WO2006032384A1 - Neue pyrimidin-derivate und ihre verwendung als ppar-alpha-modulatoren - Google Patents
Neue pyrimidin-derivate und ihre verwendung als ppar-alpha-modulatoren Download PDFInfo
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- WO2006032384A1 WO2006032384A1 PCT/EP2005/009734 EP2005009734W WO2006032384A1 WO 2006032384 A1 WO2006032384 A1 WO 2006032384A1 EP 2005009734 W EP2005009734 W EP 2005009734W WO 2006032384 A1 WO2006032384 A1 WO 2006032384A1
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- formula
- compound
- phenyl
- mmol
- alkyl
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- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract description 4
- 150000003230 pyrimidines Chemical class 0.000 title abstract description 3
- 238000000034 method Methods 0.000 claims abstract description 129
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 13
- 201000010099 disease Diseases 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 claims abstract description 8
- 208000032928 Dyslipidaemia Diseases 0.000 claims abstract description 6
- 208000001145 Metabolic Syndrome Diseases 0.000 claims abstract description 6
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims abstract description 6
- 206010003210 Arteriosclerosis Diseases 0.000 claims abstract description 5
- 208000007536 Thrombosis Diseases 0.000 claims abstract description 5
- 208000011775 arteriosclerosis disease Diseases 0.000 claims abstract description 5
- 208000017170 Lipid metabolism disease Diseases 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims description 329
- 239000002904 solvent Substances 0.000 claims description 107
- -1 trifluoromethoxy, amino Chemical group 0.000 claims description 98
- 239000001257 hydrogen Substances 0.000 claims description 50
- 229910052739 hydrogen Inorganic materials 0.000 claims description 50
- 239000003112 inhibitor Substances 0.000 claims description 42
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 42
- 150000003839 salts Chemical class 0.000 claims description 42
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 38
- 239000012453 solvate Substances 0.000 claims description 35
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 29
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 28
- 125000004432 carbon atom Chemical group C* 0.000 claims description 28
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 28
- 229910052736 halogen Inorganic materials 0.000 claims description 25
- 150000002367 halogens Chemical class 0.000 claims description 25
- 239000012442 inert solvent Substances 0.000 claims description 24
- 238000011282 treatment Methods 0.000 claims description 23
- 239000000126 substance Substances 0.000 claims description 22
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
- 125000000999 tert-butyl group Chemical class [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 16
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
- 239000000018 receptor agonist Substances 0.000 claims description 13
- 229940044601 receptor agonist Drugs 0.000 claims description 13
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 12
- 230000015572 biosynthetic process Effects 0.000 claims description 12
- 229910052763 palladium Inorganic materials 0.000 claims description 12
- 150000002431 hydrogen Chemical class 0.000 claims description 11
- 238000003786 synthesis reaction Methods 0.000 claims description 11
- 241001465754 Metazoa Species 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 239000003054 catalyst Substances 0.000 claims description 9
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical class [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 239000000556 agonist Substances 0.000 claims description 8
- 239000003146 anticoagulant agent Substances 0.000 claims description 8
- 239000003613 bile acid Substances 0.000 claims description 8
- 239000000460 chlorine Chemical class 0.000 claims description 8
- 229910052801 chlorine Inorganic materials 0.000 claims description 8
- 229910052731 fluorine Inorganic materials 0.000 claims description 8
- 239000011737 fluorine Substances 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- 230000002265 prevention Effects 0.000 claims description 8
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 claims description 7
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- 150000001735 carboxylic acids Chemical class 0.000 claims description 7
- 238000011321 prophylaxis Methods 0.000 claims description 7
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 6
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 6
- 206010019280 Heart failures Diseases 0.000 claims description 6
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims description 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 5
- 239000005541 ACE inhibitor Substances 0.000 claims description 5
- 229940127291 Calcium channel antagonist Drugs 0.000 claims description 5
- 229910021595 Copper(I) iodide Inorganic materials 0.000 claims description 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 5
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims description 5
- 150000007513 acids Chemical class 0.000 claims description 5
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 5
- 229940127218 antiplatelet drug Drugs 0.000 claims description 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
- 239000002876 beta blocker Substances 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 claims description 5
- LSXDOTMGLUJQCM-UHFFFAOYSA-M copper(i) iodide Chemical compound I[Cu] LSXDOTMGLUJQCM-UHFFFAOYSA-M 0.000 claims description 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 5
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 5
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- 229940031439 squalene Drugs 0.000 claims description 5
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims description 5
- 229940127470 Lipase Inhibitors Drugs 0.000 claims description 4
- 108700010041 Nicotinic acid receptor Proteins 0.000 claims description 4
- 108010016731 PPAR gamma Proteins 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 229940127219 anticoagulant drug Drugs 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 230000001906 cholesterol absorption Effects 0.000 claims description 4
- 230000032050 esterification Effects 0.000 claims description 4
- 238000005886 esterification reaction Methods 0.000 claims description 4
- 125000002541 furyl group Chemical group 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- 125000002883 imidazolyl group Chemical group 0.000 claims description 4
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 4
- 125000000956 methoxy group Chemical class [H]C([H])([H])O* 0.000 claims description 4
- 125000001715 oxadiazolyl group Chemical group 0.000 claims description 4
- 125000002971 oxazolyl group Chemical group 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 125000004076 pyridyl group Chemical group 0.000 claims description 4
- 102000005962 receptors Human genes 0.000 claims description 4
- 108020003175 receptors Proteins 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 125000001113 thiadiazolyl group Chemical group 0.000 claims description 4
- 125000000335 thiazolyl group Chemical group 0.000 claims description 4
- 125000001544 thienyl group Chemical group 0.000 claims description 4
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 4
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 3
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 3
- 108090000854 Oxidoreductases Proteins 0.000 claims description 3
- 102000004316 Oxidoreductases Human genes 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 230000009435 amidation Effects 0.000 claims description 3
- 238000007112 amidation reaction Methods 0.000 claims description 3
- 230000003178 anti-diabetic effect Effects 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 125000001449 isopropyl group Chemical class [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 230000000019 pro-fibrinolytic effect Effects 0.000 claims description 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 2
- 125000004487 4-tetrahydropyranyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims description 2
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 claims description 2
- 238000005903 acid hydrolysis reaction Methods 0.000 claims description 2
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- 239000000824 cytostatic agent Substances 0.000 claims description 2
- 206010061428 decreased appetite Diseases 0.000 claims description 2
- XMSZANIMCDLNKA-UHFFFAOYSA-N methyl hypofluorite Chemical compound COF XMSZANIMCDLNKA-UHFFFAOYSA-N 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 210000001685 thyroid gland Anatomy 0.000 claims description 2
- 239000005495 thyroid hormone Substances 0.000 claims description 2
- 229940036555 thyroid hormone Drugs 0.000 claims description 2
- SMBZJSVIKJMSFP-UHFFFAOYSA-N trifluoromethyl hypofluorite Chemical compound FOC(F)(F)F SMBZJSVIKJMSFP-UHFFFAOYSA-N 0.000 claims description 2
- 150000002221 fluorine Chemical class 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 1
- 102100038824 Peroxisome proliferator-activated receptor delta Human genes 0.000 claims 1
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- 108091008765 peroxisome proliferator-activated receptors β/δ Proteins 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 231
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 153
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 126
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 104
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 54
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- 235000019253 formic acid Nutrition 0.000 description 52
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- 235000011152 sodium sulphate Nutrition 0.000 description 49
- 239000000203 mixture Substances 0.000 description 46
- 238000002953 preparative HPLC Methods 0.000 description 40
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- 229910000041 hydrogen chloride Inorganic materials 0.000 description 31
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 30
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 28
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- 235000011181 potassium carbonates Nutrition 0.000 description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 21
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- 239000002585 base Substances 0.000 description 19
- 238000002360 preparation method Methods 0.000 description 19
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 18
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- 238000000605 extraction Methods 0.000 description 12
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- 238000006243 chemical reaction Methods 0.000 description 11
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2007003428A MX2007003428A (es) | 2004-09-25 | 2005-09-10 | Nuevos derivados de pirimidina y su uso como moduladores del ppar-alfa. |
EP05782757A EP1797045A1 (de) | 2004-09-25 | 2005-09-10 | Neue pyrimidin-derivate und ihre verwendung als ppar-alpha-modulatoren |
CA002582492A CA2582492A1 (en) | 2004-09-25 | 2005-09-10 | Novel pyrimidine derivatives and their use |
BRPI0517327-2A BRPI0517327A (pt) | 2004-09-25 | 2005-09-10 | derivados de pirimidina e seu uso como moduladores ppar-alfa |
US11/663,813 US20080261990A1 (en) | 2004-09-25 | 2005-09-10 | Novel Pyrimidine Derivatives and their Use |
AU2005287589A AU2005287589A1 (en) | 2004-09-25 | 2005-09-10 | Novel pyrimidine derivatives and their use as PPAR-alpha modulators |
JP2007532798A JP2008514559A (ja) | 2004-09-25 | 2005-09-10 | 新規ピリミジン誘導体およびそれらの使用 |
IL182136A IL182136A0 (en) | 2004-09-25 | 2007-03-22 | Novel pyrimidine derivatives and their use as ppar-alpha modulators |
NO20072051A NO20072051L (no) | 2004-09-25 | 2007-04-20 | Nye pyrimidinderivater og deres anvendelse som PPAR-alfa modulatorar |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004046623.8 | 2004-09-25 | ||
DE102004046623A DE102004046623A1 (de) | 2004-09-25 | 2004-09-25 | Neue Pyrimidin-Derivate und ihre Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006032384A1 true WO2006032384A1 (de) | 2006-03-30 |
Family
ID=35063041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/009734 WO2006032384A1 (de) | 2004-09-25 | 2005-09-10 | Neue pyrimidin-derivate und ihre verwendung als ppar-alpha-modulatoren |
Country Status (22)
Country | Link |
---|---|
US (1) | US20080261990A1 (de) |
EP (1) | EP1797045A1 (de) |
JP (1) | JP2008514559A (de) |
KR (1) | KR20070055621A (de) |
CN (1) | CN101065364A (de) |
AR (1) | AR051295A1 (de) |
AU (1) | AU2005287589A1 (de) |
BR (1) | BRPI0517327A (de) |
CA (1) | CA2582492A1 (de) |
DE (1) | DE102004046623A1 (de) |
EC (1) | ECSP077340A (de) |
GT (1) | GT200500266A (de) |
IL (1) | IL182136A0 (de) |
MA (1) | MA28882B1 (de) |
MX (1) | MX2007003428A (de) |
NO (1) | NO20072051L (de) |
PE (1) | PE20060657A1 (de) |
RU (1) | RU2007115215A (de) |
SV (1) | SV2007002235A (de) |
TW (1) | TW200628451A (de) |
UY (1) | UY29127A1 (de) |
WO (1) | WO2006032384A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008127682A3 (en) * | 2007-04-13 | 2009-05-07 | Millennium Pharm Inc | Combination anticoagulant therapy with a compound that acts as a factor xa inhibitor |
WO2012030165A2 (ko) | 2010-08-31 | 2012-03-08 | 서울대학교산학협력단 | P P A R δ 활성물질의 태자재프로그래밍용도 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100813387B1 (ko) * | 2007-06-26 | 2008-03-12 | 신명곤 | 부형제 첨가없이 인삼농축액으로 유동성 및 저장성이우수한 인삼농축액환 제조 방법 |
EP2575821B1 (de) | 2010-05-26 | 2015-08-12 | Satiogen Pharmaceuticals, Inc. | Gallensäurerückflusshemmer und satiogene zur behandlung von diabetes, adipositas und entzündlichen magen-darm-erkrankungen |
CN107375932B (zh) | 2011-10-28 | 2021-12-21 | 夏尔人类遗传性治疗公司 | 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂 |
EA029581B1 (ru) | 2011-10-28 | 2018-04-30 | ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи | Применение ингибиторов рециркуляции желчных кислот для лечения холестатического заболевания печени или прурита |
CN103130732A (zh) * | 2011-11-22 | 2013-06-05 | 上海博康精细化工有限公司 | 3,5-二甲基-4-氯甲基异噁唑的制备方法 |
EP2968262A1 (de) | 2013-03-15 | 2016-01-20 | Lumena Pharmaceuticals, Inc. | Gallensäurerückflusshemmer zur behandlung von barrett-ösophagus und gastroösophagealem reflux |
CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
WO2017190050A1 (en) * | 2016-04-28 | 2017-11-02 | Cornell University | Inhibitors of soluble adenylyl cyclase |
MX2021009622A (es) | 2019-02-12 | 2021-11-04 | Mirum Pharmaceuticals Inc | Metodos para tratar la colestasis. |
CN115598267B (zh) * | 2022-12-13 | 2023-05-09 | 山东省食品药品检验研究院 | 一种格列齐特中潜在遗传毒性杂质的分析方法 |
Citations (2)
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---|---|---|---|---|
WO2000064888A1 (en) * | 1999-04-28 | 2000-11-02 | Aventis Pharma Deutschland Gmbh | Di-aryl acid derivatives as ppar receptor ligands |
WO2004000762A2 (en) * | 2002-06-20 | 2003-12-31 | Smithkline Beecham Corporation | Propionic acid derivatives and their use as hppars activators |
-
2004
- 2004-09-25 DE DE102004046623A patent/DE102004046623A1/de not_active Withdrawn
-
2005
- 2005-09-10 BR BRPI0517327-2A patent/BRPI0517327A/pt not_active Application Discontinuation
- 2005-09-10 AU AU2005287589A patent/AU2005287589A1/en not_active Abandoned
- 2005-09-10 RU RU2007115215/04A patent/RU2007115215A/ru not_active Application Discontinuation
- 2005-09-10 EP EP05782757A patent/EP1797045A1/de not_active Withdrawn
- 2005-09-10 JP JP2007532798A patent/JP2008514559A/ja active Pending
- 2005-09-10 CA CA002582492A patent/CA2582492A1/en not_active Abandoned
- 2005-09-10 WO PCT/EP2005/009734 patent/WO2006032384A1/de active Application Filing
- 2005-09-10 CN CNA2005800404273A patent/CN101065364A/zh active Pending
- 2005-09-10 US US11/663,813 patent/US20080261990A1/en not_active Abandoned
- 2005-09-10 MX MX2007003428A patent/MX2007003428A/es not_active Application Discontinuation
- 2005-09-10 KR KR1020077009268A patent/KR20070055621A/ko not_active Application Discontinuation
- 2005-09-20 AR ARP050103930A patent/AR051295A1/es unknown
- 2005-09-23 SV SV2005002235A patent/SV2007002235A/es not_active Application Discontinuation
- 2005-09-23 GT GT200500266A patent/GT200500266A/es unknown
- 2005-09-23 UY UY29127A patent/UY29127A1/es not_active Application Discontinuation
- 2005-09-23 PE PE2005001101A patent/PE20060657A1/es not_active Application Discontinuation
- 2005-09-23 TW TW094132926A patent/TW200628451A/zh unknown
-
2007
- 2007-03-22 IL IL182136A patent/IL182136A0/en unknown
- 2007-03-23 EC EC2007007340A patent/ECSP077340A/es unknown
- 2007-03-30 MA MA29787A patent/MA28882B1/fr unknown
- 2007-04-20 NO NO20072051A patent/NO20072051L/no not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000064888A1 (en) * | 1999-04-28 | 2000-11-02 | Aventis Pharma Deutschland Gmbh | Di-aryl acid derivatives as ppar receptor ligands |
WO2004000762A2 (en) * | 2002-06-20 | 2003-12-31 | Smithkline Beecham Corporation | Propionic acid derivatives and their use as hppars activators |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008127682A3 (en) * | 2007-04-13 | 2009-05-07 | Millennium Pharm Inc | Combination anticoagulant therapy with a compound that acts as a factor xa inhibitor |
JP2010523679A (ja) * | 2007-04-13 | 2010-07-15 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 第Xa因子阻害薬として作用する化合物との併用抗凝固療法 |
EP2591783A1 (de) * | 2007-04-13 | 2013-05-15 | Millennium Pharmaceuticals, Inc. | Gerinnungshemmende Kombinationstherapie mit einer Verbindung als Faktor-Xa-Hemmer |
US8455440B2 (en) | 2007-04-13 | 2013-06-04 | Millennium Pharmaceuticals, Inc. | Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor |
EA020531B1 (ru) * | 2007-04-13 | 2014-11-28 | Милленниум Фармасьютикалз, Инк. | КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИКОАГУЛИРУЮЩЕГО СРЕДСТВА С СОЕДИНЕНИЕМ, КОТОРОЕ ДЕЙСТВУЕТ КАК ИНГИБИТОР ФАКТОРА Ха |
WO2012030165A2 (ko) | 2010-08-31 | 2012-03-08 | 서울대학교산학협력단 | P P A R δ 활성물질의 태자재프로그래밍용도 |
Also Published As
Publication number | Publication date |
---|---|
CA2582492A1 (en) | 2006-03-30 |
SV2007002235A (es) | 2007-03-20 |
BRPI0517327A (pt) | 2008-10-07 |
US20080261990A1 (en) | 2008-10-23 |
MX2007003428A (es) | 2008-03-13 |
AR051295A1 (es) | 2007-01-03 |
EP1797045A1 (de) | 2007-06-20 |
MA28882B1 (fr) | 2007-09-03 |
ECSP077340A (es) | 2007-04-26 |
PE20060657A1 (es) | 2006-08-12 |
GT200500266A (es) | 2006-05-11 |
RU2007115215A (ru) | 2008-11-10 |
UY29127A1 (es) | 2006-04-28 |
NO20072051L (no) | 2007-06-07 |
TW200628451A (en) | 2006-08-16 |
KR20070055621A (ko) | 2007-05-30 |
AU2005287589A1 (en) | 2006-03-30 |
JP2008514559A (ja) | 2008-05-08 |
IL182136A0 (en) | 2007-07-24 |
CN101065364A (zh) | 2007-10-31 |
DE102004046623A1 (de) | 2006-03-30 |
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