WO2008031501A3 - 2-phenoxynikotinsäure-derivate und ihre verwendung - Google Patents

2-phenoxynikotinsäure-derivate und ihre verwendung Download PDF

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Publication number
WO2008031501A3
WO2008031501A3 PCT/EP2007/007575 EP2007007575W WO2008031501A3 WO 2008031501 A3 WO2008031501 A3 WO 2008031501A3 EP 2007007575 W EP2007007575 W EP 2007007575W WO 2008031501 A3 WO2008031501 A3 WO 2008031501A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenoxy
acid derivative
nicotine acid
prophylaxis
treating
Prior art date
Application number
PCT/EP2007/007575
Other languages
English (en)
French (fr)
Other versions
WO2008031501A2 (de
Inventor
Heinrich Meier
Peter Kolkhof
Axel Kretschmer
Arounarith Tuch
Lars BÄRFACKER
Yolanda Cancho Grande
Original Assignee
Bayer Schering Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Aktiengesellschaft filed Critical Bayer Schering Pharma Aktiengesellschaft
Priority to US12/440,725 priority Critical patent/US20100298221A1/en
Priority to CA002662879A priority patent/CA2662879A1/en
Priority to EP07801996A priority patent/EP2066635A2/de
Priority to JP2009527717A priority patent/JP2010507569A/ja
Publication of WO2008031501A2 publication Critical patent/WO2008031501A2/de
Publication of WO2008031501A3 publication Critical patent/WO2008031501A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die vorliegende Anmeldung betrifft 2-Phenoxy-6-phenyl- und 2- Phenoxy-6-pyridylnikotinsäure-Derivate der allgemeinen Formel (I). Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, vorzugsweise zur Behandlung und/oder Prophylaxe kardiovaskulärer Erkrankungen, insbesondere von Dyslipidämien, Arteriosklerose und Herzinsuffizienz.
PCT/EP2007/007575 2006-09-12 2007-08-30 2-phenoxynikotinsäure-derivate und ihre verwendung WO2008031501A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/440,725 US20100298221A1 (en) 2006-09-12 2007-08-30 2-phenoxy nicotine acid derivative and use thereof
CA002662879A CA2662879A1 (en) 2006-09-12 2007-08-30 2-phenoxynicotinic acid derivatives and use thereof
EP07801996A EP2066635A2 (de) 2006-09-12 2007-08-30 2-phenoxynikotinsäure-derivate und ihre verwendung
JP2009527717A JP2010507569A (ja) 2006-09-12 2007-08-30 ２−フェノキシニコチン酸誘導体およびそれらの使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006043520.6 2006-09-12
DE102006043520A DE102006043520A1 (de) 2006-09-12 2006-09-12 2-Phenoxynikotinsäure-Derivate und ihre Verwendung

Publications (2)

Publication Number Publication Date
WO2008031501A2 WO2008031501A2 (de) 2008-03-20
WO2008031501A3 true WO2008031501A3 (de) 2011-04-14

Family

ID=38681456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/007575 WO2008031501A2 (de) 2006-09-12 2007-08-30 2-phenoxynikotinsäure-derivate und ihre verwendung

Country Status (11)

Country Link
US (1) US20100298221A1 (de)
EP (1) EP2066635A2 (de)
JP (1) JP2010507569A (de)
AR (1) AR062586A1 (de)
CA (1) CA2662879A1 (de)
CL (1) CL2007002637A1 (de)
DE (1) DE102006043520A1 (de)
PE (1) PE20081371A1 (de)
TW (1) TW200829553A (de)
UY (1) UY30582A1 (de)
WO (1) WO2008031501A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007042754A1 (de) 2007-09-07 2009-03-12 Bayer Healthcare Ag Substituierte 6-Phenylnikotinsäuren und ihre Verwendung
EP3593802A3 (de) 2010-05-26 2020-03-25 Satiogen Pharmaceuticals, Inc. Gallensäurerückflusshemmer zur behandlung von diabetes, adipositas und entzündlichen magen-darm-erkrankungen
BR112014010228B1 (pt) 2011-10-28 2020-09-29 Lumena Pharmaceuticals Llc Uso de inibidores de reciclagem de ácido biliar para o tratamento de hipercolemia e doença hepática colestática
PL2771003T3 (pl) 2011-10-28 2017-10-31 Lumena Pharmaceuticals Llc Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby
RU2015139732A (ru) 2013-03-15 2017-04-24 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Ингибиторы рециркуляции желчных кислот для лечения пищевода барретта и гастроэзофагеальной рефлюксной болезни
BR112015023646A2 (pt) 2013-03-15 2017-07-18 Lumena Pharmaceuticals Inc inibidores de ácidos biliares de reciclagem para tratamento de colangite esclerosante primária e doença inflamatória do intestino
AU2020221834A1 (en) 2019-02-12 2021-09-02 Mirum Pharmaceuticals, Inc. Genotype and dose-dependent response to an ASBTI in patients with bile salt export pump deficiency

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082191A2 (en) * 2002-03-28 2003-10-09 Merck & Co., Inc. Substituted 2,3-diphenyl pyridines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005027150A1 (de) * 2005-03-12 2006-09-28 Bayer Healthcare Ag Pyrimidincarbonsäure-Derivate und ihre Verwendung

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082191A2 (en) * 2002-03-28 2003-10-09 Merck & Co., Inc. Substituted 2,3-diphenyl pyridines

Also Published As

Publication number Publication date
TW200829553A (en) 2008-07-16
UY30582A1 (es) 2008-05-02
AR062586A1 (es) 2008-11-19
DE102006043520A1 (de) 2008-03-27
EP2066635A2 (de) 2009-06-10
PE20081371A1 (es) 2008-10-16
CA2662879A1 (en) 2008-03-20
WO2008031501A2 (de) 2008-03-20
CL2007002637A1 (es) 2008-03-14
JP2010507569A (ja) 2010-03-11
US20100298221A1 (en) 2010-11-25

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