WO2005113788A3 - Diagnostics and therapeutics for diseases associated with g protein-coupled receptor kinase 6 (grk6) - Google Patents

Diagnostics and therapeutics for diseases associated with g protein-coupled receptor kinase 6 (grk6) Download PDF

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Publication number
WO2005113788A3
WO2005113788A3 PCT/EP2005/004902 EP2005004902W WO2005113788A3 WO 2005113788 A3 WO2005113788 A3 WO 2005113788A3 EP 2005004902 W EP2005004902 W EP 2005004902W WO 2005113788 A3 WO2005113788 A3 WO 2005113788A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
grk6
therapeutics
diagnostics
protein
Prior art date
Application number
PCT/EP2005/004902
Other languages
French (fr)
Other versions
WO2005113788A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Publication of WO2005113788A2 publication Critical patent/WO2005113788A2/en
Publication of WO2005113788A3 publication Critical patent/WO2005113788A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a human GRK6 which is associated with cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, hematological diseases, respiratory diseases, inflammation, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, hematological diseases, respiratory diseases, inflammation, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GRK6 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/004902 2004-05-21 2005-05-06 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor kinase 6 (grk6) WO2005113788A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04012032 2004-05-21
EP04012032.1 2004-05-21

Publications (2)

Publication Number Publication Date
WO2005113788A2 WO2005113788A2 (en) 2005-12-01
WO2005113788A3 true WO2005113788A3 (en) 2006-03-23

Family

ID=35033356

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/004902 WO2005113788A2 (en) 2004-05-21 2005-05-06 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor kinase 6 (grk6)

Country Status (1)

Country Link
WO (1) WO2005113788A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10252984B2 (en) 2011-10-27 2019-04-09 Mayo Foundation For Medical Education And Research Inhibiting G protein coupled receptor 6 kinase polypeptides
EP3134399A4 (en) 2014-04-21 2017-12-27 Mayo Foundation for Medical Education and Research Small molecule inhibitors of g protein coupled receptor 6 kinases polypeptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002079492A2 (en) * 2001-02-14 2002-10-10 Protein Design Labs, Inc. Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators
WO2003105783A2 (en) * 2002-06-12 2003-12-24 Avalon Pharmaceuticals, Inc. Cancer-linked gene as target for chemotherapy
WO2004004451A1 (en) * 2002-07-03 2004-01-15 Duke University Methods of screening compounds for grk6 modulating activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002079492A2 (en) * 2001-02-14 2002-10-10 Protein Design Labs, Inc. Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators
WO2003105783A2 (en) * 2002-06-12 2003-12-24 Avalon Pharmaceuticals, Inc. Cancer-linked gene as target for chemotherapy
WO2004004451A1 (en) * 2002-07-03 2004-01-15 Duke University Methods of screening compounds for grk6 modulating activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 200303, Derwent World Patents Index; Class B04, AN 2003-040681, XP002348549 *

Also Published As

Publication number Publication date
WO2005113788A2 (en) 2005-12-01

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