WO2003059281A3 - Novel variants of rankl protein - Google Patents

Novel variants of rankl protein Download PDF

Info

Publication number
WO2003059281A3
WO2003059281A3 PCT/US2003/000393 US0300393W WO03059281A3 WO 2003059281 A3 WO2003059281 A3 WO 2003059281A3 US 0300393 W US0300393 W US 0300393W WO 03059281 A3 WO03059281 A3 WO 03059281A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel variants
rankl protein
rankl
variants
novel
Prior art date
Application number
PCT/US2003/000393
Other languages
French (fr)
Other versions
WO2003059281A9 (en
WO2003059281A2 (en
Inventor
John R Desjarlais
Rene S Hubert
Jamal El Yazal
Shannon Alicia Marshall
Original Assignee
Xencor Inc
John R Desjarlais
Rene S Hubert
Jamal El Yazal
Shannon Alicia Marshall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc, John R Desjarlais, Rene S Hubert, Jamal El Yazal, Shannon Alicia Marshall filed Critical Xencor Inc
Priority to AU2003217174A priority Critical patent/AU2003217174A1/en
Priority to EP03713210A priority patent/EP1560843A4/en
Priority to US10/611,363 priority patent/US7381792B2/en
Publication of WO2003059281A2 publication Critical patent/WO2003059281A2/en
Publication of WO2003059281A9 publication Critical patent/WO2003059281A9/en
Publication of WO2003059281A3 publication Critical patent/WO2003059281A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to novel, soluble, recombinant variants RANKL (Receptor Actovator of Nuclear Factor -kB ligand) proteins, which may be expressed solubly in E. coli, variants that act as RANKL antagonists, and methods for generating the same.
PCT/US2003/000393 2002-01-04 2003-01-06 Novel variants of rankl protein WO2003059281A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003217174A AU2003217174A1 (en) 2002-01-04 2003-01-06 Novel variants of rankl protein
EP03713210A EP1560843A4 (en) 2002-01-04 2003-01-06 Novel variants of rankl protein
US10/611,363 US7381792B2 (en) 2002-01-04 2003-07-01 Variants of RANKL protein

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US34580502P 2002-01-04 2002-01-04
US60/345,805 2002-01-04
US37345302P 2002-04-17 2002-04-17
US60/373,453 2002-04-17
US37403502P 2002-04-19 2002-04-19
US60/374,035 2002-04-19

Publications (3)

Publication Number Publication Date
WO2003059281A2 WO2003059281A2 (en) 2003-07-24
WO2003059281A9 WO2003059281A9 (en) 2004-04-22
WO2003059281A3 true WO2003059281A3 (en) 2005-06-02

Family

ID=32096834

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/000393 WO2003059281A2 (en) 2002-01-04 2003-01-06 Novel variants of rankl protein

Country Status (3)

Country Link
EP (1) EP1560843A4 (en)
AU (1) AU2003217174A1 (en)
WO (1) WO2003059281A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166559A1 (en) 2002-01-04 2003-09-04 Desjarlais John R. Dominant negative proteins and methods thereof
US7381792B2 (en) 2002-01-04 2008-06-03 Xencor, Inc. Variants of RANKL protein
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
DE102004014983A1 (en) * 2004-03-26 2005-10-20 Univ Stuttgart Recombinant polypeptides of the members of the TNF ligand family and their use
WO2005113598A2 (en) * 2004-05-21 2005-12-01 Xencor, Inc. Tnf super family members with altered immunogenicity
CN104059141B (en) * 2014-04-14 2017-09-12 江苏省原子医学研究所 A kind of structure of mouse RANKL mutant and its expression vector, expression and application
US9914761B2 (en) 2014-07-10 2018-03-13 Washington University Oligomers for TNF superfamily inhibition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242213B1 (en) * 1996-12-23 2001-06-05 Immunex Corporation Isolated DNA molecules encoding RANK-L

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID28386A (en) * 1998-09-15 2001-05-17 M & E Biotech As METHOD OF DECREASE IN LIGAN OSTEOPROTEGERIN ACTIVITIES
US7300774B1 (en) * 1999-12-09 2007-11-27 The Regents Of The University Of California Multimeric fusion proteins of the TNF superfamily ligands
AR025984A1 (en) * 1999-10-07 2002-12-26 Maxygen Aps SIMPLE CHAIN OLIGOMERIC POLYPEPTIDES
AU4541101A (en) * 2000-03-02 2001-09-12 Xencor Inc Design and discovery of protein based tnf-alpha variants for the treatment of tnf-alpha related disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242213B1 (en) * 1996-12-23 2001-06-05 Immunex Corporation Isolated DNA molecules encoding RANK-L

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1560843A4 *

Also Published As

Publication number Publication date
EP1560843A4 (en) 2006-09-06
AU2003217174A8 (en) 2003-07-30
AU2003217174A1 (en) 2003-07-30
WO2003059281A9 (en) 2004-04-22
WO2003059281A2 (en) 2003-07-24
EP1560843A2 (en) 2005-08-10

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