MX2007003428A - Nuevos derivados de pirimidina y su uso como moduladores del ppar-alfa. - Google Patents
Nuevos derivados de pirimidina y su uso como moduladores del ppar-alfa.Info
- Publication number
- MX2007003428A MX2007003428A MX2007003428A MX2007003428A MX2007003428A MX 2007003428 A MX2007003428 A MX 2007003428A MX 2007003428 A MX2007003428 A MX 2007003428A MX 2007003428 A MX2007003428 A MX 2007003428A MX 2007003428 A MX2007003428 A MX 2007003428A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrimidine derivatives
- ppar
- novel pyrimidine
- treating
- alpha modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La presente invencion se refiere a nuevos derivados de pirimidina, a procedimientos para su preparacion, a su uso para el tratamiento y/o la profilaxis de enfermedades, asi como a su uso para la preparacion de medicamentos para el tratamiento y/o la profilaxis de enfermedades, preferentemente para el tratamiento y/o la prevencion de enfermedades cardiovasculares, en particular, dislipidemias, arteriosclerosis, insuficiencia cardiaca, trombosis y sindrome metabolico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004046623A DE102004046623A1 (de) | 2004-09-25 | 2004-09-25 | Neue Pyrimidin-Derivate und ihre Verwendung |
PCT/EP2005/009734 WO2006032384A1 (de) | 2004-09-25 | 2005-09-10 | Neue pyrimidin-derivate und ihre verwendung als ppar-alpha-modulatoren |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007003428A true MX2007003428A (es) | 2008-03-13 |
Family
ID=35063041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007003428A MX2007003428A (es) | 2004-09-25 | 2005-09-10 | Nuevos derivados de pirimidina y su uso como moduladores del ppar-alfa. |
Country Status (22)
Country | Link |
---|---|
US (1) | US20080261990A1 (es) |
EP (1) | EP1797045A1 (es) |
JP (1) | JP2008514559A (es) |
KR (1) | KR20070055621A (es) |
CN (1) | CN101065364A (es) |
AR (1) | AR051295A1 (es) |
AU (1) | AU2005287589A1 (es) |
BR (1) | BRPI0517327A (es) |
CA (1) | CA2582492A1 (es) |
DE (1) | DE102004046623A1 (es) |
EC (1) | ECSP077340A (es) |
GT (1) | GT200500266A (es) |
IL (1) | IL182136A0 (es) |
MA (1) | MA28882B1 (es) |
MX (1) | MX2007003428A (es) |
NO (1) | NO20072051L (es) |
PE (1) | PE20060657A1 (es) |
RU (1) | RU2007115215A (es) |
SV (1) | SV2007002235A (es) |
TW (1) | TW200628451A (es) |
UY (1) | UY29127A1 (es) |
WO (1) | WO2006032384A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2591783A1 (en) * | 2007-04-13 | 2013-05-15 | Millennium Pharmaceuticals, Inc. | Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor |
KR100813387B1 (ko) * | 2007-06-26 | 2008-03-12 | 신명곤 | 부형제 첨가없이 인삼농축액으로 유동성 및 저장성이우수한 인삼농축액환 제조 방법 |
EP2575821B1 (en) | 2010-05-26 | 2015-08-12 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
KR101898610B1 (ko) | 2010-08-31 | 2018-09-14 | 서울대학교산학협력단 | PPARδ 활성물질의 태자 재프로그래밍 용도 |
CN107375932B (zh) | 2011-10-28 | 2021-12-21 | 夏尔人类遗传性治疗公司 | 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂 |
EA029581B1 (ru) | 2011-10-28 | 2018-04-30 | ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи | Применение ингибиторов рециркуляции желчных кислот для лечения холестатического заболевания печени или прурита |
CN103130732A (zh) * | 2011-11-22 | 2013-06-05 | 上海博康精细化工有限公司 | 3,5-二甲基-4-氯甲基异噁唑的制备方法 |
EP2968262A1 (en) | 2013-03-15 | 2016-01-20 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
WO2017190050A1 (en) * | 2016-04-28 | 2017-11-02 | Cornell University | Inhibitors of soluble adenylyl cyclase |
MX2021009622A (es) | 2019-02-12 | 2021-11-04 | Mirum Pharmaceuticals Inc | Metodos para tratar la colestasis. |
CN115598267B (zh) * | 2022-12-13 | 2023-05-09 | 山东省食品药品检验研究院 | 一种格列齐特中潜在遗传毒性杂质的分析方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1177187B1 (en) * | 1999-04-28 | 2007-07-25 | Sanofi-Aventis Deutschland GmbH | Di-aryl acid derivatives as ppar receptor ligands |
GB0214254D0 (en) * | 2002-06-20 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
-
2004
- 2004-09-25 DE DE102004046623A patent/DE102004046623A1/de not_active Withdrawn
-
2005
- 2005-09-10 BR BRPI0517327-2A patent/BRPI0517327A/pt not_active Application Discontinuation
- 2005-09-10 AU AU2005287589A patent/AU2005287589A1/en not_active Abandoned
- 2005-09-10 RU RU2007115215/04A patent/RU2007115215A/ru not_active Application Discontinuation
- 2005-09-10 EP EP05782757A patent/EP1797045A1/de not_active Withdrawn
- 2005-09-10 JP JP2007532798A patent/JP2008514559A/ja active Pending
- 2005-09-10 CA CA002582492A patent/CA2582492A1/en not_active Abandoned
- 2005-09-10 WO PCT/EP2005/009734 patent/WO2006032384A1/de active Application Filing
- 2005-09-10 CN CNA2005800404273A patent/CN101065364A/zh active Pending
- 2005-09-10 US US11/663,813 patent/US20080261990A1/en not_active Abandoned
- 2005-09-10 MX MX2007003428A patent/MX2007003428A/es not_active Application Discontinuation
- 2005-09-10 KR KR1020077009268A patent/KR20070055621A/ko not_active Application Discontinuation
- 2005-09-20 AR ARP050103930A patent/AR051295A1/es unknown
- 2005-09-23 SV SV2005002235A patent/SV2007002235A/es not_active Application Discontinuation
- 2005-09-23 GT GT200500266A patent/GT200500266A/es unknown
- 2005-09-23 UY UY29127A patent/UY29127A1/es not_active Application Discontinuation
- 2005-09-23 PE PE2005001101A patent/PE20060657A1/es not_active Application Discontinuation
- 2005-09-23 TW TW094132926A patent/TW200628451A/zh unknown
-
2007
- 2007-03-22 IL IL182136A patent/IL182136A0/en unknown
- 2007-03-23 EC EC2007007340A patent/ECSP077340A/es unknown
- 2007-03-30 MA MA29787A patent/MA28882B1/fr unknown
- 2007-04-20 NO NO20072051A patent/NO20072051L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2582492A1 (en) | 2006-03-30 |
SV2007002235A (es) | 2007-03-20 |
BRPI0517327A (pt) | 2008-10-07 |
US20080261990A1 (en) | 2008-10-23 |
AR051295A1 (es) | 2007-01-03 |
EP1797045A1 (de) | 2007-06-20 |
MA28882B1 (fr) | 2007-09-03 |
ECSP077340A (es) | 2007-04-26 |
PE20060657A1 (es) | 2006-08-12 |
GT200500266A (es) | 2006-05-11 |
RU2007115215A (ru) | 2008-11-10 |
UY29127A1 (es) | 2006-04-28 |
WO2006032384A1 (de) | 2006-03-30 |
NO20072051L (no) | 2007-06-07 |
TW200628451A (en) | 2006-08-16 |
KR20070055621A (ko) | 2007-05-30 |
AU2005287589A1 (en) | 2006-03-30 |
JP2008514559A (ja) | 2008-05-08 |
IL182136A0 (en) | 2007-07-24 |
CN101065364A (zh) | 2007-10-31 |
DE102004046623A1 (de) | 2006-03-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |