de) |
DE (2) | DE102005033100B3 (de) |
IL (1) | IL188606A0 (de) |
MA (1) | MA29620B1 (de) |
MX (1) | MX2008000355A (de) |
NO (1) | NO20080728L (de) |
NZ (1) | NZ565293A (de) |
RU (1) | RU2008105741A (de) |
TW (1) | TW200745070A (de) |
WO (1) | WO2007009656A2 (de) |
ZA (1) | ZA200710360B (de) |
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
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Also Published As
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CA2614697A1 (en) | 2007-01-25 |
WO2007009656A3 (de) | 2007-04-19 |
DE502006002956D1 (de) | 2009-04-09 |
BRPI0613041A2 (pt) | 2010-12-14 |
AR058433A1 (es) | 2008-02-06 |
AR055076A1 (es) | 2007-08-01 |
DE102005033100B3 (de) | 2007-01-25 |
ZA200710360B (en) | 2008-11-26 |
NZ565293A (en) | 2010-01-29 |
NO20080728L (no) | 2008-02-08 |
US20080207592A1 (en) | 2008-08-28 |
KR20080027841A (ko) | 2008-03-28 |
ATE423774T1 (de) | 2009-03-15 |
CN101218217A (zh) | 2008-07-09 |
EP1907370A2 (de) | 2008-04-09 |
AU2006272043A1 (en) | 2007-01-25 |
MX2008000355A (es) | 2008-03-07 |
TW200745070A (en) | 2007-12-16 |
RU2008105741A (ru) | 2009-08-20 |
EP1907370B1 (de) | 2009-02-25 |
JP2009501178A (ja) | 2009-01-15 |
MA29620B1 (fr) | 2008-07-01 |
IL188606A0 (en) | 2008-04-13 |
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