WO2006016275A3 - Arn interférant spécifique vis-à-vis de la gastrine - Google Patents
Arn interférant spécifique vis-à-vis de la gastrineInfo
- Publication number
- WO2006016275A3 WO2006016275A3 PCT/IB2005/002686 IB2005002686W WO2006016275A3 WO 2006016275 A3 WO2006016275 A3 WO 2006016275A3 IB 2005002686 W IB2005002686 W IB 2005002686W WO 2006016275 A3 WO2006016275 A3 WO 2006016275A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gastrin
- molecules
- rnai
- specific interfering
- rnai molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05775595A EP1778841A2 (fr) | 2004-08-11 | 2005-08-10 | Arn interférant spécifique vis-à-vis de la gastrine |
AU2005270917A AU2005270917A1 (en) | 2004-08-11 | 2005-08-10 | Gastrin-specific interfering RNA |
CA002576576A CA2576576A1 (fr) | 2004-08-11 | 2005-08-10 | Arn interferant specifique vis-a-vis de la gastrine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60069604P | 2004-08-11 | 2004-08-11 | |
US60/600,696 | 2004-08-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006016275A2 WO2006016275A2 (fr) | 2006-02-16 |
WO2006016275A3 true WO2006016275A3 (fr) | 2006-05-18 |
Family
ID=35759261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/002686 WO2006016275A2 (fr) | 2004-08-11 | 2005-08-10 | Arn interférant spécifique vis-à-vis de la gastrine |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1778841A2 (fr) |
KR (1) | KR20070062515A (fr) |
AU (1) | AU2005270917A1 (fr) |
CA (1) | CA2576576A1 (fr) |
WO (1) | WO2006016275A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2520010C (fr) | 2003-03-28 | 2012-07-10 | Aphton Corporation | Dosages immunologiques pour la detection de l'hormone gastrine |
US8889640B1 (en) * | 2008-06-20 | 2014-11-18 | Jill P. Smith | Composition and method for the treatment of gastrin mediated cancers |
CN111050789A (zh) | 2017-06-15 | 2020-04-21 | 癌症进展有限公司 | 用于诱导针对肿瘤和癌症的体液免疫和细胞免疫的组合物和方法 |
CA3204163A1 (fr) * | 2021-01-13 | 2022-07-21 | Cancer Advances Inc. | Compositions et procedes destines a la prevention de tumeurs et de cancer |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003010180A1 (fr) * | 2001-07-23 | 2003-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methodes et compositions pour l'inhibition induite par l'arni de l'expression genetique chez des mammiferes |
WO2004042061A1 (fr) * | 2002-11-08 | 2004-05-21 | Klaus Strebhardt | Composition pharmaceutique de suppression de l'expression non souhaitee d'un gene |
-
2005
- 2005-08-10 WO PCT/IB2005/002686 patent/WO2006016275A2/fr not_active Application Discontinuation
- 2005-08-10 KR KR1020077005675A patent/KR20070062515A/ko not_active Application Discontinuation
- 2005-08-10 EP EP05775595A patent/EP1778841A2/fr not_active Withdrawn
- 2005-08-10 AU AU2005270917A patent/AU2005270917A1/en not_active Abandoned
- 2005-08-10 CA CA002576576A patent/CA2576576A1/fr not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003010180A1 (fr) * | 2001-07-23 | 2003-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methodes et compositions pour l'inhibition induite par l'arni de l'expression genetique chez des mammiferes |
WO2004042061A1 (fr) * | 2002-11-08 | 2004-05-21 | Klaus Strebhardt | Composition pharmaceutique de suppression de l'expression non souhaitee d'un gene |
Non-Patent Citations (5)
Title |
---|
GRABOWSKA A ET AL: "Downregulation of the gastrin gene using small interfering RNA", REGULATORY PEPTIDES, vol. 122, no. 1, September 2004 (2004-09-01), & 15TH INTERNATIONAL SYMPOSIUM ON REGULATORY PEPTIDES; TOULOUSE, FRANCE; SEPTEMBER 19 -22, 2004, pages 46, XP009061814, ISSN: 0167-0115 * |
SINGH P ET AL: "TUMORIGENICITY OF A HUMAN COLON CANCER CELL LINE IS SIGNIFICANCE REDUCED IN VIVO, IN THE PRESENCE OF COLON CANCER CELLS OVEREXPRESSING ANTISENSE GASTRIN MRNA: ROLE OF INHIBITORY (ENDOCRINE) FACTORS IN THE OBSERVED BYSTANDER EFFECTS", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, US, vol. 114, no. 4, PART 2, 15 April 1998 (1998-04-15), pages A680, XP008056925, ISSN: 0016-5085 * |
SMITH J P ET AL: "Antisense oligonucleotides to gastrin inhibit growth of human pancreatic cancer", CANCER LETTERS, NEW YORK, NY, US, vol. 135, no. 1, 8 January 1999 (1999-01-08), pages 107 - 112, XP002357825, ISSN: 0304-3835 * |
TAKHAR A S ET AL: "The role of gastrin in colorectal carcinogenesis.", THE SURGEON : JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND. OCT 2004, vol. 2, no. 5, October 2004 (2004-10-01), pages 251 - 257, XP009061845, ISSN: 1479-666X * |
WATSON S ET AL: "GASTRIN INHIBITION INCREASES THE POTENCY OF CYTOTOXIC AGENTS IN PANCREATIC CANCER", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, US, vol. 122, no. 4, SUPPL 1, April 2002 (2002-04-01), pages A241, XP008056958, ISSN: 0016-5085 * |
Also Published As
Publication number | Publication date |
---|---|
EP1778841A2 (fr) | 2007-05-02 |
AU2005270917A8 (en) | 2006-02-16 |
AU2005270917A1 (en) | 2006-02-16 |
WO2006016275A2 (fr) | 2006-02-16 |
KR20070062515A (ko) | 2007-06-15 |
CA2576576A1 (fr) | 2006-02-16 |
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