WO2006103657A3 - Composition solide de distribution intra-buccale d'insuline - Google Patents

Composition solide de distribution intra-buccale d'insuline Download PDF

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Publication number
WO2006103657A3
WO2006103657A3 PCT/IL2006/000381 IL2006000381W WO2006103657A3 WO 2006103657 A3 WO2006103657 A3 WO 2006103657A3 IL 2006000381 W IL2006000381 W IL 2006000381W WO 2006103657 A3 WO2006103657 A3 WO 2006103657A3
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
intra
solid composition
oral delivery
phospholipid
Prior art date
Application number
PCT/IL2006/000381
Other languages
English (en)
Other versions
WO2006103657A2 (fr
Inventor
Adel Pinhasi
Mila Gomberg
Original Assignee
Dexcel Pharma Technologies Ltd
Adel Pinhasi
Mila Gomberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL174387A external-priority patent/IL174387A0/en
Application filed by Dexcel Pharma Technologies Ltd, Adel Pinhasi, Mila Gomberg filed Critical Dexcel Pharma Technologies Ltd
Priority to US11/887,653 priority Critical patent/US20090274758A1/en
Publication of WO2006103657A2 publication Critical patent/WO2006103657A2/fr
Publication of WO2006103657A3 publication Critical patent/WO2006103657A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une composition solide de distribution intra-buccale d'insuline, qui contient: de l'insuline; une matrice polymère hydrophile; et un phospholipide qui permet une biodisponibilité de l'insuline d'au moins 5 %.
PCT/IL2006/000381 2005-03-31 2006-03-27 Composition solide de distribution intra-buccale d'insuline WO2006103657A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/887,653 US20090274758A1 (en) 2005-03-31 2006-03-27 Solid Composition for Intra-Oral Delivery of Insulin

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66658105P 2005-03-31 2005-03-31
US60/666,581 2005-03-31
IL174387A IL174387A0 (en) 2005-03-31 2006-03-19 A solid composition for intra-oral delivery of insulin
IL174,387 2006-03-19

Publications (2)

Publication Number Publication Date
WO2006103657A2 WO2006103657A2 (fr) 2006-10-05
WO2006103657A3 true WO2006103657A3 (fr) 2007-05-31

Family

ID=36717145

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/000381 WO2006103657A2 (fr) 2005-03-31 2006-03-27 Composition solide de distribution intra-buccale d'insuline

Country Status (1)

Country Link
WO (1) WO2006103657A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883201B2 (en) 2006-04-07 2014-11-11 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US8999383B2 (en) 2008-05-07 2015-04-07 Merrion Research Iii Limited Compositions of GnRH related compounds and processes of preparation
US9089484B2 (en) 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1980240A1 (fr) * 2007-04-11 2008-10-15 Cephalon France Composition pharmaceutique lyophilisée et leurs procédés de fabrication et d'utilisation
EP2164466A1 (fr) * 2007-06-01 2010-03-24 Novo Nordisk A/S Préconcentrés spontanément dispersibles comprenant un médicament peptidique dans un excipient solide ou semi-solide
JP5749155B2 (ja) 2008-03-18 2015-07-15 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化アシル化インスリンアナログ
EP2331072B8 (fr) 2008-08-18 2020-08-26 Entera Bio Ltd. Méthodes et compositions pour l administration de protéines par voie orale
EP2526971A1 (fr) 2011-05-25 2012-11-28 ArisGen SA Administration de médicaments par les muqueuses
MX2014012096A (es) 2012-04-11 2014-11-21 Novo Nordisk As Formulaciones de insulina.
WO2015188946A1 (fr) 2014-06-13 2015-12-17 Fricker, Gert Liposomes stabilisés par matrice
RU2665367C2 (ru) * 2014-11-12 2018-08-29 Общество с ограниченной ответственностью "Изварино Фарма" Пероральная система доставки вещества белковой природы (варианты), защитная оболочка системы доставки (варианты)
ES2975708T3 (es) 2015-01-29 2024-07-12 Novo Nordisk As Comprimidos que comprenden agonista del GLP-1 y recubrimiento entérico
ES2886837T3 (es) 2016-12-16 2021-12-21 Novo Nordisk As Composiciones farmacéuticas que contienen insulina
CN110464836A (zh) * 2018-05-11 2019-11-19 中国医学科学院药物研究所 一种胰岛素柔性微粒组合物
WO2020171727A2 (fr) * 2019-02-19 2020-08-27 Bluepharma - Industria Farmacêutica, S.A. Compositions mucoadhésives et leurs utilisations
WO2021029467A1 (fr) * 2019-08-14 2021-02-18 Sam Chun Dang Pharm. Co., Ltd. Forme posologique solide pour administration orale

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
WO2000033817A1 (fr) * 1998-12-08 2000-06-15 Phares Pharmaceutical Research N.V. Compositions de phospholipides
WO2004041118A2 (fr) * 2002-10-31 2004-05-21 Umd, Inc. Compositions therapeutiques pour une administration de medicament a l'epithelium de surface et a travers l'epithelium couvrant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
WO2000033817A1 (fr) * 1998-12-08 2000-06-15 Phares Pharmaceutical Research N.V. Compositions de phospholipides
WO2004041118A2 (fr) * 2002-10-31 2004-05-21 Umd, Inc. Compositions therapeutiques pour une administration de medicament a l'epithelium de surface et a travers l'epithelium couvrant

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DE GIM I TUNCER ET AL: "ORAL ADMINISTRATION OF LIPOSOMAL INSULIN", JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, AMERICAN SCIENTIFIC PUBLISHERS, US, vol. 6, no. 9-10, September 2006 (2006-09-01), pages 2945 - 2949, XP009078004, ISSN: 1533-4880 *
DUBOLAZOV ARTEM V ET AL: "Design of mucoadhesive polymeric films based on blends of poly(acrylic acid) and (hydroxypropyl)cellulose", BIOMACROMOLECULES, vol. 7, no. 5, May 2006 (2006-05-01), pages 1637 - 1643, XP002419441, ISSN: 1525-7797 *
IWANAGA K ET AL: "APPLICATION OF SURFACE-COATED LIPOSOMES FOR ORAL DELIVERY OF PEPTIDE: EFFECTS OF COATING THE LIPOSOME'S SURFACE ON THE GL TRANSIT OF INSULIN", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 88, no. 2, February 1999 (1999-02-01), pages 248 - 252, XP000792262, ISSN: 0022-3549 *
LAÏLA BOULMEDARAT ET AL: "Cyclodextrin-Mediated Drug Release from Liposomes Dispersed Within a Bioadhesive Gel", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 22, no. 6, 1 June 2005 (2005-06-01), pages 962 - 971, XP019370873, ISSN: 1573-904X *
TAKEUCHI H ET AL: "ENTERAL ABSORPTION OF INSULIN IN RATS FROM MUCOADHESIVE CHITOSAN- COATED LIPOSOMES", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 13, no. 6, June 1996 (1996-06-01), pages 896 - 901, XP002055070, ISSN: 0724-8741 *
TAO S L ET AL: "Gastrointestinal patch systems for oral drug delivery", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 10, no. 13, 1 July 2005 (2005-07-01), pages 909 - 915, XP004966897, ISSN: 1359-6446 *
YANG T-Z ET AL: "PHOSPHOLIPID DEFORMABLE VESCILES FOR BUCCAL DELIVERY OF INSULIN", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 50, no. 6, 2002, pages 749 - 753, XP001116742, ISSN: 0009-2363 *
ZHANG N ET AL: "Investigation of lectin-modified insulin liposomes as carriers for oral administration", INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 294, no. 1-2, 27 April 2005 (2005-04-27), pages 247 - 259, XP004825478, ISSN: 0378-5173 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883201B2 (en) 2006-04-07 2014-11-11 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US8883203B2 (en) 2006-04-07 2014-11-11 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US8999383B2 (en) 2008-05-07 2015-04-07 Merrion Research Iii Limited Compositions of GnRH related compounds and processes of preparation
US9089484B2 (en) 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration

Also Published As

Publication number Publication date
WO2006103657A2 (fr) 2006-10-05

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