WO2006049983A3 - Peptide yy modified transferrin fusion proteins - Google Patents

Peptide yy modified transferrin fusion proteins Download PDF

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Publication number
WO2006049983A3
WO2006049983A3 PCT/US2005/038531 US2005038531W WO2006049983A3 WO 2006049983 A3 WO2006049983 A3 WO 2006049983A3 US 2005038531 W US2005038531 W US 2005038531W WO 2006049983 A3 WO2006049983 A3 WO 2006049983A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
peptide
transferrin fusion
modified transferrin
modified
Prior art date
Application number
PCT/US2005/038531
Other languages
French (fr)
Other versions
WO2006049983A2 (en
Inventor
Christopher P Prior
Homayoun Sadeghi
David J Ballance
Andrew Turner
Original Assignee
Biorexis Pharmaceutical Corp
Christopher P Prior
Homayoun Sadeghi
David J Ballance
Andrew Turner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorexis Pharmaceutical Corp, Christopher P Prior, Homayoun Sadeghi, David J Ballance, Andrew Turner filed Critical Biorexis Pharmaceutical Corp
Publication of WO2006049983A2 publication Critical patent/WO2006049983A2/en
Publication of WO2006049983A3 publication Critical patent/WO2006049983A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif

Abstract

Modified fusion proteins of transferring and therapeutic proteins or peptides including, with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor.
PCT/US2005/038531 2004-10-27 2005-10-27 Peptide yy modified transferrin fusion proteins WO2006049983A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62214704P 2004-10-27 2004-10-27
US60/622,147 2004-10-27

Publications (2)

Publication Number Publication Date
WO2006049983A2 WO2006049983A2 (en) 2006-05-11
WO2006049983A3 true WO2006049983A3 (en) 2007-02-01

Family

ID=36319627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/038531 WO2006049983A2 (en) 2004-10-27 2005-10-27 Peptide yy modified transferrin fusion proteins

Country Status (1)

Country Link
WO (1) WO2006049983A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129504B2 (en) 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
NZ555464A (en) * 2004-12-02 2010-03-26 Domantis Ltd Bispecific domain antibodies targeting serum albumin and glp-1 or pyy
EP2046826B1 (en) 2006-07-24 2011-09-14 Biorexis Pharmaceutical Corporation Exendin fusion proteins
KR20090098880A (en) 2006-12-12 2009-09-17 바이오렉시스 파마슈티칼 코포레이션 Transferrin fusion protein libraries
EP4089169A1 (en) 2009-10-12 2022-11-16 Larry J. Smith Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
CN110105453A (en) 2011-08-17 2019-08-09 科罗拉多大学董事会法人团体 Transferrin-tumor chalone fused protein and its generation and application method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PARKER S.L. ET AL.: "Agonist internalization by cloned Y1 neuropeptide (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling", REGULATORY PEPTIDES, vol. 107, 2002, pages 49 - 62, XP003006298 *

Also Published As

Publication number Publication date
WO2006049983A2 (en) 2006-05-11

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