WO2005075983A3 - Diagnostics and therapeutics for diseases associated with human nuclear receptor nr4a3 (nr4a3) - Google Patents

Diagnostics and therapeutics for diseases associated with human nuclear receptor nr4a3 (nr4a3) Download PDF

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Publication number
WO2005075983A3
WO2005075983A3 PCT/EP2005/000678 EP2005000678W WO2005075983A3 WO 2005075983 A3 WO2005075983 A3 WO 2005075983A3 EP 2005000678 W EP2005000678 W EP 2005000678W WO 2005075983 A3 WO2005075983 A3 WO 2005075983A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
nr4a3
therapeutics
diagnostics
diseases associated
Prior art date
Application number
PCT/EP2005/000678
Other languages
French (fr)
Other versions
WO2005075983A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Publication of WO2005075983A2 publication Critical patent/WO2005075983A2/en
Publication of WO2005075983A3 publication Critical patent/WO2005075983A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins

Abstract

The invention provides a human NR4A3 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, muscle-skeleton disorders, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, muscle-skeleton disorders, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NR4A3 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/000678 2004-02-07 2005-01-25 Diagnostics and therapeutics for diseases associated with human nuclear receptor nr4a3 (nr4a3) WO2005075983A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04002758.3 2004-02-07
EP04002758 2004-02-07

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/964,671 Continuation US7741390B2 (en) 2005-06-23 2007-12-26 Coordination-polymeric triethanolamineperchlorato(triflato)metal inner complexes as additives for synthetic polymers

Publications (2)

Publication Number Publication Date
WO2005075983A2 WO2005075983A2 (en) 2005-08-18
WO2005075983A3 true WO2005075983A3 (en) 2005-10-06

Family

ID=34833575

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/000678 WO2005075983A2 (en) 2004-02-07 2005-01-25 Diagnostics and therapeutics for diseases associated with human nuclear receptor nr4a3 (nr4a3)

Country Status (1)

Country Link
WO (1) WO2005075983A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2152897B1 (en) 2007-06-05 2015-02-18 Melica HB Methods and materials related to hair pigmentation and cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087923A1 (en) * 2000-05-12 2001-11-22 Baylor College Of Medicine Therapeutic approaches to diseases by suppression of the nurr subfamily of nuclear transcription factors
WO2003088812A2 (en) * 2002-04-17 2003-10-30 Baylor College Of Medecine Nor-1 and nur77 nuclear receptors as targets for anti-leukemia therapy
WO2004045369A2 (en) * 2002-11-14 2004-06-03 Nura, Inc. Nuclear receptor-based diagnostic, therapeutic, and screening methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087923A1 (en) * 2000-05-12 2001-11-22 Baylor College Of Medicine Therapeutic approaches to diseases by suppression of the nurr subfamily of nuclear transcription factors
WO2003088812A2 (en) * 2002-04-17 2003-10-30 Baylor College Of Medecine Nor-1 and nur77 nuclear receptors as targets for anti-leukemia therapy
WO2004045369A2 (en) * 2002-11-14 2004-06-03 Nura, Inc. Nuclear receptor-based diagnostic, therapeutic, and screening methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARTINEZ-GONZALEZ J ET AL: "The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells", CARDIOVASCULAR RESEARCH, vol. 65, no. 3, 15 February 2005 (2005-02-15), pages 609 - 618, XP004722369, ISSN: 0008-6363 *
OHKURA N ET AL: "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 211, no. 1, 28 April 1998 (1998-04-28), pages 79 - 85, XP004118682, ISSN: 0378-1119 *

Also Published As

Publication number Publication date
WO2005075983A2 (en) 2005-08-18

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