WO2006002443A1 - Pharmaceutical or cosmetic preparation based on kigelia africana - Google Patents
Pharmaceutical or cosmetic preparation based on kigelia africana Download PDFInfo
- Publication number
- WO2006002443A1 WO2006002443A1 PCT/ZA2005/000087 ZA2005000087W WO2006002443A1 WO 2006002443 A1 WO2006002443 A1 WO 2006002443A1 ZA 2005000087 W ZA2005000087 W ZA 2005000087W WO 2006002443 A1 WO2006002443 A1 WO 2006002443A1
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- Prior art keywords
- preparation
- extract
- fruit
- tree
- pendulum
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Definitions
- This invention relates to a pharmaceutical and/or cosmetic preparation.
- the inventor is aware of a need for a treatment for various medical and 0 cosmetic conditions including Psoriasis, Eczema, Solar Keratosis, Cancerous Sores, and other conditions.
- Such a treatment could be a general pain 5 reliever, an anti-septic, an anti-inflammatory, and/or an anti-pruritic.
- the treatment should preferably be natural in origin and thus the inventor has sought to provide a preparation made from plant extracts.
- a pharmaceutical and/or cosmetic preparation which contains an extract of one or more parts of the Kigelia Af ricana, or Sausage Tree. 5
- the parts of the tree which may conveniently be used include fruit, stembark, and pendulum i.e. where the fruit hangs from, or a product thereof.
- the preparation will contain 50% extract and the remainder will be 0 carrier, excipients, colourants, and the like.
- a cream, ointment, gel, or the like contains 50% extract of one or more of fruit, bark, and pendulum.
- the preparation may i be applied to the skin.
- the preparation for skin application may be in the form of a cream, an emulsion, an ointment, an aerosol, a powder, a dust, a tincture, a suspension, a gel, or the like.
- the preparation may be taken internally as a protein, a mineral, a vitamin, or the like. It may conveniently be provided in the form of a capsule, a tablet, a syrup, a health tonic, or the like.
- the invention extends to a method of preparing a topical application medicament and/or cosmetic preparation for the treatment of the skin of a mammal such as a human, said method including blending a Kigelia Africana fruit extract with a Kigelia Africana stembark and/or pendulum extract in a ratio of from 1 :99 to 99:1 by volume.
- the fruit extract and stembark and/or pendulum extract are blended in a volumetric ratio of from 1 :9 to 9:1 , usually from 1 :2 to 10:1.
- the fruit extract and stemabrk and/or pendulum extract is blended in a volumetric ratio of 9:1.
- the invention extends yet further to a method of preparing a topical application medicament and/or cosmetic preparation for the treatment of the skin of a mammal such as a human, said method including blending a Kigelia Africana fruit extract with skin cream or ointment components.
- the invention extends to a method of treatment of the human or animal body, said method including the application of a pharmaceutically or cosmetically active quantity of a preparation as described above to a skin ailment site requiring treatment.
- the method of treatment may be suited for the treatment of Psoriasis, Eczema, Neurodermitis, Solar Keratosis, Cancerous Sores, and other such skin conditions.
- a topical preparation for cuts, bruises, insect bites, stings, and sun exposure of the skin which preparation contains less than 40% m/m of an extract of one or more parts of the Kigelia Africana, or Sausage Tree.
- the topical preparation may be a general pain reliever, an anti-septic, an anti ⁇ inflammatory, and/or an anti-pruritic.
- the topical preparation may be useful in treating fever blisters.
- ingredients may include tea tree oil, propylene glycol, and triethanolamine.
- the parts of the tree which may conveniently be used include fruit, stembark, and pendulum i.e. where the fruit hangs from, or a product thereof.
- the preparation will contain less than 40% extract and the remainder will be carrier, excipients, colourants, and the like.
- a cream, ointment, gel, or the like contains 30% extract of one or more of fruit, bark, and pendulum.
- the preparation may be applied to the skin to relieve the symptoms and/or assist in healing of the skin when the skin has been damaged as a result of cuts, bruises, insect bites, stings and/or sun exposure or over exposure.
- Sun exposure or over exposure can also be referred to as sun burn and products for the treatment of sun burn are sometimes referred to as after sun products.
- the invention extends to a method of treatment using the preparation for the treatment of cuts, bruises, insect bites, stings, and exposure to sun.
- the fruit extract may be prepared in the following way: - select ripe fruit which are not harbouring insect borers and which are still fresh - skin the fruit and de-seeding it so that the skin and seeds are discarded and are not included in the extract - cut the skinned, de-seeded fruit into approximatley 3cm-thick slices - pulp the slices in a mortar or by mechanical means until a stringy mass of pulp is achieved - pass the pulp through a squeezing-type mincer or equivalent device thus obtaining a dark-coloured soft pulpy mass of thick consistency - mix the pulp with ethyl alcohol of about 96% in a ratio of about 3 parts by volume of pulp to 1 part of alcohol - stir the mixture thoroughly to achieve maximum extraction - filter the stirred mixture - store the filtrate and discard the filtered solids, typically at 4°C.
- the stembark and/or pendulum extract may be prepared in the following manner: dice the whole pendulum i.e. the string from which the fruit is hanging on, and/or stripped bark into small pieces of about 2cm thick - cover the diced material with ethyl alcohol for about fourteen days, and typically store at 4°C pulp the mass through a mincer or equivalent device using alcohol as a further extractant, if required for better extraction squeeze the liquid out of the pulp and remove all the solid particles by filtration store the filtrate at about 4 0 C.
- Solar keratosis and pre-cancerous sores which result from excessive exposure to the sun's ultraviolet rays may be treated by applying a preparation as described above
- the preparation may be applied to the affected areas, usually the hands, arms, face, ears, upper chest and neck which removes those spots gradually by changing into darker encrustations (lesions) which eventually fall off or can be rubbed off the skin.
- Certain inflammatory diseases of the skin which are accompanied by itching and the exudation of serous matter may be treated by the application of a preparation as described above
- Cuts, bruises, insect bites, stings, and sun burn can be treated with a lotion having a composition which is similar to that which follows: INGREDIENTS :
- a cream and a scalp application can be prepared as per the attached data sheets.
- Kigalia Africana extracts of Kigalia Africana include some or all of the compounds listed below, however, it is not the individual compounds which form the subject matter of this invention but rather the use of extracts of plant material.
- Botanical Name Kigelia africana (syn. Kigelia pinnata)
- Iridoids from Kigelia africana Oglucose Catalpol Iridoids : Specioside Verminoside Minecoside Norviburtinal Naphthaquinoids from Kigelia africana Lapachol Kigelinone 2-acetylnaphtho[2,3-b]furan-4,9-quinone 2-(l-hydroxyethyl)naphtho[2,3-b]furan-4,9-quinone Pinnatal Isopinnatal Kigelinol Isokigelinol Flavonoids & other shikimate-derived compounds from Kigelia africana Quercetin Luteolin 6-OH luteolin Luteolin-7-glucoside 6-OH luteolin-7-glucoside 6-Methoxymellein Kigelin 6-Demethylkigelin Kigeliol Balanophonin ⁇ -Sitosterol Stigmasterol ⁇ -Sitosterol isoWgeli ⁇ o lridoids from Kigelia africana
Abstract
A pharmaceutical and/or cosmetic preparation which contains an extract of one or more parts of Kigelia Africana tree, also known asa the Sausage tree, preparation thereof and uses thereof.
Description
PHARMACEUTICAL OR COSMETIC PREPARATION BASED ON KIGELIA AFRICANA
Field of the Invention
5 This invention relates to a pharmaceutical and/or cosmetic preparation.
Background to the Invention
The inventor is aware of a need for a treatment for various medical and 0 cosmetic conditions including Psoriasis, Eczema, Solar Keratosis, Cancerous Sores, and other conditions.
The inventor is aware of a need for a treatment for cuts, bruises, skin exposed to the sun, insect bites and stings. Such a treatment could be a general pain 5 reliever, an anti-septic, an anti-inflammatory, and/or an anti-pruritic.
The treatment should preferably be natural in origin and thus the inventor has sought to provide a preparation made from plant extracts.
0 Summary of the Invention
According to a first aspect of the invention, there is provided a pharmaceutical and/or cosmetic preparation which contains an extract of one or more parts of the Kigelia Af ricana, or Sausage Tree. 5 The parts of the tree which may conveniently be used include fruit, stembark, and pendulum i.e. where the fruit hangs from, or a product thereof.
Typically, the preparation will contain 50% extract and the remainder will be 0 carrier, excipients, colourants, and the like.
Thus, in some examples, a cream, ointment, gel, or the like contains 50% extract of one or more of fruit, bark, and pendulum.
5 In use, as a pharmaceutical and/or cosmetic preparation, the preparation may i
be applied to the skin.
The preparation for skin application may be in the form of a cream, an emulsion, an ointment, an aerosol, a powder, a dust, a tincture, a suspension, a gel, or the like.
As a pharmaceutical preparation, the preparation may be taken internally as a protein, a mineral, a vitamin, or the like. It may conveniently be provided in the form of a capsule, a tablet, a syrup, a health tonic, or the like.
The invention extends to a method of preparing a topical application medicament and/or cosmetic preparation for the treatment of the skin of a mammal such as a human, said method including blending a Kigelia Africana fruit extract with a Kigelia Africana stembark and/or pendulum extract in a ratio of from 1 :99 to 99:1 by volume.
Typically, the fruit extract and stembark and/or pendulum extract are blended in a volumetric ratio of from 1 :9 to 9:1 , usually from 1 :2 to 10:1.
In one embodiment, for the treatment of solar keratosis, precancerous sores, and other ailments of the skin, the fruit extract and stemabrk and/or pendulum extract is blended in a volumetric ratio of 9:1.
The invention extends yet further to a method of preparing a topical application medicament and/or cosmetic preparation for the treatment of the skin of a mammal such as a human, said method including blending a Kigelia Africana fruit extract with skin cream or ointment components.
The invention extends to a method of treatment of the human or animal body, said method including the application of a pharmaceutically or cosmetically active quantity of a preparation as described above to a skin ailment site requiring treatment.
The method of treatment may be suited for the treatment of Psoriasis, Eczema, Neurodermitis, Solar Keratosis, Cancerous Sores, and other such
skin conditions.
According to a further aspect of the invention, there is provided a topical preparation for cuts, bruises, insect bites, stings, and sun exposure of the skin, which preparation contains less than 40% m/m of an extract of one or more parts of the Kigelia Africana, or Sausage Tree.
The topical preparation may be a general pain reliever, an anti-septic, an anti¬ inflammatory, and/or an anti-pruritic.
The topical preparation may be useful in treating fever blisters.
Other ingredients may include tea tree oil, propylene glycol, and triethanolamine.
The parts of the tree which may conveniently be used include fruit, stembark, and pendulum i.e. where the fruit hangs from, or a product thereof.
Typically, the preparation will contain less than 40% extract and the remainder will be carrier, excipients, colourants, and the like.
Thus, in some examples, a cream, ointment, gel, or the like contains 30% extract of one or more of fruit, bark, and pendulum.
In use the preparation may be applied to the skin to relieve the symptoms and/or assist in healing of the skin when the skin has been damaged as a result of cuts, bruises, insect bites, stings and/or sun exposure or over exposure. Sun exposure or over exposure can also be referred to as sun burn and products for the treatment of sun burn are sometimes referred to as after sun products.
The invention extends to a method of treatment using the preparation for the treatment of cuts, bruises, insect bites, stings, and exposure to sun.
The fruit extract may be prepared in the following way:
- select ripe fruit which are not harbouring insect borers and which are still fresh - skin the fruit and de-seeding it so that the skin and seeds are discarded and are not included in the extract - cut the skinned, de-seeded fruit into approximatley 3cm-thick slices - pulp the slices in a mortar or by mechanical means until a stringy mass of pulp is achieved - pass the pulp through a squeezing-type mincer or equivalent device thus obtaining a dark-coloured soft pulpy mass of thick consistency - mix the pulp with ethyl alcohol of about 96% in a ratio of about 3 parts by volume of pulp to 1 part of alcohol - stir the mixture thoroughly to achieve maximum extraction - filter the stirred mixture - store the filtrate and discard the filtered solids, typically at 4°C.
The stembark and/or pendulum extract may be prepared in the following manner: dice the whole pendulum i.e. the string from which the fruit is hanging on, and/or stripped bark into small pieces of about 2cm thick - cover the diced material with ethyl alcohol for about fourteen days, and typically store at 4°C pulp the mass through a mincer or equivalent device using alcohol as a further extractant, if required for better extraction squeeze the liquid out of the pulp and remove all the solid particles by filtration store the filtrate at about 40C.
Examples of Uses of the Preparation of the Invention
Example 1
Solar keratosis and pre-cancerous sores which result from excessive exposure to the sun's ultraviolet rays may be treated by applying a preparation as described above
The preparation may be applied to the affected areas, usually the hands, arms, face, ears, upper chest and neck which removes those spots gradually by changing into darker encrustations (lesions) which eventually fall off or can be rubbed off the skin.
In one case, Dr Kim Hilne noted that after 3 weeks of application of the cream 3 times daily canker sores cleared up.
Depending how serious the condition is application may be required for 3 - 12 weeks / 3 x daily.
Example 2
Certain inflammatory diseases of the skin which are accompanied by itching and the exudation of serous matter may be treated by the application of a preparation as described above
These cases of eczema and psoriasis have been cured within a short period.
Example 3
Cuts, bruises, insect bites, stings, and sun burn can be treated with a lotion having a composition which is similar to that which follows:
INGREDIENTS :
Polysorbate 20 6.00 % Propylene Glycol 2.00 %
Tea Tree Oil EO 2.00 %
Triethanolamine 0.64 %
Carbomer 940 0.80 %
Methyl paraben 0.24 %
Propyl paraben 0.02 %
Water 58.30 %
Subtotal 70.00 %
Kigelia Extract 30.00 %
Total 100.00 %
Example 4
A cream and a scalp application can be prepared as per the attached data sheets.
For skin ailments like: eczema, psoriasis the same gel, cream ointment etc. is used as for cancerous sores - for scalp problems Kigela Scalp Application
It is believed that extracts of Kigalia Africana include some or all of the compounds listed below, however, it is not the individual compounds which form the subject matter of this invention but rather the use of extracts of plant material.
Botanical Name: Kigelia africana (syn. Kigelia pinnata)
INCI Name (CTFA/Linne): Family = Bignoniaceae Genus = Kigelia Species = africana (syn. pinnata)
Parts used: Fruit, bark of the stem and the pendulum
Composition: Iridoids from Kigelia africana Oglucose : Catalpol Iridoids : Specioside Verminoside Minecoside Norviburtinal Naphthaquinoids from Kigelia africana Lapachol Kigelinone 2-acetylnaphtho[2,3-b]furan-4,9-quinone 2-(l-hydroxyethyl)naphtho[2,3-b]furan-4,9-quinone Pinnatal Isopinnatal Kigelinol Isokigelinol Flavonoids & other shikimate-derived compounds from Kigelia africana Quercetin Luteolin 6-OH luteolin Luteolin-7-glucoside 6-OH luteolin-7-glucoside 6-Methoxymellein Kigelin 6-Demethylkigelin Kigeliol Balanophonin β-Sitosterol Stigmasterol γ-Sitosterol
isoWgeliπo
lridoids from Kigelia africana Naphthaquinoids from Kigelia africana
Flavonoids and other shikimate-derived compounds from Kigelia africana
Claims
1. A pharmaceutical and/or cosmetic preparation which contains an extract of one or more parts of Kigelia Africana tree, also known as the Sausage tree.
2. A preparation as claimed in claim 1 , containing one or more parts of the tree selected from fruit, stembark, and pendulum, or a product thereof.
3. A preparation as claimed in any one of the preceding claims, containing 50 mass% extract.
4. A preparation as claimed in any one of the preceding claims, in the form of a cream, an emulsion, an ointment, an aerosol, a powder, a dust, a tincture, a suspension, or a gel for skin application.
5. A preparation as claimed in any one of the preceding claims which is a cream, ointment, or gel containing 50% extract of one or more of the fruit, bark, and pendulum.
6. A preparation as claimed in any one of claims 1 to 3, which is in the form of a capsule, a tablet, a syrup, or a tonic.
7. A method of preparing a topical application medicament and/or cosmetic preparation for the treatment of the skin of a mammal, said method including blending a Kigelia Africana tree fruit extract with a Kigelia Africana tree stembark and/or pendulum extract in a ratio of from 1 :99 to 99:1 by volume.
8. A method as claimed in claim 7, wherein the fruit extract, and stembark and/or pendulum extract are blended in a volumetric ratio of from 1 :9 to 9:1.
9. A method as claimed in claim 7, wherein the fruit extract, and stembark and/or pendulum extract are blended in a volumetric ratio of from 1 :2 to 10:1.
10. A method as claimed in claim 7, wherein for the treatment of solar keratosis, Neurodermitis, precancerous sores, and other ailments of the skin, the fruit extract and stembark and/or pendulum extract is blended in a volumetric ratio of 9:1.
1 1. A method of preparing a topical application medicament and/or cosmetic preparation for the treatment of the skin of a mammal, said method including blending the Kigelia Africana tree fruit extract with skin cream or ointment components.
12. A topical preparation for cuts, bruises, insect bites, stings, and sun exposure of the skin, which preparation contains less than 40% m/m of an extract of one or more parts of the Kigelia Africana, or Sausage Tree.
13. A topical preparation as claimed in claim 12, which preparation is a general pain reliever, an anti-septic, an anti-inflammatory, and/or an anti¬ pruritic.
14. A topical preparation as claimed in claim 12, which preparation is useful in treating fever blisters.
15. A topical preparation as claimed in any one of claims 12 to 14, including one or more of tea tree oil, propylene glycol, and triethanolamine.
16. A topical preparation as claimed in any one of claims 12 to 15, wherein the parts of the tree which are used include fruit, stembark, and pendulum, or a product thereof.
17, A topical preparation as claimed in any one of claims 12 to 16, wherein the preparation contains less than 40 mass% extract.
18. A process for the preparation of an extract from the fruit of the Kigalia Africana tree, the process including: - selecting ripe fruit which are not harbouring insect borers and which are still fresh; - skinning the fruit and de-seeding it so that the skin and seeds are discarded and are not included in the extract; - cutting the skinned, de-seeded fruit into approximatley 3cm-thick slices; - pulping the slices in a mortar or by mechanical means until a stringy mass of pulp is achieved; - passing the pulp through a squeezing-type mincer or equivalent device thus obtaining a dark-coloured soft pulpy mass of thick consistency; - mixing the pulp with ethyl alcohol of about 96% in a ratio of about 3 parts by volume of pulp to 1 part of alcohol; - stirring the mixture thoroughly to achieve maximum extraction; - filtering the stirred mixture; and - storing the filtrate and discarding the filtered solids.
19. A process as claimed in claim 18, wherein the filtrate is stored at about 4°C.
20. A process for the preparation of an extract of the stembark and/or pendulum of the Kigalia Africana tree, the process including: dicing the whole pendulum and/or stripped bark into small pieces of about 2cm thick; covering the diced material with ethyl alcohol for about fourteen days; pulping the mass through a mincer or equivalent device using alcohol as a further extractant, if required for better extraction; squeezing the liquid out of the pulp and remove all the solid particles by filtration.
21. A process as claimed in claim 20, wherein the diced material is covered with alcohol for 14 days at about 4°C.
22. A process as claimed in claim 20 or claim 21 , wherein the filtrate is stored at about 4°C.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA2004/4991 | 2004-06-24 | ||
| ZA200404991 | 2004-06-24 | ||
| ZA2005/2350 | 2005-03-22 | ||
| ZA200502350 | 2005-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2006002443A1 true WO2006002443A1 (en) | 2006-01-05 |
Family
ID=35197933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/ZA2005/000087 WO2006002443A1 (en) | 2004-06-24 | 2005-06-21 | Pharmaceutical or cosmetic preparation based on kigelia africana |
Country Status (1)
| Country | Link |
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| WO (1) | WO2006002443A1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20120027A1 (en) * | 2012-01-12 | 2013-07-13 | New Yemaya Internat Srl | COSMETIC COMPOSITION WITH REVITALIZING ACTION ON THE EPIDERMIDE |
| US8574540B2 (en) | 2008-02-08 | 2013-11-05 | Vale S.A. | Process for manufacturing prefluxed metal oxide from metal hydroxide and metal carbonate precursors |
| WO2014015881A2 (en) | 2012-07-25 | 2014-01-30 | Kimovi Aps | A cosmetic or medical composition with kigelia africana |
| WO2015028035A1 (en) * | 2013-09-02 | 2015-03-05 | Unigroup Aps | Dermatological composition |
| CN104645119A (en) * | 2015-03-15 | 2015-05-27 | 王秀珍 | Preparation method of medicament for treating neurodermatitis in neurosurgery department center |
| CN104667008A (en) * | 2015-03-15 | 2015-06-03 | 王秀珍 | Medicament for treating neurodermatitis in neurosurgical center |
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2005
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| GB1465321A (en) * | 1973-04-17 | 1977-02-23 | Otto H | Production having cytostatic activity and a process for its preparation |
| FR2759910A1 (en) * | 1997-02-24 | 1998-08-28 | Greentech Sa | Cosmetic and dermo-pharmaceutical use of extracts of Kigelia africana |
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