WO2006099877A1 - Suppositoires rectaux et vaginaux contenant de la bromocriptine et un poloxamere bioadhesifs - Google Patents

Suppositoires rectaux et vaginaux contenant de la bromocriptine et un poloxamere bioadhesifs Download PDF

Info

Publication number
WO2006099877A1
WO2006099877A1 PCT/EG2005/000032 EG2005000032W WO2006099877A1 WO 2006099877 A1 WO2006099877 A1 WO 2006099877A1 EG 2005000032 W EG2005000032 W EG 2005000032W WO 2006099877 A1 WO2006099877 A1 WO 2006099877A1
Authority
WO
WIPO (PCT)
Prior art keywords
rectal
bromocriptine
poloxamer
vaginal suppositories
suppositories containing
Prior art date
Application number
PCT/EG2005/000032
Other languages
English (en)
Inventor
Atef Mohammed Mostafa Darwish
Original Assignee
Atef Mohammed Mostafa Darwish
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atef Mohammed Mostafa Darwish filed Critical Atef Mohammed Mostafa Darwish
Publication of WO2006099877A1 publication Critical patent/WO2006099877A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules

Definitions

  • Bromocriptine methylate is a water insoluble drug. It is associated with a lot of side effects that lead to 10% discontinuation rate. Its solubility and subsequently absorption could be increased by adding pluronics as demonstrated in a previous study ( Darwish et al. Fertility and sterility- April, 2005 (755)
  • the previous formula is mixed with bioadhesive polymers including caobopol 974P, chitosan and is created in a suppository form suitable for both male ( rectal ) and female ( vaginal ) usage to extend the scope of this treatment modality.
  • bioadhesive polymers including caobopol 974P, chitosan

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention a trait à des suppositoires qui peuvent être introduits rectalement ou vaginalement, contenant du mésylate de bromocriptine et un poloxamère. Pour la réalisation de bioadhésivité, la formulation contient un carbopol ou chitosane.
PCT/EG2005/000032 2005-03-24 2005-10-01 Suppositoires rectaux et vaginaux contenant de la bromocriptine et un poloxamere bioadhesifs WO2006099877A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EG2005030150 2005-03-24
EG2005030150 2005-03-24

Publications (1)

Publication Number Publication Date
WO2006099877A1 true WO2006099877A1 (fr) 2006-09-28

Family

ID=37023380

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EG2005/000032 WO2006099877A1 (fr) 2005-03-24 2005-10-01 Suppositoires rectaux et vaginaux contenant de la bromocriptine et un poloxamere bioadhesifs

Country Status (1)

Country Link
WO (1) WO2006099877A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3752814A (en) * 1968-05-31 1973-08-14 Sandoz Ltd 2-bromo-alpha-ergocryptine
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3752814A (en) * 1968-05-31 1973-08-14 Sandoz Ltd 2-bromo-alpha-ergocryptine
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions

Similar Documents

Publication Publication Date Title
WO2006106514A3 (fr) Forme dosifiee electrofilee et procede de fabrication correspondant
JP5583012B2 (ja) 口腔内速崩壊錠及びその製造方法
PE20080249A1 (es) Composicion farmaceutica que contiene pioglitazona
MX2008016508A (es) Uso de una matriz hidrofilica que contiene un derivado de acido poliacrilico, un eter de celulosa y un desintegrante para la elaboracion de un medicamento para tratar trastornos genitales femeninos.
JP2020512328A5 (fr)
NZ595663A (en) Immediate release pharmaceutical compositions comprising oxycodone and naloxone
Srinivasan et al. Safety and pharmacokinetics of quick-dissolving polymeric vaginal films delivering the antiretroviral IQP-0528 for preexposure prophylaxis
MX2008000087A (es) Formulaciones orales rapidamente absorbentes de inhibidores de la fosfodiesterasa 5.
Pereira et al. Pharmacokinetic and safety analyses of tenofovir and tenofovir-emtricitabine vaginal tablets in pigtailed macaques
WO2005115339A3 (fr) Composition pour accroitre l'absorption d'un medicament et methode associee
WO2004074444A3 (fr) Composes organiques ferriques, utilisations desdits composes et procedes de fabrication associes
NZ597760A (en) Tamper resistant oral pharmaceutical dosage forms comprising polyethylene oxide and an opioid analgesic
JP2008521929A5 (fr)
JP2009280621A5 (fr)
MX2007006635A (es) Formulacion farmaceutica de inhibidores dela carboxamida vih integrasa que contienen una composicion que controla la velocidad de liberacion.
CN101889974A (zh) 一种壳聚糖避孕凝胶及其制备方法
TW200916127A (en) Extended release formulation of nevirapine
JP2005510505A5 (fr)
LV13887A (lv) Pretmikrobu līdzeklis
AR065720A1 (es) Polvos para reconstitucion que comprenden rilpivirina dispersos en ciertos polimeros. uso. proceso.
WO2006099877A1 (fr) Suppositoires rectaux et vaginaux contenant de la bromocriptine et un poloxamere bioadhesifs
WO2006125450A1 (fr) Suppositoires rectaux et vaginaux contenant du misoprostol
FI3345604T3 (fi) Nalmefeeni alkoholikulutuksen vähentämiseksi spesifisissä kohdepopulaatioissa
RU2010126615A (ru) Композиции и способы лечения рака мочевого пузыря
ATE437628T1 (de) Reizlinderndes hustenmittel enthaltend extrakte aus isländischem moos und malve sowie zinkverbindungen

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

WWW Wipo information: withdrawn in national office

Country of ref document: RU

122 Ep: pct application non-entry in european phase

Ref document number: 05787836

Country of ref document: EP

Kind code of ref document: A1

WWW Wipo information: withdrawn in national office

Ref document number: 5787836

Country of ref document: EP