WO2005095364A8 - フェノキシ酢酸誘導体及びそれを用いた医薬 - Google Patents

フェノキシ酢酸誘導体及びそれを用いた医薬

Info

Publication number
WO2005095364A8
WO2005095364A8 PCT/JP2005/005740 JP2005005740W WO2005095364A8 WO 2005095364 A8 WO2005095364 A8 WO 2005095364A8 JP 2005005740 W JP2005005740 W JP 2005005740W WO 2005095364 A8 WO2005095364 A8 WO 2005095364A8
Authority
WO
WIPO (PCT)
Prior art keywords
same
acid derivative
phenoxyacetic acid
optionally substituted
medicine containing
Prior art date
Application number
PCT/JP2005/005740
Other languages
English (en)
French (fr)
Other versions
WO2005095364A1 (ja
Inventor
Katsuji Kagechika
Yoshihiro Shibata
Hiroyuki Usui
Original Assignee
Daiichi Seiyaku Co
Katsuji Kagechika
Yoshihiro Shibata
Hiroyuki Usui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co, Katsuji Kagechika, Yoshihiro Shibata, Hiroyuki Usui filed Critical Daiichi Seiyaku Co
Priority to EP05727808A priority Critical patent/EP1731513A4/en
Priority to JP2006511645A priority patent/JPWO2005095364A1/ja
Priority to US11/547,283 priority patent/US20070208021A1/en
Publication of WO2005095364A1 publication Critical patent/WO2005095364A1/ja
Publication of WO2005095364A8 publication Critical patent/WO2005095364A8/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

　優れたＰＰＡＲα／γアゴニスト作用を有し、医薬品として望ましい性質を有する新規化合物を提供する。 　一般式（Ｉ）（式中、Ｑは置換されてもよい、ベンゼン環またはピリジン環を示し、Ｒ1およびＲ2は、置換されてもよい、フェニル基または５～６員の芳香族複素環基を示し、Ｘ、ＹおよびＺは、各々独立にＣ、Ｏ、ＳまたはＮを示し、Ｒ3～Ｒ9は水素原子、低級アルキル基等を示し、ｎは０～３の整数を示す）で表されるペルオキシソーム増殖活性化受容体α／γアルゴニスト。
PCT/JP2005/005740 2004-03-30 2005-03-28 フェノキシ酢酸誘導体及びそれを用いた医薬 WO2005095364A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05727808A EP1731513A4 (en) 2004-03-30 2005-03-28 PHENOXYACETIC ACID DERIVATIVE AND MEDICAMENT CONTAINING THE SAME
JP2006511645A JPWO2005095364A1 (ja) 2004-03-30 2005-03-28 フェノキシ酢酸誘導体及びそれを用いた医薬
US11/547,283 US20070208021A1 (en) 2004-03-30 2005-03-28 Phenoxyacetic Acid Derivatives and Drug Comprising The Same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2004-099201 2004-03-30
JP2004099201 2004-03-30
JP2005-015954 2005-01-24
JP2005015954 2005-01-24

Publications (2)

Publication Number Publication Date
WO2005095364A1 WO2005095364A1 (ja) 2005-10-13
WO2005095364A8 true WO2005095364A8 (ja) 2006-01-05

Family

ID=35063695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/005740 WO2005095364A1 (ja) 2004-03-30 2005-03-28 フェノキシ酢酸誘導体及びそれを用いた医薬

Country Status (4)

Country Link
US (1) US20070208021A1 (ja)
EP (1) EP1731513A4 (ja)
JP (1) JPWO2005095364A1 (ja)
WO (1) WO2005095364A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2759112B2 (ja) * 1989-08-15 1998-05-28 ライオン株式会社 粒状洗剤組成物
DK1206457T3 (da) * 1999-08-27 2004-02-16 Lilly Co Eli Biaryl-oxa(thia)zolderivater og deres anvendelse som modulatorer PPAP'ER
TW200528436A (en) * 1999-09-22 2005-09-01 Bristol Myers Squibb Co Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
PE20011010A1 (es) * 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
ES2275887T3 (es) * 2001-06-07 2007-06-16 Eli Lilly And Company Moduladores de receptores activados por proliferadores de peroxisoma (ppar).
JP4383177B2 (ja) * 2002-03-01 2009-12-16 スミスクライン ビーチャム コーポレーション ｈＰＰＡＲ活性化剤
GB0214139D0 (en) * 2002-06-19 2002-07-31 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
US20070208021A1 (en) 2007-09-06
EP1731513A4 (en) 2007-10-31
JPWO2005095364A1 (ja) 2008-02-21
WO2005095364A1 (ja) 2005-10-13
EP1731513A1 (en) 2006-12-13

Similar Documents

Publication Publication Date Title
MXPA04003398A (es) Activador para el receptor o activado con el proliferador de peroxisoma.
NO20054224L (no) Nye 2-pyridinkarboksamidderivater
ATE469160T1 (de) Platinkomplexverbindungen und organische elektrolumineszenzvorrichtung dafür
EP1714958A4 (en) AMIDE DERIVATIVES, PROCESS FOR MANUFACTURING AND METHOD OF APPLICATION AS INSECTICIDE
TW200619199A (en) 3-carbamoyl-2-pyridone derivatives
BRPI0314344B8 (pt) composto 2,3-diidro-6-nitroimidazo[2,1-b]oxazol, composição farmacêutica compreendendo o mesmo e método para produzir um composto
MY141468A (en) 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
EP1496052A4 (en) NEW AMINOBENZAMID DERIVATIVES
MY123337A (en) Oxyiminoalkanoic acid derivatives.
EA200600527A1 (ru) Активирующее ppar соединение и содержащая его фармацевтическая композиция
AU2001277723A1 (en) Ppardelta activators
TW200716528A (en) Cyclopropanecarboxamide derivatives
MX2010008361A (es) Derivados de arilamida oxazepinopirimidona sustituidos.
NO995783D0 (no) Nye cykliske diaminforbindelser og medisiner inneholdende de samme
MXPA05008600A (es) Compuestos para el tratamiento de desordenes metabolicos.
DK1008592T3 (da) Cykliske amidderivater, som inhiberer cathepsin K
EP1394154A4 (en) HETEROCYCLIC DERIVATIVE WITH FIVE MEMBERS OF ALKANOIC ACID
EP1642880A4 (en) PROTEIN INHIBITOR OF THE HSP90 FAMILY
EP1813270A4 (en) PROTEIN INHIBITORS OF THE HSP90 FAMILY
WO2008155670A3 (en) Arylamide pyrimidone compounds
MY140325A (en) Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them
NO20003773L (no) Syklobutenderivater, deres fremstilling og deres terapeutiske anvendelser
WO2003059907A1 (fr) Composes heterocycliques azotes : procede de preparation et d'utilisation
WO2005095364A8 (ja) フェノキシ酢酸誘導体及びそれを用いた医薬
AU755654C (en) Novel amide compounds and drugs containing the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 41/2005 UNDER (72, 75) REPLACE THE EXISTING TEXT BY "KAGECHIKA, KATSUJI [JP/JP]; C/O DAIICHI PHARMACEUTICAL CO., LTD., TOKYO R & D CENTER, 16-13, KITAKASAI 1-CHOME, EDOGAWA-KU, TOKYO 1348630 (JP)., SHIBATA, YOSHIHIRO [JP/JP]; C/O DAIICHI PHARMACEUTICAL CO., LTD., TOKYO R & D CENTER, 16-13, KITAKASAI 1-CHOME, EDOGAWA-KU, TOKYO 1348630 (JP)., USUI, HIROYUKI [JP/JP]; C/O DAIICHI PHARMACEUTICAL CO., LTD., TOKYO R & D CENTER, 16-13, KITAKASAI 1-CHOME, EDOGAWA-KU, TOKYO 1348630 (JP)."

WWE Wipo information: entry into national phase

Ref document number: 200580009800.9

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2006511645

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 11547283

Country of ref document: US

Ref document number: 2005727808

Country of ref document: EP

Ref document number: 2007208021

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Ref document number: DE

WWP Wipo information: published in national office

Ref document number: 2005727808

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 11547283

Country of ref document: US