WO2006061849A1 - Nouveaux aliments fonctionnels favorables a la sante renforces en herbes medicinales - Google Patents

Nouveaux aliments fonctionnels favorables a la sante renforces en herbes medicinales Download PDF

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Publication number
WO2006061849A1
WO2006061849A1 PCT/IN2004/000383 IN2004000383W WO2006061849A1 WO 2006061849 A1 WO2006061849 A1 WO 2006061849A1 IN 2004000383 W IN2004000383 W IN 2004000383W WO 2006061849 A1 WO2006061849 A1 WO 2006061849A1
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WIPO (PCT)
Prior art keywords
composition
formulation
herbal
herbal composition
plant
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PCT/IN2004/000383
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English (en)
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WO2006061849B1 (fr
Inventor
Palpu Pushpangadan
Ajay Kumar Singh Rawat
Chandana Venkateswara Rao
Sharad Kumar Srivastava
Raghavan Govindarajan
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Council Of Scientific And Industrial Research
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Priority to PCT/IN2004/000383 priority Critical patent/WO2006061849A1/fr
Publication of WO2006061849A1 publication Critical patent/WO2006061849A1/fr
Publication of WO2006061849B1 publication Critical patent/WO2006061849B1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A23L21/10—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to development of a jam with novel herbal composition(s).
  • the present invention provides to a novel herbal composition, ' which promotes the proven pharmacological activities such as anti-oxidant, anti-stress and adaptogenic activities.
  • Composition(s) comprises of plant juices or extracts together with the conventional recipients to form a paste/jelly/jam/cake/cream puff/chocolate forms fortified with these plants are added which are used as functional foods.
  • nutraceutical is dietary disease preventive food component.
  • Food industries have rather high demand for the products that meet the consumer's demand for a healthy life style.
  • functional food fortified with the plant ingredients plays an important role. These foods are not intended only to satisfy hunger and provide humans with necessary nutrients but also to prevent mal-nutrition related diseases and increases physical and mental well being of consumers.
  • Functional foods are substances that provide health benefits beyond the normal nutritional values and nutrients added, which are not naturally occurring in that food are called as functional fortified food.
  • the main objective of the present invention is to provide a synergistic novel health promoting functional foods fortified with herbs having anti-stress and adaptogenic activity. Another important objective is that the product should be cost effective and of socio-economic benefits.
  • the present invention provides an herbal formulation useful in stress conditions as an anti-stress agent and adaptogenic activity.
  • the herbal formulation comprising of Evo ⁇ vulus alsinoides along with this, Mangifera indica,, Wiihania somnifera, Asparagus recemosus and Amaranthus hypochondriacus are added to provide adaptogenic activity and relief in other symptoms.
  • W. somnifera showed 30-40% protection in stress induced gastric ulcers.
  • the formulation of the present invention showed highly significant (about 80%) results in stress induced gastric ulcers and therefore the formulation can be used as an adaptogenic and showed antistress activity.
  • the plants used in the invention have the following properties as reported.
  • Botanical description A large, evergreen tree, 10-45 m tall, with a heavy, dome - shaped crown and a straight, stout bole. Bark thick, dark grey, flaking off when old. Leaves linear oblong or elliptic - lanceolate, 10-30 cm long and 2-9 cm wide, with an aromatic, resinous odour when crushed. Inflorescence a large panicle, containing up to 3000 flowers; flowers tiny, reddish- white or yellowish green with a pungent odour; staminate and hermaphrodite flowers borne in the same panicle.
  • Fruit a large drupe, highly variable in form and size; fruit skin thick or thin, leathery, green, yellowish or red, often dotted with numerous glands; flesh (mesocarp) whitish-yellow, yellow or orange, firm, soft or juicy, slightly acidic to sweet, richly aromatic; seed solitary, ovoid-oblique, encased in a hard, compressed, fibrous endocarp (stone).
  • Ripe mango fruit is a rich source of vitamins A and C, recommended as a laxative and diuretic and a restorative tonic, and useful for treating heat stroke. It is also thought to be useful for treating haemorrhage of the uterus, lungs and intestine.
  • the unripe fruits are used for treating ophthalmia.
  • the leaves are chewed to give tone to the gums.
  • a c old aqueous extract of the tender leaves is taken internally to relieve diarrhoea in parts of southern orissa.
  • the gum resin exuded from the cut bark is used in dressing s for cracked feet and scabies, and is considered anti-syphilitic.
  • Botanical Description A perennial herb with a small woody and branched rootstock. Its branches are annual, numerous, more than 30 cm long, often prostrate, slender and wiry with long hairs. Leaves are small, entire, elliptic to oblong, obtuse, apiculate, base acute and densely hairy. Petiole is minute or nearly absent. Bracts are linear and persistent. Flowers mostly solitary in upper axils. Corolla blue rotate and broad funnel shaped, Calyx 4 is lobed, lanceolate and the tip acute. Peduncle is long and axillary. Capsule is globose and 4 valved. Seeds are 4 and glabrous.
  • the plant contains an alkaloid-shankhapushpine. Fresh plant contains volatile 11 oil. It also contains a yellow neutral fat, an organic acid and saline substances. Three alkaloids- evolvine, betaine, and an unidentified compound have been isolated.
  • Botanical description An erect, evergreen, grayish tomentose shrub 0.3- 2 m tall, with fairly long, stout, fleshy, whitish-brown roots.Leaves simple, alternate or subopposite, broadly ovate, glabrous, 5-12 cm long and 2.5 - 7 cm wide, apex subacute, base un equal, marginsentire, finely stellate-pubescent beneath; main nerves about 6 pairs; petioles 0.3- 1.7 cm long.
  • Phytochemistry Two new withnolides- 5- dehydroxy withnolide R and with a somniferin A isolated and their structure established (Phytochemistry 1991).
  • the roots are considered alternative, germicidal, aphrodisiac and diuretic; they are used in Ayurveda to treat ulcers, fever,dyspnoea, cough, consumption, dropsy, rheumatism, toxicosis and memory loss.
  • the powdered roots mixed with equal parts of honey and ghee is thought to be beneficial for impotence or seminal debility.
  • the roots as well as the bruised leaves are also used externally to treat ulcers, painful swellings and scabies.
  • the total alkaloids present in the roots produce relaxant and anti spasmodic effects.
  • the fruits and seeds are diuretic.
  • the leaves are considered anthelmintic and bitter, and their infusion is given to relieve fever.
  • Asparagus racemosus Family Asparagaceae
  • Botanical description A tall climbing, much-branched, spiny shrub with annual woody, white - grey or brown stems armed with strong, straight or recurved spines 0.5 - 1.3 cm long; rootstock short, tuberous, bearing numerous fusiform, succulent tuberous roots 30 - 100 cm long and 1-2 cm thick. Flowers white, fragrant, small, crowded in simple and branched racemes 5 - 15 cm long. Fruits globose, red when ripe, 3-lobed, 0.4 - 0.6 cm in diameter.
  • A. hypochondriacus is a beautiful crop with red or green leaves. The plant is monoecious. An erect, branched, annual or perennial herb, varying in colour from green to purple, 30-60 cm tall with hard, strainght, paired axillary spines, Leaves long — petioled, oblong, ovate-elliptic or lanceolate, acute or obtuse, base cuneate, generally 1-6 cm long and 0.5-2.6 cm wide. Flowers minute, grayish-green, borne in dense axillary clusters or terminal spikes; bracts and bracteoles narrowly ovate-lanceolate.
  • the grain contains proteins, and is high in lysine, an essential amino acid in which cereal crops are low. Sulphur containing amino acids such as tryptophan, found to be deficient in pulses are present in amaranth seeds. The seeds are also rich in calcium, iron and the b complex vitamins (Subramaniam and srinivasan 1952, Smith et al 1959). Pharmacology:
  • the plant is considered diuretic, emollient sudoritic and febrifuge, and is recommended for treating eruptive fevers, as a galactagogue and as a remedy for colic.
  • a decoction of the plant is considered useful for improving digestion.
  • the leaves are applied as a poultice to relieve bruises, abscesses, burns, wounds and inflammations; their infusion is used as a diuretic.
  • the root is used to treat menorrhagia, gonorrhoea, eczema and inflammatory swelling.
  • the powdered root is used as a cure for paronychia.
  • the roots and leaves are boiled and given to children as a laxative.
  • the present invention provides a novel aqntistress herbal synergistic formulation useful for the treatment of acute adaptogenic and antioxidant said formulation comprising:
  • aqueous alcoholic extracts of the plants comprising Mangifera indica 65-75 wt. %, Withania somnifera 3.5-5wt. %, Asparagus recemosus 3.5-5wt. %, and Amaranthus hypochondriacus 10-20wt. %, Evolvulus alsinoides 0.2-0.6wt % in an oral dosage form selected from a group consisting of a jam/jellies/chocolates etc.
  • the novelty of the present investigation is (1) herbal formulation for the treatment of anti-stress (2) the herbal formulation for the treatment of adaptogenic activities.
  • composition(s) wherein the plant selected from powdered plants or lyophilized juice/extracts of plants Mangifera indica, Evolvulus alsinoides, Withania somnifera, Asparagus recemosus and Amaranthus hypochondriacus.
  • herbal formulation(s) used in the fields of foods and pharmaceuticals as a nutrient comprises of plant juice or extracts together with the conventional recipients.
  • a composition(s) wherein the plants are selected from Mangifera indica fruit.
  • composition(s) wherein the powder of obtained from Withania somnifera leaves or roots.
  • composition(s) wherein the powder of obtained from Asparagus recemosus tubers.
  • herbal composition(s) as claimed in claim 1 wherein the said composition is used as a nutrient supplement and acts as a free radical scavenger.
  • herbal composition(s) as claimed in claim 1 wherein said composition forms a paste/jelly/jam/cake/cream puff/chocolate.
  • herbal composition(s) as claimed in claim 1 wherein the plant extracts are obtained from plant parts selected from leaf, seeds, rhizome, tubers and aerial parts.
  • a method of preparing a herbal composition(s) as claimed in claim 1 comprising: a. obtaining the individual part of medicinal plants from a group comprising leaves, fruits, seeds, root, rhizome, tubers and aerial parts of equal proposition. b. fresh or shade dried plant materials were used, c. crushed/Powdered the plant material to Juice/coarse powder, d. extracting the powdered dried plant material with (40-50% aqueous ethanol) at 25 - 35 0 C, e. preparation of syrup by heating 40-70% w/v sugar in water, f.
  • step (e) mixing of plant extract or juice obtained in step (e) like Mangifera indica, Evolvulus alsinoides, Withania somnifera, Asparagus recemosus Amaranthus hypochondriacus in syrup. g. concentrating the composition at high temperature (80-120 0 C) to form a paste/jelly/jam/cake/cream puff/chocolate.
  • herbal composition(s) as claimed in claim 1 wherein the formulation showed as a potent antioxidant activity.
  • herbal composition(s) as claimed in claim 1 wherein the formulation showed as a potent adaptogenic activity.
  • herbal composition(s) as claimed in claim 1 wherein the formulation showed as a potent antistress activity.
  • herbal composition(s) as claimed in claim 1 wherein the formulation showed as a potent nonenzymic antioxidant activity.
  • herbal composition(s) as claimed in claim 1 wherein the formulation showed an enhanced protein content (0.03-0.06 g/ 1Og).
  • herbal composition(s) as claimed in claim 1 wherein the formulation showed an enhanced total carbohydrate and low fat content (0.01 g/ 1Og).
  • herbal formulation(s) as claimed in claim 1 wherein the extracts on the basis of one or more bioactive components and are combined in one convenient but tasty formula of fruits in the form of jam or jellies.
  • herbal formulation(s) as claimed in claim 1 wherein the formulation helpful in defending the body against the effects of stressful environment and provide vitality and energy.
  • the first step in the preparation of these formulations involves a process for making, the plant material suitable for formulating into a solid/semi solid form.
  • the specified portion of the plant is collected and dried under shade at room temperature (25 -35 0 C) for 72 hours or until the material gets dried.
  • the material is then powdered into a fine powdered.
  • a specified amount of the powdered material is then extracted exhaustively with 50 % aqueous alcohol at room temperature (25-35 0 C). Extraction was carried out in a closed container immersing specified amount of the plant material in specified solvent (1 : 8 or 1 : 15 ratio) for 4-7 days. At the end of this stage, solvent is decanted and filtered if necessary to make it free from plant debris.
  • Mangifera indica, Evolvulus alsinoides, Withania somnifera, Asparagus recemosus and Amaranthus hypochondriacus were collected and dried in shade.
  • the dried material (IKg) is then powdered and extracted with 50 % aqueous alcohol (3 L) for 5 days. At the end of this, the solvent is decanted and filtered if necessary to remove the plant debris.
  • the extract is then concentrated under vacuum at less than 50 0 C. Then the extract is lyophilised to obtain the extract in powder form.
  • the blood was collected and serum was separated and enzyme like alkaline phosphatase, acid phosphatase, glutamic pyruvic transaminase, lipid peroxidation, superoxide dismutase and catalase are estimated by span diagnostic kit method.
  • the formulation Fl- contains the extracts of Mangifera indica (65wt.%), Evolvulus alsinoides (0.4wt.%), Withania somnifera (3wt. %), Asparagus recemosus (4wt.%) and Amaranthus hypochondriacus (14wt. %).
  • the formulation F2- contains the extracts of Mangifera indica (65wt.%), Evolvulus alsinoides (0.5wt.%), Withania somnifera (6wt%), Asparagus recemosus (6wt%) and Amaranthus hypochondriacus (15wt%).
  • the Formulation F2 acts as an antiulcer agent in stress as indicated in reduction of ulcer index from 100 % to 40 %, number of ulcers from 19.5 to 8.2 and also decrease in severity of ulcers from 32.8 to 12.5.
  • Formulation F2 is more significant than Fl formulation.
  • the formulation Fl- contains the extracts of Mangifera indica (65wt.%), Evolvulus alsinoides (0.4wt.%), Withania somnifera (3wt. %), Asparagus recemosus (4wt.%) and Amaranthus hypochondriacus (14wt. %).
  • the formulation F2- contains the extracts of Mangifera indica (65wt.%), Evolvulus alsinoides (0.5wt.%), Withania somnifera (6wt%), Asparagus recemosus (6wt%) and Amaranthus hypochondriacus (15wt%).
  • Adrenal gland weight was increased in chronic stress with the formulation Fl and F2.
  • the lipid peroxidation was significantly increased in vehicle + stress group compared to the vehicle group, when we treated with the developed formulations there is a significant decrease in the increased levels and attained to near to normal values.
  • the antioxidant enzyme catalase was concomitantly increased from 19.5 to 29.3 and this showed a positive effect compared to the vehicle plus stress group.
  • the formulation Fl- contains the extracts of Mangifera indica (65wt.%), Evolvulus alsinoides (0.4wt.%), Withania somnifera (3wt. %), Asparagus recemosus (4wt.%) and Amaranthus hypochondriacus (14wt. %).
  • the formulation F2- contains the extracts of Mangifera indica (65wt.%), Evolvulus alsinoides (0.5wt.%), Withania somnifera (6wt%), Asparagus recemosus (6wt%) and Amaranthus hypochondriacus (15wt%). There is no change in the levels of the enzymes viz. alkaline phosphatase, acid phosphatase and glutamic pyruvic transaminase. Quality control of jam
  • Hydroxymethylfurfural is a recognised indicator of quality deterioration, as a result of excessive heating or storage in a wide range of foods containing carbohydrates. Its content is practically zero in fresh, untreated fruit juice and HMF formation is judged to be the most useful method for assessing the effectiveness of heat treatment in destroying spoilage organisms in jams and fruit products.
  • HMF content immediately after preparation 1.34 mg HMF/ lOOg of Jam and after 1 year, it is 1.64 mg HMF/ 100 g Jam at room temperature.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

La présente invention concerne une nouvelle composition à base d’herbes médicinales qui stimule les activités pharmacologiques avérées telles que les activités anti-oxydantes, anti-stress et adaptogènes. La/les composition(s) comprend/comprennent des jus ou extraits de plantes associés aux excipients conventionnels afin de former un(e) pâte/gelée/confiture/cake/chou à la crème/des formes chocolatées et est/sont renforcée(s) en plantes telles que Mangifera indica, Evolvulus alsinoides, Withania somnifera et Asparagus recemosus Amaranthus hypochondriacus, etc., lesquelles sont utilisées en tant qu’aliments fonctionnels.
PCT/IN2004/000383 2004-12-10 2004-12-10 Nouveaux aliments fonctionnels favorables a la sante renforces en herbes medicinales WO2006061849A1 (fr)

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PCT/IN2004/000383 WO2006061849A1 (fr) 2004-12-10 2004-12-10 Nouveaux aliments fonctionnels favorables a la sante renforces en herbes medicinales

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3364990A4 (fr) * 2015-10-22 2019-09-18 Benny Antony Procédé pour augmenter la bioactivité d'extraits d'ashwaganda

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010055625A1 (en) * 2000-03-28 2001-12-27 Katiyar Chandra Kant Herbal composition and method of manufacturing such composition for the management of gynecological disorders
WO2003017784A1 (fr) * 2001-08-30 2003-03-06 Council Of Scientific And Industrial Research Composition nutraceutique a base d'herbes destinee aux femmes/femmes enceintes et son procede de preparation
JP2003160503A (ja) * 2001-11-21 2003-06-03 Pola Chem Ind Inc アサガオカラクサ属植物のエキスからなる血管内皮増殖因子産生促進剤
US20030185913A1 (en) * 2002-03-26 2003-10-02 Palpu Pushpangadan Herbal health protective and promotive nutraceutical formulation for diabetics and process for preparing the same
WO2003079812A1 (fr) * 2002-03-25 2003-10-02 Council Of Scientific And Industrial Research Aliments fonctionnels d'origine vegetale et procede de preparation correspondant
US20040121029A1 (en) * 2002-12-19 2004-06-24 Council Of Scientific & Industrial Research Antiulcer herbal composition(s)
WO2004056382A1 (fr) * 2002-12-20 2004-07-08 Council Of Scientific And Industrial Research Boisson sans alcool a base d'herbes ayurvediques

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010055625A1 (en) * 2000-03-28 2001-12-27 Katiyar Chandra Kant Herbal composition and method of manufacturing such composition for the management of gynecological disorders
WO2003017784A1 (fr) * 2001-08-30 2003-03-06 Council Of Scientific And Industrial Research Composition nutraceutique a base d'herbes destinee aux femmes/femmes enceintes et son procede de preparation
JP2003160503A (ja) * 2001-11-21 2003-06-03 Pola Chem Ind Inc アサガオカラクサ属植物のエキスからなる血管内皮増殖因子産生促進剤
WO2003079812A1 (fr) * 2002-03-25 2003-10-02 Council Of Scientific And Industrial Research Aliments fonctionnels d'origine vegetale et procede de preparation correspondant
US20030185913A1 (en) * 2002-03-26 2003-10-02 Palpu Pushpangadan Herbal health protective and promotive nutraceutical formulation for diabetics and process for preparing the same
US20040121029A1 (en) * 2002-12-19 2004-06-24 Council Of Scientific & Industrial Research Antiulcer herbal composition(s)
WO2004056382A1 (fr) * 2002-12-20 2004-07-08 Council Of Scientific And Industrial Research Boisson sans alcool a base d'herbes ayurvediques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 2003, no. 10 8 October 2003 (2003-10-08) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3364990A4 (fr) * 2015-10-22 2019-09-18 Benny Antony Procédé pour augmenter la bioactivité d'extraits d'ashwaganda

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