WO2005108998A3 - Diagnostics and therapeutics for diseases associated with g protein-coupled receptor beta-3 adreno (adrb3) - Google Patents

Diagnostics and therapeutics for diseases associated with g protein-coupled receptor beta-3 adreno (adrb3) Download PDF

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Publication number
WO2005108998A3
WO2005108998A3 PCT/EP2005/004552 EP2005004552W WO2005108998A3 WO 2005108998 A3 WO2005108998 A3 WO 2005108998A3 EP 2005004552 W EP2005004552 W EP 2005004552W WO 2005108998 A3 WO2005108998 A3 WO 2005108998A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorders
diseases
adrb3
adreno
therapeutics
Prior art date
Application number
PCT/EP2005/004552
Other languages
French (fr)
Other versions
WO2005108998A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Holger Summer
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Holger Summer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts, Holger Summer filed Critical Bayer Healthcare Ag
Publication of WO2005108998A2 publication Critical patent/WO2005108998A2/en
Publication of WO2005108998A3 publication Critical patent/WO2005108998A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

The invention provides a human ADRB3 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of ADRB3 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/004552 2004-05-11 2005-04-28 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor beta-3 adreno (adrb3) WO2005108998A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04011153.6 2004-05-11
EP04011153 2004-05-11

Publications (2)

Publication Number Publication Date
WO2005108998A2 WO2005108998A2 (en) 2005-11-17
WO2005108998A3 true WO2005108998A3 (en) 2006-03-16

Family

ID=34965044

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/004552 WO2005108998A2 (en) 2004-05-11 2005-04-28 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor beta-3 adreno (adrb3)

Country Status (1)

Country Link
WO (1) WO2005108998A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107271675B (en) * 2017-03-24 2020-06-02 郑猛 Anti-human ADRB3 monoclonal antibody and application thereof in disease diagnosis and treatment
CN115998883B (en) * 2023-03-21 2023-09-12 中国医学科学院基础医学研究所 Use of CFLAR inhibitors for the treatment of ARID1A deficient tumors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002071070A2 (en) * 2001-02-13 2002-09-12 University Of Florida β-ADRENOCEPTOR GENETIC POLYMORPHISMS AND OBESITY

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002071070A2 (en) * 2001-02-13 2002-09-12 University Of Florida β-ADRENOCEPTOR GENETIC POLYMORPHISMS AND OBESITY

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHANDRAN R ET AL: "Human pressor responses: Heritability estimations in white American twins and genotypic associations at adrenergic loci.", November 2003, AMERICAN JOURNAL OF HUMAN GENETICS, VOL. 73, NR. 5, PAGE(S) 383, 53RD ANNUAL MEETING OF THE AMERICAN SOCIETY OF HUMAN GENETICS; LOS ANGELES, CA, USA; NOVEMBER 04-08, 2003, ISSN: 0002-9297, XP009052340 *

Also Published As

Publication number Publication date
WO2005108998A2 (en) 2005-11-17

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