WO2005051314A3 - Genes irak utilises en tant que modificateurs de morphogenese de ramification et procedes d'utilisation associes - Google Patents

Genes irak utilises en tant que modificateurs de morphogenese de ramification et procedes d'utilisation associes Download PDF

Info

Publication number
WO2005051314A3
WO2005051314A3 PCT/US2004/039408 US2004039408W WO2005051314A3 WO 2005051314 A3 WO2005051314 A3 WO 2005051314A3 US 2004039408 W US2004039408 W US 2004039408W WO 2005051314 A3 WO2005051314 A3 WO 2005051314A3
Authority
WO
WIPO (PCT)
Prior art keywords
branching morphogenesis
methods
iraks
modifiers
irak
Prior art date
Application number
PCT/US2004/039408
Other languages
English (en)
Other versions
WO2005051314A2 (fr
Inventor
Hinrich Alexander Habeck
Felix D Karim
Thomas I Koblizek
Ulrike Langheinrich
Gregory D Plowman
Stefan Schulte-Merker
Gordon Mark Stott
Candace Swimmer
Original Assignee
Exelixis Inc
Trowe Torsten
Vogel Andreas Michael
Jin Yisheng
Scheel Jochen Konrad
Odenthal Jorg Heinrich
Will Torsten Tilmann
Bjerke Lynn Margaret
Heuer Timothy S
Hinrich Alexander Habeck
Felix D Karim
Thomas I Koblizek
Ulrike Langheinrich
Gregory D Plowman
Stefan Schulte-Merker
Gordon Mark Stott
Candace Swimmer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Trowe Torsten, Vogel Andreas Michael, Jin Yisheng, Scheel Jochen Konrad, Odenthal Jorg Heinrich, Will Torsten Tilmann, Bjerke Lynn Margaret, Heuer Timothy S, Hinrich Alexander Habeck, Felix D Karim, Thomas I Koblizek, Ulrike Langheinrich, Gregory D Plowman, Stefan Schulte-Merker, Gordon Mark Stott, Candace Swimmer filed Critical Exelixis Inc
Publication of WO2005051314A2 publication Critical patent/WO2005051314A2/fr
Publication of WO2005051314A3 publication Critical patent/WO2005051314A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des gènes IRAK humains identifiés en tant que modulateurs de morphogenèse de ramification, qui constituent par conséquent des agents thérapeutiques destinés au traitement de troubles associés à une fonction déficiente de morphogenèse de ramification. L'invention concerne également des procédés d'identification de modulateurs de morphogenèse de ramification, qui consistent à cribler des agents qui modulent l'activité des gènes IRAK.
PCT/US2004/039408 2003-11-24 2004-11-23 Genes irak utilises en tant que modificateurs de morphogenese de ramification et procedes d'utilisation associes WO2005051314A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52455003P 2003-11-24 2003-11-24
US60/524,550 2003-11-24

Publications (2)

Publication Number Publication Date
WO2005051314A2 WO2005051314A2 (fr) 2005-06-09
WO2005051314A3 true WO2005051314A3 (fr) 2007-04-26

Family

ID=34632906

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2004/039790 WO2005052132A2 (fr) 2003-11-24 2004-11-22 Utilisation de modulateurs de la morphogenese de ramification comme genes modificateurs de la morphogenese de ramification et leurs procedes d'utilisation
PCT/US2004/039550 WO2005051320A2 (fr) 2003-11-24 2004-11-23 Gck utilises comme modificateurs de la morphogenese de ramification et leurs methodes d'utilisation
PCT/US2004/039408 WO2005051314A2 (fr) 2003-11-24 2004-11-23 Genes irak utilises en tant que modificateurs de morphogenese de ramification et procedes d'utilisation associes

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2004/039790 WO2005052132A2 (fr) 2003-11-24 2004-11-22 Utilisation de modulateurs de la morphogenese de ramification comme genes modificateurs de la morphogenese de ramification et leurs procedes d'utilisation
PCT/US2004/039550 WO2005051320A2 (fr) 2003-11-24 2004-11-23 Gck utilises comme modificateurs de la morphogenese de ramification et leurs methodes d'utilisation

Country Status (1)

Country Link
WO (3) WO2005052132A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0809069D0 (en) 2008-05-19 2008-06-25 Univ Leuven Kath Gene signatures
BRPI0912802A2 (pt) 2008-05-16 2015-10-13 Takeda San Diego Inc ativadores de glicoquinase
AP3277A (en) * 2009-01-07 2015-05-31 Haidong Huang Gene encoding human glucokinase mutant, enzyme encoded by the same, recombinant vectors and hosts, pharmaceutical compositions and uses thereof, methods for treating and preventing diseases

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018641A1 (fr) * 1991-04-10 1992-10-29 The Trustees Of Boston University Recepteurs d'interleukine 8, molecules et procedes apparentes
WO1997000690A1 (fr) * 1995-06-23 1997-01-09 Tularik, Inc. Proteine kinase associee au recepteur de l'interleukine-1 et dosages
US5654397A (en) * 1985-06-23 1997-08-05 Tularik, Inc. Interleukin-1 receptor-associated protein kinase and assays
US20020192695A1 (en) * 2001-06-05 2002-12-19 Lori Friedman PIBs as modifiers of the p53 pathway and methods of use
US20030059916A1 (en) * 2000-01-13 2003-03-27 Holger Wesche IRAK-4: compositions and methods of use
US20030064917A1 (en) * 1998-07-23 2003-04-03 Crawford Susan E. Methods and compositions for inhibiting angiogenesis
US20030100005A1 (en) * 2001-11-26 2003-05-29 Karim Felix D. CRBs as modifiers of branching morphogenesis and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020026037A1 (en) * 1995-06-06 2002-02-28 Jing-Shan Hu Vascular endothelial growth factor 3 antibodies
US6365356B1 (en) * 1999-03-17 2002-04-02 Cornell Research Foundation, Inc. Receptors that regulate cell signaling relating to chemokines

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654397A (en) * 1985-06-23 1997-08-05 Tularik, Inc. Interleukin-1 receptor-associated protein kinase and assays
WO1992018641A1 (fr) * 1991-04-10 1992-10-29 The Trustees Of Boston University Recepteurs d'interleukine 8, molecules et procedes apparentes
WO1997000690A1 (fr) * 1995-06-23 1997-01-09 Tularik, Inc. Proteine kinase associee au recepteur de l'interleukine-1 et dosages
US20030064917A1 (en) * 1998-07-23 2003-04-03 Crawford Susan E. Methods and compositions for inhibiting angiogenesis
US20030059916A1 (en) * 2000-01-13 2003-03-27 Holger Wesche IRAK-4: compositions and methods of use
US20020192695A1 (en) * 2001-06-05 2002-12-19 Lori Friedman PIBs as modifiers of the p53 pathway and methods of use
US20030100005A1 (en) * 2001-11-26 2003-05-29 Karim Felix D. CRBs as modifiers of branching morphogenesis and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AURON P.E.: "The interleukin 1 receptor: ligand interactions and signal transduction", CYTOKINE & GROWTH FACTOR REVIEWS, vol. 9, no. 3/4, 1998, pages 221 - 237, XP003010748 *

Also Published As

Publication number Publication date
WO2005051320A3 (fr) 2006-10-12
WO2005052132A2 (fr) 2005-06-09
WO2005052132A3 (fr) 2007-06-07
WO2005051314A2 (fr) 2005-06-09
WO2005051320A2 (fr) 2005-06-09

Similar Documents

Publication Publication Date Title
WO2007002080A3 (fr) Eya2s utilises comme modificateurs de la voie de pten/akt et leurs procedes d'utilisation
WO2003045321A3 (fr) Mbm en tant que modificateurs de morphogenese par ramification et procedes d'utilisation
WO2003006614A3 (fr) Ube2 en tant qu'agents de modification du passage p21 et procedes permettant leur utilisation
WO2006009962A3 (fr) Acacs utilises comme genes modificateurs de la voie igf et leurs procedes d'utilisation
WO2005016287A3 (fr) Prkwnk utilises en tant que modificateurs de la voie rac et methodes d'utilisation associees
WO2004038371A3 (fr) Ccr8 (recepteur de chimiokines 8) utilise comme modificateur d'une morphogenese de ramification et procedes d'utilisation
WO2005002418A3 (fr) Mpten en tant que modulateurs du passage pten/igf et procedes d'utilisation
WO2005051314A3 (fr) Genes irak utilises en tant que modificateurs de morphogenese de ramification et procedes d'utilisation associes
WO2004066948A3 (fr) Mapcax en tant que modificateurs des voies apc et axine et procedes d'utilisation associes
WO2005003297A3 (fr) Genes mpten utilises en tant que modificateurs de la voie pten/igf et procedes d'utilisation associes
WO2004024882A3 (fr) Flj20647 utilise en tant que modificateur de la voie p21 et procedes d'utilisation associes
WO2005090992A3 (fr) Genes mpten modifiant le trajet pten, et procedes d'utilisation
WO2005072470A3 (fr) Genes mbm en tant que modificateurs de la morphogenese de ramification et methodes d'utilisation
WO2004005483A3 (fr) Adcy3s modificateurs de la voie p21 et methodes d'utilisation
WO2004037990A3 (fr) Genes mbm en tant que modificateurs de la morphogenese ramifiee et leurs procedes d'utilisation
WO2004005484A3 (fr) Snrks utilises comme modificateurs de chk et de la morphogenese de branchement et leurs procedes d'utilisation
WO2005017123A3 (fr) Mptens utilises comme modificateurs de la voie pten et procedes d'utilisation
WO2003045314A3 (fr) Mhyps comme modificateurs de morphogenese de ramification et procedes d'utilisation
WO2005003303A3 (fr) Genes nadk utilises comme modificateurs de la morphogenese de ramification et procedes d'utilisation
WO2004014301A3 (fr) Genes psmc utilises comme modificateurs du trajet retiniblastome (rb) et techniques d'utilisation
WO2004015071A3 (fr) Genes csnk1gs utilises en tant que modificateurs de la voie p21 et procede d'utilisation associe
WO2004048538A3 (fr) Caseine kinases modifiant la voie rac et leurs procedes d'utilisation
WO2004005486A3 (fr) Genes mp21 utilises comme modificateurs de la voie p21 et leurs procedes d'utilisation
WO2004024891A3 (fr) Genes mbm en tant que modificateurs de la morphogenese ramifiee et leurs procedes d'utilisation
WO2005001026A3 (fr) Adenosines kinases en tant que modificateurs de la voie pten et leurs procedes d'utilisation

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase