Classifications

• • H—ELECTRICITY
  • H01—ELECTRIC ELEMENTS
  • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
  • H01J49/00—Particle spectrometers or separator tubes
  • H01J49/26—Mass spectrometers or separator tubes
  • H01J49/34—Dynamic spectrometers
  • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
  • H01J49/4205—Device types
  • H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
  • H01J49/4215—Quadrupole mass filters
• • H—ELECTRICITY
  • H01—ELECTRIC ELEMENTS
  • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
  • H01J49/00—Particle spectrometers or separator tubes
  • H01J49/26—Mass spectrometers or separator tubes
  • H01J49/34—Dynamic spectrometers
  • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
  • H01J49/426—Methods for controlling ions
  • H01J49/427—Ejection and selection methods
  • H01J49/428—Applying a notched broadband signal

Definitions

• the centre and/or width of the one or more mass to charge ratio transmission windows may vary in a substantially progressive, non-progressive, linear, non-linear, quadratic, smooth, stepped, regular, random or quasi-random manner.
• the ion guide or mass filter device preferably has an ion entrance region and an ion exit region and wherein in a mode of operation y% of the ions received by the preferred ion guide or mass filter device at the ion entrance region are preferably attenuated and/or radially ejected from the preferred ion guide or mass filter device before reaching the ion exit region, wherein y is selected from the group consisting of: (i) ⁇ 1; (ii) 1-5; (iii) 5-10; (iv) 10-15; (v) 15-20; (vi) 20-25; (vii) 25-30; (viii) 30-35; (ix) 35-40; (x) 40-45; (xi) 45-50; (xii) 50-55; (xiii) 55-60; (xiv) 60-65; (xv) 65-70; (xvi) 70-75; (xvii) 75-80; (xviii) 80-85; (xix) 85-90; (xx) 90
• the multipole rod set preferably comprises a quadrupole rod set, a hexapole rod set, an octapole rod set or a rod set comprising more than eight rods.
• the ion tunnel or ion funnel preferably comprises a plurality of electrodes or at least 2, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 electrodes having apertures through which ions are transmitted in use and wherein at least 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95% or 100% of the electrodes have apertures which are of substantially the same size or area or which have apertures which become progressively larger and/or smaller in size or in area.
• planar, plate or mesh electrodes are preferably arranged generally in the plane in which ions travel in use.
• AC or RF voltage means are preferably provided for supplying the plurality of planar, plate or mesh electrodes with an AC or RF voltage and wherein adjacent planar, plate or mesh electrodes are preferably supplied with opposite phases of the AC or RF voltage.
• the stack or array of planar, plate or mesh electrodes preferably comprises a plurality or at least 2, 3, 4, 5, 6, I 1 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 planar, plate or mesh electrodes arranged generally in the plane in which ions travel in use. At least some or at least 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95% or 100% of the planar, plate or mesh electrodes are preferably supplied with an AC or RF voltage and wherein adjacent planar, plate or mesh electrodes are supplied with opposite phases of the AC or RF voltage.
• the ion mobility spectrometer or separator preferably comprises a plurality of axial segments or at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 or 100 axial segments.
• the mass spectrometer preferably further comprises an ion trap or ion trapping region arranged upstream and/or downstream of the preferred ion guide or mass filter device.
• Ions are preferably arranged in a mode of operation to be mass selectively and/or resonantly ejected from the ion trap or ion trapping region.
• ions may in a mode of operation be arranged to be non-mass selectively and/or resonantly ejected from the ion trap or ion trapping region.
• Fig. 4A illustrates an embodiment wherein a broadband frequency signal having a relatively wide range of frequencies is applied to a quadrupole rod set ion guide and Fig. 4B illustrates an alternative embodiment wherein a broadband frequency signal having a narrower range of frequencies is applied to a quadrupole rod set mass filter operating as a low resolution mass filter;
• All four rods 2a,2b are maintained at substantially the same DC voltage or potential.
• a two phase RF voltage supply 3 is connected to the rods 2a, 2b such that adjacent rods have opposite phases of an RF voltage applied to them whilst diametrically opposed rods 2a;2b have the same phase RF voltage applied to them.
• the RF voltage applied to the rods 2a, 2b creates a radial pseudo-potential well which acts to confine ions radially within the ion guide 1. Ions are not confined axially within the ion guide 1.
• a second preferred ion guide or mass filter device 6b may be provided upstream of an ion accumulation or ion storage device 20 (such as an ion trap) and preferably downstream of an ion source 11.
• the second preferred ion guide or mass filter device 6b is preferably arranged so as to reduce the total ion current entering the ion accumulation or ion storage device 20 by only selectively transmitting species of parent or precursor ions which are known or considered to be of analytical interest. This can also help to reduce space charge effects and capacity effects.
• An ion source 11 is preferably arranged to emit a beam of ions 18 which is preferably received by the second preferred ion guide or mass filter device 6b.
• the mass to charge ratio profile or transmission window of the fragment, daughter, adduct or product ions and/or unfragmented parent or precursor ions which are preferably arranged to be onwardly transmitted by the first preferred ion guide or mass filter device 6a may or may not be arranged so as to be generally or substantially synchronised with the temporal arrival of specific parent or precursor ions or other ions which preferably emerge from the ion temporal separation region or device 22 and arrive at the entrance to the collision, fragmentation or reaction device 14.
• the mass to charge ratio profile or transmission window or windows of the fragment, daughter, adduct or product ions and/or unfragmented parent or precursor ions which are transmitted by the first preferred ion guide or mass filter device 6a may therefore preferably vary or be scanned with time.

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• Chemical & Material Sciences (AREA)
• Analytical Chemistry (AREA)
• Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
• Electron Tubes For Measurement (AREA)

Priority Applications (4)

Applications Claiming Priority (4)

Publications (2)

Family

ID=33548493

Family Applications (1)

Country Status (6)

Cited By (7)

Families Citing this family (42)

Family Cites Families (20)

• 2004
  • 2004-11-18 GB GBGB0425426.4A patent/GB0425426D0/en not_active Ceased
• 2005
  • 2005-11-18 WO PCT/GB2005/004457 patent/WO2006054101A2/en not_active Ceased
  • 2005-11-18 CA CA002586519A patent/CA2586519A1/en not_active Abandoned
  • 2005-11-18 EP EP05804395A patent/EP1812950A2/en not_active Withdrawn
  • 2005-11-18 JP JP2007542101A patent/JP2008521189A/ja active Pending
  • 2005-11-18 US US11/719,665 patent/US8952320B2/en active Active
  • 2005-11-18 GB GB0523569A patent/GB2421842B/en not_active Expired - Fee Related

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