WO2006108559A3 - Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit - Google Patents

Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit Download PDF

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Publication number
WO2006108559A3
WO2006108559A3 PCT/EP2006/003156 EP2006003156W WO2006108559A3 WO 2006108559 A3 WO2006108559 A3 WO 2006108559A3 EP 2006003156 W EP2006003156 W EP 2006003156W WO 2006108559 A3 WO2006108559 A3 WO 2006108559A3
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WO
WIPO (PCT)
Prior art keywords
sample liquid
chambers
analyzing
different
reaction
Prior art date
Application number
PCT/EP2006/003156
Other languages
English (en)
French (fr)
Other versions
WO2006108559A2 (de
Inventor
Ilse Ballhorn
Gert Blankenstein
Ralf-Peter Peters
Birgit Mueller-Chorus
Michael Schlueter
Original Assignee
Boehringer Ingelheim Micropart
Ilse Ballhorn
Gert Blankenstein
Ralf-Peter Peters
Birgit Mueller-Chorus
Michael Schlueter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102005016509A external-priority patent/DE102005016509A1/de
Priority claimed from DE102005042601A external-priority patent/DE102005042601A1/de
Application filed by Boehringer Ingelheim Micropart, Ilse Ballhorn, Gert Blankenstein, Ralf-Peter Peters, Birgit Mueller-Chorus, Michael Schlueter filed Critical Boehringer Ingelheim Micropart
Priority to EP06742544A priority Critical patent/EP1899702A2/de
Priority to CN200680020607XA priority patent/CN101194155B/zh
Priority to JP2008504691A priority patent/JP4837725B2/ja
Publication of WO2006108559A2 publication Critical patent/WO2006108559A2/de
Publication of WO2006108559A3 publication Critical patent/WO2006108559A3/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0605Metering of fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0621Control of the sequence of chambers filled or emptied
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0803Disc shape
    • B01L2300/0806Standardised forms, e.g. compact disc [CD] format
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087Multiple sequential chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0688Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Es werden eine Vorrichtung und ein Verfahren zur Untersuchung einer Probenflüssigkeit vorgeschlagen, wobei insbesondere das ELISA-Verfahren sehr einfach, schnell und mit hoher Genauigkeit durchgeführt werden kann. Hierzu werden eine Probenflüssigkeit und eine Verdünnungsflüssigkeit jeweils mehreren Dosierkammern unterschiedlicher Volumina zugeführt, so daß die Probenflüssigkeit in zugeordnete Reaktionskammern in einem Verdünnungsschritt in unterschiedlichen Verdünnungsverhältnissen verdünnbar ist. Den Reaktionskammern sind verschiedene Flüssigkeiten nacheinander mittels einer gemeinsamen Aufnahmekammer zuführbar. Zum Anhalten der Nachweisreaktion werden die Flüssigkeiten aus dem Reaktionskammern in zugeordnete Untersuchungskammern überführt.
PCT/EP2006/003156 2005-04-09 2006-04-07 Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit WO2006108559A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06742544A EP1899702A2 (de) 2005-04-09 2006-04-07 Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit
CN200680020607XA CN101194155B (zh) 2005-04-09 2006-04-07 用于测试样品液的装置和方法
JP2008504691A JP4837725B2 (ja) 2005-04-09 2006-04-07 サンプル液の検査装置及び方法

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE102005016509A DE102005016509A1 (de) 2005-04-09 2005-04-09 Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit
DE102005016509.5 2005-04-09
DE102005016503 2005-04-09
DE102005016503.6 2005-04-09
DE102005042601A DE102005042601A1 (de) 2005-04-09 2005-09-07 Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit
DE102005042601.8 2005-09-07

Publications (2)

Publication Number Publication Date
WO2006108559A2 WO2006108559A2 (de) 2006-10-19
WO2006108559A3 true WO2006108559A3 (de) 2007-03-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/003156 WO2006108559A2 (de) 2005-04-09 2006-04-07 Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit

Country Status (4)

Country Link
US (1) US7731907B2 (de)
EP (1) EP1899702A2 (de)
JP (1) JP4837725B2 (de)
WO (1) WO2006108559A2 (de)

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US9063121B2 (en) * 2012-05-09 2015-06-23 Stat-Diagnostica & Innovation, S.L. Plurality of reaction chambers in a test cartridge
DE102012213044B3 (de) * 2012-07-25 2014-01-23 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren zur Erzeugung von Kombinationen von Flüssigkeiten und Verfahren zur Herstellung einer Vorrichtung zur Erzeugung von Kombinationen von Flüssigkeiten
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TWI550274B (zh) * 2014-08-20 2016-09-21 紹興普施康生物科技有限公司 微流體檢驗裝置及其運作方法
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Also Published As

Publication number Publication date
US7731907B2 (en) 2010-06-08
WO2006108559A2 (de) 2006-10-19
JP2008534972A (ja) 2008-08-28
JP4837725B2 (ja) 2011-12-14
US20070189927A1 (en) 2007-08-16
EP1899702A2 (de) 2008-03-19

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