WO2006108559A3 - Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit - Google Patents

Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit Download PDF

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Publication number
WO2006108559A3
WO2006108559A3 PCT/EP2006/003156 EP2006003156W WO2006108559A3 WO 2006108559 A3 WO2006108559 A3 WO 2006108559A3 EP 2006003156 W EP2006003156 W EP 2006003156W WO 2006108559 A3 WO2006108559 A3 WO 2006108559A3
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WO
WIPO (PCT)
Prior art keywords
sample liquid
chambers
analyzing
different
reaction
Prior art date
Application number
PCT/EP2006/003156
Other languages
English (en)
French (fr)
Other versions
WO2006108559A2 (de
Inventor
Ilse Ballhorn
Gert Blankenstein
Ralf-Peter Peters
Birgit Mueller-Chorus
Michael Schlueter
Original Assignee
Boehringer Ingelheim Micropart
Ilse Ballhorn
Gert Blankenstein
Ralf-Peter Peters
Birgit Mueller-Chorus
Michael Schlueter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102005016509A external-priority patent/DE102005016509A1/de
Priority claimed from DE102005042601A external-priority patent/DE102005042601A1/de
Application filed by Boehringer Ingelheim Micropart, Ilse Ballhorn, Gert Blankenstein, Ralf-Peter Peters, Birgit Mueller-Chorus, Michael Schlueter filed Critical Boehringer Ingelheim Micropart
Priority to JP2008504691A priority Critical patent/JP4837725B2/ja
Priority to EP06742544A priority patent/EP1899702A2/de
Priority to CN200680020607XA priority patent/CN101194155B/zh
Publication of WO2006108559A2 publication Critical patent/WO2006108559A2/de
Publication of WO2006108559A3 publication Critical patent/WO2006108559A3/de

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Es werden eine Vorrichtung und ein Verfahren zur Untersuchung einer Probenflüssigkeit vorgeschlagen, wobei insbesondere das ELISA-Verfahren sehr einfach, schnell und mit hoher Genauigkeit durchgeführt werden kann. Hierzu werden eine Probenflüssigkeit und eine Verdünnungsflüssigkeit jeweils mehreren Dosierkammern unterschiedlicher Volumina zugeführt, so daß die Probenflüssigkeit in zugeordnete Reaktionskammern in einem Verdünnungsschritt in unterschiedlichen Verdünnungsverhältnissen verdünnbar ist. Den Reaktionskammern sind verschiedene Flüssigkeiten nacheinander mittels einer gemeinsamen Aufnahmekammer zuführbar. Zum Anhalten der Nachweisreaktion werden die Flüssigkeiten aus dem Reaktionskammern in zugeordnete Untersuchungskammern überführt.
PCT/EP2006/003156 2005-04-09 2006-04-07 Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit WO2006108559A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008504691A JP4837725B2 (ja) 2005-04-09 2006-04-07 サンプル液の検査装置及び方法
EP06742544A EP1899702A2 (de) 2005-04-09 2006-04-07 Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit
CN200680020607XA CN101194155B (zh) 2005-04-09 2006-04-07 用于测试样品液的装置和方法

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE102005016503 2005-04-09
DE102005016503.6 2005-04-09
DE102005016509.5 2005-04-09
DE102005016509A DE102005016509A1 (de) 2005-04-09 2005-04-09 Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit
DE102005042601.8 2005-09-07
DE102005042601A DE102005042601A1 (de) 2005-04-09 2005-09-07 Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit

Publications (2)

Publication Number Publication Date
WO2006108559A2 WO2006108559A2 (de) 2006-10-19
WO2006108559A3 true WO2006108559A3 (de) 2007-03-22

Family

ID=36729237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/003156 WO2006108559A2 (de) 2005-04-09 2006-04-07 Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit

Country Status (4)

Country Link
US (1) US7731907B2 (de)
EP (1) EP1899702A2 (de)
JP (1) JP4837725B2 (de)
WO (1) WO2006108559A2 (de)

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JP5182366B2 (ja) * 2008-05-09 2013-04-17 コニカミノルタエムジー株式会社 マイクロチップ、マイクロチップ送液システム、及びマイクロチップの送液方法
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US10196700B2 (en) * 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
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Also Published As

Publication number Publication date
JP4837725B2 (ja) 2011-12-14
JP2008534972A (ja) 2008-08-28
WO2006108559A2 (de) 2006-10-19
US7731907B2 (en) 2010-06-08
US20070189927A1 (en) 2007-08-16
EP1899702A2 (de) 2008-03-19

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