WO2006020573A2 - Noncardiotoxic pharmaceutical compounds - Google Patents
Noncardiotoxic pharmaceutical compounds Download PDFInfo
- Publication number
- WO2006020573A2 WO2006020573A2 PCT/US2005/028137 US2005028137W WO2006020573A2 WO 2006020573 A2 WO2006020573 A2 WO 2006020573A2 US 2005028137 W US2005028137 W US 2005028137W WO 2006020573 A2 WO2006020573 A2 WO 2006020573A2
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- WIPO (PCT)
- Prior art keywords
- compound
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- substituted
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- hydrogen
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- 0 CCS(C(C*1)NC1=O)(=O)=O Chemical compound CCS(C(C*1)NC1=O)(=O)=O 0.000 description 23
- AQMDCPKJNABBJN-SRHMSIETSA-N C=C/C=C(\C=C(/CNc1c2cccc1)\N=C2N(CC1)CCN1P(O)(O)=O)/Cl Chemical compound C=C/C=C(\C=C(/CNc1c2cccc1)\N=C2N(CC1)CCN1P(O)(O)=O)/Cl AQMDCPKJNABBJN-SRHMSIETSA-N 0.000 description 1
- OYPVPXBUOORGOI-UHFFFAOYSA-N CC(C1)NCCN1c(c(F)c1)cc(N(C=C2C(O)=O)c(cc3)cc(F)c3F)c1C2=O Chemical compound CC(C1)NCCN1c(c(F)c1)cc(N(C=C2C(O)=O)c(cc3)cc(F)c3F)c1C2=O OYPVPXBUOORGOI-UHFFFAOYSA-N 0.000 description 1
- AMHGRXJIPDILAD-UHFFFAOYSA-N CCCCCCCCOC(N(C)CCCN(c1c(CC2)cccc1)c1c2cccc1)=O Chemical compound CCCCCCCCOC(N(C)CCCN(c1c(CC2)cccc1)c1c2cccc1)=O AMHGRXJIPDILAD-UHFFFAOYSA-N 0.000 description 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N CCN(C=C(C(O)=O)C(c1c2)=O)c1cc(N1CCNCC1)c2F Chemical compound CCN(C=C(C(O)=O)C(c1c2)=O)c1cc(N1CCNCC1)c2F OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 description 1
- URXPLYXAKUIEBI-UHFFFAOYSA-N CCS(N1NC=[N]=C1)(=O)=O Chemical compound CCS(N1NC=[N]=C1)(=O)=O URXPLYXAKUIEBI-UHFFFAOYSA-N 0.000 description 1
- QSPPRYLTQFCUCH-UHFFFAOYSA-N CCS(NC)(=O)=O Chemical compound CCS(NC)(=O)=O QSPPRYLTQFCUCH-UHFFFAOYSA-N 0.000 description 1
- VBQUDDWATQWCPP-UHFFFAOYSA-N CCS(c1ccccc1)(=O)=O Chemical compound CCS(c1ccccc1)(=O)=O VBQUDDWATQWCPP-UHFFFAOYSA-N 0.000 description 1
- QZUDBNBUXVUHMW-UHFFFAOYSA-N CN(CC1)CCN1C1=Nc2cc(Cl)ccc2Nc2c1cccc2 Chemical compound CN(CC1)CCN1C1=Nc2cc(Cl)ccc2Nc2c1cccc2 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 description 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N CN(CCC1(C(C2)O3)C=CC2O)Cc(cc2)c1c3c2OC Chemical compound CN(CCC1(C(C2)O3)C=CC2O)Cc(cc2)c1c3c2OC ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 description 1
- WSIVMDXBGLVKPB-UHFFFAOYSA-N CN(CCCN(c1c(CC2)cccc1)c1c2cccc1)P(O)(Oc1ccccc1)=O Chemical compound CN(CCCN(c1c(CC2)cccc1)c1c2cccc1)P(O)(Oc1ccccc1)=O WSIVMDXBGLVKPB-UHFFFAOYSA-N 0.000 description 1
- PKYKTIZEBFFWES-UHFFFAOYSA-N CN(CCCN(c1c(CC2)cccc1)c1c2cccc1)P(OC)(OC)=O Chemical compound CN(CCCN(c1c(CC2)cccc1)c1c2cccc1)P(OC)(OC)=O PKYKTIZEBFFWES-UHFFFAOYSA-N 0.000 description 1
- JEHZZLODNYZLJN-UHFFFAOYSA-N CN(CCCN(c1c(CC2)cccc1)c1c2cccc1)P(OC)(Oc1ccccc1)=O Chemical compound CN(CCCN(c1c(CC2)cccc1)c1c2cccc1)P(OC)(Oc1ccccc1)=O JEHZZLODNYZLJN-UHFFFAOYSA-N 0.000 description 1
- QEQSQRASBLCCFE-UHFFFAOYSA-N CN(CCc1c[nH]c2cc(CS(N3CCCC3)(=O)=O)ccc12)P(O)(OC)=O Chemical compound CN(CCc1c[nH]c2cc(CS(N3CCCC3)(=O)=O)ccc12)P(O)(OC)=O QEQSQRASBLCCFE-UHFFFAOYSA-N 0.000 description 1
- YBQBXVULJVWTEJ-UHFFFAOYSA-N CN(CCc1c[nH]c2ccc(C[n]3ncnc3)cc12)P(OC)(Oc1ccccc1)=O Chemical compound CN(CCc1c[nH]c2ccc(C[n]3ncnc3)cc12)P(OC)(Oc1ccccc1)=O YBQBXVULJVWTEJ-UHFFFAOYSA-N 0.000 description 1
- QWKMSPDIKTVREH-UHFFFAOYSA-N CNS(Cc1ccc(c(C(CC2)CC[NH+]2[PH2-](O)(OC)=O)c[nH]2)c2c1)(=O)=O Chemical compound CNS(Cc1ccc(c(C(CC2)CC[NH+]2[PH2-](O)(OC)=O)c[nH]2)c2c1)(=O)=O QWKMSPDIKTVREH-UHFFFAOYSA-N 0.000 description 1
- YCGOQAAPSBXLBZ-UHFFFAOYSA-N COP(N(CC1)CCN1C1=Nc2cc(Cl)ccc2Nc2c1cccc2)(O)=O Chemical compound COP(N(CC1)CCN1C1=Nc2cc(Cl)ccc2Nc2c1cccc2)(O)=O YCGOQAAPSBXLBZ-UHFFFAOYSA-N 0.000 description 1
- SQSYQZOZIOONGS-UHFFFAOYSA-N COP(N(CC1)CCN1C1=Nc2cc(Cl)ccc2Nc2c1cccc2)(Oc1ccccc1)=O Chemical compound COP(N(CC1)CCN1C1=Nc2cc(Cl)ccc2Nc2c1cccc2)(Oc1ccccc1)=O SQSYQZOZIOONGS-UHFFFAOYSA-N 0.000 description 1
- NSSXEEHTFFXSMF-UHFFFAOYSA-N COP(N(CC1)CCN1C1=Nc2ccccc2Oc(cc2)c1cc2Cl)(O)=O Chemical compound COP(N(CC1)CCN1C1=Nc2ccccc2Oc(cc2)c1cc2Cl)(O)=O NSSXEEHTFFXSMF-UHFFFAOYSA-N 0.000 description 1
- CKJNGHLWPBSLNH-UHFFFAOYSA-N COP(N(CC1)CCN1C1=Nc2ccccc2Oc(cc2)c1cc2Cl)(OC)=O Chemical compound COP(N(CC1)CCN1C1=Nc2ccccc2Oc(cc2)c1cc2Cl)(OC)=O CKJNGHLWPBSLNH-UHFFFAOYSA-N 0.000 description 1
- ONSKBAQEOMXRFT-UHFFFAOYSA-N COP(N(CC1)CCN1C1=Nc2ccccc2Oc(cc2)c1cc2Cl)(Oc1ccccc1)=O Chemical compound COP(N(CC1)CCN1C1=Nc2ccccc2Oc(cc2)c1cc2Cl)(Oc1ccccc1)=O ONSKBAQEOMXRFT-UHFFFAOYSA-N 0.000 description 1
- DRAZHAJWLHZEDK-UHFFFAOYSA-N COP(N(CC1)CCN1c1cccc(Cl)c1)(OC)=O Chemical compound COP(N(CC1)CCN1c1cccc(Cl)c1)(OC)=O DRAZHAJWLHZEDK-UHFFFAOYSA-N 0.000 description 1
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- BBHHCMIAWKXDQW-UHFFFAOYSA-N COP(N(CCC1)CCC1N1N=C(Cc2cccc(Cl)c2)c2ccccc2C1=O)(Oc1ccccc1)=O Chemical compound COP(N(CCC1)CCC1N1N=C(Cc2cccc(Cl)c2)c2ccccc2C1=O)(Oc1ccccc1)=O BBHHCMIAWKXDQW-UHFFFAOYSA-N 0.000 description 1
- GMQPIGJXSZAXSJ-UHFFFAOYSA-N CS(N1CCCC1)(=O)=O Chemical compound CS(N1CCCC1)(=O)=O GMQPIGJXSZAXSJ-UHFFFAOYSA-N 0.000 description 1
- JNNOSTQEZICQQP-UHFFFAOYSA-N Clc1ccc2Nc(cccc3)c3C(N3CCNCC3)=Nc2c1 Chemical compound Clc1ccc2Nc(cccc3)c3C(N3CCNCC3)=Nc2c1 JNNOSTQEZICQQP-UHFFFAOYSA-N 0.000 description 1
- YCXCLZSLZGBCTA-UHFFFAOYSA-N Fc(cc1)ccc1-[n](cc(C1CCNCC1)c1c2)c1ccc2Cl Chemical compound Fc(cc1)ccc1-[n](cc(C1CCNCC1)c1c2)c1ccc2Cl YCXCLZSLZGBCTA-UHFFFAOYSA-N 0.000 description 1
- MYSWGUAQZAJSOK-UHFFFAOYSA-N OC(C1=CN(C2CC2)c(cc(c(F)c2)N3CCNCC3)c2C1=O)=O Chemical compound OC(C1=CN(C2CC2)c(cc(c(F)c2)N3CCNCC3)c2C1=O)=O MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 1
- MZZGOLMZNNWPFZ-SFQUDFHCSA-N OC(CC1=CC=CC/C1=N\c(c(Cl)ccc1)c1Cl)=O Chemical compound OC(CC1=CC=CC/C1=N\c(c(Cl)ccc1)c1Cl)=O MZZGOLMZNNWPFZ-SFQUDFHCSA-N 0.000 description 1
- VNQURRWYKFZKJZ-UHFFFAOYSA-N OC(Cc1cc(O)ccc1Nc(c(Cl)ccc1)c1Cl)=O Chemical compound OC(Cc1cc(O)ccc1Nc(c(Cl)ccc1)c1Cl)=O VNQURRWYKFZKJZ-UHFFFAOYSA-N 0.000 description 1
- VZUOQICFLGRINW-UHFFFAOYSA-N OP(N(CC1)CCN1C1=Nc(cccc2)c2Oc(cc2)c1cc2Cl)(Oc1ccccc1)=O Chemical compound OP(N(CC1)CCN1C1=Nc(cccc2)c2Oc(cc2)c1cc2Cl)(Oc1ccccc1)=O VZUOQICFLGRINW-UHFFFAOYSA-N 0.000 description 1
- PYCKYSRVEKGUIP-UHFFFAOYSA-N OP(N(CC1)CCN1C1=Nc2ccccc2Oc(cc2)c1cc2Cl)(O)=O Chemical compound OP(N(CC1)CCN1C1=Nc2ccccc2Oc(cc2)c1cc2Cl)(O)=O PYCKYSRVEKGUIP-UHFFFAOYSA-N 0.000 description 1
- ICGCRWYUYFRHSL-UHFFFAOYSA-N OP(N(CC1)CCN1c1cccc(Cl)c1)(Oc1ccccc1)=O Chemical compound OP(N(CC1)CCN1c1cccc(Cl)c1)(Oc1ccccc1)=O ICGCRWYUYFRHSL-UHFFFAOYSA-N 0.000 description 1
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- C07F9/247—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aromatic amines (N-C aromatic linkage)
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- C07F9/2475—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aralkylamines
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
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- C07F9/5532—Seven-(or more) membered rings
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65525—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring
- C07F9/65527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
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JP2007525709A JP2008509909A (ja) | 2004-08-11 | 2005-08-09 | 心毒性のない医薬化合物 |
AU2005273961A AU2005273961A1 (en) | 2004-08-11 | 2005-08-09 | Noncardiotoxic pharmaceutical compounds |
CA002576530A CA2576530A1 (en) | 2004-08-11 | 2005-08-09 | Noncardiotoxic pharmaceutical compounds |
EP05786819A EP1778252A4 (en) | 2004-08-11 | 2005-08-09 | NON-CARDIOTOXIC PHARMACEUTICAL COMPOUNDS |
MX2007001713A MX2007001713A (es) | 2004-08-11 | 2005-08-09 | Compuestos farmaceuticos no cardiotoxicos. |
IL181229A IL181229A0 (en) | 2004-08-11 | 2007-02-08 | Noncardiotoxic pharmaceutical compounds |
NO20071259A NO20071259L (no) | 2004-08-11 | 2007-03-08 | Ikke-kardiotoksiske farmasoytiske forbindelser. |
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US60069904P | 2004-08-11 | 2004-08-11 | |
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US67354505P | 2005-04-21 | 2005-04-21 | |
US60/673,545 | 2005-04-21 |
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WO2006020573A2 true WO2006020573A2 (en) | 2006-02-23 |
WO2006020573A3 WO2006020573A3 (en) | 2009-04-16 |
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PCT/US2005/028137 WO2006020573A2 (en) | 2004-08-11 | 2005-08-09 | Noncardiotoxic pharmaceutical compounds |
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Cited By (2)
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CN101636182B (zh) * | 2006-10-25 | 2013-01-16 | 雷蒙特亚特特拉维夫大学有限公司 | 具有谷氨酸nmda活性的新型精神病治疗剂 |
KR20190053200A (ko) * | 2016-09-29 | 2019-05-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 및 추가적인 질환의 치료를 위한 피리미딘 프로드러그 |
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CA2605481A1 (en) * | 2005-04-21 | 2007-02-15 | Targanta Therapeutics Inc. | Phosphonated fluoroquinolones, antibacterial analogs thereof, and methods for the prevention and treatment of bone and joint infections |
AU2008239841B2 (en) * | 2007-04-12 | 2013-07-18 | Teva Pharmaceuticals International Gmbh | N-oxide and/or di-N-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles |
US9187439B2 (en) | 2011-09-21 | 2015-11-17 | Inception Orion, Inc. | Tricyclic compounds useful as neurogenic and neuroprotective agents |
US9198916B1 (en) * | 2014-05-27 | 2015-12-01 | B&G Partners, Llc | Compounds and methods for treating tumors |
EP2998303B1 (en) | 2014-09-17 | 2018-06-13 | B & G Partners, LLC | Phenothiazine derivatives and methods for treating tumors |
US11845736B2 (en) | 2021-10-01 | 2023-12-19 | Empathbio, Inc. | Prodrugs of MDMA, MDA, and derivatives thereof |
US11912680B2 (en) | 2021-12-28 | 2024-02-27 | Empathbio, Inc. | Nitric oxide releasing prodrugs of MDA and MDMA |
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- 2005-08-09 CA CA002576530A patent/CA2576530A1/en not_active Abandoned
- 2005-08-09 EP EP05786819A patent/EP1778252A4/en not_active Withdrawn
- 2005-08-09 US US11/199,866 patent/US8088918B2/en not_active Expired - Fee Related
- 2005-08-09 JP JP2007525709A patent/JP2008509909A/ja active Pending
- 2005-08-09 SG SG200905339-8A patent/SG169238A1/en unknown
- 2005-08-09 WO PCT/US2005/028137 patent/WO2006020573A2/en active Application Filing
- 2005-08-09 AU AU2005273961A patent/AU2005273961A1/en not_active Abandoned
- 2005-08-09 MX MX2007001713A patent/MX2007001713A/es not_active Application Discontinuation
-
2007
- 2007-02-08 IL IL181229A patent/IL181229A0/en unknown
- 2007-03-08 NO NO20071259A patent/NO20071259L/no not_active Application Discontinuation
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101636182B (zh) * | 2006-10-25 | 2013-01-16 | 雷蒙特亚特特拉维夫大学有限公司 | 具有谷氨酸nmda活性的新型精神病治疗剂 |
US8394790B2 (en) | 2006-10-25 | 2013-03-12 | Ramot At Tel-Aviv University Ltd. | Psychotropic agents having glutamate NMDA activity |
US8828993B2 (en) | 2006-10-25 | 2014-09-09 | Ramot At Tel-Aviv University Ltd. | Psychotropic agents having glutamate NMDA activity |
KR20190053200A (ko) * | 2016-09-29 | 2019-05-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 및 추가적인 질환의 치료를 위한 피리미딘 프로드러그 |
KR102450287B1 (ko) * | 2016-09-29 | 2022-09-30 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 및 추가적인 질환의 치료를 위한 피리미딘 프로드러그 |
Also Published As
Publication number | Publication date |
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AU2005273961A1 (en) | 2006-02-23 |
MX2007001713A (es) | 2007-07-13 |
JP2008509909A (ja) | 2008-04-03 |
EP1778252A2 (en) | 2007-05-02 |
US8088918B2 (en) | 2012-01-03 |
CA2576530A1 (en) | 2006-02-23 |
SG169238A1 (en) | 2011-03-30 |
NO20071259L (no) | 2007-03-09 |
EP1778252A4 (en) | 2010-01-27 |
WO2006020573A3 (en) | 2009-04-16 |
US20060035863A1 (en) | 2006-02-16 |
IL181229A0 (en) | 2007-07-04 |
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