WO2005052132A3 - Utilisation de modulateurs de la morphogenese de ramification comme genes modificateurs de la morphogenese de ramification et leurs procedes d'utilisation - Google Patents

Utilisation de modulateurs de la morphogenese de ramification comme genes modificateurs de la morphogenese de ramification et leurs procedes d'utilisation Download PDF

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Publication number
WO2005052132A3
WO2005052132A3 PCT/US2004/039790 US2004039790W WO2005052132A3 WO 2005052132 A3 WO2005052132 A3 WO 2005052132A3 US 2004039790 W US2004039790 W US 2004039790W WO 2005052132 A3 WO2005052132 A3 WO 2005052132A3
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WO
WIPO (PCT)
Prior art keywords
branching morphogenesis
methods
mbms
modifiers
mbm
Prior art date
Application number
PCT/US2004/039790
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English (en)
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WO2005052132A2 (fr
Inventor
Gregory D Plowman
Felix D Karim
Candance Swimmer
Hinrich Alexander Habeck
Thomas I Koblizek
Stefan Schulte-Merker
Ulrike Langheinrich
Gordon Mark Stott
Torsten Trowe
Andreas Michael Vogel
Joerg Heinrich Odenthal
Jochen Konrad Scheel
Torsten Tilmann Will
Yisheng Jin
Lynn Margaret Bjerke
Kathryn Swan
Original Assignee
Exelixis Inc
Gregory D Plowman
Felix D Karim
Candance Swimmer
Hinrich Alexander Habeck
Thomas I Koblizek
Stefan Schulte-Merker
Ulrike Langheinrich
Gordon Mark Stott
Torsten Trowe
Andreas Michael Vogel
Joerg Heinrich Odenthal
Jochen Konrad Scheel
Torsten Tilmann Will
Yisheng Jin
Lynn Margaret Bjerke
Kathryn Swan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Gregory D Plowman, Felix D Karim, Candance Swimmer, Hinrich Alexander Habeck, Thomas I Koblizek, Stefan Schulte-Merker, Ulrike Langheinrich, Gordon Mark Stott, Torsten Trowe, Andreas Michael Vogel, Joerg Heinrich Odenthal, Jochen Konrad Scheel, Torsten Tilmann Will, Yisheng Jin, Lynn Margaret Bjerke, Kathryn Swan filed Critical Exelixis Inc
Publication of WO2005052132A2 publication Critical patent/WO2005052132A2/fr
Publication of WO2005052132A3 publication Critical patent/WO2005052132A3/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention a trait à des gènes modulateurs de la morphogenèse de ramification humains identifiés en tant que modulateurs de la morphogenèse de ramification, constituant ainsi des cibles thérapeutiques pour des troubles associés à une fonction déficiente de la morphogenèse de ramification. L'invention a également trait à des procédés pour l'identification de modulateurs de la morphogenèse de ramification, comprenant le criblage pour des agents de modulation de l'activité de modulation de la morphogenèse de ramification.
PCT/US2004/039790 2003-11-24 2004-11-22 Utilisation de modulateurs de la morphogenese de ramification comme genes modificateurs de la morphogenese de ramification et leurs procedes d'utilisation WO2005052132A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52455003P 2003-11-24 2003-11-24
US60/524,550 2003-11-24

Publications (2)

Publication Number Publication Date
WO2005052132A2 WO2005052132A2 (fr) 2005-06-09
WO2005052132A3 true WO2005052132A3 (fr) 2007-06-07

Family

ID=34632906

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2004/039790 WO2005052132A2 (fr) 2003-11-24 2004-11-22 Utilisation de modulateurs de la morphogenese de ramification comme genes modificateurs de la morphogenese de ramification et leurs procedes d'utilisation
PCT/US2004/039550 WO2005051320A2 (fr) 2003-11-24 2004-11-23 Gck utilises comme modificateurs de la morphogenese de ramification et leurs methodes d'utilisation
PCT/US2004/039408 WO2005051314A2 (fr) 2003-11-24 2004-11-23 Genes irak utilises en tant que modificateurs de morphogenese de ramification et procedes d'utilisation associes

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2004/039550 WO2005051320A2 (fr) 2003-11-24 2004-11-23 Gck utilises comme modificateurs de la morphogenese de ramification et leurs methodes d'utilisation
PCT/US2004/039408 WO2005051314A2 (fr) 2003-11-24 2004-11-23 Genes irak utilises en tant que modificateurs de morphogenese de ramification et procedes d'utilisation associes

Country Status (1)

Country Link
WO (3) WO2005052132A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0809069D0 (en) 2008-05-19 2008-06-25 Univ Leuven Kath Gene signatures
EP2294053B1 (fr) 2008-05-16 2016-01-06 Takeda California, Inc. Activateurs de la glucokinase
EP2388317B1 (fr) * 2009-01-07 2017-08-30 Hangzhou Yiyuan Biotechnology Co. Ltd. Un gène codant pour un mutant de la glucokinase humaine, et son utilisation dans le traitement et le prévention des maladies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020026037A1 (en) * 1995-06-06 2002-02-28 Jing-Shan Hu Vascular endothelial growth factor 3 antibodies
US6365356B1 (en) * 1999-03-17 2002-04-02 Cornell Research Foundation, Inc. Receptors that regulate cell signaling relating to chemokines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654397A (en) * 1985-06-23 1997-08-05 Tularik, Inc. Interleukin-1 receptor-associated protein kinase and assays
JPH06506596A (ja) * 1991-04-10 1994-07-28 ザ　トラスティーズ　オブ　ボストン　ユニバーシティー インターロイキン−８受容体及び関連分子及び方法
WO1997000690A1 (fr) * 1995-06-23 1997-01-09 Tularik, Inc. Proteine kinase associee au recepteur de l'interleukine-1 et dosages
US20030064917A1 (en) * 1998-07-23 2003-04-03 Crawford Susan E. Methods and compositions for inhibiting angiogenesis
US6818419B2 (en) * 2000-01-13 2004-11-16 Tularik Inc. IRAK-4: compositions and methods of use
ATE483976T1 (de) * 2001-06-05 2010-10-15 Exelixis Inc Gfats als modifikatoren des p53-wegs und verwendungsverfahren
WO2003046139A2 (fr) * 2001-11-26 2003-06-05 Exelixis, Inc. Genes crb en tant que modificateurs de la morphogenese ramifiee et ses methodes d'utilisation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020026037A1 (en) * 1995-06-06 2002-02-28 Jing-Shan Hu Vascular endothelial growth factor 3 antibodies
US6365356B1 (en) * 1999-03-17 2002-04-02 Cornell Research Foundation, Inc. Receptors that regulate cell signaling relating to chemokines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SITTAMPALAM G.S. ET AL.: "High-Throuhgput Screening: Advances in Assay Technologies", CURR. OPIN. CHEM. BIOL., vol. 1, 1997, pages 384 - 391, XP002939332 *

Also Published As

Publication number Publication date
WO2005051320A2 (fr) 2005-06-09
WO2005051314A2 (fr) 2005-06-09
WO2005051320A3 (fr) 2006-10-12
WO2005052132A2 (fr) 2005-06-09
WO2005051314A3 (fr) 2007-04-26

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