WO2005074389A1 - ビタミンｄ化合物及びそれらの合成中間体の合成方法 - Google Patents

ビタミンｄ化合物及びそれらの合成中間体の合成方法

Info

Publication number
WO2005074389A1
WO2005074389A1 PCT/JP2005/001586 JP2005001586W WO2005074389A1 WO 2005074389 A1 WO2005074389 A1 WO 2005074389A1 JP 2005001586 W JP2005001586 W JP 2005001586W WO 2005074389 A1 WO2005074389 A1 WO 2005074389A1
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
synthesis
vitamin
intermediates
aldehyde
Prior art date
Application number
PCT/JP2005/001586
Other languages
English (en)
French (fr)
Other versions
WO2005074389A2 (ja
WO2005074389A3 (ja
Inventor
Hirotaka Kashiwagi
Yoshiyuki Ono
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to US10/588,201 priority Critical patent/US9221753B2/en
Priority to JP2005517719A priority patent/JP4795023B2/ja
Publication of WO2005074389A1 publication Critical patent/WO2005074389A1/ja
Publication of WO2005074389A2 publication Critical patent/WO2005074389A2/ja
Publication of WO2005074389A3 publication Critical patent/WO2005074389A3/ja

Links

Abstract

　本発明の目的は、簡単な操作で低コストにビタミンＤ化合物を合成する方法を提供することである。 　本発明により、（ａ）ケトンまたはアルデヒドと、ウィッティッヒ試薬と、塩基とを混合する工程；または、（ｂ）ケトンまたはアルデヒドとウィッティッヒ試薬とを混合し、得られた混合物に塩基を加える工程；を含む、ビタミンＤ化合物およびその合成中間体の製造方法が提供される。                                                                               
PCT/JP2005/001586 2004-02-03 2005-02-03 ビタミンｄ化合物及びそれらの合成中間体の合成方法 WO2005074389A2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/588,201 US9221753B2 (en) 2004-02-03 2005-02-03 Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
JP2005517719A JP4795023B2 (ja) 2004-02-03 2005-02-03 ビタミンｄ化合物及びそれらの合成中間体の合成方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004026291 2004-02-03
JP2004-026291 2004-02-03

Publications (3)

Publication Number Publication Date
WO2005074389A1 true WO2005074389A1 (ja) 2005-08-18
WO2005074389A2 WO2005074389A2 (ja) 2005-08-18
WO2005074389A3 WO2005074389A3 (ja) 2005-10-06

Family

ID=34835841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/001586 WO2005074389A2 (ja) 2004-02-03 2005-02-03 ビタミンｄ化合物及びそれらの合成中間体の合成方法

Country Status (3)

Country Link
US (1) US9221753B2 (ja)
JP (1) JP4795023B2 (ja)
WO (1) WO2005074389A2 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2001842B1 (en) * 2006-04-06 2012-06-06 Wisconsin Alumni Research Foundation 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof
JP2010505739A (ja) * 2006-04-06 2010-02-25 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１α，２５−ジヒドロキシ−１９，２１−ジノルビタミンＤ３類縁体およびその使用
BRPI0715636A2 (pt) * 2006-08-29 2013-07-02 Teva Pharma composiÇÕes farmacologicamente ativas estÁveis incluindo compostos contendo vitamina d e corticosteràide com compatibilidade para ph baixo
US20080171728A1 (en) * 2007-01-12 2008-07-17 Quatrx Pharmaceuticals Co. Efficient Process for Preparing Steroids and Vitamin D Derivatives With the Unnatural Configuration at C20 (20 Alpha-Methyl) from Pregnenolone
US20120130133A1 (en) * 2008-11-26 2012-05-24 Cytochroma Inc. Method For Synthesizing Vitamin D Analogs
WO2011002756A2 (en) * 2009-07-01 2011-01-06 Vitamin Derivatives, Inc. Vitamin d compounds and methods for preparing same
US9416102B2 (en) * 2013-01-23 2016-08-16 Wisconsin Alumni Research Foundation (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
DE69005897D1 (de) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferolderivate.
PE28297A1 (es) * 1995-01-26 1997-08-20 Hoffmann La Roche Empleo dermatologico de derivados de vitamina d
PT980354E (pt) 1997-04-28 2002-10-31 Hoffmann La Roche Analogos de vitamina d3 com cadeias laterais bis-c-20
US6030962A (en) * 1997-04-28 2000-02-29 Synttex (U.S.A.) Inc. Vitamin D3 analogs with bis C-20 side chains
JPH10316652A (ja) 1997-05-02 1998-12-02 Duphar Internatl Res Bv １６−デヒドロビタミンｄ化合物の製造方法
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln

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