WO2005095972A3 - Diagnostics and therapeutics for diseases associated with g protein-coupled receptor etb (etb) - Google Patents

Diagnostics and therapeutics for diseases associated with g protein-coupled receptor etb (etb) Download PDF

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Publication number
WO2005095972A3
WO2005095972A3 PCT/EP2005/002336 EP2005002336W WO2005095972A3 WO 2005095972 A3 WO2005095972 A3 WO 2005095972A3 EP 2005002336 W EP2005002336 W EP 2005002336W WO 2005095972 A3 WO2005095972 A3 WO 2005095972A3
Authority
WO
WIPO (PCT)
Prior art keywords
etb
disorders
therapeutics
diagnostics
protein
Prior art date
Application number
PCT/EP2005/002336
Other languages
French (fr)
Other versions
WO2005095972A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Holger Summer
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Holger Summer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts, Holger Summer filed Critical Bayer Healthcare Ag
Publication of WO2005095972A2 publication Critical patent/WO2005095972A2/en
Publication of WO2005095972A3 publication Critical patent/WO2005095972A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Abstract

The invention provides a human ETB which is associated with the cardiovascular disorders, neurological disorders, urological disorders, respiratory diseases and inflammatory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, neurological disorders, urological disorders, respiratory diseases and inflammatory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of ETB as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/002336 2004-03-19 2005-03-05 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor etb (etb) WO2005095972A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04006665 2004-03-19
EP04006665.6 2004-03-19

Publications (2)

Publication Number Publication Date
WO2005095972A2 WO2005095972A2 (en) 2005-10-13
WO2005095972A3 true WO2005095972A3 (en) 2006-04-06

Family

ID=34961193

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/002336 WO2005095972A2 (en) 2004-03-19 2005-03-05 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor etb (etb)

Country Status (1)

Country Link
WO (1) WO2005095972A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012009215A (en) * 2010-02-23 2012-11-23 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor.
FR2965810B1 (en) * 2010-10-06 2012-12-28 Commissariat Energie Atomique ANTAGONIST ANTIBODY OF ENDOTHELIN RECEPTOR B-SUBTYPE B AND USES THEREOF
WO2013152076A1 (en) * 2012-04-04 2013-10-10 The Brigham And Women's Hospital, Inc. Compositions and methods for treating hypertension
WO2014022679A2 (en) 2012-08-02 2014-02-06 Genentech, Inc. Anti-etbr antibodies and immunoconjugates
EP2879711A4 (en) 2012-08-02 2016-03-16 Genentech Inc Anti-etbr antibodies and immunoconjugates

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002080960A2 (en) * 2001-04-05 2002-10-17 Medical Research Council Treatment of neuropathologies associated with expression of tnf-alpha
WO2003009805A2 (en) * 2001-07-23 2003-02-06 Brigham And Women's Hospital, Inc. Analgesic methods using endothelin receptor ligands
WO2003039539A2 (en) * 2001-11-09 2003-05-15 Merck Patent Gmbh Use of endothelin receptor antagonists in the treatment of tumour diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002080960A2 (en) * 2001-04-05 2002-10-17 Medical Research Council Treatment of neuropathologies associated with expression of tnf-alpha
WO2003009805A2 (en) * 2001-07-23 2003-02-06 Brigham And Women's Hospital, Inc. Analgesic methods using endothelin receptor ligands
WO2003039539A2 (en) * 2001-11-09 2003-05-15 Merck Patent Gmbh Use of endothelin receptor antagonists in the treatment of tumour diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CARPENTER TODD ET AL: "Endothelin B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression.", CIRCULATION RESEARCH, vol. 93, no. 5, 5 September 2003 (2003-09-05), pages 456 - 463, XP002339617, ISSN: 0009-7330 *
KOHZUKI M ET AL: "ENDOTHELIN RECEPTORS IN ISCHEMIC RAT BRAIN AND ALZHEIMER BRAIN", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, NEW YORK, NY, US, vol. 26, no. SUPPL 3, 1995, pages S329 - S331, XP009023544, ISSN: 0160-2446 *
LEHRKE INGO ET AL: "Renal endothelin-1 and endothelin receptor type B expression in glomerular diseases with proteinuria", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 12, no. 11, November 2001 (2001-11-01), pages 2321 - 2329, XP002339616, ISSN: 1046-6673 *
OUE T ET AL: "Altered endothelin-3 and endothelin-B receptor mRNA expression in Hirschsprung's disease.", JOURNAL OF PEDIATRIC SURGERY. AUG 1999, vol. 34, no. 8, August 1999 (1999-08-01), pages 1257 - 1260, XP009052047, ISSN: 0022-3468 *
YAGAMI T ET AL: "EFFCTS OF ENDOTHELIN B RECEPTOR AGONISTS ON AMYLOID BETA PROTEIN (25-35)-INDUCED NEURONAL CELL DEATH", BRAIN RESEARCH, AMSTERDAM, NL, vol. 948, no. 1/2, 6 September 2002 (2002-09-06), pages 72 - 81, XP001156395, ISSN: 0006-8993 *

Also Published As

Publication number Publication date
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