CA2586519A1 - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

Info

Publication number
CA2586519A1
CA2586519A1 CA002586519A CA2586519A CA2586519A1 CA 2586519 A1 CA2586519 A1 CA 2586519A1 CA 002586519 A CA002586519 A CA 002586519A CA 2586519 A CA2586519 A CA 2586519A CA 2586519 A1 CA2586519 A1 CA 2586519A1
Authority
CA
Canada
Prior art keywords
mass
ion
ion guide
filter device
ions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002586519A
Other languages
English (en)
French (fr)
Inventor
Robert Harold Bateman
Kevin Giles
Steven Derek Pringle
Jason Lee Wildgoose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2586519A1 publication Critical patent/CA2586519A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
    • H01J49/4215—Quadrupole mass filters
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods
    • H01J49/428—Applying a notched broadband signal

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA002586519A 2004-11-18 2005-11-18 Mass spectrometer Abandoned CA2586519A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0425426.4 2004-11-18
GBGB0425426.4A GB0425426D0 (en) 2004-11-18 2004-11-18 Mass spectrometer
US63195604P 2004-11-30 2004-11-30
US60/631,956 2004-11-30
PCT/GB2005/004457 WO2006054101A2 (en) 2004-11-18 2005-11-18 Mass spectrometer

Publications (1)

Publication Number Publication Date
CA2586519A1 true CA2586519A1 (en) 2006-05-26

Family

ID=33548493

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002586519A Abandoned CA2586519A1 (en) 2004-11-18 2005-11-18 Mass spectrometer

Country Status (6)

Country Link
US (1) US8952320B2 (enExample)
EP (1) EP1812950A2 (enExample)
JP (1) JP2008521189A (enExample)
CA (1) CA2586519A1 (enExample)
GB (2) GB0425426D0 (enExample)
WO (1) WO2006054101A2 (enExample)

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GB2432712B (en) * 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
CA2656197C (en) * 2006-07-10 2015-06-16 John Brian Hoyes Mass spectrometer
GB0622780D0 (en) * 2006-11-15 2006-12-27 Micromass Ltd Mass spectrometer
GB0701476D0 (en) * 2007-01-25 2007-03-07 Micromass Ltd Mass spectrometer
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DE102007009272B3 (de) * 2007-02-26 2008-05-15 Bruker Daltonik Gmbh Auswertung von Spektren in Schwingungs-Massenspektrometern
DE102007017055B4 (de) * 2007-04-11 2011-06-22 Bruker Daltonik GmbH, 28359 Messung der Mobilität massenselektierter Ionen
US7964843B2 (en) 2008-07-18 2011-06-21 The George Washington University Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
US8901487B2 (en) 2007-07-20 2014-12-02 George Washington University Subcellular analysis by laser ablation electrospray ionization mass spectrometry
US8067730B2 (en) 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry
US7718957B2 (en) * 2008-06-03 2010-05-18 Battelle Memorial Institute Dynamic multiplexed analysis method using ion mobility spectrometer
US20100237236A1 (en) * 2009-03-20 2010-09-23 Applera Corporation Method Of Processing Multiple Precursor Ions In A Tandem Mass Spectrometer
EP2732457A4 (en) 2011-07-14 2015-09-16 Univ George Washington EMISSION CONTROL FOR MASS SPECTROMETRY WITH LASER DISPOSAL ELECTROSPRAY IONIZATION
GB201118579D0 (en) * 2011-10-27 2011-12-07 Micromass Ltd Control of ion populations
EP2807669A2 (en) * 2012-01-24 2014-12-03 Thermo Finnigan LLC Multinotch isolation for ms3 mass analysis
GB201205009D0 (en) * 2012-03-22 2012-05-09 Micromass Ltd Multi-dimensional survey scans for improved data dependent acquisitions (DDA)
WO2013176901A1 (en) 2012-05-23 2013-11-28 President And Fellows Of Harvard College Mass spectrometry for multiplexed quantitation using multiple frequency notches
CN103515183B (zh) * 2012-06-20 2017-06-23 株式会社岛津制作所 离子导引装置和离子导引方法
EP2909618B1 (en) 2012-10-22 2021-02-17 President and Fellows of Harvard College Accurate and interference-free multiplexed quantitative proteomics using mass spectrometry
JP2016514343A (ja) * 2013-02-18 2016-05-19 マイクロマス ユーケー リミテッド 自動放出イオントラップを用いた質量分析計における気相反応物の改善された反応監視を可能にする装置
US20150380231A1 (en) * 2013-02-18 2015-12-31 Micromass Uk Limited Improved Efficiency and Precise Control of Gas Phase Reactions in Mass Spectrometers Using an Auto Ejection Ion Trap
WO2014159478A1 (en) * 2013-03-14 2014-10-02 President And Fellows Of Harvard College Adjusting precursor ion populations in mass spectrometry using dynamic isolation waveforms
GB201315145D0 (en) 2013-08-23 2013-10-09 Smiths Detection Watford Ltd Ion Modification
EP3044805A4 (en) * 2013-09-13 2017-03-15 DH Technologies Development PTE. Ltd. Rf-only detection scheme and simultaneous detection of multiple ions
WO2015056066A1 (en) 2013-10-16 2015-04-23 Dh Technologies Development Pte. Ltd. Systems and methods for identifying precursor ions from product ions using arbitrary transmission windowing
EP3066682B1 (en) * 2013-11-07 2021-03-31 DH Technologies Development PTE. Ltd. Multiplexing of ions for improved sensitivity
WO2015071648A2 (en) 2013-11-12 2015-05-21 Micromass Uk Limited Ion trap mass spectrometers
GB201319942D0 (en) * 2013-11-12 2013-12-25 Micromass Ltd Ion Trap Mass Spectrometers
WO2015118321A1 (en) 2014-02-04 2015-08-13 Micromass Uk Limited Optimized multiple reaction monitoring or single ion recording method
WO2015162415A1 (en) * 2014-04-23 2015-10-29 Micromass Uk Limited Identification and removal of chemical noise for improved ms and ms/ms analysis
CN106663590B (zh) * 2014-06-10 2019-03-26 英国质谱公司 离子引导器
US9875885B2 (en) * 2015-05-11 2018-01-23 Thermo Finnigan Llc Systems and methods for ion isolation
EP3357080B1 (en) 2015-10-01 2024-05-01 DH Technologies Development PTE. Ltd. Mass-selective axial ejection linear ion trap
US9741552B2 (en) * 2015-12-22 2017-08-22 Bruker Daltonics, Inc. Triple quadrupole mass spectrometry coupled to trapped ion mobility separation
US11085927B2 (en) 2016-06-03 2021-08-10 President And Fellows Of Harvard College Techniques for high throughput targeted proteomic analysis and related systems and methods
US10651019B2 (en) 2016-07-25 2020-05-12 Dh Technologies Development Pte. Ltd. Systems and methods for identifying precursor and product ion pairs in scanning SWATH data
JP7101195B2 (ja) 2017-02-01 2022-07-14 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド フーリエ変換質量分析計
GB2563565B (en) 2017-04-13 2022-05-11 Micromass Ltd Mass spectrometry with increased duty cycle
US11361958B2 (en) 2018-02-16 2022-06-14 Micromass Uk Limited Quadrupole devices
JP7268178B2 (ja) 2019-03-11 2023-05-02 マイクロマス ユーケー リミテッド 四重極デバイス
JP2022534468A (ja) 2019-05-31 2022-08-01 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 走査型ｓｗａｔｈデータのリアルタイムエンコーディングおよび前駆体推測のための確率的フレームワークのための方法
CN111309060A (zh) * 2020-03-27 2020-06-19 北京环拓科技有限公司 一种大气负氧离子观测仪的控制方法
EP3916755A1 (en) * 2020-05-26 2021-12-01 Thermo Finnigan LLC Methods and apparatus for high speed mass spectrometry
GB202011470D0 (en) 2020-07-24 2020-09-09 Micromass Ltd ION mobility separation
GB202306186D0 (en) * 2023-04-27 2023-06-14 Micromass Ltd Mass spectrometer having parallel precursor ion isolation

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US3334225A (en) * 1964-04-24 1967-08-01 California Inst Res Found Quadrupole mass filter with means to generate a noise spectrum exclusive of the resonant frequency of the desired ions to deflect stable ions
US5449905A (en) * 1992-05-14 1995-09-12 Teledyne Et Method for generating filtered noise signal and broadband signal having reduced dynamic range for use in mass spectrometry
US5134286A (en) * 1991-02-28 1992-07-28 Teledyne Cme Mass spectrometry method using notch filter
US5187365A (en) * 1991-02-28 1993-02-16 Teledyne Mec Mass spectrometry method using time-varying filtered noise
US5672870A (en) * 1995-12-18 1997-09-30 Hewlett Packard Company Mass selective notch filter with quadrupole excision fields
US5598001A (en) 1996-01-30 1997-01-28 Hewlett-Packard Company Mass selective multinotch filter with orthogonal excision fields
US6177668B1 (en) 1996-06-06 2001-01-23 Mds Inc. Axial ejection in a multipole mass spectrometer
US5793038A (en) * 1996-12-10 1998-08-11 Varian Associates, Inc. Method of operating an ion trap mass spectrometer
CA2287499C (en) * 1997-05-12 2006-11-07 Mds Inc. Rf-only mass spectrometer with auxiliary excitation
US6093929A (en) 1997-05-16 2000-07-25 Mds Inc. High pressure MS/MS system
GB9717926D0 (en) 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
JP4463978B2 (ja) * 1997-12-04 2010-05-19 ユニヴァーシティー オブ マニトバ 四重極イオンガイド中でイオンを選択的に衝突誘発解離する方法および装置
GB2381653A (en) * 2001-11-05 2003-05-07 Shimadzu Res Lab Europe Ltd A quadrupole ion trap device and methods of operating a quadrupole ion trap device
AU2002350343A1 (en) * 2001-12-21 2003-07-15 Mds Inc., Doing Business As Mds Sciex Use of notched broadband waveforms in a linear ion trap
US6630662B1 (en) 2002-04-24 2003-10-07 Mds Inc. Setup for mobility separation of ions implementing an ion guide with an axial field and counterflow of gas
JP4312708B2 (ja) * 2002-04-29 2009-08-12 エムディーエス インコーポレイテッド ドゥーイング ビジネス アズ エムディーエス サイエックス 衝突エネルギーを変化させることによる質量分析における広いイオンフラグメント化範囲を得る方法
JP3791455B2 (ja) * 2002-05-20 2006-06-28 株式会社島津製作所 イオントラップ型質量分析装置
US6900431B2 (en) * 2003-03-21 2005-05-31 Predicant Biosciences, Inc. Multiplexed orthogonal time-of-flight mass spectrometer
CA2574965A1 (en) * 2004-07-27 2006-02-09 John A. Mclean Multiplex data acquisition modes for ion mobility-mass spectrometry
US7456396B2 (en) * 2004-08-19 2008-11-25 Thermo Finnigan Llc Isolating ions in quadrupole ion traps for mass spectrometry

Also Published As

Publication number Publication date
US8952320B2 (en) 2015-02-10
WO2006054101A2 (en) 2006-05-26
GB2421842A (en) 2006-07-05
GB0425426D0 (en) 2004-12-22
GB0523569D0 (en) 2005-12-28
US20090194688A1 (en) 2009-08-06
EP1812950A2 (en) 2007-08-01
GB2421842B (en) 2007-08-01
JP2008521189A (ja) 2008-06-19
WO2006054101A3 (en) 2007-01-18

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20121119