WO2005082234A1 - Capteur permettant de mesurer un analyte dans l'air exhale - Google Patents

Capteur permettant de mesurer un analyte dans l'air exhale Download PDF

Info

Publication number
WO2005082234A1
WO2005082234A1 PCT/US2004/002440 US2004002440W WO2005082234A1 WO 2005082234 A1 WO2005082234 A1 WO 2005082234A1 US 2004002440 W US2004002440 W US 2004002440W WO 2005082234 A1 WO2005082234 A1 WO 2005082234A1
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
disposable
sensing element
analyte
sensor according
Prior art date
Application number
PCT/US2004/002440
Other languages
English (en)
Inventor
Bryan Flaherty
Bhairavi Parikh
Kevin Nason
David Chazan
John Kaiser
Jonathan Fay
Original Assignee
Aperon Biosystems Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/334,625 external-priority patent/US20040017570A1/en
Application filed by Aperon Biosystems Corp. filed Critical Aperon Biosystems Corp.
Publication of WO2005082234A1 publication Critical patent/WO2005082234A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/783—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour for analysing gases

Definitions

  • This invention relates to sensors for use in measuring an analyte or analytes in a gaseous sample.
  • nitric oxide (NO) concentration in exhaled breath can indicate a change in the level of inflammation in the airway of an asthmatic, indicating an increase in the likelihood of an asthmatic attack.
  • Excessive carbon monoxide (CO) can indicate hemolytic jaundice, and high levels of hydrogen can indicate carbohydrate malabsorption.
  • breath analysis can be used by law enforcement officials and others to test for the concentration of alcohol in a subject's breath.
  • breath analysis could be used to manage chronic diseases such as asthma. Indeed, some of the present inventors have developed both a device (U.S. Ser. No. 10/334,625) for quantifying breath analytes, and a method for managing asthma by monitoring NO levels (U.S. Ser. No. 10/659,408). The disclosures of these applications are incorporated herein by reference as if set out in full.
  • a necessary part of any portable breath analysis system is the sensor that responds in some way to the analyte in the subject's breath.
  • sensors that are appropriate for a portable system are not re-usable or may require calibration or user intervention to function adequately.
  • the present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing surrounding said sensing element.
  • the housing need not be a disposable component, but could be integrated into the reusable portion of the system.
  • Fig. 1 is a perspective view of a disposable sensor according to an embodiment of the present invention.
  • Fig. 2 is an exploded perspective view of a disposable sensor according to an embodiment of the present invention.
  • Fig. 3 is a cross-sectional view of a disposable sensor according to an embodiment of the present invention, showing the sensor as it is being attached to gas analysis device.
  • Fig. 4 is a close-up of the circled area on Fig. 3.
  • Fig. 5 depicts the sequence of assembling and packaging a disposable sensor according to an embodiment of the present invention.
  • Fig. 6 is an exploded perspective view of a disposable sensor according to an embodiment of the present invention, in which the sensor has only a single sensing element and a single cell.
  • Fig. 7 is an exploded perspective view of a disposable sensor according to an embodiment of the present invention, in which the sensor has two sensing elements and a single cell.
  • Fig. 8 is a perspective view of a disposable sensing element and a gas analysis device with a sensor housing and door according to an embodiment of the present invention.
  • Figs. 9a - 9c depict the operation of a non-reuse tab in a disposable sensor according to an embodiment of the present invention.
  • Fig. 10 depicts a disposable sensor with interface means according to an embodiment of the present invention being installed into a gas analysis device.
  • Fig. 11 is a close up of the sensor and sensor recess as depicted in Fig. 10.
  • Fig. 12 is a perspective view of a sensor with diffusion ports, with its housing cover removed, according to an embodiment of the present invention.
  • Fig. 13 depicts a sensor with electrical pads, according to an embodiment of the present invention, as it is being installed into the housing recess of a gas analysis device.
  • Fig. 14 is a close-up cross section of the sensing element, electrical pads, and electrical pins of the sensor and gas analysis device shown in Fig. 13.
  • the present invention is a disposable sensor comprising a sensing element 10, a means for interfacing 20 the disposable sensor with a gas analysis device, and a housing 30.
  • the sensing element 10 responds in some quantifiable way to the concentration of an analyte or analytes in the gaseous sample.
  • the sensing element is a sol-gel matrix that encapsulates cytochrome-c, which reacts with gaseous NO to produce an optically quantifiable change in the sensing element.
  • cytochrome-c cytochrome-c
  • Other potential sensing elements for analysis of NO include other bioactive materials encapsulated within a sol-gel, such as hemoglobin(3+ or 2+ or 0 2 ), myoglobin(3+, 2+ or 0 2 ), other heme-binding proteins, porphyrin group-containing proteins, heme group-containing proteins, dye-labeled porphyrin group-containing proteins, dye-labeled heme group-containing proteins, and fragments thereof. These materials could be configured to respond in an optically quantifiable manner, or could be configured to respond by a different transduction mechanism, such as electrical impedance or surface acoustic waves.
  • Other suitable sensing materials include organics, inorganics or synthetics that would respond to the analyte in a quantifiable manner.
  • sensing methods could be used to detect clinically relevant analytes that are present in exhaled breath. These include electrical (impedance, conductance, or resistive)), chemical (electrochemical, spectrophotometric including absorbance, transmission, scattering, reflectance and fluorescence) and acoustic (surface acoustic wave).
  • electrochemistry could be use to detect a wide variety of relevant analytes including hydrogen, nitric oxide, carbon monoxide, provided that the electrochemical sensing element could be inexpensive enough to be practical for a disposable sensor, and also provided that the clinically-required measurement specifications could be met.
  • the disposable sensor could be configured to detect one or more analytes in the exhaled breath. Whenever this patent refers to measurement or analysis of an analyte, such a reference also includes measurement or analysis of more than one analyte.
  • the sensing element 10 typically has at least two parts: one or more sensing materials (such as cytochrome-c), and a substrate (such as a sol-gel matrix).
  • the sensing material is the molecule that reacts or responds in a quantifiable way to the gas sample or gas sample in the housing 30 surrounding it.
  • the substrate is the carrier or base for the sensing element. It might be (i) a liquid that can hold the bioactive sensing compound in suspension, emulsion or dissolved, or (ii) a polymer or glass that immobilizes the sensing compound.
  • Suitable immobilization agents include sol-gels, sol-gel hybrids (ormosils), Polyvinyl alcohol, Polymethylmethacrylate, polydimethylsiloxane, glass, or related compounds. Any polymer or immobilization agent that allows reaction of the sensing compound with the gas can be used.
  • the sensing element 10 responds in a quantifiable way to the analyte or analytes of interest.
  • the cytochrome-c complex adds a NO adduct, its spectral peak red-shifts in the blue region of the spectrum, and this change can be detected.
  • optically-quantifiable characteristics include but are not limited to color, absorption, transmission, reflectance, scattering, luminescence, fluorescence, or phosphorescence.
  • the disposable sensor has an interface means 20 for interfacing with an appropriate gas analysis device, such as the device described in U.S. Ser. No. 10/334,625. See Figs. 10 and 11.
  • This interface means 20 ensures that the sensor is properly aligned and installed into the device.
  • This means 20 could take the form of a slot or recess 96 in the device, and the sensor would be shaped appropriately to fit into the slot 96. See Figs. 10 and 11.
  • the slot 96 would be configured to allow alignment of the transparent portion 64a, 64b, 66a, 66b of the sensor housing 30 with the optical transducers that would be used to measure the change in the optical characteristics of the sensor. See Figs. 10 and 11.
  • the slot and the sensor could be configured into a shape that would prevent incorrect insertion of the sensor such as an "L" shape or a triangle, or the shape depicted in Figs. 10 and 11.
  • the slot and sensor could have a detent and tab combination positioned such that the sensor is locked into place when it is correctly positioned within the device.
  • the gas analysis device could have a hinged or sliding door 70 that would secure and position the sensor in place when closed. See Figs. 8, 10 and 11.
  • the sensor may also have alignment aids to ensure that the sensor is properly installed. These alignment aids may take the form of locating pins and holes, guiding rails, hand stops, precise pockets etc., and these aids may be in either the device or the sensor.
  • a bayonet structure, a screw-on structure, or a peg-structure could be used to secure the sensor to the gas analysis device, so that the optical components are properly aligned.
  • the sensing element 10 could be mounted on a sensing element holder 36 within the housing 30, and the housing 30 creates at least one chamber or cell 32 to contain the gaseous sample. See Figs. 2, 3, 4, 6, 7, 8, and 12.
  • the housing 30 also protects the sensing element, from the time that it is manufactured until the time that is used, from exposure to the analyte or other gasses that may interfere with its performance.
  • the housing will have a transparent portion (window) 64a, 64b, 66a, 66b to facilitate detection of the optical changes to the sensing element 10.
  • the housing would have the appropriate detector interface mechanism for that transduction mechanism.
  • the sensing element were electro-chemical
  • the sensor may have electrical leads or pads 80 that would allow the analyzer to measure the current or charge produced by the sensor. See Figs. 13 and 14. These leads or pad would contact electrical pins or electrodes 100 in the gas analysis device 90. See Figs. 13 and 14. Electrical contact would be made when the housing 30 is correctly placed within the housing recess 98 of the gas analysis device 90. See Figs. 13 and 14.
  • the housing 30 will also have an inlet port or ports 38, 40 for entry of the gaseous sample and an outlet port or ports 46, 48 for exit of the gas. See Figs. 2, 3, 6, 7, 9a - 9c, and 12. If necessary to protect the sensing elements fro ambient gasses, these ports could have protective covers 42, 44, 50, 52 that would be punctured, removed or otherwise opened when the sensor was ready to perform a measurement. See Figs.
  • the inlet and outlet tubes 92, 94 of the device would be inserted into the ports to allow the device to flow a gaseous sample through the sensor housing, and if the ports had protective covers these tubes could be made from stainless steel and be sharpened to facilitate puncturing of the covers. See Fig.
  • the protective cover could be made of a relatively impermeable membrane such as polymer-foil laminate material or polymer film to prevent the diffusion of interfering gasses into the housing. If protection from the environment was not required to maintain the performance of the sensor the housing could be substantially built into the analyzer rather than part of the disposable. See Fig. 8.
  • the housing 30 may also have a cover 62 that in conjunction with sealed inlet and outlet ports seals and protects the sensor and creates an enclosed, controllable environment within the gas cell or cells.. See Fig. 2.
  • the sensor also may have means for sealing the ports 38, 40, 6, 48 after opening so that the sensor is ready for use.
  • the housing 30 will typically be small, but obviously it must be large enough to hold the sensing element 10, and should be sized so that it can be easily inserted into the gas analysis device 90. In one embodiment, where the exhaled gas is trapped in the housing for the measurement, the sensor housing 30 must be large enough to hold a sufficient quantity of exhaled gas so that the concentration of the analyte does not decrease appreciably during the measurement process. If the volume is too small the sensing element 10 could use a significant portion of the analyte reducing the amplitude of the sensing element's response and, in turn, reducing the sensitivity of device.
  • the volume of the measurement sample inside the housing should be larger than approximately 3 milliliters. If the exhaled gas is allowed to flow past the sensing element 10 during the measurement procedure, then the size of the housing 30 is not limited in this fashion. All or part of the housing need not be disposable and the inlet and outlet ports can attach to the disposable or non-disposable parts of the housing.
  • the housing 30 could be made of many different materials, such as polycarbonate, acrylic, fluorocarbon polymer, polypropylene, polystyrene, glass, or metal and should be inert to the analyte that is being measured.
  • the transparent portions of the housing (windows) 64a, 64b, 66a, 66b could be placed within recesses 68, 69, thereby placing the windows out of the reach of the user's fingers.
  • Other protective embodiments include a window lining that is removable prior to insertion or is self- removed upon insertion, covering the window with ribs /mesh or building up the wall around the windows to prevent smudges or other optical interferences.
  • the sensor may also have a use limitation means 82 for ensuring that it is not reused more than a certain number of times, or after removal from the gas analysis device, or after an expiration date. See Figs. 2, 9a - 9c.
  • the use limitation means 82 could be an information storage device containing a code, such as an integrated circuit (such as an EEPROM or RF tag) or a magnetic strip or bar code.
  • the gas analysis device could read that code, and prevent or discourage reuse after the code has been used a certain number of times (such as once, or 30 times).
  • the code could indicate an expiration date, and the gas analysis device could prevent or discourage use of any sensor installed after its installation date.
  • the use limitation means 82 could also be mechanical or electrical, such as a tab 72 that is sensed mechanically prior to use and then broken or perforated during the measurement process. See Figs. 9a - 9c. Or the use limitation means 82 could be a single-use electrical fuse that is burned during use, or a mechanism that senses the force required to puncture the inlet or outlet protective covers of the housing, or a system that interfaces with either the inlet or outlet ports and then draws and measures a vacuum or pressure leaks inside the housing, thereby identifying sensors that have been already used once. Finally, the use limitations means 82 could include a device for obtaining a spectral measurement to monitor a baseline level that is consistent with a reaction with nitric oxide.
  • Another feature of the present invention is the ability to provide pre-calibrated disposable sensors to the user, thereby eliminating the requirement that the analyzer be periodically calibrated by the user. This provides a significant advantage to the user because calibration typically requires a cumbersome and difficult procedure whereby certified gases are injected into the device in order to determine calibration coefficients that are used in the calculation of the analyte concentration during a test.
  • the calibration coefficients can be determined at the factory for each sensor. Depending on the repeatability of the manufacturing process, calibration coefficients could be determined for a batch of sensors or, if necessary, for each individual sensor.
  • the calibration coefficients or code corresponding to a lookup table could then be printed on the sensor packaging so that they can be entered into the analyzer and used for the calculation of the analyte concentration.
  • a batch of sensors could be provided with a calibration code that, when entered into the device, could be used as an index in a lookup table to find the appropriate coefficients.
  • the calibration coefficients could be stored in an EEPROM, RF tag or magnetic strip in the sensor that could be read by the gas analysis device 90 prior to use. See Fig. 2.
  • the sensor could have a calibration resistor or capacitor (or combination) whose value or values would be read by the gas analysis device 90 and used to calculate or look up the coefficients.
  • the analyzer could read a bar code printed on the sensor and use that code to look up coefficients.
  • the sensor could have an optical code such as a precise aperture that is read by the analyzer and then converted to calibration coefficient. It is also possible that the device will take an initial measurement of the sensor prior to breath introduction and this will be used to calibrate the device.
  • calibration information includes but is not limited to any of the foregoing methods of providing calibration data to the gas analysis device 90 or user. See Figs. 1, 2.
  • the sensor housing could contain a sample conditioning unit or units 54, 56 that filter out unwanted substances from the exhaled breath or other gaseous sample. See Figs. 2, 3. These sample conditioning units could fit into the sample conditioning unit recesses 58, 60 in the housing 30. See Figs. 2, 3, 6, 7, 12.
  • the sensor housing could contain a desiccant such as zeolite to remove water vapor from the sample. Other "gettering" or filtering materials could be used to remove interferents from the sample stream.
  • activated charcoal or silica gels could be used to remove alcohols or other polar molecules
  • potassium permanganate in combination with charcoal could be used to remove NO and other oxides of nitrogen
  • zeolites could be used to remove a variety of gasses based on their molecular size.
  • the sample conditioning units 54, 56 could also be used to maintain a storage environment for the sensing element.
  • the sample conditioning units 54, 56 could include "art sorb” (a material designed to maintain a fixed humidity over a wide range of environmental conditions), a saturated salt solution that maintains a fixed humidity, or a desiccant to remove water vapor from the interior of the housing. If equilibration with the environment is required, National, or equivalent, tubing could be incorporated into the device to equilibrate with room humidity and temperature. When separate sensing elements are used to measure different analytes, different sample conditioning units 54, 56 could be used for each analyte.
  • the sensor may also have a system or systems for ensuring that the integrity of the measurement is not compromised by "noise” or other extraneous signals.
  • a common approach to reducing the amount of noise in a measurement is to take a differential measurement. In its simplest implementation this technique requires two channels, one that responds to both the measurement of interest and the noise or interference and one channel that responds primarily to the source of noise. In other, more complicated implementations the signal of interest is reconstructed via a mathematical manipulation of two or more channels. For example, if the two channels respond to the noise in a similar manner but the reference channel has a different gain, the reference channel could be scaled prior to subtraction to better cancel the noise signal. This concept can be extrapolated such that one or both of the channels can be mathematically transformed by linear, nonlinear, time dependent and time varying functions to remove noise from the measurement. There are many common accepted mathematical techniques to determine the transformation required to separate signal from the noise.
  • one channel could contain the sensing element in its path while the second channel does not.
  • the channel without the sensing element would respond to noise caused by variations in the light output or changes in ambient conditions while the channel with the sensing element would respond to the same "common mode" noise as well as the changes caused by the analyte.
  • the ratio of the two signals could be measured or the signals could be scaled appropriately and then subtracted.
  • sensing elements 10, 12 could be used, one in each of the cells 32, 34, or both in the same cell 32, where one element has been treated so that it does not respond to the analyte but does respond to other interfering signals. See Figs. 2 and 7.
  • Examples of such treatment include chemically, thermally, electrically or photonically denaturing the sensing material, coating the sensing element with a material that is not permeable to the analyte such as National, removing the cytochrome c from the sensing element, modifying the cytochrome-c structure to make it unresponsive to the analyte or using a sensing material that responds similarly to interferents (such as a porphyrin ring or similar protein) but not to the analyte.
  • a material that is not permeable to the analyte such as National
  • removing the cytochrome c from the sensing element modifying the cytochrome-c structure to make it unresponsive to the analyte or using a sensing material that responds similarly to interferents (such as a porphyrin ring or similar protein) but not to the analyte.
  • the gas sample could be split into two separate gas cells 32, 34, where the analyte is selectively removed from one cell so that both channels respond to potential interfering gases in addition to other noise sources (like light intensity , variations) while one channel responds to the analyte as well.
  • Nitric oxide could be removed by using a potassium permanganate filter to react the NO to produce NOx and charcoal to remove the NOx, or a zeolite could be used to trap the NO.
  • one gas cell may have a sample conditioning unit 54 or both cells may have different sample conditioners.
  • the diffusion ports 76, 78 can take the form apertures in a sensing element barrier 74 which shields the sensing element 12 from the bulk of the sample inside the gas cell 32, 34, as shown in Fig. 12. Packaging
  • sensing elements need to be stored in precisely controlled environments to maintain their sensitivity to the analyte at the desired level during storage.
  • cytochrome-c encapsulated in a sol gel matrix has different sensitivity to NO depending on the level of ambient water vapor present.
  • the water vapor concentration may also play a role in maintaining the sensitivity of the sensor over time and could be important in determining the shelf -life of the sensor. It might also be necessary to protect the sensor from the ambient levels of the analyte.
  • a storage compound 112 such as a desiccant and /or a saturated salt solution may need to be placed in the storage pouch 110 for the sensor. See Fig. 5.
  • the storage compound may need to be stored with each individual sensor or with groups of sensors in their primary packaging 110, particularly if the pouch is re-sealable.
  • the primary packaging can then be in the secondary packaging 120. See Fig. 5
  • the sensing element will need to have certain performance characteristics.
  • the sensing element may have a measurement range of 0 - 200 ppb, with a minimum detection limit of 5 ppb, and a resolution of 2.5 ppb.
  • the user would insert the disposable sensor into the device, and then use a breath-sampling system to transport the breath to the sensor housing. Breath analysis would then occur one or more times, and afterwards, the user would remove and dispose of the sensor.
  • the sensor may be used to perform more than one measurement. Subsequently, upon next use, the user would install a new sensor. No tools would typically be required to install or remove the disposable sensor.
  • the sensor of the present invention is disposable, but that does not mean that it must necessarily be disposed of after a single use. Instead, for purposes of the present patent, "disposable" merely denotes that the sensor should not be used more than thirty times, and that it should not be re-used after removal from the device.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un capteur jetable utilisé avec un dispositif qui quantifie des analytes dans un échantillon gazeux. Ledit capteur comprend: i) un élément de détection (10), ii) des moyens (20) permettant d'établir une interface entre l'élément de détection (10) et un dispositif d'analyse de gaz, et iii) un logement (30). Lorsqu'on l'utilise avec un dispositif qui peut quantifier la concentration d'un analyte dans un échantillon gazeux, l'invention facilite l'emploi de l'analyse d'air exhalé comme outil clinique.
PCT/US2004/002440 2002-12-30 2004-01-28 Capteur permettant de mesurer un analyte dans l'air exhale WO2005082234A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/334,625 US20040017570A1 (en) 2002-07-23 2002-12-30 Device and system for the quantification of breath gases

Publications (1)

Publication Number Publication Date
WO2005082234A1 true WO2005082234A1 (fr) 2005-09-09

Family

ID=34910598

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002440 WO2005082234A1 (fr) 2002-12-30 2004-01-28 Capteur permettant de mesurer un analyte dans l'air exhale

Country Status (1)

Country Link
WO (1) WO2005082234A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013115933A1 (fr) * 2012-02-01 2013-08-08 Invoy Technologies, Llc Système de mesure d'analytes du souffle
WO2016024808A1 (fr) * 2014-08-12 2016-02-18 Samsung Electronics Co., Ltd. Appareil de diagnostic in vitro, et procédé de diagnostic in vitro exécuté par l'appareil de diagnostic in vitro
US9636044B2 (en) 2012-02-01 2017-05-02 Invoy Technologies, Llc Breath analyzer with expandable range of measurement
US9689864B2 (en) 2012-02-01 2017-06-27 Invoy Technologies, Llc Method and apparatus for rapid quantification of an analyte in breath
US9848075B1 (en) 2015-05-14 2017-12-19 Invoy Technologies, Llc Communication system for pairing user devices with medical devices
US10068494B2 (en) 2016-10-14 2018-09-04 Invoy Holdings, Llc Artificial intelligence based health coaching based on ketone levels of participants
US10226201B2 (en) 2015-10-29 2019-03-12 Invoy Holdings, Llc Flow regulation device for breath analysis and related method
US10278617B1 (en) 2013-03-15 2019-05-07 Invoy Holdings, Llc Method and apparatus for sensing ammonia in breath
US10278640B2 (en) 2014-07-23 2019-05-07 Invoy Holdings, Llc Breath ketone measurement system with analysis unit that communicates with mobile application
US10285642B2 (en) 2016-02-03 2019-05-14 Invoy Holdings, Llc Breath analysis device with watch band that holds breath analysis cartridges
US10343170B2 (en) 2010-03-19 2019-07-09 Invoy Holdings, Llc Breath analyte sensing apparatus that generates gas streams that #flow over a nanoparticle-based sensor
US10352940B2 (en) 2012-05-15 2019-07-16 Invoy Holdings, Llc Method and apparatus for analyzing acetone in breath
US10694978B2 (en) 2015-05-14 2020-06-30 Invoy Holdings, Llc Breath analysis system, device and method employing nanoparticle-based sensor
US10736548B2 (en) 2016-05-18 2020-08-11 Invoy Holdings, Inc. Ketone measurement system for monitoring medical conditions

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317156A (en) * 1992-01-29 1994-05-31 Sri International Diagnostic tests using near-infrared laser absorption spectroscopy
US6076392A (en) * 1997-08-18 2000-06-20 Metasensors, Inc. Method and apparatus for real time gas analysis
US6095986A (en) * 1998-07-28 2000-08-01 Square One Technology, Inc. Disposable anti-fog airway adapter
US6419634B1 (en) * 1996-03-28 2002-07-16 Nitromed, Inc. Condensate colorimetric nitrogen oxide analyzer
US6479019B1 (en) * 1999-04-15 2002-11-12 Quantum Group, Inc. Sensor and sensor assembly for detecting a target gas in a breath sample
US20030105407A1 (en) * 2001-11-30 2003-06-05 Pearce, Edwin M. Disposable flow tube for respiratory gas analysis
US6632402B2 (en) * 2001-01-24 2003-10-14 Ntc Technology Inc. Oxygen monitoring apparatus

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317156A (en) * 1992-01-29 1994-05-31 Sri International Diagnostic tests using near-infrared laser absorption spectroscopy
US6419634B1 (en) * 1996-03-28 2002-07-16 Nitromed, Inc. Condensate colorimetric nitrogen oxide analyzer
US6076392A (en) * 1997-08-18 2000-06-20 Metasensors, Inc. Method and apparatus for real time gas analysis
US6095986A (en) * 1998-07-28 2000-08-01 Square One Technology, Inc. Disposable anti-fog airway adapter
US6479019B1 (en) * 1999-04-15 2002-11-12 Quantum Group, Inc. Sensor and sensor assembly for detecting a target gas in a breath sample
US6632402B2 (en) * 2001-01-24 2003-10-14 Ntc Technology Inc. Oxygen monitoring apparatus
US20030105407A1 (en) * 2001-11-30 2003-06-05 Pearce, Edwin M. Disposable flow tube for respiratory gas analysis

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10343170B2 (en) 2010-03-19 2019-07-09 Invoy Holdings, Llc Breath analyte sensing apparatus that generates gas streams that #flow over a nanoparticle-based sensor
US10589277B2 (en) 2010-03-19 2020-03-17 Invoy Holdings, Llc Breath analyte sensing apparatus that generates gas streams that flow over a nanoparticle-based sensor
WO2013115933A1 (fr) * 2012-02-01 2013-08-08 Invoy Technologies, Llc Système de mesure d'analytes du souffle
US9689864B2 (en) 2012-02-01 2017-06-27 Invoy Technologies, Llc Method and apparatus for rapid quantification of an analyte in breath
US9636044B2 (en) 2012-02-01 2017-05-02 Invoy Technologies, Llc Breath analyzer with expandable range of measurement
US11977079B2 (en) 2012-05-15 2024-05-07 Invoy Holdings Inc. Method and apparatus for analyzing acetone in breath
US11353462B2 (en) 2012-05-15 2022-06-07 Invoy Holdings Inc. Method and apparatus for analyzing acetone in breath
US10352940B2 (en) 2012-05-15 2019-07-16 Invoy Holdings, Llc Method and apparatus for analyzing acetone in breath
US10278617B1 (en) 2013-03-15 2019-05-07 Invoy Holdings, Llc Method and apparatus for sensing ammonia in breath
US11832963B2 (en) 2014-07-23 2023-12-05 Invoy Holdings Inc. Breath analysis system
US11779271B2 (en) 2014-07-23 2023-10-10 Invoy Holdings Inc. Breath analysis system with measurement tagging interface
US10278640B2 (en) 2014-07-23 2019-05-07 Invoy Holdings, Llc Breath ketone measurement system with analysis unit that communicates with mobile application
US10433786B2 (en) 2014-07-23 2019-10-08 Invoy Holdings, Llc Breath ketone measurements system capable of detecting ketone measurement patterns associated with program non-compliance events
US11253194B2 (en) 2014-07-23 2022-02-22 Invoy Holdings Inc. Analyte measurement analysis using baseline levels
US9874498B2 (en) 2014-08-12 2018-01-23 Samsung Electronics Co., Ltd. In-vitro diagnostic apparatus and in-vitro diagnostic method performed by in-vitro diagnostic apparatus
WO2016024808A1 (fr) * 2014-08-12 2016-02-18 Samsung Electronics Co., Ltd. Appareil de diagnostic in vitro, et procédé de diagnostic in vitro exécuté par l'appareil de diagnostic in vitro
US9848075B1 (en) 2015-05-14 2017-12-19 Invoy Technologies, Llc Communication system for pairing user devices with medical devices
US10750004B2 (en) 2015-05-14 2020-08-18 Invoy Holdings Inc. Communication system for pairing user devices with medical devices
US10694978B2 (en) 2015-05-14 2020-06-30 Invoy Holdings, Llc Breath analysis system, device and method employing nanoparticle-based sensor
US11696702B2 (en) 2015-05-14 2023-07-11 Invoy Holdings Inc. Breath analysis system, device and method employing nanoparticle-based sensor
US11806128B2 (en) 2015-10-29 2023-11-07 Invoy Holdings Inc. Breath analysis device
US10226201B2 (en) 2015-10-29 2019-03-12 Invoy Holdings, Llc Flow regulation device for breath analysis and related method
US10285642B2 (en) 2016-02-03 2019-05-14 Invoy Holdings, Llc Breath analysis device with watch band that holds breath analysis cartridges
US11819340B2 (en) 2016-02-03 2023-11-21 Invoy Holdings Inc. Portable device for measuring ketone levels
US10736548B2 (en) 2016-05-18 2020-08-11 Invoy Holdings, Inc. Ketone measurement system for monitoring medical conditions
US10068494B2 (en) 2016-10-14 2018-09-04 Invoy Holdings, Llc Artificial intelligence based health coaching based on ketone levels of participants
US11170662B2 (en) 2016-10-14 2021-11-09 Invoy Holdings Inc. Artificial intelligence based health coaching based on ketone levels of participants

Similar Documents

Publication Publication Date Title
US7220387B2 (en) Disposable sensor for use in measuring an analyte in a gaseous sample
US7803322B2 (en) Universal optical imaging and processing system
WO2005082234A1 (fr) Capteur permettant de mesurer un analyte dans l'air exhale
JP2768899B2 (ja) 液体サンプルに含有される化合物の分析システム
EP1488736B1 (fr) Boîtier de lecture et de traitement de réactifs de diagnostiques et procédé d'utilisation
JP2010503422A (ja) 最適組立空間を有する携帯式測定システム
JP5529823B2 (ja) 気体検体の検出器中の一酸化炭素干渉の低減
US6319375B1 (en) Apparatus for identifying a gas
EP0901634B1 (fr) Systeme de determination d'au moins un parametre d'au moins un echantillon d'un liquide physiologique et cassette
JP5185596B2 (ja) 液体中の汚染物質の検出方法
US6435003B1 (en) Method of identifying a gas and associated apparatus
US5346604A (en) Self-activating chemical sensor system
WO1994019683A1 (fr) Cartouche de mesure electrochimique jetable
JP2009216651A (ja) 多項目検出装置
JPS6256839A (ja) ガス状媒体用の拡散試料採集装置
JPS59135365A (ja) 検出管
US11982669B2 (en) Flow test unit, kit, and use of a flow test unit for performing a detection reaction
KR20050044586A (ko) 유체 분석기 시스템
JP3750310B2 (ja) ガス発生量簡易試験方法
US20080319682A1 (en) Method and System For Operating In-Situ (Sampling) Chemical Sensors
US20060191321A1 (en) Trace gas sensor with reduced degradation
Peach et al. Air sampling and analysis for gases and vapors
CN217587022U (zh) 一种样品检测装置
KR20020094096A (ko) 비색법을 이용한 대기나 배기가스 중의 질소산화물의측정장치 및 측정방법
Chludziński et al. System of breath collection and analysis for diseases detection

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase