WO2006095027A1 - Methodes et appareil de navigation et visualisation a des fins chirurgicales a l'aide d'un microscope - Google Patents

Methodes et appareil de navigation et visualisation a des fins chirurgicales a l'aide d'un microscope Download PDF

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Publication number
WO2006095027A1
WO2006095027A1 PCT/EP2006/060654 EP2006060654W WO2006095027A1 WO 2006095027 A1 WO2006095027 A1 WO 2006095027A1 EP 2006060654 W EP2006060654 W EP 2006060654W WO 2006095027 A1 WO2006095027 A1 WO 2006095027A1
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WIPO (PCT)
Prior art keywords
microscope
probe
image
camera
virtual
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PCT/EP2006/060654
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English (en)
Inventor
Chuanggui Zhu
Kusuma Agusanto
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Bracco Imaging S.P.A.
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Publication date
Priority claimed from PCT/SG2005/000244 external-priority patent/WO2007011306A2/fr
Application filed by Bracco Imaging S.P.A. filed Critical Bracco Imaging S.P.A.
Priority to JP2008500215A priority Critical patent/JP2008532602A/ja
Priority to EP06708740A priority patent/EP1861035A1/fr
Priority to CA002600731A priority patent/CA2600731A1/fr
Publication of WO2006095027A1 publication Critical patent/WO2006095027A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/101—Computer-aided simulation of surgical operations
    • A61B2034/105—Modelling of the patient, e.g. for ligaments or bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/107—Visualisation of planned trajectories or target regions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046—Tracking techniques
    • A61B2034/2055—Optical tracking systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2068—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis using pointers, e.g. pointers having reference marks for determining coordinates of body points
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B2090/364—Correlation of different images or relation of image positions in respect to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B2090/364—Correlation of different images or relation of image positions in respect to the body
    • A61B2090/365—Correlation of different images or relation of image positions in respect to the body augmented reality, i.e. correlating a live optical image with another image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/371—Surgical systems with images on a monitor during operation with simultaneous use of two cameras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/25—User interfaces for surgical systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/20—Surgical microscopes characterised by non-optical aspects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/361—Image-producing devices, e.g. surgical cameras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation

Definitions

  • the present invention relates to image-based surgical guidance and visualization systems.
  • Neurosurgery is routinely conducted in two operational modes: a macroscopic mode and a microscopic mode.
  • a surgical field is generally viewed with the naked eye, and in the latter the surgical field is viewed through a microscope.
  • image based navigation and visualization systems have been used with success in aiding physicians to perform a wide variety of delicate surgical procedures.
  • images depicting the internal anatomies of a patient are generated, usually from magnetic resonance imaging (MRI), computer tomography (CT), and a variety of other technologies, prior to or during a surgery.
  • a three-dimensional (3D) representation of the patient is generated from the images.
  • the representation can be in varies forms, from volume images and 3D models of varies anatomical structures of the patient reconstructed from the images, to drawings, annotations and measurements added to illustrate a surgical plan, and a combine of them.
  • the 3D representation is aligned with the patient by registration.
  • US Published Patent Application Publication No. 20050015005 describes an improved navigation system where the probe includes a micro camera. This enables augmented reality enhanced navigation within a given operative field by viewing real-time images acquired by the micro-camera overlaid on the 3D representation of the patient.
  • an operation microscope is often used to provide a magnification of the surgical field within which a surgeon is working.
  • the microscope can be tracked for navigation purposes and its focal point can be usually shown in the 3D representation in place of the probe tip.
  • magnification of a microscope is usually set at a high level during the operation.
  • an integrated system can include a computer which has stored three dimensional representations of a patient's internal anatomy, a display, a probe and an operation microscope.
  • reference markers can be attached to the probe and the microscope, and the system can also include a tracking system which can track the 3D position and orientation of each of the probe and microscope.
  • a system can include means for detecting changes in the imaging parameters of the microscope, such as, for example, magnification and focus, which occur as a result of user adjustment and operation of the microscope.
  • the microscope can have, for example, a focal point position relative to the markers attached to the microscope and can, for example, be calibrated in the full range of microscope focus.
  • the position of the microscope can be obtained from the tracking data regarding the microscope and the focus can be obtained from, for example, a sensor integrated with the microscope.
  • a tip position of the probe can also be obtained from the tracking data of the reference markers on the probe, and means can be provided for registration of virtual representations of patient anatomical data with real images from one or more cameras on each of the probe and the microscope.
  • visualization and navigation images can be provided by each of the microscope and the probe, and when both are active the system can intelligently display either a microscopic or a macroscopic (probe based) real, virtual or augmented image according to defined rules.
  • FIGs. 1A-1C illustrate digital zooming of an augmented reality image according to an exemplary embodiment of the present invention
  • FIG. 1 D depicts an exemplary navigation system according to an exemplary embodiment of the present invention
  • FIG. 2 shows a schematic depiction of a real image of an exemplary patient head according to an exemplary embodiment of the present invention
  • FIG. 3 shows a schematic depiction of a virtual image of a tumor and blood vessel according to an exemplary embodiment of the present invention
  • FIG. 4 shows a schematic depiction of a combined (augmented reality) image according to an exemplary embodiment of the present invention
  • FIG. 5 shows a schematic depiction of a magnified augmented reality view according to an exemplary embodiment of the present invention
  • FIG. 6 shows a schematic depiction of a magnified microscopic view according to an exemplary embodiment of the present invention
  • Fig. 7 shows a schematic depiction of digitally zoomed-out (magnified) microscopic view according to an exemplary embodiment of the present invention
  • FIG. 8 shows schematic depiction of an exemplary navigational view from a probe according to an exemplary embodiment of the present invention
  • FIG. 9 shows an exemplary navigational view from a surgical microscope according to an exemplary embodiment of the present invention.
  • Fig. 10 shows the exemplary view of Fig. 9 after digitally zooming-in according to an exemplary embodiment of the present invention.
  • FIG. 11 shows an exemplary augmented reality navigational view from an exemplary probe according to an exemplary embodiment of the present invention.
  • augmented reality enhanced navigation system can be provided which can, for example, provide both microscopic and macroscopic navigational information of three-dimensional (3D) anatomic structures of the patient to a surgeon without the need to move the microscope off of, or away from, as the case may be, the surgical field.
  • a video camera can, for example, be rigidly attached to a microscope.
  • a computer can, for example, store a virtual microscope camera model having the same imaging properties and pose (position and orientation) as the corresponding actual video camera, said imaging properties including focal length, field of view and distortion parameters, zoom and focus.
  • means can be provided to generate an augmented view for microscopic navigation by overlaying the video images from the camera, or cameras, as the case may be, on the microscope with virtual rendered images of the patient's 3D anatomical structures generated by the computer according to the corresponding virtual microscope camera model in response to the position and orientation data of the microscope from the tracking device as well as magnification and focus data obtained form the microscope itself, by, for example, an integrated sensor.
  • a video camera integrated with a probe such as, for example, is described in the Camera-probe Applicaiton.
  • a virtual model of the video camera having the same imaging properties and pose (position and orientation) as the actual video camera, said imaging properties including focal length, field of view and distortion parameters, can be provided.
  • means can be provided to generate an augmented view for macroscopic navigation by overlaying video images from the camera in the probe with rendered images of the patient's 3D anatomical structures generated by the computer according to the virtual camera model in response to the position and orientation data of the probe from the tracking device.
  • an augmented microscopic view can be digitally zoomed so that a magnified view of microscopic navigation can be obtained without requiring a change of the position and settings (magnification and focus) of the microscope.
  • An anatomic structure outside of the optical field of the microscope at its current settings can thus be displayed in such a zoomed-out display, overlayed only partly by the real time video image coming from the microscope's camera in the center of the display.
  • a user need not change the setting of or move the microscope away to obtain a macroscopic navigation view.
  • a user need only move the probe, which can image the surgical field form any arbitrary viewpoint.
  • the microscopic image can be digitally zoomed.
  • Change of magnification or zoom in an AR image works by changing the field of view of the virtual camera (i.e. its frustum shape) together with the real image by ensuring that the video image plane is aligned along the frustum of virtual camera.
  • This concept is illustrated with reference to Figs. 1A-1C. It is noted that the original figures were in color, and the following description makes reference to those colors. However, the referents are easily discernable even in grayscale images.
  • Fig. 1A depicts a virtual camera (red axes at left of left image), and its frustum, represented by a near plane (dark blue; left side of left image) connected to a far plane (dark grey; right edge of left image), together with a virtual object.
  • the video image (pink rectangle), has its image centers aligned to the center of frustum.
  • the video image size is set to be the same as the near plane.
  • the full video image covers the screen-view (or viewport), and there is no zooming effect.
  • Fig. 1B the frustum has been changed such that a virtual object is projected with a magnification or zooming-in effect.
  • Such change in frustum causes a change in what is visible in the screen space for the video image. Because now only some parts of the video image are inside the projection plane (near-plane), covering the screen view, there is a zooming-in effect also in the video image.
  • Fig. 1C the frustum is changed such that the virtual object is projected with a zooming-out effect (appearing smaller).
  • This change in frustum causes the whole video image inside the projection plane (near-plane) to cover only a part of the screen-view, thus the video image appears smaller in the screen view.
  • the change of frustum can be achieved by changing the parameters of the perspective matrix of the virtual camera that produce the perspective projection.
  • a perspective projection matrix of 4x4 matrix defined in an OpenGL context can, for example, be defined with the following parameters:
  • ProjMat [10] - (Far + Near) / (Far - Near)
  • ProjMat [11] -2 * Far * Near / (Far - Near)
  • ProjMat [14] -1
  • ProjMat [15] 0 with element 1 ,3,4,7,8,9,12, and 13 having value of 0 (read from left to right, top to bottom rule).
  • the parameters Left, Right, Top, Bottom are functions of the microscope model based on the intrinsic camera calibration parameters together with focus and zoom setting of the microscope.
  • the parameter for Near and Far can be, for example, set at constant values.
  • the parameter zoomFactor ⁇ s the factor that determines the zooming-in or zooming-out effects. When its value is below 1 , the effect is zooming-out, and when greater than 1 , the effect is zooming-in. No zoom effect is operative when the value is 1.
  • the video image can be displayed as a texture map with the orthographic projection.
  • an OpenGL viewport can be adjusted by following parameters:
  • GLfloat ex fabs (Left) / (Right-Left)
  • GLfloat cy fabs (Bottom) / (Top -Bottom)
  • glViewport (1 - zoomFactor) * screenWidth * ex + originX , (1 - zoomFactor) * screenHeight * cy + originY , screenWidth * zoomFactor , screenHeight * zoomFactor ); which is, basically, scaling the size of screen view with a zoomFactor, and shifting the origin of the viewport according to the zoomFactor, video-image centers (ex, and cy), and the origin of OpenGL window such that the visible video image is overlayed correctly with the virtual image.
  • a probe can be used during microscopic surgery to obtain navigational views from varying orientations and locations.
  • the anatomic structures around the surgical field, together with the focal points and optical axis of the microscope can be displayed from the point of view of the probe camera.
  • the anatomic structures around the surgical area from various view points can, for example, thus be presented to the surgeon without the need of changing the microscope.
  • Operation microscope 115 has a camera 105, which can, for example, be a color camera, installed on its imaging port and reference markers 110 can be mounted to it.
  • the microscope 115 can, for example, have a built-in sensor to detect changes in imaging parameters of the microscope occurring as a result of adjustment of the microscope wherein said imaging parameters include parameters comprising microscope magnification and focus.
  • a sensor can be, for example, an encoder.
  • the adjustment of focus and zoom involves mechanical movement of the lenses and such an encoder can, for example, measure such movement.
  • the parameters can be available from a serial port of the microscope.
  • the data format can be, for example, of the form Zoom: +120; Focus: 362.
  • the microscope can also have an optical axis 111 and a focal point 112 which is defined as the intersection point of the optical axis and the focus plane of the microscope.
  • a focus plane is perpendicular to the optical axis. On focus plane you can get the clearest image.
  • a focal plane changes with focus adjustment.
  • a focal point's position relative to reference markers 110 can be calibrated in the full range of microscope focus and therefore can be depicted from the tracking data.
  • Fig. 1D the microscope is being viewed by a surgeon and in the microscope's light path there is a patient's head 152.
  • the exemplary patient has a tumor 155 (which is the target object of the operation) and a blood vessel structure 150 (which should be avoided during the operation) close to tumor 155.
  • a position tracking system 100 (such as, for example, NDI Polaris) can receive commands and can send tracking data to a computer 120, either, for example, wirelessly or through a cable linked with the computer.
  • Computer 120 can have 3D models 125 of the tumor 155 and blood vessel structure 150 stored in its memory prior to the navigation, such as for example, after pre-operative scanning and processing of such scan data into a volumetric data set containing various segmentations and planning data.
  • a probe 140 can, for example, contain a video camera 135, and a pointer with a tip 136 can be attached to its front end.
  • the probe 140 can be placed within easy reach of a surgeon to facilitate its use during the surgery.
  • the probe can, for example, be of the type as disclosed in the Camera-probe Application.
  • the position tracking system 100 can provide continual real time tracking data of the microscope 115 to the computer.
  • the position tracking system 100 can also provide continual real time tracking data of the probe 140 to the computer.
  • the computer can be connected to (i) a display 130, (ii) a camera and sensor of microscope 115, and (iii) a mini camera of the probe.
  • the system can further include software to detect position and orientation data of the microscope and probe from the tracking data, and from such position data to automatically select one (probe or microscope) to be used as a basis of images for navigation and/or visualization. Such automatic selection can be according to defined priority rules or various algorithms as may be appropriate to a given application and a given user's preferences.
  • a given user may prefer to get his general bearings via a macroscopic view, and then when he gets close to delicate structures, use a microscopic view. If an operation has multiple stages, it can easily be seen that such a surgeon would cycle through using the probe, then the microscope, then again the probe and then again the microscope.
  • the system could realize that for an initial period the main implement is a probe, and then once a microscope has been engaged it is the main implement until a new microscope position has been chosen, when the probe is once again used at the beginning of another stage.
  • the system could, as a result, generate a combined image on the display corresponding to a view from whichever implement was then prioritized.
  • Many alternative rules could be implemented, and a surgeon could always override such priority settings by actuating a switch or voice controlled interface.
  • the computer 120 can receives a real-time video image of a surgical scene acquired by microscope camera 105.
  • Microscope camera 105 can, for example, have a microscope virtual camera model which can be been provided and stored in computer 120.
  • a microscope virtual camera model can have a set of intrinsic parameters and extrinsic parameters wherein said intrinsic parameters can include, for example, focal length, image center and distortion, and said extrinsic parameters can include, for example, position and orientation of the virtual microscope camera model in relative to a reference coordinate system.
  • a reference coordinate system can be, for example, the coordinate system of markers 110 which are rigidly linked to microscope 115.
  • the intrinsic and extrinsic parameters of the microscope camera model can change according to changes of the microscope's magnification and focus.
  • the intrinsic and extrinsic parameters of the microscope camera model can be described as bivariate polynomial functions of the microscope magnification and focus.
  • a parameter p p represents one of the intrinsic and extrinsic parameters
  • a parameter p can be modeled as a qth order bivariate polynomial function of the values of focus (f) and zoom (z) of the microscope, as follows:
  • the microscope can be calibrated as a number of fixed cameras (with fixed focal length) across the full range of the microscope focus and zoom range. After a sufficient number of fixed camera calibrations, under different zoom and focus settings, a group of calibration data can be obtained.
  • the coefficients a m , n of the polynomial functions can then be solved, for example, by bivariate polynomial fitting.
  • An exemplary microscope camera model for an exemplary microscope in an augmented reality microscope system can be as follows:
  • Twcy -0.000000001 *F ⁇ 2*Z + (-0.000001826)*F ⁇ 2 + (0.000002707)*F*Z + (-0.004741056)*F + (-0.003616348)*Z + 5.606256436
  • Twcz 0.000000302*F ⁇ 2*Z + 0.000014187*F ⁇ 2 + (-0.000088499)*F*Z + (-0.018100412)*F + 0.061825291*Z + 422.480480324
  • Owcx, Owcy, Owcz are rotation vectors from which the rotation matrix from the microscope camera to the reference coordinate system can be calculated
  • Twcx, Twcy, and Twcz are transforms in x, y and z and from them the transform matrix to the reference coordinate system can be constructed.
  • a corresponding virtual microscope camera can be created and can be used to generate a virtual image of the virtual objects.
  • computer 120 receives the current magnification and focus values for the microscope.
  • Intrinsic and extrinsic parameters of a virtual microscope camera can thus be calculated from the stored microscope camera model.
  • the virtual microscope camera position and orientation in the position tracking system can be depicted using the tracking data of the markers on the microscope.
  • the microscope has an optical axis 111 and a focal point 112.
  • the position of the focal point changes in relative to the reference markers accordingly to the changes of the microscope focus.
  • the position of the focal point of the microscope relative to the reference markers can be calibrated before navigation.
  • An exemplary calibrated result of the focal point for an exemplary microscope from an augmented reality microscope system is presented below.
  • FocusPoint (x, y, z) (Fpx, Fpy, Fpz), wherein
  • Fpx -0.000001113*F ⁇ 2 + 0.001109120*F + 116.090108990;
  • Fpy 0.000002183*F ⁇ 2 + (-0.000711078)*F + (-27.066366422);
  • Fpx -0.000073468*F ⁇ 2 + (-0.154217215)*F + -369.813473763;
  • F represents focus
  • the calibration result of the focal point can be stored in the computer.
  • a position of focal point can be depicted from the tracking data of the reference markers.
  • the optical axis can be, for example, a line linking the focal points of various microscope focal values.
  • image data of a patient can be mapped to the patient using one of the generally known registration techniques.
  • one such registration technique maps the image data of a patient to the patient using a number of anatomical features (at least 3) on the body surface of the patient by matching their positions identified and located in the scan images and their corresponding positions on the patient determined using a tracked probe.
  • the registration accuracy may be further improved by mapping a surface of a body part of the patient generated from the imaging data to the surface data of the corresponding body part generated on the operating table.
  • the position and orientation of the patient head 152 and the position and orientation of the microscope video camera 105 can be transformed into a common coordinate system, for example the coordinate system of the position tracking system.
  • the relative position and orientation between the head 152 and the microscope video camera 105 can thus be determined dynamically using the position tracking system 100.
  • the microscope camera can capture a video image of patient head 152.
  • the tumor 155 and blood vessel 150 may not be visible in the video image (as they may be visually occluded by an as yet closed portion of the head).
  • the computer can generate a virtual image of tumor 155 and blood vessel 150 based on the intrinsic and extrinsic parameters of the virtual microscope camera and the stored model of the tumor and blood vessel.
  • real image 201 and virtual image 301 can be combined to generate an augmented reality image.
  • the augmented reality image can then, for example, be on display device 130.
  • Display 130 can be a monitor, a HMD, a display build in the microscope for "image injection", etc..
  • the 3D model of tumor and blood vessel may be generated from three-dimensional (3D) images of the patient. For example, from MRI or CT images of the patient head.
  • 3D three-dimensional
  • data can be generated using hardware and software provided by Volume Interactions Pte Ltd., such as, for example, the Dextroscope system running RadioDexter software.
  • the augmented reality image can be displayed in various ways.
  • the real image can be overlaid on the virtual image (real image is on the virtual image), or be overlaid by the virtual image (the virtual image is on the real image).
  • the transparency of the overlay image can be changed so that the augmented reality image can be displayed in various ways, with the virtual image only, real image only, or a combined view.
  • axial, coronal and sagittal planes of the 3D models according to the position changing of the focal point can be displayed in three separate windows.
  • the augmented reality in microscopic navigation can be in various microscope settings across the full magnification and focus range.
  • Fig. 5 shows an exemplary augmented reality view of the patient head in a different (greater, relative to Figs. 3-4) magnification setting.
  • digital zoom can be used to virtually change the magnification of the augmented reality image.
  • the zoom ratio can be an input of a user.
  • the zoomed field of view can, for example, be centered at the center of the window by default.
  • Fig. 6 shows an exemplary virtual image only navigation view of the surgical field through the microscope at a higher magnification.
  • the surgeon is operating on the tumor so part of the tumor is visible in the optical view of the microscope. However, most of the tumor and all of the blood vessel are either hidden under the exposed surface or out of the field of view of the microscope so that the surgeon cannot see directly.
  • a rendered image of tumor and blood vessel generated by the computer can be displayed to the surgeon, but because of the magnification, only a small part of the tumor and blood vessel can be shown.
  • FIG. 7 shows a virtually enlarged view of the microscope in which the whole structure of the tumor and blood vessel are visible.
  • this can be achieved by digital zooming.
  • Digital zooming virtually changes the field of view of the virtual microscope camera model, so that the 3D models in the virtual camera's field of view can be rendered from the same viewpoint but a different field of view.
  • Digital zooming enables the surgeon to see beyond of the microscope's field of view without changing the microscope's actual settings.
  • the video signal can also be zoomed, and thus a zoomed image can have video (real) images, virtual images or any combination of both, with varying transparency of either.
  • Fig. 7 is zoomed-out relative to the view of Fig. 6, but obviously of a much greater magnification (zoom-in) relative to the view of Fig. 5 and of course that of Fig. 3.
  • a user may frequently change zoom values, zooming in and out repeatedly over the course of a given procedure or operation.
  • FIG. 8 depicts the exemplary scene of FIG. 7 from the point of view of the mini-camera inside the probe.
  • the focal point as well as the optical path of the microscope can be shown together with the tumor and blood vessels, indicating the 3D relationship of the microscope, the surgical field and the virtual objects (tumor and blood vessels).
  • Figs. 9-11 are actual screen shots form an exemplary embodiment of the present invention.
  • Fig. 9 shows an exemplary navigational view from a surgical microscope according to an exemplary embodiment of the present invention.
  • Fig. 10 shows the exemplary view of Fig. 9 after digitally zooming-out according to an exemplary embodiment of the present invention, using the techniques described above as in connection with Fig. 7.
  • FIG. 11 shows an exemplary augmented reality navigational view from an exemplary probe according to an exemplary embodiment of the present invention, corresponding somewhat to that shown in Fig. 8, without the optical path and focal point of the microscope.
  • the selection between the microscope and probe can be performed automatically.
  • the automatic selection can be based upon (i.e., be a function of) the tracking data. In exemplary embodiments according to the present invention this can be achieved by setting a higher priority to the probe. If only the microscope tracking data is available, the microscope will be selected as the navigation instrument and its AR image will be displayed. If both the microscope and probe are tracked, the probe will be selected and its AR view be displayed. The microscope in such situation can, for example, be ignored. When the probe is not tracked, the microscope can, for example, be selected automatically for navigation. The video image can also be automatically changed accordingly.
  • the system, methods and apparatus of the present invention thus enable a user to see “beyond the normal field of view” both during macroscopic surgery as well as microscopic surgery. This allows a user to always be aware just how near he or she is to highly sensitive or important hidden structures.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Robotics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pathology (AREA)
  • Microscoopes, Condenser (AREA)
  • Processing Or Creating Images (AREA)

Abstract

L'invention porte sur un système et un procédé améliorés de navigation et visualisation macroscopique et microscopique à des fins chirurgicales. Une exécution de l'invention, donnée en exemple, comprend un système intégré comportant un ordinateur où sont stockées des représentations en 3D de l'anatomie interne du patient, un écran, une sonde et un microscope opératoire. Une autre exécution de l'invention, donnée en exemple, comprend des marqueurs de référence pouvant se fixer à la sonde et au microscope, ainsi qu'un système de poursuite pouvant suivre la position et l'orientation en 3D de la sonde et du microscope. Une autre exécution de l'invention, donnée en exemple, comprend des moyens de détection des modifications des paramètres d'imagerie du microscope, tels que par exemple son grossissement ou sa focalisation, résultant de son réglage ou de son maniement par l'utilisateur, tels que la position du foyer par rapport aux marqueurs solidaires du microscope, ce qui permet de l'étalonner sur toute la plage de ses foyers. Dans une autre exécution de l'invention, donnée en exemple, la position du microscope peut être obtenue à partir de données de poursuite relatives au microscope et au foyer, par exemple par un détecteur intégré au microscope, et on peut de plus obtenir la position de l'extrémité de la sonde à partir des données de poursuite des marqueurs de référence fixés à la sonde, et on peut prévoir des moyens de mise en coïncidence des représentations virtuelles des données anatomiques du patient avec une ou plusieurs images réelles prises par une ou plusieurs caméra solidaires de la sonde et du microscope. Dans une autre exécution de l'invention, donnée en exemple, la visualisation et la navigation peuvent être effectuées à la fois par le microscope et par la sonde, et lorsqu'ils sont tous deux actifs, le système peut présenter une image intelligente microscopique ou macroscopique (par la sonde) agrandie selon certaines normes établies.
PCT/EP2006/060654 2005-03-11 2006-03-13 Methodes et appareil de navigation et visualisation a des fins chirurgicales a l'aide d'un microscope WO2006095027A1 (fr)

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JP2008500215A JP2008532602A (ja) 2005-03-11 2006-03-13 外科手術ナビゲーションと顕微鏡による可視化の方法と装置
EP06708740A EP1861035A1 (fr) 2005-03-11 2006-03-13 Methodes et appareil de navigation et visualisation a des fins chirurgicales a l'aide d'un microscope
CA002600731A CA2600731A1 (fr) 2005-03-11 2006-03-13 Methodes et appareil de navigation et visualisation a des fins chirurgicales a l'aide d'un microscope

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CN107157588A (zh) * 2017-05-08 2017-09-15 上海联影医疗科技有限公司 影像设备的数据处理方法以及影像设备
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