WO2006054021A2 - Dispositif de distribution de produit fluide - Google Patents
Dispositif de distribution de produit fluide Download PDFInfo
- Publication number
- WO2006054021A2 WO2006054021A2 PCT/FR2005/050956 FR2005050956W WO2006054021A2 WO 2006054021 A2 WO2006054021 A2 WO 2006054021A2 FR 2005050956 W FR2005050956 W FR 2005050956W WO 2006054021 A2 WO2006054021 A2 WO 2006054021A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- piercing
- reservoir
- layer
- inhalation
- tank
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
- B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Definitions
- the present invention relates to a fluid dispenser device, and more particularly to a device for inhaling powdery product or powder.
- Powder inhalation devices are well known in the state of the art. Some of these devices comprise a common reservoir containing a plurality of doses of powder and dosing means adapted, each actuation, to take a dose of powder to be expelled to the user. Other devices provide for individual pre-dosed reservoirs, for example blisters, each of which contains a single dose of powder, each reservoir being opened individually during actuation to allow the expulsion of the product it contains.
- various solutions have been proposed to open the tank and access the contents to allow its expulsion
- predosed tanks with a peelable layer to expose the reservoir and its powder to a flow of gas, usually air for the expulsion of the dose.
- Other devices include piercing means for piercing or tearing part of the reservoir, thereby also expelling the contents thereof.
- a problem that may arise with these devices is the risk of loss of doses, partial or total, after opening the reservoir and before inhalation. This decreases the dosing accuracy and dose reproducibility (underdosing).
- Another even bigger problem is the risk of overdose. This may for example occur if, in a device having pre-dosed tanks, a reservoir is opened, but the apparatus is not used so that the contents of the reservoir are not inhaled. In this case, if the product is likely to come out of the reservoir and to be deposited in parts of the device, when the next actuation, which will cause the opening of another reservoir, the risk of overdose exists.
- the product released from the first tank can be expelled together with the full dose of the second tank.
- this overdose may be very harmful to the user.
- Another problem that arises with powder inhalation devices is the accuracy and reproducibility of the assay. Indeed, it may happen that the emptying of the reservoir or the dosing system does not always performed completely at each actuation, which causes risks of difference in dosage from one dose to another, and therefore a loss of precision and assay reproducibility.
- the present invention therefore aims to provide a fluid dispenser device that does not reproduce the aforementioned drawbacks.
- the present invention is intended in particular to provide a fluid dispenser device which ensures accurate distribution, reliable and reproducible at each actuation of the device.
- Another object of the present invention is to provide a fluid dispensing device which guarantees a distribution of the entire dose at each actuation.
- the present invention also aims to provide a fluid dispensing device which minimizes or avoids any risk of loss of dose after opening the reservoir but before inhalation, and which prohibits any risk of overdose, especially in case of opening of a pre-dosed reservoir that would not be followed by inhalation.
- the present invention also aims to provide a fluid dispenser device that prevents any risk of contamination of the product to be dispensed.
- the present invention also aims to provide a fluid dispenser device that is simple and can be expensive to manufacture and assemble.
- the subject of the present invention is therefore a device for dispensing a fluid product, comprising at least one hermetically sealed predosed reservoir containing a single dose of powdery product, an expulsion channel terminating in a mouthpiece, and an opening system.
- tank each tank having a closure layer adapted to be pierced and / or torn by said opening system to allow an expulsion of the product powder container contained in said reservoir through said expulsion channel, said reservoir opening system having at least two piercing elements actuated to create at least two distinct openings in said closure layer, forming at least one inlet passage; flow of gas, in particular air, and at least one outlet passage of the powdery product entrained by said gas flow, and in that said device comprises an inhalation triggering system creating a flow of gas in said channel expulsion only from a predetermined inhalation threshold upon inhalation of a user.
- said piercing elements are moved simultaneously.
- said piercing elements are manually moved before inhalation by the user.
- said piercing elements are movable between a rest position and a piercing position in which they penetrate into a reservoir, said piercing elements being in the piercing position during the expulsion of the dose of powdery product from the reservoir.
- each piercing element comprises an at least partially hollow piercing end, said piercing end forming part of said expulsion channel through said closure layer, in piercing position.
- said piercing end is formed by a hollow point of which a longitudinal wall portion is removed, to form a longitudinal opening on one side.
- said longitudinal opening represents between
- the longitudinal openings of said piercing ends of two piercing elements are directed away from each other, the closed sides of said piercing ends being arranged opposite one another.
- the piercing end of each piercing end is tapered.
- the peripheral dimension of the longitudinal opening increases progressively towards said end.
- each piercing element when the piercing elements are actuated, each piercing element performs a respective cut in said closure layer, said cut remaining secured to said closure layer at the open side of each piercing end.
- said piercing elements comprise a solid body.
- said triggering system by inhalation comprises a movable valve in the expulsion channel, upstream of said reservoir, said movable valve being biased towards a closed position closing said expulsion channel and moving to a position of inhalation, in which it opens said expulsion channel, allowing a flow of gas to flow towards said reservoir and said mouthpiece of the device, when the inhalation of the user reaches or exceeds said predetermined threshold.
- said movable valve closes the expulsion channel substantially tightly in the closed position.
- said device comprises a body at least partially defining said expulsion channel, said body comprising means for guiding said piercing elements.
- said support body said movable valve.
- said device comprises a plurality of predosed tanks, said device comprising transport means for, at each actuation of the device, transporting a respective pre-dosed reservoir to a dispensing position, in which it is disposed close to said expulsion channel and said opening system, allowing actuation of said opening system and inhalation of the user to effect the expulsion of a dose of powdery product.
- said plurality of predosed tanks is formed on a common support, such as an elongated strip, a disk or cylinder.
- each predosed reservoir cooperates with said expulsion channel in a substantially sealed manner.
- said device comprises a control member, such as a cover of the device, adapted to operate on the one hand the tank opening system and on the other hand said means of transport.
- a control member such as a cover of the device
- each predosed reservoir comprises a base layer comprising a cavity and a closure layer attached to the base layer to seal said cavity.
- said closure layer comprises an inner layer of product-tight material, air and moisture, such as an aluminum foil, and an outer protective layer fixed on said inner layer.
- said outer layer is made of a material having a shape memory and substantially elastic, such as an elastomeric material, so that if the piercing elements of the opening system are actuated and then returned to their rest position without that the powdery product contained in the reservoir has been expelled, the outer layer closes sealingly at the cutouts formed by said piercing elements preventing any output of powdery product from said reservoir to said expulsion channel.
- a common support comprising a common base layer provided with a plurality of cavities and a common closure layer hermetically sealing said plurality of cavities.
- the subject of the present invention is also a reservoir assembly comprising at least one hermetically sealed predosed reservoir containing a single dose of powdery product, each pre-dosed reservoir comprising a base layer forming a cavity and a closure layer attached to said base layer. to seal said cavity, said layer of closure comprising an inner layer of product-tight material, air and moisture, such as aluminum foil, and an outer protective layer attached to said inner layer.
- said outer layer is made of a material having a shape memory and substantially elastic, such as an elastomeric material, so that if said closure layer is pierced by one or more piercing element (s) with formation of cuts , and that this or these piercing element (s) are removed, said outer layer closes sealingly at said cutouts, preventing any release of powdery product out of said tank.
- a common support comprising a common base layer provided with a plurality of cavities and a common closure layer hermetically sealing said plurality of cavities.
- FIG. 1 is a diagrammatic cross-sectional view of a portion of a fluid dispensing device according to an advantageous embodiment of the present invention, prior to actuation of the tank opening system and prior to inhalation of the user;
- Figure 2 is a view similar to that of Figure 1, after actuation of said tank opening system and before inhalation of the user;
- Figure 3 is a view similar to that of Figures 1 and 2, during the inhalation of the user;
- Figure 4 is a view similar to that of Figures 1 to 3, after actuation of the tank opening system and in the absence of subsequent inhalation;
- Figure 5 is a schematic cross-sectional view of a pre-dosed reservoir as shown in Figure 4;
- Figure 6 is a top view of the reservoir of Figure 5;
- Figure 7 is a detail view of a piercing member of the device shown in Figures 1 to 4.
- the invention is more particularly applicable to powder or powder product inhalation devices, an advantageous embodiment of which will be described below. It is understood, however, that the present invention is not limited to this type of device but generally relates to any device for dispensing powdery product.
- the inhalation device of the invention comprises at least one hermetically sealed predosed reservoir containing a single dose of powdery product.
- This reservoir 10 advantageously comprises a base layer 11 forming a cavity receiving the powder.
- This base layer can be aluminum.
- a closure layer 12 is attached to said base layer 11, for example by gluing, heat sealing, welding, or any other suitable fastening means.
- This closure layer is preferably impervious to powder, air and moisture, and may include aluminum.
- Several predosed tanks may be formed on a common support, for example in the form of an elongated strip, a disk or a cylinder. In this case, the common support may comprise a common base layer 11 containing a plurality of cavities and a common closure layer 12, hermetically sealing said plurality of cavities. Other structures are also possible.
- the device further comprises an expulsion channel 20 which opens into a mouthpiece (not shown).
- a tank opening system 30 is provided to allow opening of a pre-dosed reservoir 10 upon each actuation of the
- the device when the device comprises a plurality of predosed tanks, the device further comprises transport means (not shown) which are adapted to bring a respective pre-dosed tank 10 into a tank. dispensing position at each actuation of the device to allow its opening by the tank opening system 30, and inhalation of the product it contains through the expulsion channel 20.
- transport means (not shown) which are adapted to bring a respective pre-dosed tank 10 into a tank. dispensing position at each actuation of the device to allow its opening by the tank opening system 30, and inhalation of the product it contains through the expulsion channel 20.
- the reservoir predosed 10 in dispensing position, the reservoir predosed 10 cooperates tightly with the expulsion channel 20.
- the opening system 30 comprises at least two piercing elements 31 which are actuated to create at least two distinct openings in the closure layer 12 of the pre-dosed tank 10.
- these piercing elements are moved manually and simultaneously, as shown in FIGS. 1 to 4.
- these piercing elements 31 may be movable between a rest position, represented in FIGS. 1 and 4, and a position described in FIGS. 2 and 3, said piercing elements being preferably in the piercing position at the time of expulsion of the dose of powdery product from the pre-dosed reservoir 10.
- each element piercing device 31 preferably forms part of the expulsion channel 20 at the moment of expulsion.
- the opening system 30 is actuated by means of a control member (not shown) which can be a cover or protective cover of the device.
- a control member can be a cover or protective cover of the device.
- the pre-dosed reservoir 10 cooperates with an upstream part of the expulsion channel 20 located upstream of the reservoir 10 and a downstream part of the expulsion channel. 20 disposed downstream of said reservoir.
- a flow of gas especially air, is created through said expulsion channel 20, the flow of gas flowing from the upstream part of the expulsion channel.
- This flow can then enter the interior of the pre-dosed reservoir 10 through at least one inlet opening 25 formed by at least one of the piercing elements 31.
- the flow of gas then mixes with the powder which is contained therein.
- FIG. 3 This sequence is schematically represented in FIG. 3, the arrow A1 showing the flow of gas in the upstream portion of the expulsion channel, arrow A2 showing the flow of the gas flow inside the pre-dosed tank 10, and the arrow A3 showing the flow of gas and powder moving towards the mouthpiece.
- the dispensing device also comprises an inhalation triggering system 50.
- This inhalation triggering system 50 advantageously comprises a valve 51 movable between a closed position and an inhalation position. In the closed position shown in Figures 1, 2 and 4, the movable valve 51 closes the upstream portion of the expulsion channel 20. Preferably, this closure is substantially sealed.
- the movable valve 51 is biased towards its closed position, by any means, for example gravity, or separate means, such as a spring.
- the movable valve 51 is adapted to move to its position of inhalation when the inhalation of the user reaches a predetermined threshold.
- the mobile valve 51 remains closed and no flow of gas can propagate inside the expulsion channel 20, so that the product can not to be expelled from the tank 10.
- the movable valve 51 opens, for example pivots as shown in Figure 3, which causes the creation of a flow of gas, especially air, which will cause the expulsion of the powdery product as explained above.
- the piercing elements 31 are preferably in their drilling position, into which they penetrate inside the pre-dosed tank 10, through the closure layer 12. In this position, if user agitates or moves the device, the risks of loss of powdery product are almost non-existent.
- the specific shape of the piercing elements 31 makes any output of powder virtually impossible.
- the expulsion channel has a form specifically adapted to further avoid the risk of loss of dose.
- deflectors or bent parts could be provided that would retain any loss of powder in the channel, so that during inhalation, the entire dose would be distributed.
- the invention therefore makes it possible to very greatly limit the risk of a loss of dose (underdosing) after opening the reservoir and before inhalation.
- the device comprises a body 40 which at least partially defines the expulsion channel 20.
- This body 40 may further comprise guide means 41 for the piercing elements 31 of the opening system 30.
- this body 40 also forms the support of the movable valve element 51.
- this body 40 advantageously cooperates in a sealed manner with said reservoir ensuring a reliable, total, complete and reproducible expulsion at each actuation.
- This implementation makes it possible to simplify the manufacture and assembly of the device, and therefore to reduce the cost in a significant way.
- FIG. 7 shows a detail view of a piercing element 31, it can be seen that this piercing element 31 has a solid body portion 33 and a watertight end. drilling 32 at least partially hollow. It is this piercing end 32 which forms part of the expulsion channel 20 in the piercing position. To do this, the piercing end 32 is advantageously made in the form of a hollow point of which a longitudinal wall portion is cut or removed to form a longitudinal opening 35 on one side of said end.
- the example shown in Figure 7 shows an opening 35 forming about one third of the periphery of the tip, but of course this opening could have larger or smaller dimensions than those shown.
- the longitudinal opening could be from about 20% to about 80% of the periphery of the tip.
- the peripheral dimension of the longitudinal opening 35 can also be modified at said end 39, for example gradually increase toward said end.
- the tapered portion forming the tip 39 of the piercing end 32 advantageously forms an inclined slope which allows for progressive and precise cutting as the piercing element enters the reservoir 10 through the closure layer
- a shoulder 36 may be provided at the junction between the inclined slope of the tip 39 and an edge of the longitudinal opening 35, in order to improve the tilting of the cutout 17, 18 formed by the element of FIG. drilling
- FIG. 6 schematically shows a top view of the closure layer 12, and shows the two cutouts 17, 18 formed by the two piercing elements 31. It can be seen that these cutouts 17, 18 remain attached to each other. of the closure layer 12 at the open side 35 of each piercing element 31.
- the piercing elements 31 are identical, but differences could also be envisaged between the piercing element (s) forming the one or more inlet passage (s) 25, and the piercing element (s) forming the outlet passage (s) 26, for example at certain dimensions.
- the open sides 35 of the two piercing elements 31 are arranged at a distance from one another, which means that the closed sides of these piercing ends 32 face each other.
- the piercing end 32 extends along the piercing element 31 over a distance such that, in the piercing position (shown in FIG. 2), the edge of the piercing end 32 opposite the end
- the predosed reservoir 10 may comprise a closure layer 12 of complex structure.
- the reservoir 10 may be formed by a base layer 11, for example made of aluminum, and which comprises the cavity (s) containing the powder.
- the closure layer 12 then comprises an inner layer 15 made of a product-tight material with air and moisture, preferably aluminum. This inner layer 15 is fixed on the base layer 11 in any manner appropriate to seal the cavity (s).
- the closure layer further comprises an outer layer 16 attached to said inner layer 15, also in any suitable manner.
- This outer layer 16 is a protective layer which is preferably made of a relatively flexible material and having a shape memory, such as an elastomeric material.
- the advantage of this structure is that when the opening system is actuated and the piercing elements 31 pierce the closure layer 12, passages are created between the expulsion channel 20 and the inside of the tank 10. If the user returns the opening system 30 to the rest position, that is to say bring out the piercing elements 31 out of the tank 10 to bring them back to their respective rest positions, the outer protection layer 16 closes tightly to prevent loss of product from the tank. This can happen, for example, if the user opens the inhaler hood and closes it without inhaling.
- the outer protective layer 16 closes by its elasticity thus closing the reservoir 10, preferably sealingly at least one powdery product. This is particularly advantageously to avoid the risks of overdose. Indeed, in the absence of external protective layer, in the event that the user opens the tank and then brings out the opening system without inhaling, a potential risk may exist only powder contained in the open tank flows into the expulsion channel, this powder being then dispensed at the next actuation together with the full dose of the next pre-dosed reservoir. This overdose, in the case of pharmaceutical product, can be highly detrimental, and the invention makes it possible effectively and at low cost to avoid this risk. Of course, the presence of the outer protective layer 16 also avoids any risk of loss of dose or underdosing particularly effectively.
- this particular closure layer structure 12 could be implemented independently of the inhalation device described above, and in particular independently of the inhalation triggering system 50.
- such an external protective layer could also be effective with systems having any number of piercing elements, namely one or more.
- the invention has been described with reference to a particular embodiment thereof, it is not limited to the examples shown. Thus, the shape of the tank can be any. Likewise, the materials described are only given as examples, and other materials are conceivable.
- the invention has been described with reference to the use of two piercing elements 31. It is understood that three or more of such piercing elements could be used in the context of the present invention.
- piercing elements are not necessarily identical and the piercing element forming the outlet opening of the reservoir could have different dimensions, notably larger than the forming the entrance opening.
- the structure of the triggering system by inhalation can be arbitrary, the shape of the valve 51 is not limiting.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/667,853 US8739783B2 (en) | 2004-11-16 | 2005-11-16 | Fluid product dispensing device |
JP2007540696A JP4890460B2 (ja) | 2004-11-16 | 2005-11-16 | 流体投与装置 |
EP05819153.7A EP1814619B1 (fr) | 2004-11-16 | 2005-11-16 | Dispositif de distribution de produit fluide |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0452641A FR2877925B1 (fr) | 2004-11-16 | 2004-11-16 | Dispositif de distribution de produit fluide. |
FR0452641 | 2004-11-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006054021A2 true WO2006054021A2 (fr) | 2006-05-26 |
WO2006054021A3 WO2006054021A3 (fr) | 2006-09-21 |
Family
ID=34954142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2005/050956 WO2006054021A2 (fr) | 2004-11-16 | 2005-11-16 | Dispositif de distribution de produit fluide |
Country Status (6)
Country | Link |
---|---|
US (1) | US8739783B2 (fr) |
EP (2) | EP1814619B1 (fr) |
JP (1) | JP4890460B2 (fr) |
CN (1) | CN100584404C (fr) |
FR (1) | FR2877925B1 (fr) |
WO (1) | WO2006054021A2 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008051621A2 (fr) * | 2006-10-25 | 2008-05-02 | Novartis Ag | Appareil de dispersion de poudre, procédé de fabrication et d'utilisation de l'appareil et composant pouvant être utilisé sur l'appareil et d'autres dispositifs |
WO2009117112A2 (fr) * | 2008-03-21 | 2009-09-24 | Novartis Ag | Appareil de dispersion de poudre, procédé de fabrication et d’utilisation de l’appareil, composants pouvant être utilisés sur l’appareil et d’autres dispositifs, et divers agents actifs |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8869794B1 (en) | 2003-04-09 | 2014-10-28 | Novartis Pharma Ag | Aerosolization apparatus with capsule puncturing member |
FR2909642B1 (fr) * | 2006-12-11 | 2009-02-20 | Valois Sas | Dispositif de distribution de produit fluide |
ES2394589T3 (es) | 2007-12-14 | 2013-02-04 | Aerodesigns, Inc | Suministro de productos alimenticios transformables en aerosol |
EP2198907A1 (fr) * | 2008-12-19 | 2010-06-23 | Boehringer Ingelheim International GmbH | Inhalateur |
WO2012012827A1 (fr) * | 2010-07-28 | 2012-02-02 | Advent Pharmaceuticals Pty Ltd | Inhalateur |
US20170128679A1 (en) * | 2014-06-27 | 2017-05-11 | Sergio BELFORTI | A powder inhaler device |
WO2016168274A1 (fr) * | 2015-04-15 | 2016-10-20 | Sansa Corporation (Barbados) Inc. | Inhalateur de poudre sèche et procédé d'utilisation |
DE102016119789A1 (de) * | 2016-07-04 | 2018-01-04 | Alfred Von Schuckmann | Vorrichtung zur Ausgabe einer durch Luft austragbaren Substanz |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993015972A1 (fr) * | 1992-02-13 | 1993-08-19 | Tecnilens S.R.L. | Emballage multiple pour produits pharmaceutiques |
US5492112A (en) * | 1991-05-20 | 1996-02-20 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
EP0796628A2 (fr) * | 1996-03-21 | 1997-09-24 | Unisia Jecs Corporation | Inhalateur |
DE19805336A1 (de) * | 1998-02-11 | 1999-08-12 | Alfred Von Schuckmann | Verfahren zum Tiefziehen von Kavitäten in dünne Metallfolien |
GB2340758A (en) * | 1998-08-21 | 2000-03-01 | Bespak Plc | Drug dispensing system |
EP1106196A2 (fr) * | 1999-12-10 | 2001-06-13 | Unisia Jecs Corporation | Inhalateur de médicaments |
WO2004011070A1 (fr) * | 2002-07-25 | 2004-02-05 | Glaxo Group Limited | Appareil servant a administrer des medicaments |
WO2004041672A2 (fr) * | 2002-11-02 | 2004-05-21 | Glaxo Group Limited | Support de medicament pour inhalation sous forme de plaquette alveolaire |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9409852D0 (en) * | 1994-05-17 | 1994-07-06 | Cambridge Consultants | Device for administering single doses of a medicament |
US6209538B1 (en) * | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
JP3533023B2 (ja) * | 1995-12-11 | 2004-05-31 | 積水化学工業株式会社 | 血液検査容器 |
JPH09262295A (ja) * | 1996-03-29 | 1997-10-07 | Maeda Sangyo Kk | 粉末状薬剤吸入装置 |
US6606992B1 (en) * | 1999-06-30 | 2003-08-19 | Nektar Therapeutics | Systems and methods for aerosolizing pharmaceutical formulations |
US6948494B1 (en) * | 2000-05-10 | 2005-09-27 | Innovative Devices, Llc. | Medicament container with same side airflow inlet and outlet and method of use |
GB0015043D0 (en) * | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Medicament dispenser |
EG24184A (en) * | 2001-06-15 | 2008-10-08 | Otsuka Pharma Co Ltd | Dry powder inhalation system for transpulmonary |
JP2006504446A (ja) * | 2002-03-26 | 2006-02-09 | グラクソ グループ リミテッド | ラミネート・アセンブリーの形成方法、およびそれにより形成される製品 |
-
2004
- 2004-11-16 FR FR0452641A patent/FR2877925B1/fr active Active
-
2005
- 2005-11-16 EP EP05819153.7A patent/EP1814619B1/fr active Active
- 2005-11-16 JP JP2007540696A patent/JP4890460B2/ja not_active Expired - Fee Related
- 2005-11-16 US US11/667,853 patent/US8739783B2/en not_active Expired - Fee Related
- 2005-11-16 WO PCT/FR2005/050956 patent/WO2006054021A2/fr active Application Filing
- 2005-11-16 CN CN200580045495A patent/CN100584404C/zh not_active Expired - Fee Related
- 2005-11-16 EP EP15173970.3A patent/EP2949599B1/fr active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5492112A (en) * | 1991-05-20 | 1996-02-20 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
WO1993015972A1 (fr) * | 1992-02-13 | 1993-08-19 | Tecnilens S.R.L. | Emballage multiple pour produits pharmaceutiques |
EP0796628A2 (fr) * | 1996-03-21 | 1997-09-24 | Unisia Jecs Corporation | Inhalateur |
DE19805336A1 (de) * | 1998-02-11 | 1999-08-12 | Alfred Von Schuckmann | Verfahren zum Tiefziehen von Kavitäten in dünne Metallfolien |
GB2340758A (en) * | 1998-08-21 | 2000-03-01 | Bespak Plc | Drug dispensing system |
EP1106196A2 (fr) * | 1999-12-10 | 2001-06-13 | Unisia Jecs Corporation | Inhalateur de médicaments |
WO2004011070A1 (fr) * | 2002-07-25 | 2004-02-05 | Glaxo Group Limited | Appareil servant a administrer des medicaments |
WO2004041672A2 (fr) * | 2002-11-02 | 2004-05-21 | Glaxo Group Limited | Support de medicament pour inhalation sous forme de plaquette alveolaire |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008051621A2 (fr) * | 2006-10-25 | 2008-05-02 | Novartis Ag | Appareil de dispersion de poudre, procédé de fabrication et d'utilisation de l'appareil et composant pouvant être utilisé sur l'appareil et d'autres dispositifs |
WO2008051621A3 (fr) * | 2006-10-25 | 2008-11-13 | Nektar Therapeutics | Appareil de dispersion de poudre, procédé de fabrication et d'utilisation de l'appareil et composant pouvant être utilisé sur l'appareil et d'autres dispositifs |
AU2007309412B2 (en) * | 2006-10-25 | 2011-10-20 | Novartis Ag | Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices |
RU2463085C2 (ru) * | 2006-10-25 | 2012-10-10 | Новартис Аг | Аппарат для распыления порошка, способ его изготовления и применения и его компоненты |
US8573197B2 (en) | 2006-10-25 | 2013-11-05 | Novartis Ag | Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices |
US10245394B2 (en) | 2006-10-25 | 2019-04-02 | Mark Glusker | Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices |
WO2009117112A2 (fr) * | 2008-03-21 | 2009-09-24 | Novartis Ag | Appareil de dispersion de poudre, procédé de fabrication et d’utilisation de l’appareil, composants pouvant être utilisés sur l’appareil et d’autres dispositifs, et divers agents actifs |
WO2009117112A3 (fr) * | 2008-03-21 | 2010-04-22 | Novartis Ag | Appareil de dispersion de poudre, procédé de fabrication et d’utilisation de l’appareil, composants pouvant être utilisés sur l’appareil et d’autres dispositifs, et divers agents actifs |
Also Published As
Publication number | Publication date |
---|---|
CN101094705A (zh) | 2007-12-26 |
EP1814619B1 (fr) | 2016-08-17 |
JP4890460B2 (ja) | 2012-03-07 |
US8739783B2 (en) | 2014-06-03 |
EP2949599A1 (fr) | 2015-12-02 |
FR2877925A1 (fr) | 2006-05-19 |
FR2877925B1 (fr) | 2008-09-19 |
CN100584404C (zh) | 2010-01-27 |
EP1814619A2 (fr) | 2007-08-08 |
JP2008520262A (ja) | 2008-06-19 |
US20070295333A1 (en) | 2007-12-27 |
WO2006054021A3 (fr) | 2006-09-21 |
EP2949599B1 (fr) | 2017-03-29 |
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