WO2005037865A3 - Ztnfr14, A TUMOR NECROSIS FACTOR RECEPTOR - Google Patents

Ztnfr14, A TUMOR NECROSIS FACTOR RECEPTOR Download PDF

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Publication number
WO2005037865A3
WO2005037865A3 PCT/US2004/034375 US2004034375W WO2005037865A3 WO 2005037865 A3 WO2005037865 A3 WO 2005037865A3 US 2004034375 W US2004034375 W US 2004034375W WO 2005037865 A3 WO2005037865 A3 WO 2005037865A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
necrosis factor
factor receptor
tumor necrosis
ztnfr14
Prior art date
Application number
PCT/US2004/034375
Other languages
French (fr)
Other versions
WO2005037865A2 (en
Inventor
Brian A Fox
James L Holloway
Paul O Sheppard
Stacey R Dillon
Original Assignee
Zymogenetics Inc
Brian A Fox
James L Holloway
Paul O Sheppard
Stacey R Dillon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Brian A Fox, James L Holloway, Paul O Sheppard, Stacey R Dillon filed Critical Zymogenetics Inc
Priority to EP04795522A priority Critical patent/EP1673390A2/en
Priority to JP2006535407A priority patent/JP2008500804A/en
Priority to CA002542482A priority patent/CA2542482A1/en
Publication of WO2005037865A2 publication Critical patent/WO2005037865A2/en
Publication of WO2005037865A3 publication Critical patent/WO2005037865A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.
PCT/US2004/034375 2003-10-16 2004-10-18 Ztnfr14, A TUMOR NECROSIS FACTOR RECEPTOR WO2005037865A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP04795522A EP1673390A2 (en) 2003-10-16 2004-10-18 Ztnfr14, A TUMOR NECROSIS FACTOR RECEPTOR
JP2006535407A JP2008500804A (en) 2003-10-16 2004-10-18 ztnfr14, tumor necrosis factor receptor
CA002542482A CA2542482A1 (en) 2003-10-16 2004-10-18 Ztnfr14, a tumor necrosis factor receptor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51169803P 2003-10-16 2003-10-16
US60/511,698 2003-10-16
US61955204P 2004-10-18 2004-10-18
US60/619,652 2004-10-18

Publications (2)

Publication Number Publication Date
WO2005037865A2 WO2005037865A2 (en) 2005-04-28
WO2005037865A3 true WO2005037865A3 (en) 2005-08-04

Family

ID=34468001

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/034375 WO2005037865A2 (en) 2003-10-16 2004-10-18 Ztnfr14, A TUMOR NECROSIS FACTOR RECEPTOR

Country Status (1)

Country Link
WO (1) WO2005037865A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9028822B2 (en) 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor
GB0410021D0 (en) * 2004-05-05 2004-06-09 Celltech R&D Ltd A protein involved in cancer
CA2649387A1 (en) * 2006-04-19 2008-03-27 Genentech, Inc. Novel gene disruptions, compositions and methods relating thereto
WO2008140565A2 (en) * 2006-11-08 2008-11-20 Zymogenetics, Inc. Use of tumor necrosis factor receptor 14 antagonists for treating psoriasis
NZ582815A (en) 2007-08-03 2012-07-27 Abbott Biotherapeutics Corp Therapeutic use of anti- tweak receptor antibodies to treat cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004001A1 (en) * 1997-07-21 1999-01-28 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-5
WO1999011790A1 (en) * 1997-09-04 1999-03-11 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-6
WO2001098353A2 (en) * 2000-06-20 2001-12-27 Incyte Genomics, Inc. Secreted proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004001A1 (en) * 1997-07-21 1999-01-28 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-5
WO1999011790A1 (en) * 1997-09-04 1999-03-11 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-6
WO2001098353A2 (en) * 2000-06-20 2001-12-27 Incyte Genomics, Inc. Secreted proteins

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BODMER J-L ET AL: "The molecular architecture of the TNF superfamily", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 27, no. 1, 1 January 2002 (2002-01-01), pages 19 - 26, XP004332356, ISSN: 0968-0004 *
DATABASE EMBL 16 September 2003 (2003-09-16), XP002317141, retrieved from EBI Database accession no. AK000591 *
DATABASE EMBL 17 September 2003 (2003-09-17), XP002317143, retrieved from EBI Database accession no. BC008788 *
DATABASE EMBL 7 June 2002 (2002-06-07), XP002317186, retrieved from EBI Database accession no. AX402506 *
DATABASE UniProt 1 December 2001 (2001-12-01), XP002317185, retrieved from EBI Database accession no. Q96HA4 *
DATABASE UniProt 1 October 2000 (2000-10-01), XP002317142, retrieved from EBI Database accession no. Q9NWV0 *

Also Published As

Publication number Publication date
WO2005037865A2 (en) 2005-04-28

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